A comprehensive mapping of stress system interactions with pain and their contribution to chronification of musculoskeletal pain: Protocol of the STRAIN study

Stress is suggested to be an important factor contributing to the development and persistence of musculoskeletal pain. Although stress and pain interactions are well known, it remains largely unclear how (dys)function of the major stress systems (i.e., the autonomic nervous system and the hypothalam...

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Bibliographic Details
Published in:	PloS one Vol. 20; no. 6; p. e0324089
Main Authors:	Moerkerke, Matthijs, Vyverman, Joren, De Baere, Robrecht, Clement, Patricia, Smeets, Tom, Coppieters, Iris, Timmers, Inge, Van Oosterwijck, Jessica
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 24.06.2025 Public Library of Science (PLoS)
Subjects:	Adult Autonomic nervous system Autonomic Nervous System - physiopathology Back pain Biology and Life Sciences Blood pressure Brain research Chronic pain Chronic Pain - physiopathology Cross-Sectional Studies Development and progression Diagnosis Female Fibromyalgia Functional anatomy Health aspects Heart rate Hormones Humans Hydrocortisone Hypothalamic-pituitary-adrenal axis Hypothalamo-Hypophyseal System - physiopathology Hypothalamus Longitudinal Studies Low back pain Magnetic resonance Magnetic resonance imaging Male Medicine and Health Sciences Middle Aged Musculoskeletal Pain - physiopathology Musculoskeletal Pain - psychology Neuroimaging Oxytocin Pain Pain Measurement Physiology Pituitary Pituitary-Adrenal System - physiopathology Recovery Research and Analysis Methods Respiration Respiratory rate Risk factors Sensory testing Skin temperature Social Sciences Stress Stress (Psychology) Stress response Stress, Psychological - complications Stress, Psychological - physiopathology Structure-function relationships Study Protocol α-Amylase Belgium
ISSN:	1932-6203, 1932-6203
Online Access:	Get full text
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