Dietary polyphenols as a safe and novel intervention for modulating pain associated with intervertebral disc degeneration in an in-vivo rat model
Developing effective therapies for back pain associated with intervertebral disc (IVD) degeneration is a research priority since it is a major socioeconomic burden and current conservative and surgical treatments have limited success. Polyphenols are naturally occurring compounds in plant-derived fo...
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| Vydáno v: | PloS one Ročník 14; číslo 10; s. e0223435 |
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| Hlavní autoři: | , , , , , , , , , |
| Médium: | Journal Article |
| Jazyk: | angličtina |
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United States
Public Library of Science
02.10.2019
Public Library of Science (PLoS) |
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| ISSN: | 1932-6203, 1932-6203 |
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| Abstract | Developing effective therapies for back pain associated with intervertebral disc (IVD) degeneration is a research priority since it is a major socioeconomic burden and current conservative and surgical treatments have limited success. Polyphenols are naturally occurring compounds in plant-derived foods and beverages, and evidence suggests dietary supplementation with select polyphenol preparations can modulate diverse neurological and painful disorders. This study tested whether supplementation with a select standardized Bioactive-Dietary-Polyphenol-Preparation (BDPP) may alleviate pain symptoms associated with IVD degeneration. Painful IVD degeneration was surgically induced in skeletally-mature rats by intradiscal saline injection into three consecutive lumbar IVDs. Injured rats were given normal or BDPP-supplemented drinking water. In-vivo hindpaw mechanical allodynia and IVD height were assessed weekly for 6 weeks following injury. Spinal column, dorsal-root-ganglion (DRG) and serum were collected at 1 and 6 weeks post-operative (post-op) for analyses of IVD-related mechanical and biological pathogenic processes. Dietary BDPP significantly alleviated the typical behavioral sensitivity associated with surgical procedures and IVD degeneration, but did not modulate IVD degeneration nor changes of pro-inflammatory cytokine levels in IVD. Gene expression analyses suggested BDPP might have an immunomodulatory effect in attenuating the expression of pro-inflammatory cytokines in DRGs. This study supports the idea that dietary supplementation with BDPP has potential to alleviate IVD degeneration-related pain, and further investigations are warranted to identify the mechanisms of action of dietary BDPP. |
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| AbstractList | Developing effective therapies for back pain associated with intervertebral disc (IVD) degeneration is a research priority since it is a major socioeconomic burden and current conservative and surgical treatments have limited success. Polyphenols are naturally occurring compounds in plant-derived foods and beverages, and evidence suggests dietary supplementation with select polyphenol preparations can modulate diverse neurological and painful disorders. This study tested whether supplementation with a select standardized Bioactive-Dietary-Polyphenol-Preparation (BDPP) may alleviate pain symptoms associated with IVD degeneration. Painful IVD degeneration was surgically induced in skeletally-mature rats by intradiscal saline injection into three consecutive lumbar IVDs. Injured rats were given normal or BDPP-supplemented drinking water. In-vivo hindpaw mechanical allodynia and IVD height were assessed weekly for 6 weeks following injury. Spinal column, dorsal-root-ganglion (DRG) and serum were collected at 1 and 6 weeks post-operative (post-op) for analyses of IVD-related mechanical and biological pathogenic processes. Dietary BDPP significantly alleviated the typical behavioral sensitivity associated with surgical procedures and IVD degeneration, but did not modulate IVD degeneration nor changes of pro-inflammatory cytokine levels in IVD. Gene expression analyses suggested BDPP might have an immunomodulatory effect in attenuating the expression of pro-inflammatory cytokines in DRGs. This study supports the idea that dietary supplementation with BDPP has potential to alleviate IVD degeneration-related pain, and further investigations are warranted to identify the mechanisms of action of dietary BDPP. Developing effective therapies for back pain associated with intervertebral disc (IVD) degeneration is a research priority since it is a major socioeconomic burden and current conservative and surgical treatments have limited success. Polyphenols are naturally occurring compounds in plant-derived foods and beverages, and evidence suggests dietary supplementation with select polyphenol preparations can modulate diverse neurological and painful disorders. This study tested whether supplementation with a select standardized Bioactive-Dietary-Polyphenol-Preparation (BDPP) may alleviate pain symptoms associated with IVD degeneration. Painful IVD degeneration was surgically induced in skeletally-mature rats by intradiscal saline injection into three consecutive lumbar IVDs. Injured rats were given normal or BDPP-supplemented drinking water. In-vivo hindpaw mechanical allodynia and IVD height were assessed weekly for 6 weeks following injury. Spinal column, dorsal-root-ganglion (DRG) and serum were collected at 1 and 6 weeks post-operative (post-op) for analyses of IVD-related mechanical and biological pathogenic processes. Dietary BDPP significantly alleviated the typical behavioral sensitivity associated with surgical procedures and IVD degeneration, but did not modulate IVD degeneration nor changes of pro-inflammatory cytokine levels in IVD. Gene expression analyses suggested BDPP might have an immunomodulatory effect in attenuating the expression of pro-inflammatory cytokines in DRGs. This study supports the idea that dietary supplementation with BDPP has potential to alleviate IVD degeneration-related pain, and further investigations are warranted to identify the mechanisms of action of dietary BDPP.Developing effective therapies for back pain associated with intervertebral disc (IVD) degeneration is a research priority since it is a major socioeconomic burden and current conservative and surgical treatments have limited success. Polyphenols are naturally occurring compounds in plant-derived foods and beverages, and evidence suggests dietary supplementation with select polyphenol preparations can modulate diverse neurological and painful disorders. This study tested whether supplementation with a select standardized Bioactive-Dietary-Polyphenol-Preparation (BDPP) may alleviate pain symptoms associated with IVD degeneration. Painful IVD degeneration was surgically induced in skeletally-mature rats by intradiscal saline injection into three consecutive lumbar IVDs. Injured rats were given normal or BDPP-supplemented drinking water. In-vivo hindpaw mechanical allodynia and IVD height were assessed weekly for 6 weeks following injury. Spinal column, dorsal-root-ganglion (DRG) and serum were collected at 1 and 6 weeks post-operative (post-op) for analyses of IVD-related mechanical and biological pathogenic processes. Dietary BDPP significantly alleviated the typical behavioral sensitivity associated with surgical procedures and IVD degeneration, but did not modulate IVD degeneration nor changes of pro-inflammatory cytokine levels in IVD. Gene expression analyses suggested BDPP might have an immunomodulatory effect in attenuating the expression of pro-inflammatory cytokines in DRGs. This study supports the idea that dietary supplementation with BDPP has potential to alleviate IVD degeneration-related pain, and further investigations are warranted to identify the mechanisms of action of dietary BDPP. |
| Audience | Academic |
| Author | Watanabe, Hironobu Pasinetti, Giulio M. Ho, Lap Hecht, Andrew C. Lai, Alon Salandra, Jonathan Laudier, Damien Iatridis, James C. Evashwick-Rogler, Thomas W. Winkelstein, Beth A. |
| AuthorAffiliation | 5 Philadelphia College of Osteopathic Medicine, Philadelphia, Pennsylvania, United States of America 2 Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America 4 Keiyu Orthopedic Hospital, Tatebayashi, Japan 6 Department of Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America Zhejiang University, CHINA 1 Leni & Peter W. May Department of Orthopaedics, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America 3 James J. Peters Veterans Affairs Medical Center, Bronx, New York, United States of America |
| AuthorAffiliation_xml | – name: 1 Leni & Peter W. May Department of Orthopaedics, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America – name: 4 Keiyu Orthopedic Hospital, Tatebayashi, Japan – name: 6 Department of Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America – name: 2 Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America – name: 3 James J. Peters Veterans Affairs Medical Center, Bronx, New York, United States of America – name: Zhejiang University, CHINA – name: 5 Philadelphia College of Osteopathic Medicine, Philadelphia, Pennsylvania, United States of America |
| Author_xml | – sequence: 1 givenname: Alon orcidid: 0000-0002-0163-4588 surname: Lai fullname: Lai, Alon – sequence: 2 givenname: Lap surname: Ho fullname: Ho, Lap – sequence: 3 givenname: Thomas W. surname: Evashwick-Rogler fullname: Evashwick-Rogler, Thomas W. – sequence: 4 givenname: Hironobu surname: Watanabe fullname: Watanabe, Hironobu – sequence: 5 givenname: Jonathan surname: Salandra fullname: Salandra, Jonathan – sequence: 6 givenname: Beth A. surname: Winkelstein fullname: Winkelstein, Beth A. – sequence: 7 givenname: Damien surname: Laudier fullname: Laudier, Damien – sequence: 8 givenname: Andrew C. surname: Hecht fullname: Hecht, Andrew C. – sequence: 9 givenname: Giulio M. surname: Pasinetti fullname: Pasinetti, Giulio M. – sequence: 10 givenname: James C. orcidid: 0000-0002-2186-0590 surname: Iatridis fullname: Iatridis, James C. |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/31577822$$D View this record in MEDLINE/PubMed |
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| CitedBy_id | crossref_primary_10_1002_jsp2_1150 crossref_primary_10_1016_j_spinee_2023_04_012 crossref_primary_10_1038_s41598_023_46429_w crossref_primary_10_1002_jsp2_1212 crossref_primary_10_3389_fendo_2024_1340625 crossref_primary_10_1002_jsp2_1202 crossref_primary_10_1038_s41598_023_39334_9 crossref_primary_10_1371_journal_pone_0225674 crossref_primary_10_3389_fbioe_2025_1643222 |
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| Copyright | COPYRIGHT 2019 Public Library of Science 2019 Lai et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. 2019 Lai et al 2019 Lai et al |
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| Snippet | Developing effective therapies for back pain associated with intervertebral disc (IVD) degeneration is a research priority since it is a major socioeconomic... |
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| SubjectTerms | Animals Back pain Back Pain - diagnosis Back Pain - drug therapy Back Pain - etiology Back Pain - physiopathology Behavior Behavior, Animal Beverages Biological activity Biology and Life Sciences Biomarkers Care and treatment Chronic illnesses Cytokines Cytokines - genetics Cytokines - metabolism Degeneration Degeneration (Pathology) Diet Dietary Supplements Disease Models, Animal Drinking water Food plants Ganglia, Spinal - metabolism Ganglion cysts Gene expression Hyperalgesia - etiology Hyperalgesia - metabolism Hyperalgesia - physiopathology Immunomodulation Inflammation Inflammation Mediators - metabolism Intervertebral Disc Degeneration - complications Intervertebral discs Laboratory rats Low Back Pain - diagnosis Low Back Pain - drug therapy Low Back Pain - etiology Low Back Pain - physiopathology Male Medical research Medicine Medicine and Health Sciences Neurological diseases Pain Pain Management - methods Pain Measurement Pain perception Phenols (Class of compounds) Plants Polyphenols Polyphenols - administration & dosage Radiography Rats Research and Analysis Methods Safety and security measures Signs and symptoms Surgery Tumor necrosis factor-TNF Water |
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| Title | Dietary polyphenols as a safe and novel intervention for modulating pain associated with intervertebral disc degeneration in an in-vivo rat model |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/31577822 https://www.proquest.com/docview/2300171614 https://www.proquest.com/docview/2300596061 https://pubmed.ncbi.nlm.nih.gov/PMC6774529 https://doaj.org/article/2d3a83857bdd4963a72bdadab1e4d815 http://dx.doi.org/10.1371/journal.pone.0223435 |
| Volume | 14 |
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