OX40 Facilitates Control of a Persistent Virus Infection
During acute viral infections, clearance of the pathogen is followed by the contraction of the anti-viral T cell compartment. In contrast, T cell responses need to be maintained over a longer period of time during chronic viral infections in order to control viral replication and to avoid viral spre...
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| Vydáno v: | PLoS pathogens Ročník 8; číslo 9; s. e1002913 |
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| Hlavní autoři: | , , , , , , , |
| Médium: | Journal Article |
| Jazyk: | angličtina |
| Vydáno: |
United States
Public Library of Science
01.09.2012
Public Library of Science (PLoS) |
| Témata: | |
| ISSN: | 1553-7374, 1553-7366, 1553-7374 |
| On-line přístup: | Získat plný text |
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| Shrnutí: | During acute viral infections, clearance of the pathogen is followed by the contraction of the anti-viral T cell compartment. In contrast, T cell responses need to be maintained over a longer period of time during chronic viral infections in order to control viral replication and to avoid viral spreading. Much is known about inhibitory signals such as through PD-1 that limit T cell activity during chronic viral infection, but little is known about the stimulatory signals that allow maintenance of anti-viral T cells. Here, we show that the co-stimulatory molecule OX40 (CD134) is critically required in the context of persistent LCMV clone 13 infection. Anti-viral T cells express high levels of OX40 in the presence of their cognate antigen and T cells lacking the OX40 receptor fail to accumulate sufficiently. Moreover, the emergence of T cell dependent germinal center responses and LCMV-specific antibodies are severely impaired. Consequently, OX40-deficient mice fail to control LCMV clone 13 infection over time, highlighting the importance of this signaling pathway during persistent viral infection. |
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| Bibliografie: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 ObjectType-Article-2 ObjectType-Feature-1 Conceived and designed the experiments: TB FM SSA SC MC MvH. Performed the experiments: TB FM YC MH. Analyzed the data: TB FM. Contributed reagents/materials/analysis tools: SSA SC MC. Wrote the paper: TB FM MC SC MvH. Current address: University Hospital Freiburg, Department of Gastroenterology and Hepatology, Freiburg, Germany. The authors have declared that no competing interests exist. Current address: University College London, Division of Infection and Immunity, London, Great Britain. |
| ISSN: | 1553-7374 1553-7366 1553-7374 |
| DOI: | 10.1371/journal.ppat.1002913 |