A genome-wide association study of plasma total IgE concentrations in the Framingham Heart Study

Atopy and plasma IgE concentration are genetically complex traits, and the specific genetic risk factors that lead to IgE dysregulation and clinical atopy are an area of active investigation. We sought to ascertain the genetic risk factors that lead to IgE dysregulation. A genome-wide association st...

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Bibliographic Details
Published in:	Journal of allergy and clinical immunology Vol. 129; no. 3; pp. 840 - 845.e21
Main Authors:	Granada, Mark, Wilk, Jemma B., Tuzova, Marina, Strachan, David P., Weidinger, Stephan, Albrecht, Eva, Gieger, Christian, Heinrich, Joachim, Himes, Blanca E., Hunninghake, Gary M., Celedón, Juan C., Weiss, Scott T., Cruikshank, William W., Farrer, Lindsay A., Center, David M., O'Connor, George T.
Format:	Journal Article
Language:	English
Published:	New York, NY Mosby, Inc 01.03.2012 Elsevier Elsevier Limited
Subjects:	Adult Allergies Allergy and Immunology asthma atopy Biological and medical sciences blood groups Cardiovascular Diseases - blood Cardiovascular Diseases - epidemiology Cardiovascular Diseases - genetics Cardiovascular Diseases - immunology chemokine receptors childhood Chronic obstructive pulmonary disease, asthma Cohort Studies Female Fundamental and applied biological sciences. Psychology Fundamental immunology Genes Genetic Predisposition to Disease Genome-Wide Association Study heart HLA Antigens - genetics Humans Hypersensitivity - blood Hypersensitivity - epidemiology Hypersensitivity - genetics Hypersensitivity - immunology immunoglobulin E Immunoglobulin E - blood Immunopathology Interleukin-13 - genetics Linkage Disequilibrium loci Male Medical research Medical sciences meta-analysis Middle Aged pathogenesis Plasma Pneumology Polymorphism, Single Nucleotide Receptors, IgE - genetics Risk Factors Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis signal transduction single nucleotide polymorphism STAT6 Transcription Factor - genetics Studies Total IgE transcription factors United Kingdom United States B58C GWAS atopy asthma FHS KORA DARC CEU RAD50 SNP genome-wide association study LD Total IgE MACH STAT6 CAMP Linkage disequilibrium Signal transducer and activator of transcription 6 Markov Chain haplotyping Duffy blood group, chemokine receptor RAD50 homolog (Saccharomyces cerevisiae) Childhood Asthma Management Program Framingham Heart Study Western European British 1958 Birth Cohort Cooperative Health Research in the Region of Augsburg Single nucleotide polymorphism Heart Allergy Lung disease Immunopathology Respiratory disease IgE Concentration Asthma Atopy Blood plasma Association Immunology Bronchus disease Circulatory system Obstructive pulmonary disease Genome
ISSN:	0091-6749, 1097-6825, 1097-6825
Online Access:	Get full text
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