Fast and accurate genotype imputation in genome-wide association studies through pre-phasing

Gonçalo Abecasis, Jonathan Marchini and colleagues report a pre-phasing strategy for genotype imputation in GWAS, which they show maintains accuracy while substantially lowering computational costs. Their approach has been implemented in both MACH and IMPUTE 2.0 software. The 1000 Genomes Project an...

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Vydáno v:	Nature genetics Ročník 44; číslo 8; s. 955 - 959
Hlavní autoři:	Howie, Bryan, Fuchsberger, Christian, Stephens, Matthew, Marchini, Jonathan, Abecasis, Gonçalo R
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	New York Nature Publishing Group US 01.08.2012 Nature Publishing Group
Témata:	631/114/2415 631/208/205/2138 Accuracy Agriculture Algorithms Animal Genetics and Genomics Biological and medical sciences Biomedical and Life Sciences Biomedicine Cancer Research Computational Biology Databases, Genetic DNA sequencing Fundamental and applied biological sciences. Psychology Gene Function Genetics of eukaryotes. Biological and molecular evolution Genome-Wide Association Study - methods Genome-Wide Association Study - statistics & numerical data Genomes Genotype Genotypes Haplotypes Health promotion Human Genetics Human Genome Project Humans Methods Nucleotide sequencing Physiological aspects Studies technical-report United States Genotype Association
ISSN:	1061-4036, 1546-1718, 1546-1718
On-line přístup:	Získat plný text
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