Family and personal history of cancer in the All of Us research program for precision medicine

The All of Us ( AoU ) Research Program is making available one of the largest and most diverse collections of health data in the US to researchers. Using the All of Us database, we evaluated family and personal histories of five common types of cancer in 89,453 individuals, comparing these data to 2...

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Vydáno v:PloS one Ročník 18; číslo 7; s. e0288496
Hlavní autoři: Keeler Bruce, Lauryn, Paul, Paulina, Kim, Katherine K., Kim, Jihoon, Keegan, Theresa H. M., Hiatt, Robert A., Ohno-Machado, Lucila
Médium: Journal Article
Jazyk:angličtina
Vydáno: United States Public Library of Science 17.07.2023
Public Library of Science (PLoS)
Témata:
Biology and Life Sciences
Breast cancer
Cancer
Colorectal cancer
Data collection
Databases, Factual
Datasets
Diagnosis
Electronic health records
Ethnicity
Evaluation
Family medical history
Genetic aspects
Human subjects
Humans
Medical research
Medical screening
Medicine and Health Sciences
Medicine, Experimental
Neoplasms - genetics
Neoplasms - therapy
Oncology, Experimental
Ovarian cancer
Ovaries
Population Health
Precision Medicine
Prostate
Prostate cancer
Research and Analysis Methods
Review boards
Statistical analysis
Structured Query Language-SQL
Surveys
Surveys and Questionnaires
United States
United States > US
ISSN:1932-6203, 1932-6203
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Popis
Shrnutí:The All of Us ( AoU ) Research Program is making available one of the largest and most diverse collections of health data in the US to researchers. Using the All of Us database, we evaluated family and personal histories of five common types of cancer in 89,453 individuals, comparing these data to 24,305 participants from the 2015 National Health Interview Survey (NHIS). Comparing datasets, we found similar family cancer history (33%) rates, but higher personal cancer history in the AoU dataset (9.2% in AoU vs. 5.11% in NHIS), Methodological ( e . g . survey-versus telephone-based data collection) and demographic variability may explain these between-data differences, but more research is needed.
Bibliografie:ObjectType-Article-1
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Competing Interests: The authors have declared that no competing interests exist.
Membership of the All of Us Research Program Investigators are listed in the Acknowledgments.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0288496