Shifts in Mycobacterial Populations and Emerging Drug-Resistance in West and Central Africa

In this study, we retrospectively analysed a total of 605 clinical isolates from six West or Central African countries (Benin, Cameroon, Central African Republic, Guinea-Conakry, Niger and Senegal). Besides spoligotyping to assign isolates to ancient and modern mycobacterial lineages, we conducted p...

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Vydáno v:	PloS one Ročník 9; číslo 12; s. e110393
Hlavní autoři:	Gehre, Florian, Ejo, Mebrat, Fissette, Kristina, de Rijk, Pim, Uwizeye, Cécile, Nduwamahoro, Elie, Goovaerts, Odin, Affolabi, Dissou, Gninafon, Martin, Lingoupou, Fanny M., Barry, Mamadou Dian, Sow, Oumou, Merle, Corinne, Olliaro, Piero, Ba, Fatoumata, Sarr, Marie, Piubello, Alberto, Noeske, Juergen, Antonio, Martin, Rigouts, Leen, de Jong, Bouke C
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States Public Library of Science 10.12.2014 Public Library of Science (PLoS)
Témata:	Africa, Central Africa, Western Antitubercular Agents - pharmacology Biology and Life Sciences Clinical isolates Drug resistance Drug Resistance, Bacterial Drugs Epidemiology Genetic diversity Genotyping Techniques Medical research Medicine Medicine and Health Sciences Microbial drug resistance Mycobacterium Mycobacterium tuberculosis Mycobacterium tuberculosis - drug effects Mycobacterium tuberculosis - genetics Mycobacterium tuberculosis - isolation & purification Phylogeny Public health Retreatment Retrospective Studies Spoligotyping Tuberculosis Tuberculosis - drug therapy Tuberculosis - epidemiology Tuberculosis - microbiology New York Benin Cameroon Niger United States > US Africa Sierra Leone Ghana India Belgium Gambia Senegal West Africa Central African Republic Central Africa Nigeria
ISSN:	1932-6203, 1932-6203
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Abstract	In this study, we retrospectively analysed a total of 605 clinical isolates from six West or Central African countries (Benin, Cameroon, Central African Republic, Guinea-Conakry, Niger and Senegal). Besides spoligotyping to assign isolates to ancient and modern mycobacterial lineages, we conducted phenotypic drug-susceptibility-testing for each isolate for the four first-line drugs. We showed that phylogenetically modern Mycobacterium tuberculosis strains are more likely associated with drug resistance than ancient strains and predict that the currently ongoing replacement of the endemic ancient by a modern mycobacterial population in West/Central Africa might result in increased drug resistance in the sub-region.
AbstractList	In this study, we retrospectively analysed a total of 605 clinical isolates from six West or Central African countries (Benin, Cameroon, Central African Republic, Guinea-Conakry, Niger and Senegal). Besides spoligotyping to assign isolates to ancient and modern mycobacterial lineages, we conducted phenotypic drug-susceptibility-testing for each isolate for the four first-line drugs. We showed that phylogenetically modern Mycobacterium tuberculosis strains are more likely associated with drug resistance than ancient strains and predict that the currently ongoing replacement of the endemic ancient by a modern mycobacterial population in West/Central Africa might result in increased drug resistance in the sub-region.In this study, we retrospectively analysed a total of 605 clinical isolates from six West or Central African countries (Benin, Cameroon, Central African Republic, Guinea-Conakry, Niger and Senegal). Besides spoligotyping to assign isolates to ancient and modern mycobacterial lineages, we conducted phenotypic drug-susceptibility-testing for each isolate for the four first-line drugs. We showed that phylogenetically modern Mycobacterium tuberculosis strains are more likely associated with drug resistance than ancient strains and predict that the currently ongoing replacement of the endemic ancient by a modern mycobacterial population in West/Central Africa might result in increased drug resistance in the sub-region. In this study, we retrospectively analysed a total of 605 clinical isolates from six West or Central African countries (Benin, Cameroon, Central African Republic, Guinea-Conakry, Niger and Senegal). Besides spoligotyping to assign isolates to ancient and modern mycobacterial lineages, we conducted phenotypic drug-susceptibility-testing for each isolate for the four first-line drugs. We showed that phylogenetically modern Mycobacterium tuberculosis strains are more likely associated with drug resistance than ancient strains and predict that the currently ongoing replacement of the endemic ancient by a modern mycobacterial population in West/Central Africa might result in increased drug resistance in the sub-region.
Audience	Academic
Author	Barry, Mamadou Dian Gninafon, Martin Rigouts, Leen Affolabi, Dissou Goovaerts, Odin Sarr, Marie Uwizeye, Cécile Noeske, Juergen Ejo, Mebrat Ba, Fatoumata de Rijk, Pim Fissette, Kristina Gehre, Florian Piubello, Alberto Merle, Corinne de Jong, Bouke C Nduwamahoro, Elie Sow, Oumou Olliaro, Piero Antonio, Martin Lingoupou, Fanny M.
AuthorAffiliation	3 Laboratoire de Reference des Mycobactéries, Cotonou, Benin 9 National TB Programme, Dakar, Senegal University of Florence, Italy 6 London School of Hygiene and Tropical Medicine, London, United Kingdom 8 Laboratoire de Reference des Mycobactéries, Dakar, Senegal 11 Independent Consultant, Yaoundé, Cameroon 12 New York University, New York, United States of America 7 UNICEF/UNDP/World Bank/WHO Special Programme for Research and Training in Tropical Diseases (TDR), Geneva, Switzerland 5 Laboratoire de Reference des Mycobactéries, Conakry, Guinea-Conakry 10 Damien Foundation, Niamey, Niger 1 Institute of Tropical Medicine (ITM), Antwerp, Belgium 2 Medical Research Council (MRC), The Gambia Unit, Fajara, The Gambia 4 Laboratoire des Mycobactéries, Institut Pasteur de Bangui, Bangui, Central African Republic
AuthorAffiliation_xml	– name: 7 UNICEF/UNDP/World Bank/WHO Special Programme for Research and Training in Tropical Diseases (TDR), Geneva, Switzerland – name: 3 Laboratoire de Reference des Mycobactéries, Cotonou, Benin – name: 5 Laboratoire de Reference des Mycobactéries, Conakry, Guinea-Conakry – name: 1 Institute of Tropical Medicine (ITM), Antwerp, Belgium – name: 9 National TB Programme, Dakar, Senegal – name: University of Florence, Italy – name: 4 Laboratoire des Mycobactéries, Institut Pasteur de Bangui, Bangui, Central African Republic – name: 8 Laboratoire de Reference des Mycobactéries, Dakar, Senegal – name: 2 Medical Research Council (MRC), The Gambia Unit, Fajara, The Gambia – name: 11 Independent Consultant, Yaoundé, Cameroon – name: 6 London School of Hygiene and Tropical Medicine, London, United Kingdom – name: 12 New York University, New York, United States of America – name: 10 Damien Foundation, Niamey, Niger
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CitedBy_id	crossref_primary_10_1371_journal_pntd_0004408 crossref_primary_10_1371_journal_pntd_0010443 crossref_primary_10_1016_j_jgar_2022_11_012 crossref_primary_10_1016_j_tube_2020_101922 crossref_primary_10_1183_13993003_00952_2016 crossref_primary_10_1186_s12879_020_05031_5 crossref_primary_10_1186_s12862_016_0715_z crossref_primary_10_1371_journal_pone_0208603
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Copyright	COPYRIGHT 2014 Public Library of Science 2014 Gehre et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. 2014 Gehre et al 2014 Gehre et al
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Notes	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 Competing Interests: The authors have declared that no competing interests exist. Conceived and designed the experiments: FG ME CM PO BdJ. Performed the experiments: ME KF PdR CU EN DA MG FL MB OS CM PO FB MS AP JN. Analyzed the data: FG ME OG CM PO BdJ LR. Contributed to the writing of the manuscript: FG ME MA CM PO BdJ.
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SubjectTerms	Africa, Central Africa, Western Antitubercular Agents - pharmacology Biology and Life Sciences Clinical isolates Drug resistance Drug Resistance, Bacterial Drugs Epidemiology Genetic diversity Genotyping Techniques Medical research Medicine Medicine and Health Sciences Microbial drug resistance Mycobacterium Mycobacterium tuberculosis Mycobacterium tuberculosis - drug effects Mycobacterium tuberculosis - genetics Mycobacterium tuberculosis - isolation & purification Phylogeny Public health Retreatment Retrospective Studies Spoligotyping Tuberculosis Tuberculosis - drug therapy Tuberculosis - epidemiology Tuberculosis - microbiology
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Title	Shifts in Mycobacterial Populations and Emerging Drug-Resistance in West and Central Africa
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