Immunization with SARS Coronavirus Vaccines Leads to Pulmonary Immunopathology on Challenge with the SARS Virus

Severe acute respiratory syndrome (SARS) emerged in China in 2002 and spread to other countries before brought under control. Because of a concern for reemergence or a deliberate release of the SARS coronavirus, vaccine development was initiated. Evaluations of an inactivated whole virus vaccine in...

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Bibliographic Details
Published in:	PloS one Vol. 7; no. 4; p. e35421
Main Authors:	Tseng, Chien-Te, Sbrana, Elena, Iwata-Yoshikawa, Naoko, Newman, Patrick C., Garron, Tania, Atmar, Robert L., Peters, Clarence J., Couch, Robert B.
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 20.04.2012 Public Library of Science (PLoS)
Subjects:	Alum Aluminum sulfate Analysis Animals Biology Chemokines Chlorocebus aethiops Coronaviridae Coronaviruses Cytokines Deoxyribonucleic acid Development and progression DNA Eosinophils - immunology Epidemics Female Gene expression Histochemistry Histopathology House mouse Hypersensitivity Immunization Immunology Infections Infiltration Influenza Influenza vaccines Laboratories Leukocytes (eosinophilic) Lung - pathology Lung - virology Lung diseases Lungs Lymphocytes T Medicine Mice Mice, Inbred BALB C Mice, Inbred C57BL Primates Protection and preservation Proteins Respiratory syncytial virus Severe acute respiratory syndrome Severe Acute Respiratory Syndrome - prevention & control Severe Acute Respiratory Syndrome - virology Severe acute respiratory syndrome-related coronavirus - immunology Studies Th2 Cells - immunology Tissue Culture Techniques Vaccination Vaccination - adverse effects Vaccine development Vaccines Vaccines, Inactivated - adverse effects Vaccines, Inactivated - immunology Vero Cells Viral Envelope Proteins - immunology Viral Vaccines - adverse effects Viral Vaccines - immunology Virology Viruses United States > US Texas
ISSN:	1932-6203, 1932-6203
Online Access:	Get full text
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