Virus Infections Incite Pain Hypersensitivity by Inducing Indoleamine 2,3 Dioxygenase

Increased pain sensitivity is a comorbidity associated with many clinical diseases, though the underlying causes are poorly understood. Recently, chronic pain hypersensitivity in rodents treated to induce chronic inflammation in peripheral tissues was linked to enhanced tryptophan catabolism in brai...

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Bibliographic Details
Published in:	PLoS pathogens Vol. 12; no. 5; p. e1005615
Main Authors:	Huang, Lei, Ou, Rong, Rabelo de Souza, Guilherme, Cunha, Thiago M., Lemos, Henrique, Mohamed, Eslam, Li, Lingqian, Pacholczyk, Gabriela, Randall, Janice, Munn, David H., Mellor, Andrew L.
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 01.05.2016 Public Library of Science (PLoS)
Subjects:	Animals Biology and Life Sciences Brain research Cytokines Disease Models, Animal Enzymes Experiments Flow Cytometry Genetic aspects Health aspects HIV Human immunodeficiency virus Hyperalgesia - enzymology Hyperalgesia - etiology Hypersensitivity Hypotheses Indoleamine-Pyrrole 2,3,-Dioxygenase - biosynthesis Infections Inflammation Influenza Influenza A virus Kynurenine - metabolism Laboratory animals Leukemia Medicine and Health Sciences Mice Orthomyxoviridae Pain Pain management Physiological aspects Polymerase Chain Reaction Research and Analysis Methods Retroviridae Rodents Spinal cord Spleen Tryptophan Virus diseases Virus Diseases - complications Viruses
ISSN:	1553-7374, 1553-7366, 1553-7374
Online Access:	Get full text
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