Integrated analysis of somatic mutations and focal copy-number changes identifies key genes and pathways in hepatocellular carcinoma

Jessica Zucman-Rossi and colleagues report exome sequencing of 24 hepatocellular carcinomas and non-tumor liver tissues and copy-number analysis of 125 tumors. They identify new recurrent mutations in ARID1A , RPS6KA3 , NFE2L2 and IRF2 in HCC. Hepatocellular carcinoma (HCC) is the most common primar...

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Bibliographic Details
Published in:	Nature genetics Vol. 44; no. 6; pp. 694 - 698
Main Authors:	Guichard, Cécile, Amaddeo, Giuliana, Imbeaud, Sandrine, Ladeiro, Yannick, Pelletier, Laura, Maad, Ichrafe Ben, Calderaro, Julien, Bioulac-Sage, Paulette, Letexier, Mélanie, Degos, Françoise, Clément, Bruno, Balabaud, Charles, Chevet, Eric, Laurent, Alexis, Couchy, Gabrielle, Letouzé, Eric, Calvo, Fabien, Zucman-Rossi, Jessica
Format:	Journal Article
Language:	English
Published:	New York Nature Publishing Group US 01.06.2012 Nature Publishing Group Nature Pub. Co
Subjects:	631/208/2489/144 631/208/69 Agriculture Alcohol use Animal Genetics and Genomics Biological and medical sciences Biomedical and Life Sciences Biomedicine Cancer Cancer Research Carcinogenesis Carcinoma, Hepatocellular - genetics Chromosomes Copy number variations DNA Copy Number Variations Fundamental and applied biological sciences. Psychology Gastroenterology. Liver. Pancreas. Abdomen Gene expression Gene Function Gene mutations Genetic aspects Genetics of eukaryotes. Biological and molecular evolution Genomes Health aspects Hepatitis B virus Hepatoma Human Genetics Humans Inactivation Interferon Regulatory Factor-2 - genetics letter Liver cancer Liver Neoplasms - genetics Liver. Biliary tract. Portal circulation. Exocrine pancreas Medical sciences Mutation Oxidative stress Risk factors Signal Transduction - genetics Tumors France Somatic mutation Gene Digestive system Copy number Liver Digestive diseases Hepatic disease Hepatocellular carcinoma Identification Malignant tumor Cancer
ISSN:	1061-4036, 1546-1718, 1546-1718
Online Access:	Get full text
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