predictive value of the 70-gene signature for adjuvant chemotherapy in early breast cancer

Multigene assays have been developed and validated to determine the prognosis of breast cancer. In this study, we assessed the additional predictive value of the 70-gene MammaPrint signature for chemotherapy (CT) benefit in addition to endocrine therapy (ET) from pooled study series. For 541 patient...

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Bibliographic Details
Published in:	Breast cancer research and treatment Vol. 120; no. 3; pp. 655 - 661
Main Authors:	Knauer, Michael, Mook, Stella, Rutgers, Emiel J. T, Bender, Richard A, Hauptmann, Michael, van de Vijver, Marc J, Koornstra, Rutger H. T, Bueno-de-Mesquita, Jolien M, Linn, Sabine C, van 't Veer, Laura J
Format:	Journal Article
Language:	English
Published:	Boston Boston : Springer US 01.04.2010 Springer US Springer Springer Nature B.V Springer Verlag
Subjects:	Adenocarcinoma - drug therapy Adenocarcinoma - genetics Adenocarcinoma - metabolism Adenocarcinoma - pathology Adenocarcinoma - radiotherapy Adenocarcinoma - surgery Adjuvant treatment Adult Aged Analysis Anthracyclines - administration & dosage Antineoplastic Agents, Hormonal - administration & dosage Antineoplastic Agents, Hormonal - therapeutic use Antineoplastic Combined Chemotherapy Protocols - therapeutic use Biological and medical sciences Breast cancer Breast Neoplasms - drug therapy Breast Neoplasms - genetics Breast Neoplasms - metabolism Breast Neoplasms - pathology Breast Neoplasms - radiotherapy Breast Neoplasms - surgery Cancer Cancer research Cancer therapies Care and treatment Chemotherapy Chemotherapy, Adjuvant Clinical Trial Clinical trials Combined Modality Therapy Endocrine therapy Female Gene expression Gene Expression Profiling Gene Expression Regulation, Neoplastic Genes Genetic aspects Gynecology. Andrology. Obstetrics Health aspects Health risk assessment Humans Mammary gland diseases Medical sciences Medicine Medicine & Public Health Middle Aged Neoplasm Invasiveness - genetics Neoplasm Metastasis - genetics Neoplasm Proteins - biosynthesis Neoplasm Proteins - genetics Neoplasm Staging Oncology Predictive Value of Tests Prognosis Radiotherapy, Adjuvant Risk Assessment Taxoids - administration & dosage Tumor Burden Tumors Adjuvant chemotherapy Breast cancer Gene expression profiling Risk assessment Evaluation Breast disease Adjuvant treatment Malignant tumor Gene expression profile Mammary gland diseases Chemotherapy Treatment Risk factor Predictive value Early Cancer
ISSN:	0167-6806, 1573-7217, 1573-7217
Online Access:	Get full text
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