A genome-wide association study with 1,126,563 individuals identifies new risk loci for Alzheimer’s disease

Late-onset Alzheimer’s disease is a prevalent age-related polygenic disease that accounts for 50–70% of dementia cases. Currently, only a fraction of the genetic variants underlying Alzheimer’s disease have been identified. Here we show that increased sample sizes allowed identification of seven pre...

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Vydáno v:	Nature genetics Ročník 53; číslo 9; s. 1276 - 1282
Hlavní autoři:	Wightman, Douglas P., Jansen, Iris E., Savage, Jeanne E., Shadrin, Alexey A., Bahrami, Shahram, Holland, Dominic, Rongve, Arvid, Børte, Sigrid, Winsvold, Bendik S., Drange, Ole Kristian, Martinsen, Amy E., Skogholt, Anne Heidi, Willer, Cristen, Bråthen, Geir, Bosnes, Ingunn, Nielsen, Jonas Bille, Fritsche, Lars G., Thomas, Laurent F., Pedersen, Linda M., Gabrielsen, Maiken E., Johnsen, Marianne Bakke, Meisingset, Tore Wergeland, Zhou, Wei, Proitsi, Petroula, Hodges, Angela, Dobson, Richard, Velayudhan, Latha, Heilbron, Karl, Auton, Adam, Sealock, Julia M., Davis, Lea K., Pedersen, Nancy L., Reynolds, Chandra A., Karlsson, Ida K., Magnusson, Sigurdur, Stefansson, Hreinn, Thordardottir, Steinunn, Jonsson, Palmi V., Snaedal, Jon, Zettergren, Anna, Skoog, Ingmar, Kern, Silke, Waern, Margda, Zetterberg, Henrik, Blennow, Kaj, Stordal, Eystein, Hveem, Kristian, Zwart, John-Anker, Athanasiu, Lavinia, Selnes, Per, Saltvedt, Ingvild, Sando, Sigrid B., Ulstein, Ingun, Djurovic, Srdjan, Fladby, Tormod, Aarsland, Dag, Selbæk, Geir, Ripke, Stephan, Stefansson, Kari, Andreassen, Ole A., Posthuma, Danielle
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	New York Nature Publishing Group US 01.09.2021 Nature Publishing Group
Témata:	631/208/205/2138 631/378 Agriculture Alzheimer Disease - genetics Alzheimer's disease Animal Genetics and Genomics Biomedical and Life Sciences Biomedicine Cancer Research drivers Gene Function gene-expression Genetic aspects Genetic Predisposition to Disease - genetics Genetic variation Genetics & Heredity Genome-wide association studies Genome-Wide Association Study Health aspects heritability Human Genetics Humans Identification and classification ld score regression metaanalysis Methods Microglia - cytology Multifactorial Inheritance - genetics Neurosciences Neurovetenskaper polygenic risk Polymorphism, Single Nucleotide - genetics Proteins - metabolism Proteolysis Risk factors rna-seq Sample Size signatures transcriptome Sweden
ISSN:	1061-4036, 1546-1718, 1546-1718
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