Exome sequencing of hepatocellular carcinomas identifies new mutational signatures and potential therapeutic targets

Jessica Zucman-Rossi and colleagues report exome sequences of 243 hepatocellular carcinomas. They identify mutational signatures associated with specific risk factors such as alcohol, tobacco and aflatoxin B1 and find genetic alterations potentially targetable by FDA-approved drugs in 28% of the tum...

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Veröffentlicht in:	Nature genetics Jg. 47; H. 5; S. 505 - 511
Hauptverfasser:	Schulze, Kornelius, Imbeaud, Sandrine, Letouzé, Eric, Alexandrov, Ludmil B, Calderaro, Julien, Rebouissou, Sandra, Couchy, Gabrielle, Meiller, Clément, Shinde, Jayendra, Soysouvanh, Frederic, Calatayud, Anna-Line, Pinyol, Roser, Pelletier, Laura, Balabaud, Charles, Laurent, Alexis, Blanc, Jean-Frederic, Mazzaferro, Vincenzo, Calvo, Fabien, Villanueva, Augusto, Nault, Jean-Charles, Bioulac-Sage, Paulette, Stratton, Michael R, Llovet, Josep M, Zucman-Rossi, Jessica
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	New York Nature Publishing Group US 01.05.2015 Nature Publishing Group
Schlagworte:	13 13/106 45 45/23 45/61 631/208/514/1948 692/699/67/1504/1610 Aflatoxins Aged Agriculture Animal Genetics and Genomics Antineoplastic Agents - pharmacology BASIC BIOLOGICAL SCIENCES Benzoquinones - pharmacology Biomedical and Life Sciences Biomedicine Cancer Cancer Research Carcinoma, Hepatocellular - drug therapy Carcinoma, Hepatocellular - genetics Cell Line, Tumor Development and progression DNA Mutational Analysis DNA sequencing Exome Exome sequencing Female Gene Function Gene mutations Genetic aspects Genetic Association Studies Genetics Genomes Health aspects Hepatoma HSP90 Heat-Shock Proteins - antagonists & inhibitors Human Genetics Human health and pathology Humans Hépatology and Gastroenterology Identification and classification Infections Lactams, Macrocyclic - pharmacology letter Life Sciences liver cancer Liver Neoplasms - drug therapy Liver Neoplasms - genetics Male Medical research Metabolism Methods Molecular Targeted Therapy Mutation NAD(P)H Dehydrogenase (Quinone) - genetics NAD(P)H Dehydrogenase (Quinone) - metabolism Patients Quantitative Methods Risk Factors Sequence Deletion Tobacco Tumors
ISSN:	1061-4036, 1546-1718
Online-Zugang:	Volltext
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