Long-term mortality in HIV patients virally suppressed for more than three years with incomplete CD4 recovery: A cohort study
Background The mortality in patients with persistent low CD4 count despite several years of HAART with sustained viral suppression is poorly documented. We aimed to identify predictors for inadequate CD4 cell recovery and estimate mortality in patients with low CD4 count but otherwise successful HAA...
Saved in:
| Published in: | BMC infectious diseases Vol. 10; no. 1; p. 318 |
|---|---|
| Main Authors: | , , , , , , , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
London
BioMed Central
02.11.2010
BioMed Central Ltd Springer Nature B.V BMC |
| Subjects: | |
| ISSN: | 1471-2334, 1471-2334 |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Abstract | Background
The mortality in patients with persistent low CD4 count despite several years of HAART with sustained viral suppression is poorly documented. We aimed to identify predictors for inadequate CD4 cell recovery and estimate mortality in patients with low CD4 count but otherwise successful HAART.
Method
In a nationwide cohort of HIV patients we identified all individuals who started HAART before 1 January 2005 with CD4 cell count ≤ 200 cells/μL and experienced three years with sustained viral suppression. Patients were categorized according to CD4 cell count after the three years suppressed period (≤ 200 cells/μL; immunological non-responders (INRs), >200 cells/μL; immunological responders (IRs)). We used logistic regression and Kaplan-Meier analysis to estimated risk factors and mortality for INRs compared to IRs.
Results
We identified 55 INRs and 236 IRs. In adjusted analysis age > 40 years and > one year from first CD4 cell count ≤ 200 cells/μL to start of the virologically suppressed period were associated with increased risk of INR. INRs had substantially higher mortality compared to IRs. The excess mortality was mainly seen in the INR group with > one year of immunological suppression prior to viral suppression and injection drug users (IDUs).
Conclusion
Age and prolonged periods of immune deficiency prior to successful HAART are risk factors for incomplete CD4 cell recovery. INRs have substantially increased long-term mortality mainly associated with prolonged immunological suppression prior to viral suppression and IDU. |
|---|---|
| AbstractList | The mortality in patients with persistent low CD4 count despite several years of HAART with sustained viral suppression is poorly documented. We aimed to identify predictors for inadequate CD4 cell recovery and estimate mortality in patients with low CD4 count but otherwise successful HAART.BACKGROUNDThe mortality in patients with persistent low CD4 count despite several years of HAART with sustained viral suppression is poorly documented. We aimed to identify predictors for inadequate CD4 cell recovery and estimate mortality in patients with low CD4 count but otherwise successful HAART.In a nationwide cohort of HIV patients we identified all individuals who started HAART before 1 January 2005 with CD4 cell count ≤ 200 cells/μL and experienced three years with sustained viral suppression. Patients were categorized according to CD4 cell count after the three years suppressed period (≤ 200 cells/μL; immunological non-responders (INRs), >200 cells/μL; immunological responders (IRs)). We used logistic regression and Kaplan-Meier analysis to estimated risk factors and mortality for INRs compared to IRs.METHODIn a nationwide cohort of HIV patients we identified all individuals who started HAART before 1 January 2005 with CD4 cell count ≤ 200 cells/μL and experienced three years with sustained viral suppression. Patients were categorized according to CD4 cell count after the three years suppressed period (≤ 200 cells/μL; immunological non-responders (INRs), >200 cells/μL; immunological responders (IRs)). We used logistic regression and Kaplan-Meier analysis to estimated risk factors and mortality for INRs compared to IRs.We identified 55 INRs and 236 IRs. In adjusted analysis age > 40 years and > one year from first CD4 cell count ≤ 200 cells/μL to start of the virologically suppressed period were associated with increased risk of INR. INRs had substantially higher mortality compared to IRs. The excess mortality was mainly seen in the INR group with > one year of immunological suppression prior to viral suppression and injection drug users (IDUs).RESULTSWe identified 55 INRs and 236 IRs. In adjusted analysis age > 40 years and > one year from first CD4 cell count ≤ 200 cells/μL to start of the virologically suppressed period were associated with increased risk of INR. INRs had substantially higher mortality compared to IRs. The excess mortality was mainly seen in the INR group with > one year of immunological suppression prior to viral suppression and injection drug users (IDUs).Age and prolonged periods of immune deficiency prior to successful HAART are risk factors for incomplete CD4 cell recovery. INRs have substantially increased long-term mortality mainly associated with prolonged immunological suppression prior to viral suppression and IDU.CONCLUSIONAge and prolonged periods of immune deficiency prior to successful HAART are risk factors for incomplete CD4 cell recovery. INRs have substantially increased long-term mortality mainly associated with prolonged immunological suppression prior to viral suppression and IDU. The mortality in patients with persistent low CD4 count despite several years of HAART with sustained viral suppression is poorly documented. We aimed to identify predictors for inadequate CD4 cell recovery and estimate mortality in patients with low CD4 count but otherwise successful HAART. In a nationwide cohort of HIV patients we identified all individuals who started HAART before 1 January 2005 with CD4 cell count [less than or equal to] 200 cells/[mu]L and experienced three years with sustained viral suppression. Patients were categorized according to CD4 cell count after the three years suppressed period ([less than or equal to] 200 cells/[mu]L; immunological non-responders (INRs), >200 cells/[mu]L; immunological responders (IRs)). We used logistic regression and Kaplan-Meier analysis to estimated risk factors and mortality for INRs compared to IRs. We identified 55 INRs and 236 IRs. In adjusted analysis age > 40 years and > one year from first CD4 cell count [less than or equal to] 200 cells/[mu]L to start of the virologically suppressed period were associated with increased risk of INR. INRs had substantially higher mortality compared to IRs. The excess mortality was mainly seen in the INR group with > one year of immunological suppression prior to viral suppression and injection drug users (IDUs). Age and prolonged periods of immune deficiency prior to successful HAART are risk factors for incomplete CD4 cell recovery. INRs have substantially increased long-term mortality mainly associated with prolonged immunological suppression prior to viral suppression and IDU. Background The mortality in patients with persistent low CD4 count despite several years of HAART with sustained viral suppression is poorly documented. We aimed to identify predictors for inadequate CD4 cell recovery and estimate mortality in patients with low CD4 count but otherwise successful HAART. Method In a nationwide cohort of HIV patients we identified all individuals who started HAART before 1 January 2005 with CD4 cell count ≤ 200 cells/μL and experienced three years with sustained viral suppression. Patients were categorized according to CD4 cell count after the three years suppressed period (≤ 200 cells/μL; immunological non-responders (INRs), >200 cells/μL; immunological responders (IRs)). We used logistic regression and Kaplan-Meier analysis to estimated risk factors and mortality for INRs compared to IRs. Results We identified 55 INRs and 236 IRs. In adjusted analysis age > 40 years and > one year from first CD4 cell count ≤ 200 cells/μL to start of the virologically suppressed period were associated with increased risk of INR. INRs had substantially higher mortality compared to IRs. The excess mortality was mainly seen in the INR group with > one year of immunological suppression prior to viral suppression and injection drug users (IDUs). Conclusion Age and prolonged periods of immune deficiency prior to successful HAART are risk factors for incomplete CD4 cell recovery. INRs have substantially increased long-term mortality mainly associated with prolonged immunological suppression prior to viral suppression and IDU. The mortality in patients with persistent low CD4 count despite several years of HAART with sustained viral suppression is poorly documented. We aimed to identify predictors for inadequate CD4 cell recovery and estimate mortality in patients with low CD4 count but otherwise successful HAART. In a nationwide cohort of HIV patients we identified all individuals who started HAART before 1 January 2005 with CD4 cell count ≤ 200 cells/μL and experienced three years with sustained viral suppression. Patients were categorized according to CD4 cell count after the three years suppressed period (≤ 200 cells/μL; immunological non-responders (INRs), >200 cells/μL; immunological responders (IRs)). We used logistic regression and Kaplan-Meier analysis to estimated risk factors and mortality for INRs compared to IRs. We identified 55 INRs and 236 IRs. In adjusted analysis age > 40 years and > one year from first CD4 cell count ≤ 200 cells/μL to start of the virologically suppressed period were associated with increased risk of INR. INRs had substantially higher mortality compared to IRs. The excess mortality was mainly seen in the INR group with > one year of immunological suppression prior to viral suppression and injection drug users (IDUs). Age and prolonged periods of immune deficiency prior to successful HAART are risk factors for incomplete CD4 cell recovery. INRs have substantially increased long-term mortality mainly associated with prolonged immunological suppression prior to viral suppression and IDU. Abstract Background The mortality in patients with persistent low CD4 count despite several years of HAART with sustained viral suppression is poorly documented. We aimed to identify predictors for inadequate CD4 cell recovery and estimate mortality in patients with low CD4 count but otherwise successful HAART. Method In a nationwide cohort of HIV patients we identified all individuals who started HAART before 1 January 2005 with CD4 cell count ≤ 200 cells/μL and experienced three years with sustained viral suppression. Patients were categorized according to CD4 cell count after the three years suppressed period (≤ 200 cells/μL; immunological non-responders (INRs), >200 cells/μL; immunological responders (IRs)). We used logistic regression and Kaplan-Meier analysis to estimated risk factors and mortality for INRs compared to IRs. Results We identified 55 INRs and 236 IRs. In adjusted analysis age > 40 years and > one year from first CD4 cell count ≤ 200 cells/μL to start of the virologically suppressed period were associated with increased risk of INR. INRs had substantially higher mortality compared to IRs. The excess mortality was mainly seen in the INR group with > one year of immunological suppression prior to viral suppression and injection drug users (IDUs). Conclusion Age and prolonged periods of immune deficiency prior to successful HAART are risk factors for incomplete CD4 cell recovery. INRs have substantially increased long-term mortality mainly associated with prolonged immunological suppression prior to viral suppression and IDU. Background The mortality in patients with persistent low CD4 count despite several years of HAART with sustained viral suppression is poorly documented. We aimed to identify predictors for inadequate CD4 cell recovery and estimate mortality in patients with low CD4 count but otherwise successful HAART. Method In a nationwide cohort of HIV patients we identified all individuals who started HAART before 1 January 2005 with CD4 cell count [less than or equal to] 200 cells/[mu]L and experienced three years with sustained viral suppression. Patients were categorized according to CD4 cell count after the three years suppressed period ([less than or equal to] 200 cells/[mu]L; immunological non-responders (INRs), >200 cells/[mu]L; immunological responders (IRs)). We used logistic regression and Kaplan-Meier analysis to estimated risk factors and mortality for INRs compared to IRs. Results We identified 55 INRs and 236 IRs. In adjusted analysis age > 40 years and > one year from first CD4 cell count [less than or equal to] 200 cells/[mu]L to start of the virologically suppressed period were associated with increased risk of INR. INRs had substantially higher mortality compared to IRs. The excess mortality was mainly seen in the INR group with > one year of immunological suppression prior to viral suppression and injection drug users (IDUs). Conclusion Age and prolonged periods of immune deficiency prior to successful HAART are risk factors for incomplete CD4 cell recovery. INRs have substantially increased long-term mortality mainly associated with prolonged immunological suppression prior to viral suppression and IDU. |
| ArticleNumber | 318 |
| Audience | Academic |
| Author | Larsen, Carsten S Jensen, Janne Røge, Birgit Kronborg, Gitte Nielsen, Lars N Gerstoft, Jan Pedersen, Gitte Obel, Niels Engsig, Frederik N |
| AuthorAffiliation | 1 Department of Infectious Diseases, Copenhagen University Hospital, Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen Ø, Denmark 6 Department of Infectious Diseases, Fredericia and Kolding Sygehus, Skovvangen 2-8, 6000 Kolding, Denmark 5 Department of Infectious Diseases, Odense University Hospital, Sønderbouldevard 65, 5000 Odense C, Denmark 7 Department of Infectious Diseases - Hillerød, Hillerød Sygehus, Dyrehavevej 29, Hillerød 3400, Denmark 4 Department of Infectious Diseases, Aalborg University Hospital, 9000 Aalborg, Denmark 2 Department of Infectious Diseases, Copenhagen University Hospital, Hvidovre Hospital, Kettegårds Allé 30, 2650 Hvidovre, Denmark 3 Department of Infectious Diseases, Aarhus University Hospital, Skejby Sygehus, Brendstrupgårdsvej, DK8200 Aarhus N, Denmark |
| AuthorAffiliation_xml | – name: 4 Department of Infectious Diseases, Aalborg University Hospital, 9000 Aalborg, Denmark – name: 7 Department of Infectious Diseases - Hillerød, Hillerød Sygehus, Dyrehavevej 29, Hillerød 3400, Denmark – name: 6 Department of Infectious Diseases, Fredericia and Kolding Sygehus, Skovvangen 2-8, 6000 Kolding, Denmark – name: 1 Department of Infectious Diseases, Copenhagen University Hospital, Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen Ø, Denmark – name: 3 Department of Infectious Diseases, Aarhus University Hospital, Skejby Sygehus, Brendstrupgårdsvej, DK8200 Aarhus N, Denmark – name: 2 Department of Infectious Diseases, Copenhagen University Hospital, Hvidovre Hospital, Kettegårds Allé 30, 2650 Hvidovre, Denmark – name: 5 Department of Infectious Diseases, Odense University Hospital, Sønderbouldevard 65, 5000 Odense C, Denmark |
| Author_xml | – sequence: 1 givenname: Frederik N surname: Engsig fullname: Engsig, Frederik N email: fren74@gmail.com organization: Department of Infectious Diseases, Copenhagen University Hospital – sequence: 2 givenname: Jan surname: Gerstoft fullname: Gerstoft, Jan organization: Department of Infectious Diseases, Copenhagen University Hospital – sequence: 3 givenname: Gitte surname: Kronborg fullname: Kronborg, Gitte organization: Department of Infectious Diseases, Copenhagen University Hospital, Hvidovre Hospital – sequence: 4 givenname: Carsten S surname: Larsen fullname: Larsen, Carsten S organization: Department of Infectious Diseases, Aarhus University Hospital – sequence: 5 givenname: Gitte surname: Pedersen fullname: Pedersen, Gitte organization: Department of Infectious Diseases, Aalborg University Hospital – sequence: 6 givenname: Birgit surname: Røge fullname: Røge, Birgit organization: Department of Infectious Diseases, Odense University Hospital – sequence: 7 givenname: Janne surname: Jensen fullname: Jensen, Janne organization: Department of Infectious Diseases, Fredericia and Kolding Sygehus – sequence: 8 givenname: Lars N surname: Nielsen fullname: Nielsen, Lars N organization: Department of Infectious Diseases - Hillerød, Hillerød Sygehus – sequence: 9 givenname: Niels surname: Obel fullname: Obel, Niels organization: Department of Infectious Diseases, Copenhagen University Hospital |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/21044307$$D View this record in MEDLINE/PubMed |
| BookMark | eNqNk8lv1DAUxiNURBe4c0IWHBCHFG_jsTkgVWXpSCNVYunVcpyXGVdJPNjOwBz433GYtnQqNkXK8vL7vpd8eu-w2Ot9D0XxmOBjQqR4SfiUlJQxXhJcMiLvFQc3pb1b9_vFYYyXGJOppOpBsU8J5pzh6UHxfe77RZkgdKjzIZnWpQ1yPTqbXaCVSQ76FNHaBdO2GxSH1SpAjFCjxodRACgtTZ9PAQBtwISIvrq0zA7Wd6sWEqDTNxwFsH4NYfMKnSDrl7kRimmoNw-L-41pIzy6uh4Vn9-9_XR6Vs7P389OT-alFWqaSgZCKNswBYIIUzfUyEnVgCUTXiuwoqqlbSwnFcYTLCdKmPGJ24pNa8A1ZUfFbOtbe3OpV8F1Jmy0N07_LPiw0CYkZ1vQDSNN00gq60pxWlupsBGECga4Usrg7PV667Uaqg5qmxPK6eyY7r7p3VIv_FpTJSWesGzw_Mog-C8DxKQ7Fy20renBD1HLqaBc8NzynySWfMIo45l8eoe89EPoc6ZaYUoIk2ps_GwLLUz-Udc3Pn-fHS31CeWUS84xydTxb6h81NA5m-evcbm-I3ixI8hMgm9pYYYY9ezjh_9nzy922Se3g75J-Hp4MyC2gA0-xgCNti7lmfVj7q7VBOtxS_S4Bnpcg7GStyQL8R3htfdfJGQriRntFxB-BfxHzQ9yWyBs |
| CitedBy_id | crossref_primary_10_1038_s41419_022_05225_6 crossref_primary_10_1155_2012_670957 crossref_primary_10_1186_s12879_018_3643_2 crossref_primary_10_1371_journal_pone_0217742 crossref_primary_10_1038_nri2970 crossref_primary_10_3389_fimmu_2019_01966 crossref_primary_10_1097_QAD_0b013e32835cba4c crossref_primary_10_1016_j_glohj_2020_04_001 crossref_primary_10_1097_QAI_0000000000000549 crossref_primary_10_3389_fimmu_2025_1635523 crossref_primary_10_1097_QAD_0b013e328359aa89 crossref_primary_10_1002_JLB_4MR1019_189R crossref_primary_10_1097_QAI_0000000000000173 crossref_primary_10_1172_JCI120245 crossref_primary_10_1097_COH_0b013e3283476c72 crossref_primary_10_1093_cid_ciu038 crossref_primary_10_1371_journal_pone_0124741 crossref_primary_10_1002_jmv_70170 crossref_primary_10_1172_JCI149571 crossref_primary_10_1186_s12889_023_16738_w crossref_primary_10_1517_17460441_2015_1041497 crossref_primary_10_1097_QAI_0000000000002157 crossref_primary_10_1093_jac_dkr594 crossref_primary_10_4049_jimmunol_2300777 crossref_primary_10_3389_fimmu_2019_00291 crossref_primary_10_1016_j_jinf_2020_09_014 crossref_primary_10_1016_j_antiviral_2015_03_002 crossref_primary_10_3390_jcm12031176 crossref_primary_10_1016_j_jinf_2017_10_010 crossref_primary_10_1093_infdis_jis230 crossref_primary_10_9778_cmajo_20180159 crossref_primary_10_1016_j_lana_2021_100175 crossref_primary_10_3389_fmed_2023_1182359 crossref_primary_10_1517_17425255_2014_854330 crossref_primary_10_3389_fimmu_2022_829126 crossref_primary_10_1097_QAD_0000000000000022 crossref_primary_10_1097_TP_0000000000001506 crossref_primary_10_1371_journal_pone_0072874 crossref_primary_10_1093_ofid_ofw025 crossref_primary_10_1038_s41598_022_04866_z crossref_primary_10_1089_aid_2016_0034 crossref_primary_10_1186_s12865_019_0311_2 crossref_primary_10_1371_journal_pone_0156099 crossref_primary_10_1007_s10096_020_03954_0 crossref_primary_10_1093_ofid_ofv063 crossref_primary_10_3389_fimmu_2021_601298 crossref_primary_10_1097_gscm_0000000000000036 crossref_primary_10_3390_v5112898 crossref_primary_10_1016_j_jiph_2023_12_022 crossref_primary_10_1155_2012_161584 crossref_primary_10_2217_fvl_12_80 crossref_primary_10_1371_journal_pone_0039356 crossref_primary_10_3389_fimmu_2021_658420 crossref_primary_10_1097_QAD_0b013e32835cb747 crossref_primary_10_1097_QAI_0000000000001967 crossref_primary_10_1186_s12879_022_07417_z crossref_primary_10_1016_j_ijmmb_2023_100423 crossref_primary_10_4102_sajhivmed_v21i1_1165 crossref_primary_10_1097_QAD_0000000000000354 crossref_primary_10_1093_ofid_ofw037 crossref_primary_10_1016_j_lanwpc_2023_100724 crossref_primary_10_1371_journal_pone_0117118 crossref_primary_10_1590_0102_311x00009618 |
| Cites_doi | 10.1086/319861 10.1089/aid.2006.22.163 10.1016/S1470-2045(09)70282-7 10.1097/QAI.0b013e31817bebb3 10.1371/journal.pone.0000089 10.1046/j.1468-1293.2003.00156.x 10.1038/nm0298-208 10.1002/jmv.20352 10.2174/157016208783885038 10.1016/S1473-3099(06)70463-7 10.1086/344769 10.1086/429670 10.1097/00002030-200202150-00007 10.1086/595851 10.1097/QAI.0b013e318042e1c3 10.1093/ije/dyn192 10.2105/AJPH.79.3.340 10.1080/00365540510031692 10.1086/588480 10.1001/archinte.163.18.2187 10.1086/510746 10.7326/0003-4819-138-8-200304150-00007 10.7326/0003-4819-146-2-200701160-00003 10.1182/blood-2006-09-047308 10.1177/135965350400900218 |
| ContentType | Journal Article |
| Copyright | Engsig et al; licensee BioMed Central Ltd. 2010 COPYRIGHT 2010 BioMed Central Ltd. 2010 Engsig et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Copyright ©2010 Engsig et al; licensee BioMed Central Ltd. 2010 Engsig et al; licensee BioMed Central Ltd. |
| Copyright_xml | – notice: Engsig et al; licensee BioMed Central Ltd. 2010 – notice: COPYRIGHT 2010 BioMed Central Ltd. – notice: 2010 Engsig et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. – notice: Copyright ©2010 Engsig et al; licensee BioMed Central Ltd. 2010 Engsig et al; licensee BioMed Central Ltd. |
| DBID | C6C AAYXX CITATION CGR CUY CVF ECM EIF NPM IOV ISR 3V. 7QL 7T2 7U9 7X7 7XB 88E 8C1 8FI 8FJ 8FK ABUWG AEUYN AFKRA AZQEC BENPR C1K CCPQU DWQXO FYUFA GHDGH H94 K9. M0S M1P M7N PHGZM PHGZT PIMPY PJZUB PKEHL PPXIY PQEST PQQKQ PQUKI 7X8 5PM DOA |
| DOI | 10.1186/1471-2334-10-318 |
| DatabaseName | Springer Nature OA Free Journals CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed Opposing Viewpoints (Gale In Context) Gale In Context: Science ProQuest Central (Corporate) Bacteriology Abstracts (Microbiology B) Health and Safety Science Abstracts (Full archive) Virology and AIDS Abstracts Health & Medical Collection ProQuest Central (purchase pre-March 2016) Medical Database (Alumni Edition) Public Health Database ProQuest Hospital Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) ProQuest Central (Alumni) ProQuest One Sustainability ProQuest Central UK/Ireland ProQuest Central Essentials ProQuest Central Environmental Sciences and Pollution Management ProQuest One Community College ProQuest Central Health Research Premium Collection Health Research Premium Collection (Alumni) AIDS and Cancer Research Abstracts ProQuest Health & Medical Complete (Alumni) ProQuest Health & Medical Collection PML(ProQuest Medical Library) Algology Mycology and Protozoology Abstracts (Microbiology C) ProQuest Central Premium ProQuest One Academic (New) Publicly Available Content Database ProQuest Health & Medical Research Collection ProQuest One Academic Middle East (New) ProQuest One Health & Nursing ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Academic (retired) ProQuest One Academic UKI Edition MEDLINE - Academic PubMed Central (Full Participant titles) DOAJ Directory of Open Access Journals |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) Publicly Available Content Database ProQuest One Academic Middle East (New) ProQuest Central Essentials ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) ProQuest One Community College ProQuest One Health & Nursing Environmental Sciences and Pollution Management ProQuest Central ProQuest One Sustainability ProQuest Health & Medical Research Collection Health Research Premium Collection Health and Medicine Complete (Alumni Edition) ProQuest Central Korea Bacteriology Abstracts (Microbiology B) Algology Mycology and Protozoology Abstracts (Microbiology C) Health & Medical Research Collection AIDS and Cancer Research Abstracts Health & Safety Science Abstracts ProQuest Central (New) ProQuest Medical Library (Alumni) ProQuest Public Health Virology and AIDS Abstracts ProQuest One Academic Eastern Edition ProQuest Hospital Collection Health Research Premium Collection (Alumni) ProQuest Hospital Collection (Alumni) ProQuest Health & Medical Complete ProQuest Medical Library ProQuest One Academic UKI Edition ProQuest One Academic ProQuest One Academic (New) ProQuest Central (Alumni) MEDLINE - Academic |
| DatabaseTitleList | MEDLINE - Academic AIDS and Cancer Research Abstracts MEDLINE Publicly Available Content Database |
| Database_xml | – sequence: 1 dbid: DOA name: DOAJ Directory of Open Access Journals url: https://www.doaj.org/ sourceTypes: Open Website – sequence: 2 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 3 dbid: PIMPY name: Publicly Available Content Database url: http://search.proquest.com/publiccontent sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine |
| EISSN | 1471-2334 |
| EndPage | 318 |
| ExternalDocumentID | oai_doaj_org_article_f31fff828db942dc890a61263e0b99a0 PMC2988053 2502620211 A242484401 21044307 10_1186_1471_2334_10_318 |
| Genre | Research Support, Non-U.S. Gov't Journal Article |
| GeographicLocations | Denmark |
| GeographicLocations_xml | – name: Denmark |
| GroupedDBID | --- 0R~ 23N 2VQ 2WC 4.4 53G 5VS 6J9 6PF 7X7 88E 8C1 8FI 8FJ AAFWJ AAJSJ AASML AAWTL ABDBF ABUWG ACGFO ACGFS ACIHN ACPRK ACUHS ADBBV ADRAZ ADUKV AEAQA AENEX AEUYN AFKRA AFPKN AFRAH AHBYD AHMBA AHSBF AHYZX ALMA_UNASSIGNED_HOLDINGS AMKLP AMTXH AOIJS BAPOH BAWUL BCNDV BENPR BFQNJ BMC BPHCQ BVXVI C1A C6C CCPQU CS3 DIK DU5 E3Z EAD EAP EAS EBD EBLON EBS EJD EMB EMK EMOBN ESX F5P FYUFA GROUPED_DOAJ GX1 H13 HMCUK HYE IAO IHR INH INR IOV IPNFZ ISR ITC KQ8 M1P M48 M~E O5R O5S OK1 OVT P2P PGMZT PHGZM PHGZT PIMPY PJZUB PPXIY PQQKQ PROAC PSQYO PUEGO RBZ RIG RNS ROL RPM RSV SMD SOJ SV3 TR2 TUS UKHRP W2D WOQ WOW XSB AAYXX AFFHD CITATION ALIPV CGR CUY CVF ECM EIF NPM 3V. 7QL 7T2 7U9 7XB 8FK AZQEC C1K DWQXO H94 K9. M7N PKEHL PQEST PQUKI 7X8 5PM |
| ID | FETCH-LOGICAL-c697t-3e669cf39e616adf2a85bfec154d9ec6bd8cfc41b00508596afc414cb37de0d23 |
| IEDL.DBID | DOA |
| ISICitedReferencesCount | 67 |
| ISICitedReferencesURI | http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000284321100001&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| ISSN | 1471-2334 |
| IngestDate | Fri Oct 03 12:50:50 EDT 2025 Tue Nov 04 02:03:16 EST 2025 Wed Oct 01 13:50:53 EDT 2025 Thu Oct 02 12:08:19 EDT 2025 Tue Oct 07 06:10:05 EDT 2025 Tue Nov 11 10:24:23 EST 2025 Tue Nov 04 18:08:06 EST 2025 Thu Nov 13 14:51:56 EST 2025 Thu Nov 13 15:34:18 EST 2025 Thu Apr 03 07:07:35 EDT 2025 Sat Nov 29 03:13:20 EST 2025 Tue Nov 18 22:25:27 EST 2025 Sat Sep 06 07:29:45 EDT 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 1 |
| Keywords | Viral Load Test Injection Drug User Immunological Suppression Viral Load Suppression Viral Load |
| Language | English |
| License | http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c697t-3e669cf39e616adf2a85bfec154d9ec6bd8cfc41b00508596afc414cb37de0d23 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 |
| OpenAccessLink | https://doaj.org/article/f31fff828db942dc890a61263e0b99a0 |
| PMID | 21044307 |
| PQID | 902113893 |
| PQPubID | 42582 |
| ParticipantIDs | doaj_primary_oai_doaj_org_article_f31fff828db942dc890a61263e0b99a0 pubmedcentral_primary_oai_pubmedcentral_nih_gov_2988053 proquest_miscellaneous_876246426 proquest_miscellaneous_808453234 proquest_journals_902113893 gale_infotracmisc_A242484401 gale_infotracacademiconefile_A242484401 gale_incontextgauss_ISR_A242484401 gale_incontextgauss_IOV_A242484401 pubmed_primary_21044307 crossref_citationtrail_10_1186_1471_2334_10_318 crossref_primary_10_1186_1471_2334_10_318 springer_journals_10_1186_1471_2334_10_318 |
| PublicationCentury | 2000 |
| PublicationDate | 2010-11-02 |
| PublicationDateYYYYMMDD | 2010-11-02 |
| PublicationDate_xml | – month: 11 year: 2010 text: 2010-11-02 day: 02 |
| PublicationDecade | 2010 |
| PublicationPlace | London |
| PublicationPlace_xml | – name: London – name: England |
| PublicationTitle | BMC infectious diseases |
| PublicationTitleAbbrev | BMC Infect Dis |
| PublicationTitleAlternate | BMC Infect Dis |
| PublicationYear | 2010 |
| Publisher | BioMed Central BioMed Central Ltd Springer Nature B.V BMC |
| Publisher_xml | – name: BioMed Central – name: BioMed Central Ltd – name: Springer Nature B.V – name: BMC |
| References | Pakker, Notermans, de Boer, Roos, de Wolf, Hill, Leonard, Danner, Miedema, Schellekens (CR7) 1998; 4 Florence, Lundgren, Dreezen, Fisher, Kirk, Blaxhult, Panos, Katlama, Vella, Phillips (CR19) 2003; 4 Battegay, Nüesch, Hirschel, Kaufmann (CR4) 2006; 6 Lohse, Hansen, Jensen-Fangel, Kronborg, Kvinesdal, Pedersen, Larsen, Møller, Willumsen, Obel (CR11) 2005; 37 Benveniste, Flahault, Rollot, Elbim, Estaquier, Pédron, Duval, Dereuddre-Bosquet, Clayette, Sterkers, Simon, Ameisen, Leport (CR22) 2005; 191 Kaufmann, Perrin, Pantaleo, Opravil, Furrer, Telenti, Hirschel, Ledergerber, Vernazza, Bernasconi, Rickenbach, Egger, Battegay (CR3) 2003; 163 CR10 Piketty, Weiss, Thomas, Mohamed, Belec, Kazatchkine (CR8) 2001; 183 Juel, Helweg-Larsen (CR14) 1999; 46 Kaufmann, Bloch, Finlayson, Zaunders, Smith, Cooper (CR2) 2002; 16 Tuboi, Brinkhof, Egger, Stone, Braitstein, Nash, Sprinz, Dabis, Harrison, Schechter (CR18) 2007; 45 Fernandez, Nolan, Price, Krueger, Wood, Cameron, Solomon, Lewin, French (CR25) 2006; 22 Greenland (CR16) 1989; 79 Wood, Montaner, Yip, Tyndall, Schechter, O'Shaughnessy, Hogg (CR21) 2004; 9 Obel, Engsig, Rasmussen, Larsen, Omland, Sørensen (CR12) 2009; 38 Gazzola, Tincati, Bellistrì, Monforte, Marchetti (CR24) 2009; 48 Gutierrez, Padilla, Masiá, Iribarren, Moreno, Viciana, Muñoz, Gómez Sirvent, Vidal, López-Aldeguer, Blanco, Leal, Rodríguez-Arenas, Perez Hoyos (CR17) 2006; 1 Nicastri, Chiesi, Angeletti, Sarmati, Palmisano, Geraci, Andreoni, Vella (CR20) 2005; 76 Isgrò, Leti, De Santis, Marziali, Esposito, Fimiani, Luzi, Pinti, Cossarizza, Aiuti, Mezzaroma (CR23) 2008; 46 Dion, Bordi, Zeidan, Asaad, Boulassel, Routy, Lederman, Sekaly, Cheynier (CR26) 2007; 109 Gutiérrez, Padilla, Masiá, Iribarren, Moreno, Viciana, Hernández-Quero, Alemán, Vidal, Salavert, Blanco, Leal, Dronda, Perez Hoyos, del Amo (CR9) 2008; 6 Moore, Keruly (CR5) 2007; 44 Guiguet, Boué, Cadranel, Lang, Rosenthal, Costagliola (CR28) 2009; 10 Storm, Michelsen, Clemmensen, Pihl (CR15) 1997; 44 Baker, Peng, Rapkin, Krason, Reilly, Cavert, Abrams, MacArthur, Henry, Neaton (CR6) 2008; 48 Lohse, Hansen, Pedersen, Kronborg, Gerstoft, Sørensen, Vaeth, Obel (CR1) 2007; 146 Jensen-Fangel, Pedersen, Pedersen, Larsen, Tauris, Møller, Sørensen, Obel (CR13) 2002; 35 Palella, Deloria-Knoll, Chmiel, Moorman, Wood, Greenberg, Holmberg (CR27) 2003; 138 NG Pakker (1298_CR7) 1998; 4 GR Kaufmann (1298_CR2) 2002; 16 S Greenland (1298_CR16) 1989; 79 RD Moore (1298_CR5) 2007; 44 S Jensen-Fangel (1298_CR13) 2002; 35 O Benveniste (1298_CR22) 2005; 191 K Juel (1298_CR14) 1999; 46 HH Storm (1298_CR15) 1997; 44 N Obel (1298_CR12) 2009; 38 GR Kaufmann (1298_CR3) 2003; 163 C Piketty (1298_CR8) 2001; 183 E Nicastri (1298_CR20) 2005; 76 M Guiguet (1298_CR28) 2009; 10 L Gazzola (1298_CR24) 2009; 48 JV Baker (1298_CR6) 2008; 48 N Lohse (1298_CR11) 2005; 37 A Isgrò (1298_CR23) 2008; 46 1298_CR10 M Battegay (1298_CR4) 2006; 6 F Gutiérrez (1298_CR9) 2008; 6 S Fernandez (1298_CR25) 2006; 22 ML Dion (1298_CR26) 2007; 109 E Florence (1298_CR19) 2003; 4 FJ Palella Jr (1298_CR27) 2003; 138 SH Tuboi (1298_CR18) 2007; 45 E Wood (1298_CR21) 2004; 9 N Lohse (1298_CR1) 2007; 146 F Gutierrez (1298_CR17) 2006; 1 19123868 - Clin Infect Dis. 2009 Feb 1;48(3):328-37 9461195 - Nat Med. 1998 Feb;4(2):208-14 10514943 - Dan Med Bull. 1999 Sep;46(4):354-7 15134185 - Antivir Ther. 2004 Apr;9(2):229-35 12693883 - Ann Intern Med. 2003 Apr 15;138(8):620-6 15834865 - J Med Virol. 2005 Jun;76(2):153-60 18462177 - Clin Infect Dis. 2008 Jun 15;46(12):1902-10 9408738 - Dan Med Bull. 1997 Nov;44(5):535-9 15838794 - J Infect Dis. 2005 May 15;191(10):1670-9 18799495 - Int J Epidemiol. 2009 Oct;38(5):1202-6 11294663 - J Infect Dis. 2001 May 1;183(9):1328-35 14557216 - Arch Intern Med. 2003 Oct 13;163(18):2187-95 17460471 - J Acquir Immune Defic Syndr. 2007 May 1;45(1):52-9 17164338 - Blood. 2007 Apr 1;109(7):2912-20 19818686 - Lancet Oncol. 2009 Dec;10(12):1152-9 16631548 - Lancet Infect Dis. 2006 May;6(5):280-7 18645520 - J Acquir Immune Defic Syndr. 2008 Aug 15;48(5):541-6 16051569 - Scand J Infect Dis. 2005;37(5):338-43 16478398 - AIDS Res Hum Retroviruses. 2006 Feb;22(2):163-70 12471575 - Clin Infect Dis. 2002 Dec 15;35(12):1541-8 12859325 - HIV Med. 2003 Jul;4(3):255-62 18336257 - Curr HIV Res. 2008 Mar;6(2):100-7 2916724 - Am J Public Health. 1989 Mar;79(3):340-9 17183720 - PLoS One. 2006;1:e89 17227932 - Ann Intern Med. 2007 Jan 16;146(2):87-95 17205456 - Clin Infect Dis. 2007 Feb 1;44(3):441-6 11834947 - AIDS. 2002 Feb 15;16(3):359-67 |
| References_xml | – volume: 183 start-page: 1328 issue: 9 year: 2001 end-page: 1335 ident: CR8 article-title: Long-term clinical outcome of human immunodeficiency virus-infected patients with discordant immunologic and virologic responses to a protease inhibitor-containing regimen publication-title: J Infect Dis doi: 10.1086/319861 – volume: 22 start-page: 163 issue: 2 year: 2006 end-page: 170 ident: CR25 article-title: Thymic function in severely immunodeficient HIV type 1-infected patients receiving stable and effective antiretroviral therapy publication-title: AIDS Res Hum Retroviruses doi: 10.1089/aid.2006.22.163 – volume: 10 start-page: 1152 issue: 12 year: 2009 end-page: 1159 ident: CR28 article-title: Effect of immunodeficiency, HIV viral load, and antiretroviral therapy on the risk of individual malignancies (FHDH-ANRS CO4): a prospective cohort study publication-title: Lancet Oncol doi: 10.1016/S1470-2045(09)70282-7 – volume: 48 start-page: 541 issue: 5 year: 2008 end-page: 546 ident: CR6 article-title: Poor initial CD4+ recovery with antiretroviral therapy prolongs immune depletion and increases risk for AIDS and non-AIDS diseases publication-title: J Acquir Immune Defic Syndr doi: 10.1097/QAI.0b013e31817bebb3 – ident: CR10 – volume: 109 start-page: 2912 issue: 7 year: 2007 end-page: 2920 ident: CR26 article-title: Slow disease progression and robust therapy-mediated CD4+ T-cell recovery are associated with efficient thymopoiesis during HIV-1 infection publication-title: Blood – volume: 1 start-page: e89 year: 2006 ident: CR17 article-title: Clinical outcome of HIV-infected patients with sustained virologic response to antiretroviral therapy: long-term follow-up of a multicenter cohort publication-title: PLoS One doi: 10.1371/journal.pone.0000089 – volume: 4 start-page: 255 issue: 3 year: 2003 end-page: 262 ident: CR19 article-title: Factors associated with a reduced CD4 lymphocyte count response to HAART despite full viral suppression in the EuroSIDA study publication-title: HIV Med doi: 10.1046/j.1468-1293.2003.00156.x – volume: 4 start-page: 208 issue: 2 year: 1998 end-page: 214 ident: CR7 article-title: Biphasic kinetics of peripheral blood T cells after triple combination therapy in HIV-1 infection: a composite of redistribution and proliferation publication-title: Nat Med doi: 10.1038/nm0298-208 – volume: 9 start-page: 229 issue: 2 year: 2004 end-page: 235 ident: CR21 article-title: Adherence to antiretroviral therapy and CD4 T-cell count responses among HIV-infected injection drug users publication-title: Antivir Ther – volume: 76 start-page: 153 issue: 2 year: 2005 end-page: 160 ident: CR20 article-title: Clinical outcome after 4 years follow-up of HIV-seropositive subjects with incomplete virologic or immunologic response to HAART publication-title: J Med Virol doi: 10.1002/jmv.20352 – volume: 6 start-page: 100 issue: 2 year: 2008 end-page: 107 ident: CR9 article-title: Patients' characteristics and clinical implications of suboptimal CD4 T-cell gains after 1 year of successful antiretroviral therapy publication-title: Curr HIV Res doi: 10.2174/157016208783885038 – volume: 6 start-page: 280 issue: 5 year: 2006 end-page: 287 ident: CR4 article-title: Immunological recovery and antiretroviral therapy in HIV-1 infection publication-title: Lancet Infect Dis doi: 10.1016/S1473-3099(06)70463-7 – volume: 35 start-page: 1541 issue: 12 year: 2002 end-page: 1548 ident: CR13 article-title: The effect of race/ethnicity on the outcome of highly active antiretroviral therapy for human immunodeficiency virus type 1-infected patients publication-title: Clin Infect Dis doi: 10.1086/344769 – volume: 191 start-page: 1670 issue: 10 year: 2005 end-page: 1679 ident: CR22 article-title: Mechanisms involved in the low-level regeneration of CD4+ cells in HIV-1-infected patients receiving highly active antiretroviral therapy who have prolonged undetectable plasma viral loads publication-title: J Infect Dis doi: 10.1086/429670 – volume: 16 start-page: 359 issue: 3 year: 2002 end-page: 367 ident: CR2 article-title: The extent of HIV-1-related immunodeficiency and age predict the long-term CD4 T lymphocyte response to potent antiretroviral therapy publication-title: AIDS doi: 10.1097/00002030-200202150-00007 – volume: 48 start-page: 328 issue: 3 year: 2009 end-page: 337 ident: CR24 article-title: The absence of CD4+ T cell count recovery despite receipt of virologically suppressive highly active antiretroviral therapy: clinical risk, immunological gaps, and therapeutic options publication-title: Clin Infect Dis doi: 10.1086/595851 – volume: 45 start-page: 52 issue: 1 year: 2007 end-page: 59 ident: CR18 article-title: Discordant responses to potent antiretroviral treatment in previously naive HIV-1-infected adults initiating treatment in resource-constrained countries: the antiretroviral therapy in low-income countries (ART-LINC) collaboration publication-title: J Acquir Immune Defic Syndr doi: 10.1097/QAI.0b013e318042e1c3 – volume: 38 start-page: 1202 issue: 5 year: 2009 end-page: 1206 ident: CR12 article-title: Cohort profile: the Danish HIV cohort study publication-title: Int J Epidemiol doi: 10.1093/ije/dyn192 – volume: 46 start-page: 354 issue: 4 year: 1999 end-page: 357 ident: CR14 article-title: The Danish registers of causes of death publication-title: Dan Med Bull – volume: 79 start-page: 340 issue: 3 year: 1989 end-page: 349 ident: CR16 article-title: Modeling and variable selection in epidemiologic analysis publication-title: Am J Public Health doi: 10.2105/AJPH.79.3.340 – volume: 37 start-page: 338 issue: 5 year: 2005 end-page: 343 ident: CR11 article-title: Demographics of HIV-1 infection in Denmark: results from the Danish HIV Cohort Study publication-title: Scand J Infect Dis doi: 10.1080/00365540510031692 – volume: 44 start-page: 535 issue: 5 year: 1997 end-page: 539 ident: CR15 article-title: The Danish Cancer Registry--history, content, quality and use publication-title: Dan Med Bull – volume: 46 start-page: 1902 issue: 12 year: 2008 end-page: 1910 ident: CR23 article-title: Altered clonogenic capability and stromal cell function characterize bone marrow of HIV-infected subjects with low CD4+ T cell counts despite viral suppression during HAART publication-title: Clin Infect Dis doi: 10.1086/588480 – volume: 163 start-page: 2187 issue: 18 year: 2003 end-page: 2195 ident: CR3 article-title: CD4 T-lymphocyte recovery in individuals with advanced HIV-1 infection receiving potent antiretroviral therapy for 4 years: the Swiss HIV Cohort Study publication-title: Arch Intern Med doi: 10.1001/archinte.163.18.2187 – volume: 44 start-page: 441 issue: 3 year: 2007 end-page: 446 ident: CR5 article-title: CD4+ cell count 6 years after commencement of highly active antiretroviral therapy in persons with sustained virologic suppression publication-title: Clin Infect Dis doi: 10.1086/510746 – volume: 138 start-page: 620 issue: 8 year: 2003 end-page: 626 ident: CR27 article-title: Survival benefit of initiating antiretroviral therapy in HIV-infected persons in different CD4+ cell strata publication-title: Ann Intern Med doi: 10.7326/0003-4819-138-8-200304150-00007 – volume: 146 start-page: 87 issue: 2 year: 2007 end-page: 95 ident: CR1 article-title: Survival of persons with and without HIV infection in Denmark, 1995-2005 publication-title: Ann Intern Med doi: 10.7326/0003-4819-146-2-200701160-00003 – volume: 1 start-page: e89 year: 2006 ident: 1298_CR17 publication-title: PLoS One doi: 10.1371/journal.pone.0000089 – volume: 10 start-page: 1152 issue: 12 year: 2009 ident: 1298_CR28 publication-title: Lancet Oncol doi: 10.1016/S1470-2045(09)70282-7 – volume: 46 start-page: 354 issue: 4 year: 1999 ident: 1298_CR14 publication-title: Dan Med Bull – volume: 4 start-page: 255 issue: 3 year: 2003 ident: 1298_CR19 publication-title: HIV Med doi: 10.1046/j.1468-1293.2003.00156.x – volume: 48 start-page: 328 issue: 3 year: 2009 ident: 1298_CR24 publication-title: Clin Infect Dis doi: 10.1086/595851 – volume: 138 start-page: 620 issue: 8 year: 2003 ident: 1298_CR27 publication-title: Ann Intern Med doi: 10.7326/0003-4819-138-8-200304150-00007 – volume: 16 start-page: 359 issue: 3 year: 2002 ident: 1298_CR2 publication-title: AIDS doi: 10.1097/00002030-200202150-00007 – volume: 79 start-page: 340 issue: 3 year: 1989 ident: 1298_CR16 publication-title: Am J Public Health doi: 10.2105/AJPH.79.3.340 – volume: 46 start-page: 1902 issue: 12 year: 2008 ident: 1298_CR23 publication-title: Clin Infect Dis doi: 10.1086/588480 – volume: 44 start-page: 441 issue: 3 year: 2007 ident: 1298_CR5 publication-title: Clin Infect Dis doi: 10.1086/510746 – volume: 191 start-page: 1670 issue: 10 year: 2005 ident: 1298_CR22 publication-title: J Infect Dis doi: 10.1086/429670 – volume: 76 start-page: 153 issue: 2 year: 2005 ident: 1298_CR20 publication-title: J Med Virol doi: 10.1002/jmv.20352 – volume: 6 start-page: 100 issue: 2 year: 2008 ident: 1298_CR9 publication-title: Curr HIV Res doi: 10.2174/157016208783885038 – volume: 35 start-page: 1541 issue: 12 year: 2002 ident: 1298_CR13 publication-title: Clin Infect Dis doi: 10.1086/344769 – volume: 163 start-page: 2187 issue: 18 year: 2003 ident: 1298_CR3 publication-title: Arch Intern Med doi: 10.1001/archinte.163.18.2187 – volume: 37 start-page: 338 issue: 5 year: 2005 ident: 1298_CR11 publication-title: Scand J Infect Dis doi: 10.1080/00365540510031692 – volume: 44 start-page: 535 issue: 5 year: 1997 ident: 1298_CR15 publication-title: Dan Med Bull – volume: 22 start-page: 163 issue: 2 year: 2006 ident: 1298_CR25 publication-title: AIDS Res Hum Retroviruses doi: 10.1089/aid.2006.22.163 – volume: 146 start-page: 87 issue: 2 year: 2007 ident: 1298_CR1 publication-title: Ann Intern Med doi: 10.7326/0003-4819-146-2-200701160-00003 – ident: 1298_CR10 – volume: 109 start-page: 2912 issue: 7 year: 2007 ident: 1298_CR26 publication-title: Blood doi: 10.1182/blood-2006-09-047308 – volume: 183 start-page: 1328 issue: 9 year: 2001 ident: 1298_CR8 publication-title: J Infect Dis doi: 10.1086/319861 – volume: 9 start-page: 229 issue: 2 year: 2004 ident: 1298_CR21 publication-title: Antivir Ther doi: 10.1177/135965350400900218 – volume: 48 start-page: 541 issue: 5 year: 2008 ident: 1298_CR6 publication-title: J Acquir Immune Defic Syndr doi: 10.1097/QAI.0b013e31817bebb3 – volume: 6 start-page: 280 issue: 5 year: 2006 ident: 1298_CR4 publication-title: Lancet Infect Dis doi: 10.1016/S1473-3099(06)70463-7 – volume: 45 start-page: 52 issue: 1 year: 2007 ident: 1298_CR18 publication-title: J Acquir Immune Defic Syndr doi: 10.1097/QAI.0b013e318042e1c3 – volume: 4 start-page: 208 issue: 2 year: 1998 ident: 1298_CR7 publication-title: Nat Med doi: 10.1038/nm0298-208 – volume: 38 start-page: 1202 issue: 5 year: 2009 ident: 1298_CR12 publication-title: Int J Epidemiol doi: 10.1093/ije/dyn192 – reference: 11294663 - J Infect Dis. 2001 May 1;183(9):1328-35 – reference: 16631548 - Lancet Infect Dis. 2006 May;6(5):280-7 – reference: 17183720 - PLoS One. 2006;1:e89 – reference: 18799495 - Int J Epidemiol. 2009 Oct;38(5):1202-6 – reference: 17205456 - Clin Infect Dis. 2007 Feb 1;44(3):441-6 – reference: 17164338 - Blood. 2007 Apr 1;109(7):2912-20 – reference: 11834947 - AIDS. 2002 Feb 15;16(3):359-67 – reference: 12693883 - Ann Intern Med. 2003 Apr 15;138(8):620-6 – reference: 15838794 - J Infect Dis. 2005 May 15;191(10):1670-9 – reference: 18645520 - J Acquir Immune Defic Syndr. 2008 Aug 15;48(5):541-6 – reference: 15134185 - Antivir Ther. 2004 Apr;9(2):229-35 – reference: 10514943 - Dan Med Bull. 1999 Sep;46(4):354-7 – reference: 12471575 - Clin Infect Dis. 2002 Dec 15;35(12):1541-8 – reference: 16478398 - AIDS Res Hum Retroviruses. 2006 Feb;22(2):163-70 – reference: 9408738 - Dan Med Bull. 1997 Nov;44(5):535-9 – reference: 15834865 - J Med Virol. 2005 Jun;76(2):153-60 – reference: 18462177 - Clin Infect Dis. 2008 Jun 15;46(12):1902-10 – reference: 12859325 - HIV Med. 2003 Jul;4(3):255-62 – reference: 14557216 - Arch Intern Med. 2003 Oct 13;163(18):2187-95 – reference: 17227932 - Ann Intern Med. 2007 Jan 16;146(2):87-95 – reference: 9461195 - Nat Med. 1998 Feb;4(2):208-14 – reference: 19123868 - Clin Infect Dis. 2009 Feb 1;48(3):328-37 – reference: 2916724 - Am J Public Health. 1989 Mar;79(3):340-9 – reference: 19818686 - Lancet Oncol. 2009 Dec;10(12):1152-9 – reference: 18336257 - Curr HIV Res. 2008 Mar;6(2):100-7 – reference: 17460471 - J Acquir Immune Defic Syndr. 2007 May 1;45(1):52-9 – reference: 16051569 - Scand J Infect Dis. 2005;37(5):338-43 |
| SSID | ssj0017829 |
| Score | 2.234879 |
| Snippet | Background
The mortality in patients with persistent low CD4 count despite several years of HAART with sustained viral suppression is poorly documented. We... The mortality in patients with persistent low CD4 count despite several years of HAART with sustained viral suppression is poorly documented. We aimed to... Background The mortality in patients with persistent low CD4 count despite several years of HAART with sustained viral suppression is poorly documented. We... Abstract Background: The mortality in patients with persistent low CD4 count despite several years of HAART with sustained viral suppression is poorly... Abstract Background The mortality in patients with persistent low CD4 count despite several years of HAART with sustained viral suppression is poorly... |
| SourceID | doaj pubmedcentral proquest gale pubmed crossref springer |
| SourceType | Open Website Open Access Repository Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 318 |
| SubjectTerms | Acquired immune deficiency syndrome Adult Age Factors AIDS Anti-HIV Agents - administration & dosage Antiretroviral Therapy, Highly Active Blood - virology Cancer Care and treatment CD4 Lymphocyte Count Cohort Studies Demographic aspects Denmark Female Highly active antiretroviral therapy HIV HIV infection HIV Infections - drug therapy HIV Infections - immunology HIV Infections - mortality Human immunodeficiency virus Humans Immune Tolerance Immunosuppression Infectious Diseases Internal Medicine Male Medical Microbiology Medical research Medicine Medicine & Public Health Middle Aged Mortality Parasitology Patient outcomes Research Article Risk Factors Survival Analysis Time Factors Tropical Medicine Viral Load |
| SummonAdditionalLinks | – databaseName: Public Health Database dbid: 8C1 link: http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV3db9MwELdgIMQL34OwgSyEhECKmsSuY_OCSmHaJBiIj2lvVuKPUqkkpWmR-sD_zl3qBjK0vfBSqfFZin2-L9_ld4Q8dS4xYNZ87JjJYoi_QOZsKSFKcaCSsXtYvmk2kR8fy9NT9THU5jShrHKrE1tFbWuDd-QDBcYIk2rs1fxHjE2jMLkaOmhcJlfSLOEol3LcVXikYPzUNjMpxSAFPRxnjPGN6pE9S9QC9v-rlv-yS2drJs8kTlt7dHDzP1dyi9wIjigdbU7ObXLJVXfItfch1X6X_HpXV5MYFTf93rro4K7TaUUPj05oAGNtKFYIz2Zr2qzmbUGtsxScYJzgKN7Jw8_COboGcWooXvlSBINAQOKlo-M3nGI8DsK0fklHFHv1Lpa0Bby9R74evP0yPoxDr4bYCJUvY-aEUMYz5UQqCuuzQg5L7wx4aFY5I0orjTc8RalHTDVR4D9uSpZbl9iM7ZKdqq7cA0LBgxEctK6XArN6pnRWlDzPEUxMKMkjMtjyTZsAZI79NGa6DWik0MhpjZzGJ8DpiDzvZsw3IB4X0L7Go9DRIfx2-6BeTHSQZu1Z6r2HYNWWimfWSJUU4CoK5pJSqSKJyBM8SBr3tMIKnkmxahp99OFEj_B7HMkhrD2P6POnHtGzQORrWKQpwlcTsFUI3NWj3O9RgpowveG97WnUQU01ujuKEaHdKE7EyrvK1atGy0TyIcsYv4AEDCqHOFZE5P5GSLrdyyDa52BGIpL3xKe3vf2RavqtRTnPFJiWIbzZi62g_Xnv85j38MJF7pHrbe0HJgWyfbKzXKzcI3LV_FxOm8XjVnf8BoQ2dWs priority: 102 providerName: ProQuest – databaseName: Springer LINK dbid: RSV link: http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3db9MwELfGQIgXvmFhA1kICYEULY1dx-atDKZNgoE2qPZmJY5dKnXJlLRIfeB_5875gAw2CV4qNT5Lztn3lTv_jpAX1kYGzJoLLTNxCPEXyFyeSYhSLKhk7B6WNM0mkqMjeXqqPm-QuLsL46vdu5Sk19RerKXYHYEaDWPGeKM55DVyHYydRGE8Ppn2mQOweKpLR_5l1sD8eJT-P3Xxb8boYqHkhWypN0L7d_5n-XfJ7dblpJPmjNwjG7a4T25-bJPqD8iPD2UxC1FF0zPvjINjTucFPTic0hZ2taZYC7xYrGm9Ovelszan4O7iBEvx6zv8VNbSNQhOTfHjLkXYB4QeXlq6945TjLxBbNZv6IRiV95qST207UPydf_9l72DsO3KEBqhkmXIrBDKOKasGIk0d3Eqx5mzBnyxXFkjslwaZ_gI5RvR00SK_7jJWJLbKI_ZI7JZlIXdIhR8FcFBvzopMH9nMpuLjCcJwoYJJXlAdrvN0qaFLMfOGQvtQxcpNHJVI1fxCXA1IK_6GecNXMcVtG9x_3s6BNr2D8pqplu51Y6NnHMQluaZ4nFupIpScAoFs1GmVBoF5DmeHo08LbBWZ5au6loffprqCd68kRwC2MuITo4HRC9bIlfCS5q0vR8BrEKIrgHlzoASFIIZDG93J1m3CqnWCnw5zEmzgNB-FCdijV1hy1WtZST5mMWMX0ECppNDxCoC8riRjJ57McT1HAxGQJKBzAzYOxwp5t88nnmswIiMYWWvO8n5te7LNu_JvxBvk1u-6AOzAfEO2VxWK_uU3DDfl_O6eub1x08coWp2 priority: 102 providerName: Springer Nature |
| Title | Long-term mortality in HIV patients virally suppressed for more than three years with incomplete CD4 recovery: A cohort study |
| URI | https://link.springer.com/article/10.1186/1471-2334-10-318 https://www.ncbi.nlm.nih.gov/pubmed/21044307 https://www.proquest.com/docview/902113893 https://www.proquest.com/docview/808453234 https://www.proquest.com/docview/876246426 https://pubmed.ncbi.nlm.nih.gov/PMC2988053 https://doaj.org/article/f31fff828db942dc890a61263e0b99a0 |
| Volume | 10 |
| WOSCitedRecordID | wos000284321100001&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| journalDatabaseRights | – providerCode: PRVADU databaseName: BioMed Central Open Access Free customDbUrl: eissn: 1471-2334 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0017829 issn: 1471-2334 databaseCode: RBZ dateStart: 20010101 isFulltext: true titleUrlDefault: https://www.biomedcentral.com/search/ providerName: BioMedCentral – providerCode: PRVAON databaseName: DOAJ Directory of Open Access Journals customDbUrl: eissn: 1471-2334 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0017829 issn: 1471-2334 databaseCode: DOA dateStart: 20010101 isFulltext: true titleUrlDefault: https://www.doaj.org/ providerName: Directory of Open Access Journals – providerCode: PRVHPJ databaseName: ROAD: Directory of Open Access Scholarly Resources customDbUrl: eissn: 1471-2334 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0017829 issn: 1471-2334 databaseCode: M~E dateStart: 20010101 isFulltext: true titleUrlDefault: https://road.issn.org providerName: ISSN International Centre – providerCode: PRVPQU databaseName: Health & Medical Collection customDbUrl: eissn: 1471-2334 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0017829 issn: 1471-2334 databaseCode: 7X7 dateStart: 20090101 isFulltext: true titleUrlDefault: https://search.proquest.com/healthcomplete providerName: ProQuest – providerCode: PRVPQU databaseName: ProQuest Central customDbUrl: eissn: 1471-2334 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0017829 issn: 1471-2334 databaseCode: BENPR dateStart: 20090101 isFulltext: true titleUrlDefault: https://www.proquest.com/central providerName: ProQuest – providerCode: PRVPQU databaseName: Public Health Database customDbUrl: eissn: 1471-2334 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0017829 issn: 1471-2334 databaseCode: 8C1 dateStart: 20090101 isFulltext: true titleUrlDefault: https://search.proquest.com/publichealth providerName: ProQuest – providerCode: PRVPQU databaseName: Publicly Available Content Database customDbUrl: eissn: 1471-2334 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0017829 issn: 1471-2334 databaseCode: PIMPY dateStart: 20090101 isFulltext: true titleUrlDefault: http://search.proquest.com/publiccontent providerName: ProQuest – providerCode: PRVAVX databaseName: Springer LINK customDbUrl: eissn: 1471-2334 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0017829 issn: 1471-2334 databaseCode: RSV dateStart: 20011201 isFulltext: true titleUrlDefault: https://link.springer.com/search?facet-content-type=%22Journal%22 providerName: Springer Nature |
| link | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV3db9MwELdgIMQL4puwUVkICYEUNY1dx-atK5tWiZWqg6o8WYljj0olnZoWqQ_879w5aVmGNl54iWT7LCXn833kzj8T8sbayIBZc6FlJg4h_oI9l2cSohQLKhlvD0uqyyaS4VBOp2p06aovrAmr4IErxrUd6zjnIC7IM8Xj3EgVpWCVBbNRplTqo3XwerbBVJ0_ALun_LmipBPGjPFtglKK9q6v0kCyYZA8bv_f2vmSebpaOnklf-rN0vFD8qD2J2mv-o5H5JYtHpN7p3XG_An59WlRnIeof-kP72mD101nBT0ZTGiNqVpSLPSdzze0XF_4ulibU_BlcYKl-GsdHktr6QZ2RUnxzy1FTAfEFV5Z2v_IKYbVsCc2H2iP4pW7yxX1uLVPydfjoy_9k7C-ciE0QiWrkFkhlHFMWdERae7iVHYzZw04WrmyRmS5NM7wDm5ehEYTKba4yViS2yiP2TOyVywK-4JQcEQEB-XppMDknMlsLjKeJIgJJpTkAWlv-a5NjUeO12LMtY9LpNC4UhpXCntgpQLybjfjosLiuIH2EJdyR4co2r4DZEvXsqX_JVsBeY2CoJGnBRbinKfrstSDzxPdw2M1kkN0eh3R2bhB9LYmcgv4SJPWhx-AVYi_1aA8aFDCbjeN4f2tUOpa25RagaOGCWcWELobxYlYQFfYxbrUMpK8y2LGbyABu8ghHBUBeV4J-Y57MQTtHKxBQJKG-DfY2xwpZt89WHmswEJ04c3ebzfKn_e-bvFe_o_F2yf3faUHpgDiA7K3Wq7tK3LX_FzNymWL3E6miX9KeMp-p0XuHB4NR-OWVyTQGg1OR9-gNT6b_AaRs3FI |
| linkProvider | Directory of Open Access Journals |
| linkToHtml | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1bb9MwFLamgYAX7pewARYCIZCi5uI6NhJCZWNqta4gGFPfTOI4pVJJStOC-sBP4j9yTm6QofVtD7xUanwsxc65-hx_h5AnxjgazFpiG197NsRfIHNxJCBKMaCSsXtYUDabCEYjMR7L91vkV30XBssqa51YKOo403hG3pFgjDCp5r-ef7OxaRQmV-sOGiVXHJr1D4jY8leDffi8Tz3v4O3xXt-umgrYmstgafuGc6kTXxru8jBOvFB0o8RocCViaTSPYqETzVxkTwT_4iH-Yzryg9g4MeIcgMa_AGo8wAqyYNzEdy4YW1lnQgXvuKD3bc_3WanqRMvyFQ0C_jUDf9nB0zWapxK1hf07uPaf7dx1crVytGmvlIwbZMukN8mlo6qU4Bb5OczSiY2GiX4tQhAIR-g0pf3BCa3AZnOKFdCz2Zrmq3lRMGxiCk4-TjAUcw7wszCGrmF5OcUjbYpgFwi4vDR0b59RPG8AZbF-SXsUexEvlrQA9L1NPp3L4u-Q7TRLzT1CwUPjDKxKIjhmLXVkYh6xIECwNC4Fs0in5hOlK6B27BcyU0XAJrhCzlLIWfgEOMsiz5sZ8xKkZAPtG2S9hg7hxYsH2WKiKm2lEt9NkgSC8TiSzIu1kE4IrjD3jRNJGToWeYyMq3BPU6xQmoSrPFeDdyeqh_eNBIOw_Syijx9aRM8qoiSDReqwuhUCW4XAZC3K3RYlqEHdGt6puV9VajhXDetbhDajOBErC1OTrXIlHMG6vuezDSTgMDCI07lF7pZC2eye5zqMgZm0SNAS19b2tkfS6ZcCxd2TYDq78GYvasH-895nfbz7Gxf5iFzuHx8N1XAwOtwhV4o6F0yAeLtke7lYmQfkov6-nOaLh4XeouTzeYv7b_mE1UI |
| linkToPdf | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV3db9MwELdgoIkXvj_CBlgICYEUNY1dx-atbFSrGGViUO3NShy7VCpplaRIfeB_5y4fhQw2CfESKfFZSi6-L9_5d4S8sDYwYNacb5kJfYi_QObSREKUYkElY_ewqG42EU0m8uxMnTQbbkVb7d6mJOszDYjSlJW9VepqEZei1weV6oeM8VqLyKvkGseWQRitn063WQSwfqpNTf5lVscUVYj9f-rl3wzT-aLJc5nTyiCNbv3vp9wmNxtXlA7rtXOHXLHZXbL7oUm23yM_jpfZzEfVTb9VTjo47HSe0aPxlDZwrAXFGuHFYkOL9aoqqbUpBTcYJ1iKu_Jwya2lGxCoguKmL0U4CIQkLi09OOQUI3IQp80bOqTYrTcvaQV5e598Gb37fHDkN90afCNUVPrMCqGMY8qKvohTF8ZykDhrwEdLlTUiSaVxhvdR7hFVTcR4x03CotQGacgekJ1smdlHhIIPIzjoXScF5vVMYlOR8ChCODGhJPdIr_1x2jRQ5thRY6GrkEYKjVzVyFV8Alz1yKvtjFUN43EJ7VtcC1s6BOCuHizzmW7kWTvWd85BuJomioepkSqIwVkUzAaJUnHgkee4kjTyNMManlm8Lgo9_jjVQzyRIzkEthcRnX7qEL1siNwSPtLEzbkJYBVCd3Uo9zuUoChMZ3ivXdW6UVSFVuDjYa6aeYRuR3Ei1t5ldrkutAwkH7CQ8UtIwKRyiGSFRx7WUrLlXgjxPgdD4pGoIz8d9nZHsvnXCuc8VGBcBvBmr1sp-vXeF_28x_9C_IzsnhyO9PF48n6P3KjqQjBhEO6TnTJf2yfkuvlezov8aaVWfgITxHY- |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Long-term+mortality+in+HIV+patients+virally+suppressed+for+more+than+three+years+with+incomplete+CD4+recovery%3A+A+cohort+study&rft.jtitle=BMC+infectious+diseases&rft.au=Engsig%2C+Frederik+N&rft.au=Gerstoft%2C+Jan&rft.au=Kronborg%2C+Gitte&rft.au=Larsen%2C+Carsten+S&rft.date=2010-11-02&rft.issn=1471-2334&rft.eissn=1471-2334&rft.volume=10&rft.issue=1&rft_id=info:doi/10.1186%2F1471-2334-10-318&rft.externalDBID=n%2Fa&rft.externalDocID=10_1186_1471_2334_10_318 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1471-2334&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1471-2334&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1471-2334&client=summon |