Role of ruscogenin extracted from Radix Ophiopogon Japonicus in antagonizing 5-hydroxytryptamine and dopamine receptors through computational screening

The 5-hydroxytryptamine (5-HT) and dopamine (DA) receptors have emerged as significant targets for therapeutic intervention in psychiatric disorders. Currently, the efficacy of psychiatric drugs is limited by challenges in achieving desired outcomes, the occurrence of adverse effects, dependence, an...

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Veröffentlicht in:	PloS one Jg. 19; H. 11; S. e0310960
Hauptverfasser:	Ma, Suya, Liu, Yongmei
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States Public Library of Science 19.11.2024 Public Library of Science (PLoS)
Schlagworte:	Algorithms Analysis Animal behavior Antipsychotics Anxiety Binding Binding energy Biology and Life Sciences Bonding agents Bonding strength Disorders Dopamine Dopamine D2 receptors Dopamine receptors Drug dependence Drug development Effectiveness Equilibrium Free energy Hallucinations Humans Hydrogen Hydrogen bonding Inhibitors Ligands Medicine and Health Sciences Medicine, Chinese Mental depression Mental disorders Molecular docking Molecular Docking Simulation Molecular dynamics Molecular Dynamics Simulation Natural products Pharmaceuticals Pharmacology Physical Sciences Plant Extracts - chemistry Plant Extracts - pharmacology Product development Properties Proteins Psychotropic drugs Receptor, Serotonin, 5-HT2A - chemistry Receptor, Serotonin, 5-HT2A - metabolism Receptors Receptors, Dopamine D2 - chemistry Receptors, Dopamine D2 - metabolism Research and Analysis Methods Residues Risperidone Schizophrenia Serotonin Serotonin 5-HT2 Receptor Antagonists - chemistry Serotonin 5-HT2 Receptor Antagonists - pharmacology Serotonin S2 receptors Simulation Spirostans - chemistry Spirostans - isolation & purification Spirostans - pharmacology Withdrawal China
ISSN:	1932-6203, 1932-6203
Online-Zugang:	Volltext
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