Characterizing steroid hormone receptor chromatin binding landscapes in male and female breast cancer

Male breast cancer (MBC) is rare and poorly characterized. Like the female counterpart, most MBCs are hormonally driven, but relapse after hormonal treatment is also noted. The pan-hormonal action of steroid hormonal receptors, including estrogen receptor alpha (ERα), androgen receptor (AR), progest...

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Veröffentlicht in:	Nature communications Jg. 9; H. 1; S. 482 - 12
Hauptverfasser:	Severson, Tesa M., Kim, Yongsoo, Joosten, Stacey E. P., Schuurman, Karianne, van der Groep, Petra, Moelans, Cathy B., ter Hoeve, Natalie D., Manson, Quirine F., Martens, John W., van Deurzen, Carolien H. M., Barbe, Ellis, Hedenfalk, Ingrid, Bult, Peter, Smit, Vincent T. H. B. M., Linn, Sabine C., van Diest, Paul J., Wessels, Lodewyk, Zwart, Wilbert
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	London Nature Publishing Group UK 02.02.2018 Nature Publishing Group Nature Portfolio
Schlagworte:	38/15 38/23 38/39 45/91 631/208/69 631/67/1347 692/53/2422 Adult Aged Aged, 80 and over Androgen receptors Androgens Binding Breast cancer Breast Neoplasms - metabolism Breast Neoplasms, Male - metabolism Cancer Cancer and Oncology Cancer och onkologi Chromatin Chromatin - metabolism Clinical Medicine Crosstalk Estrogen Receptor alpha - metabolism Estrogens Female GATA-3 protein GATA3 Transcription Factor - metabolism Gene expression Genomes Glucocorticoids Hepatocyte Nuclear Factor 3-alpha - metabolism Humanities and Social Sciences Humans Klinisk medicin Male Medical and Health Sciences Medicin och hälsovetenskap Mens health Middle Aged multidisciplinary Progesterone Receptors Receptors, Androgen - metabolism Receptors, Glucocorticoid - metabolism Receptors, Progesterone - metabolism Science Science (multidisciplinary) Steroids Survival Rate Tumors
ISSN:	2041-1723, 2041-1723
Online-Zugang:	Volltext
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