Patients with Tuberculosis Have a Dysfunctional Circulating B-Cell Compartment, Which Normalizes following Successful Treatment

B-cells not only produce immunoglobulins and present antigens to T-cells, but also additional key roles in the immune system. Current knowledge on the role of B-cells in infections caused by intracellular bacteria is fragmentary and contradictory. We therefore analysed the phenotypical and functiona...

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Bibliographic Details
Published in:	PLoS pathogens Vol. 12; no. 6; p. e1005687
Main Authors:	Joosten, Simone A., van Meijgaarden, Krista E., del Nonno, Franca, Baiocchini, Andrea, Petrone, Linda, Vanini, Valentina, Smits, Hermelijn H., Palmieri, Fabrizio, Goletti, Delia, Ottenhoff, Tom H. M.
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 01.06.2016 Public Library of Science (PLoS)
Subjects:	Analysis Antigens B cells B-Lymphocytes - immunology Bacillus Bacterial infections Biology and Life Sciences Care and treatment Cytokines Disease susceptibility Enzyme-Linked Immunosorbent Assay Experiments Flow Cytometry Funding Humans Immune system Immunoglobulins Immunohistochemistry Infections Infectious diseases Latent Tuberculosis - immunology Medicine and Health Sciences Mycobacterium tuberculosis Mycobacterium tuberculosis - immunology Pathogens Phenotype Research and Analysis Methods Tuberculosis Tuberculosis - drug therapy Tuberculosis - immunology
ISSN:	1553-7374, 1553-7366, 1553-7374
Online Access:	Get full text
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