Individual with Subclinical Atherosclerosis Have Impaired Proliferation of Blood Outgrowth Endothelial Cells, Which Can Be Restored by Statin Therapy

To study the regenerative capacity of the endothelium in patients with coronary artery disease (CAD), we cultured blood outgrowth endothelial cells (BOECs) of patients with premature CAD and their first degree relatives (FDR). Additionally we evaluated the influence of statin treatment on circulatin...

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Bibliographic Details
Published in:	PloS one Vol. 9; no. 6; p. e99890
Main Authors:	Martin-Ramirez, Javier, Kok, Maayke G. M., Hofman, Menno, Bierings, Ruben, Creemers, Esther E., Meijers, Joost C. M., Voorberg, Jan, Pinto-Sietsma, Sara-Joan
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 23.06.2014 Public Library of Science (PLoS)
Subjects:	Adult Aged Arteriosclerosis Atherosclerosis Atherosclerosis - drug therapy Atherosclerosis - metabolism Atherosclerosis - pathology Biology and Life Sciences Blood Blood pressure Calcification Calcification (ectopic) Cardiovascular agents Cardiovascular disease Cell proliferation Cell Proliferation - drug effects Cholesterol Colonies Comparative analysis Coronary artery Coronary artery disease Coronary heart disease Coronary vessels Endothelial cells Endothelial Cells - metabolism Endothelial Cells - pathology Endothelium Family medical history Female Health risk assessment Heart attacks Heart diseases Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors - administration & dosage Laboratories Male Medical imaging Medicine Medicine and Health Sciences Middle Aged Patients Plasma Proteins Regeneration Statins Statistical analysis Stem Cells - metabolism Stem Cells - pathology Studies Therapy
ISSN:	1932-6203, 1932-6203
Online Access:	Get full text
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