Tissue micro array analysis of ganglioside N-glycolyl GM3 expression and signal transducer and activator of transcription (STAT)-3 activation in relation to dendritic cell infiltration and microvessel density in non-small cell lung cancer

Background Tumor immune escape and angiogenesis contribute to tumor progression, and gangliosides and activation of signal transducer and activator of transcription (STAT)-3 are implicated in these processes. As both are considered as novel therapeutic targets, we assessed the possible association o...

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Bibliographic Details
Published in:	BMC cancer Vol. 9; no. 1; p. 180
Main Authors:	van Cruijsen, Hester, Ruiz, Mariëlle Gallegos, van der Valk, Paul, de Gruijl, Tanja D, Giaccone, Giuseppe
Format:	Journal Article
Language:	English
Published:	London BioMed Central 11.06.2009 BioMed Central Ltd BMC
Subjects:	Biomedical and Life Sciences Biomedicine Cancer Research Carcinoma, Non-Small-Cell Lung - blood supply Carcinoma, Non-Small-Cell Lung - immunology Dendritic cells Dendritic Cells - immunology Dendritic Cells - pathology Female G(M3) Ganglioside - biosynthesis G(M3) Ganglioside - immunology Genetic aspects Genetic transcription Health Promotion and Disease Prevention Humans Immunohistochemistry Lung cancer, Non-small cell Lung Neoplasms - blood supply Lung Neoplasms - immunology Male Medicine/Public Health Microvessels - immunology Microvessels - pathology Middle Aged Neovascularization, Pathologic - immunology Neovascularization, Pathologic - pathology Oncology Physiological aspects Research Article Risk factors STAT3 Transcription Factor - biosynthesis STAT3 Transcription Factor - immunology Surgical Oncology Tissue Array Analysis Tissue microarrays United States Netherlands Vascular Endothelial Growth Factor pSTAT3 Expression NSCLC Patient NSCLC Tissue NSCLC Sample
ISSN:	1471-2407, 1471-2407
Online Access:	Get full text
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