Vitamin D levels and food and environmental allergies in the United States: Results from the National Health and Nutrition Examination Survey 2005-2006

Previous research supports a possible link between low vitamin D levels and atopic disease. However, the association between low vitamin D levels and total and allergen-specific IgE levels has not been studied. We sought to test the association between serum 25-hydroxyvitamin D (25[OH]D) deficiency...

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Published in:	Journal of allergy and clinical immunology Vol. 127; no. 5; pp. 1195 - 1202
Main Authors:	Sharief, Shimi, Jariwala, Sunit, Kumar, Juhi, Muntner, Paul, Melamed, Michal L.
Format:	Journal Article
Language:	English
Published:	New York, NY Mosby, Inc 01.05.2011 Elsevier Elsevier Limited
Subjects:	25-Hydroxyvitamin D Adolescence Adolescent Adolescents Adult adults Age Allergens Allergens - adverse effects Allergens - immunology Allergic diseases allergic sensitization Allergies Allergy and Immunology Antigens Arachis hypogaea Atopy Biological and medical sciences blood serum Child Child, Preschool Children Children & youth Computers Cotinine Dietary supplements Digestive allergic diseases Disease control Environment Ethnic groups Female Food Food allergies Food hypersensitivity Food Hypersensitivity - complications Food Hypersensitivity - epidemiology Fundamental and applied biological sciences. Psychology Fundamental immunology Humans Hypersensitivity Hypersensitivity, Immediate - complications Hypersensitivity, Immediate - epidemiology Immunoglobulin E Immunoglobulin E - blood Immunopathology Infant Male Medical sciences Middle Aged Milk milk consumption National Health and Nutrition Examination Survey nationalities and ethnic groups Nutrient deficiency Nutrition Nutrition Surveys Nuts Obesity odds ratio peanuts Questionnaires Races Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis Sex Socio-economic aspects socioeconomic status Teenagers Television United States United States - epidemiology Vitamin D Vitamin D - analogs & derivatives Vitamin D - blood vitamin D deficiency Vitamin D Deficiency - complications Vitamin D Deficiency - epidemiology Vitamin deficiency Vitamins Web sites Young Adult United States North America America United States > US USA SES OR vitamin D allergic sensitization 25(OH)D NHANES Atopy Socioeconomic status Odds ratio National Health and Nutrition Examination Survey 25-Hydroxyvitamin D Food allergy Immunopathology Immunology Vitamin D Nutrition survey Health Digestive diseases Environment Sensitization
ISSN:	0091-6749, 1097-6825, 1097-6825
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Summary:	Previous research supports a possible link between low vitamin D levels and atopic disease. However, the association between low vitamin D levels and total and allergen-specific IgE levels has not been studied. We sought to test the association between serum 25-hydroxyvitamin D (25[OH]D) deficiency (<15 ng/mL) and insufficiency (15-29 ng/mL) and allergic sensitization measured by serum IgE levels in a US nationally representative sample of 3136 children and adolescents and 3454 adults in the National Health and Nutrition Examination Survey 2005-2006. The association of 25(OH)D deficiency with 17 different allergens was assessed after adjustment for potential confounders, including age; sex; race/ethnicity; obesity, low socioeconomic status; frequency of milk intake; daily hours spent watching television, playing videogames, or using a computer; serum cotinine levels; and vitamin D supplement use. In children and adolescents allergic sensitization to 11 of 17 allergens was more common in those with 25(OH)D deficiency. Compared with sufficient vitamin D levels of greater than 30 ng/mL, after multivariate adjustment, 25(OH)D levels of less than 15 ng/mL were associated with peanut (odds ratio [OR], 2.39; 95% CI, 1.29-4.45), ragweed (OR, 1.83; 95% CI, 1.20-2.80), and oak (OR, 4.75; 95% CI, 1.53-4.94) allergies ( P < .01 for all). Eight other allergens were associated with 25(OH)D deficiency, with P values of less than .05 but greater than .01. There were no consistent associations seen between 25(OH)D levels and allergic sensitization in adults. Vitamin D deficiency is associated with higher levels of IgE sensitization in children and adolescents. Further research is needed to confirm these findings.
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ISSN:	0091-6749 1097-6825 1097-6825
DOI:	10.1016/j.jaci.2011.01.017