Bronchial epithelial DNA methyltransferase 3b dampens pulmonary immune responses during Pseudomonas aeruginosa infection

DNA methyltransferase (Dnmt)3b mediates de novo DNA methylation and modulation of Dnmt3b in respiratory epithelial cells has been shown to affect the expression of multiple genes. Respiratory epithelial cells provide a first line of defense against pulmonary pathogens and play a crucial role in the...

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Bibliographic Details
Published in:	PLoS pathogens Vol. 17; no. 4; p. e1009491
Main Authors:	Qin, Wanhai, Brands, Xanthe, van’t Veer, Cornelis, F. de Vos, Alex, Sirard, Jean-Claude, J. T. H. Roelofs, Joris, P. Scicluna, Brendon, van der Poll, Tom
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 01.04.2021 Public Library of Science (PLoS)
Subjects:	Alveolar Epithelial Cells - immunology Alveolar Epithelial Cells - microbiology Alveoli Animal models Animals Bacterial infections Biology and Life Sciences Bronchi - immunology Bronchi - microbiology Care and treatment Cell activation Chemokines Cystic fibrosis Cytokines Defense Defensins Deoxyribonucleic acid Development and progression DNA DNA (Cytosine-5-)-Methyltransferases - genetics DNA (Cytosine-5-)-Methyltransferases - immunology DNA Methylation DNA methyltransferase DNA Methyltransferase 3B DNMT1 protein Epithelial cells Epithelial Cells - immunology Epithelial Cells - microbiology Epithelium Flagellin Flagellin - immunology Gene expression Genes Genetic aspects Health aspects Host-bacteria relationships Humans Hypotheses IL-1β Immune response Immunity In vivo methods and tests Infections Life Sciences Lung - immunology Lung - microbiology Medicine and Health Sciences Methyltransferases Mice Mucosa Neutrophil Infiltration Pathogens Pneumonia Pneumonia, Bacterial - immunology Pneumonia, Bacterial - microbiology Proteins Pseudomonas aeruginosa Pseudomonas aeruginosa - immunology Pseudomonas infections Pseudomonas Infections - immunology Pseudomonas Infections - microbiology Respiratory Mucosa - immunology Respiratory Mucosa - microbiology Respiratory tract Tumor necrosis factor-α Virulence Netherlands
ISSN:	1553-7374, 1553-7366, 1553-7374
Online Access:	Get full text
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