Shifts in Mycobacterial Populations and Emerging Drug-Resistance in West and Central Africa

In this study, we retrospectively analysed a total of 605 clinical isolates from six West or Central African countries (Benin, Cameroon, Central African Republic, Guinea-Conakry, Niger and Senegal). Besides spoligotyping to assign isolates to ancient and modern mycobacterial lineages, we conducted p...

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Veröffentlicht in:PloS one Jg. 9; H. 12; S. e110393
Hauptverfasser: Gehre, Florian, Ejo, Mebrat, Fissette, Kristina, de Rijk, Pim, Uwizeye, Cécile, Nduwamahoro, Elie, Goovaerts, Odin, Affolabi, Dissou, Gninafon, Martin, Lingoupou, Fanny M., Barry, Mamadou Dian, Sow, Oumou, Merle, Corinne, Olliaro, Piero, Ba, Fatoumata, Sarr, Marie, Piubello, Alberto, Noeske, Juergen, Antonio, Martin, Rigouts, Leen, de Jong, Bouke C
Format: Journal Article
Sprache:Englisch
Veröffentlicht: United States Public Library of Science 10.12.2014
Public Library of Science (PLoS)
Schlagworte:
Africa, Central
Africa, Western
Antitubercular Agents - pharmacology
Biology and Life Sciences
Clinical isolates
Drug resistance
Drug Resistance, Bacterial
Drugs
Epidemiology
Genetic diversity
Genotyping Techniques
Medical research
Medicine
Medicine and Health Sciences
Microbial drug resistance
Mycobacterium
Mycobacterium tuberculosis
Mycobacterium tuberculosis - drug effects
Mycobacterium tuberculosis - genetics
Mycobacterium tuberculosis - isolation & purification
Phylogeny
Public health
Retreatment
Retrospective Studies
Spoligotyping
Tuberculosis
Tuberculosis - drug therapy
Tuberculosis - epidemiology
Tuberculosis - microbiology
New York
Benin
Cameroon
Niger
United States > US
Africa
Sierra Leone
Ghana
India
Belgium
Gambia
Senegal
West Africa
Central African Republic
Central Africa
Nigeria
ISSN:1932-6203, 1932-6203
Online-Zugang:Volltext
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Beschreibung
Zusammenfassung:In this study, we retrospectively analysed a total of 605 clinical isolates from six West or Central African countries (Benin, Cameroon, Central African Republic, Guinea-Conakry, Niger and Senegal). Besides spoligotyping to assign isolates to ancient and modern mycobacterial lineages, we conducted phenotypic drug-susceptibility-testing for each isolate for the four first-line drugs. We showed that phylogenetically modern Mycobacterium tuberculosis strains are more likely associated with drug resistance than ancient strains and predict that the currently ongoing replacement of the endemic ancient by a modern mycobacterial population in West/Central Africa might result in increased drug resistance in the sub-region.
Bibliographie:ObjectType-Article-1
SourceType-Scholarly Journals-1
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Competing Interests: The authors have declared that no competing interests exist.
Conceived and designed the experiments: FG ME CM PO BdJ. Performed the experiments: ME KF PdR CU EN DA MG FL MB OS CM PO FB MS AP JN. Analyzed the data: FG ME OG CM PO BdJ LR. Contributed to the writing of the manuscript: FG ME MA CM PO BdJ.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0110393