Dietary polyphenols as a safe and novel intervention for modulating pain associated with intervertebral disc degeneration in an in-vivo rat model

Developing effective therapies for back pain associated with intervertebral disc (IVD) degeneration is a research priority since it is a major socioeconomic burden and current conservative and surgical treatments have limited success. Polyphenols are naturally occurring compounds in plant-derived fo...

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Veröffentlicht in:PloS one Jg. 14; H. 10; S. e0223435
Hauptverfasser: Lai, Alon, Ho, Lap, Evashwick-Rogler, Thomas W., Watanabe, Hironobu, Salandra, Jonathan, Winkelstein, Beth A., Laudier, Damien, Hecht, Andrew C., Pasinetti, Giulio M., Iatridis, James C.
Format: Journal Article
Sprache:Englisch
Veröffentlicht: United States Public Library of Science 02.10.2019
Public Library of Science (PLoS)
Schlagworte:
Animals
Back pain
Back Pain - diagnosis
Back Pain - drug therapy
Back Pain - etiology
Back Pain - physiopathology
Behavior
Behavior, Animal
Beverages
Biological activity
Biology and Life Sciences
Biomarkers
Care and treatment
Chronic illnesses
Cytokines
Cytokines - genetics
Cytokines - metabolism
Degeneration
Degeneration (Pathology)
Diet
Dietary Supplements
Disease Models, Animal
Drinking water
Food plants
Ganglia, Spinal - metabolism
Ganglion cysts
Gene expression
Hyperalgesia - etiology
Hyperalgesia - metabolism
Hyperalgesia - physiopathology
Immunomodulation
Inflammation
Inflammation Mediators - metabolism
Intervertebral Disc Degeneration - complications
Intervertebral discs
Laboratory rats
Low Back Pain - diagnosis
Low Back Pain - drug therapy
Low Back Pain - etiology
Low Back Pain - physiopathology
Male
Medical research
Medicine
Medicine and Health Sciences
Neurological diseases
Pain
Pain Management - methods
Pain Measurement
Pain perception
Phenols (Class of compounds)
Plants
Polyphenols
Polyphenols - administration & dosage
Radiography
Rats
Research and Analysis Methods
Safety and security measures
Signs and symptoms
Surgery
Tumor necrosis factor-TNF
Water
New York
United States > US
Pennsylvania
ISSN:1932-6203, 1932-6203
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Beschreibung
Zusammenfassung:Developing effective therapies for back pain associated with intervertebral disc (IVD) degeneration is a research priority since it is a major socioeconomic burden and current conservative and surgical treatments have limited success. Polyphenols are naturally occurring compounds in plant-derived foods and beverages, and evidence suggests dietary supplementation with select polyphenol preparations can modulate diverse neurological and painful disorders. This study tested whether supplementation with a select standardized Bioactive-Dietary-Polyphenol-Preparation (BDPP) may alleviate pain symptoms associated with IVD degeneration. Painful IVD degeneration was surgically induced in skeletally-mature rats by intradiscal saline injection into three consecutive lumbar IVDs. Injured rats were given normal or BDPP-supplemented drinking water. In-vivo hindpaw mechanical allodynia and IVD height were assessed weekly for 6 weeks following injury. Spinal column, dorsal-root-ganglion (DRG) and serum were collected at 1 and 6 weeks post-operative (post-op) for analyses of IVD-related mechanical and biological pathogenic processes. Dietary BDPP significantly alleviated the typical behavioral sensitivity associated with surgical procedures and IVD degeneration, but did not modulate IVD degeneration nor changes of pro-inflammatory cytokine levels in IVD. Gene expression analyses suggested BDPP might have an immunomodulatory effect in attenuating the expression of pro-inflammatory cytokines in DRGs. This study supports the idea that dietary supplementation with BDPP has potential to alleviate IVD degeneration-related pain, and further investigations are warranted to identify the mechanisms of action of dietary BDPP.
Bibliographie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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Competing Interests: The authors have declared that no competing interests exist.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0223435