Therapeutic potential of IL6R blockade for the treatment of sepsis and sepsis-related death: A Mendelian randomisation study

Sepsis is characterised by dysregulated, life-threatening immune responses, which are thought to be driven by cytokines such as interleukin 6 (IL-6). Genetic variants in IL6R known to down-regulate IL-6 signalling are associated with improved Coronavirus Disease 2019 (COVID-19) outcomes, a finding l...

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Bibliographic Details
Published in:	PLoS medicine Vol. 20; no. 1; p. e1004174
Main Authors:	Hamilton, Fergus W., Thomas, Matt, Arnold, David, Palmer, Tom, Moran, Ed, Mentzer, Alexander J., Maskell, Nick, Baillie, Kenneth, Summers, Charlotte, Hingorani, Aroon, MacGowan, Alasdair, Khandaker, Golam M., Mitchell, Ruth, Davey Smith, George, Ghazal, Peter, Timpson, Nicholas J.
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 30.01.2023 Public Library of Science (PLoS)
Subjects:	Analysis Biobanks Biology and Life Sciences Cardiovascular disease Care and treatment Chromosomes Consortia Coronaviruses COVID-19 Critical care Cytokines Dosage and administration Genetic diversity Genetics Glycoprotein gp130 Health aspects Hospitalization Humans Immune response Infection Infections Interleukin 6 Interleukin 6 receptors Interleukin-6 - genetics Interleukins Medicine and Health Sciences Mendelian Randomization Analysis Monoclonal antibodies Mortality Patient outcomes Physical Sciences Proteins Quality control Receptors, Interleukin-6 - genetics Research and Analysis Methods Sensitivity analysis Sepsis Sepsis - drug therapy Sepsis - genetics Single nucleotide polymorphisms Single-nucleotide polymorphism Statistics Survival Testing United Kingdom United Kingdom > UK
ISSN:	1549-1676, 1549-1277, 1549-1676
Online Access:	Get full text
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