Individual with Subclinical Atherosclerosis Have Impaired Proliferation of Blood Outgrowth Endothelial Cells, Which Can Be Restored by Statin Therapy
To study the regenerative capacity of the endothelium in patients with coronary artery disease (CAD), we cultured blood outgrowth endothelial cells (BOECs) of patients with premature CAD and their first degree relatives (FDR). Additionally we evaluated the influence of statin treatment on circulatin...
Uloženo v:
| Vydáno v: | PloS one Ročník 9; číslo 6; s. e99890 |
|---|---|
| Hlavní autoři: | , , , , , , , |
| Médium: | Journal Article |
| Jazyk: | angličtina |
| Vydáno: |
United States
Public Library of Science
23.06.2014
Public Library of Science (PLoS) |
| Témata: | |
| ISSN: | 1932-6203, 1932-6203 |
| On-line přístup: | Získat plný text |
| Tagy: |
Přidat tag
Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!
|
| Abstract | To study the regenerative capacity of the endothelium in patients with coronary artery disease (CAD), we cultured blood outgrowth endothelial cells (BOECs) of patients with premature CAD and their first degree relatives (FDR). Additionally we evaluated the influence of statin treatment on circulating BOEC precursors in subjects with subclinical atherosclerosis.
Patients with premature CAD (men <51 yr, women <56 yr) and their FDRs were included. Based on coronary calcification (CAC) scores FDRs were divided in a group of healthy subjects (CAC = 0) and subjects with subclinical atherosclerosis (CAC>0). We did not observe differences in the number of BOEC colonies and proliferation between premature CAD patients and FDRs. FDRs with subclinical atherosclerosis had lower colony numbers compared with healthy FDRs, however this was not statistically significant, and BOEC proliferation was significantly impaired (OR = 0.45, 95% CI 0.21-0.96). Unexpectedly, the number of BOEC colonies and BOEC proliferation were similar for premature CAD patients and healthy FDRs. Since a considerable number of premature CAD patients used statins, we studied the number of BOEC precursors as well as their proliferative capacity in ten individuals with subclinical atherosclerosis, before and after statin therapy. Interestingly, FDRs with subclinical atherosclerosis showed a significant increase in the number of BOEC colonies after statin therapy.
BOEC proliferation of subjects with subclinical atherosclerosis is impaired compared with healthy controls. In these subjects, statin therapy significantly increased the number of circulating BOEC precursors as well as their proliferative capacity, revealing a beneficial effect of statins on endothelial regeneration. |
|---|---|
| AbstractList | To study the regenerative capacity of the endothelium in patients with coronary artery disease (CAD), we cultured blood outgrowth endothelial cells (BOECs) of patients with premature CAD and their first degree relatives (FDR). Additionally we evaluated the influence of statin treatment on circulating BOEC precursors in subjects with subclinical atherosclerosis.
Patients with premature CAD (men <51 yr, women <56 yr) and their FDRs were included. Based on coronary calcification (CAC) scores FDRs were divided in a group of healthy subjects (CAC = 0) and subjects with subclinical atherosclerosis (CAC>0). We did not observe differences in the number of BOEC colonies and proliferation between premature CAD patients and FDRs. FDRs with subclinical atherosclerosis had lower colony numbers compared with healthy FDRs, however this was not statistically significant, and BOEC proliferation was significantly impaired (OR = 0.45, 95% CI 0.21-0.96). Unexpectedly, the number of BOEC colonies and BOEC proliferation were similar for premature CAD patients and healthy FDRs. Since a considerable number of premature CAD patients used statins, we studied the number of BOEC precursors as well as their proliferative capacity in ten individuals with subclinical atherosclerosis, before and after statin therapy. Interestingly, FDRs with subclinical atherosclerosis showed a significant increase in the number of BOEC colonies after statin therapy.
BOEC proliferation of subjects with subclinical atherosclerosis is impaired compared with healthy controls. In these subjects, statin therapy significantly increased the number of circulating BOEC precursors as well as their proliferative capacity, revealing a beneficial effect of statins on endothelial regeneration. Background To study the regenerative capacity of the endothelium in patients with coronary artery disease (CAD), we cultured blood outgrowth endothelial cells (BOECs) of patients with premature CAD and their first degree relatives (FDR). Additionally we evaluated the influence of statin treatment on circulating BOEC precursors in subjects with subclinical atherosclerosis. Methods and Results Patients with premature CAD (men <51 yr, women <56 yr) and their FDRs were included. Based on coronary calcification (CAC) scores FDRs were divided in a group of healthy subjects (CAC = 0) and subjects with subclinical atherosclerosis (CAC>0). We did not observe differences in the number of BOEC colonies and proliferation between premature CAD patients and FDRs. FDRs with subclinical atherosclerosis had lower colony numbers compared with healthy FDRs, however this was not statistically significant, and BOEC proliferation was significantly impaired (OR = 0.45, 95% CI 0.21–0.96). Unexpectedly, the number of BOEC colonies and BOEC proliferation were similar for premature CAD patients and healthy FDRs. Since a considerable number of premature CAD patients used statins, we studied the number of BOEC precursors as well as their proliferative capacity in ten individuals with subclinical atherosclerosis, before and after statin therapy. Interestingly, FDRs with subclinical atherosclerosis showed a significant increase in the number of BOEC colonies after statin therapy. Conclusion BOEC proliferation of subjects with subclinical atherosclerosis is impaired compared with healthy controls. In these subjects, statin therapy significantly increased the number of circulating BOEC precursors as well as their proliferative capacity, revealing a beneficial effect of statins on endothelial regeneration. To study the regenerative capacity of the endothelium in patients with coronary artery disease (CAD), we cultured blood outgrowth endothelial cells (BOECs) of patients with premature CAD and their first degree relatives (FDR). Additionally we evaluated the influence of statin treatment on circulating BOEC precursors in subjects with subclinical atherosclerosis.BACKGROUNDTo study the regenerative capacity of the endothelium in patients with coronary artery disease (CAD), we cultured blood outgrowth endothelial cells (BOECs) of patients with premature CAD and their first degree relatives (FDR). Additionally we evaluated the influence of statin treatment on circulating BOEC precursors in subjects with subclinical atherosclerosis.Patients with premature CAD (men <51 yr, women <56 yr) and their FDRs were included. Based on coronary calcification (CAC) scores FDRs were divided in a group of healthy subjects (CAC = 0) and subjects with subclinical atherosclerosis (CAC>0). We did not observe differences in the number of BOEC colonies and proliferation between premature CAD patients and FDRs. FDRs with subclinical atherosclerosis had lower colony numbers compared with healthy FDRs, however this was not statistically significant, and BOEC proliferation was significantly impaired (OR = 0.45, 95% CI 0.21-0.96). Unexpectedly, the number of BOEC colonies and BOEC proliferation were similar for premature CAD patients and healthy FDRs. Since a considerable number of premature CAD patients used statins, we studied the number of BOEC precursors as well as their proliferative capacity in ten individuals with subclinical atherosclerosis, before and after statin therapy. Interestingly, FDRs with subclinical atherosclerosis showed a significant increase in the number of BOEC colonies after statin therapy.METHODS AND RESULTSPatients with premature CAD (men <51 yr, women <56 yr) and their FDRs were included. Based on coronary calcification (CAC) scores FDRs were divided in a group of healthy subjects (CAC = 0) and subjects with subclinical atherosclerosis (CAC>0). We did not observe differences in the number of BOEC colonies and proliferation between premature CAD patients and FDRs. FDRs with subclinical atherosclerosis had lower colony numbers compared with healthy FDRs, however this was not statistically significant, and BOEC proliferation was significantly impaired (OR = 0.45, 95% CI 0.21-0.96). Unexpectedly, the number of BOEC colonies and BOEC proliferation were similar for premature CAD patients and healthy FDRs. Since a considerable number of premature CAD patients used statins, we studied the number of BOEC precursors as well as their proliferative capacity in ten individuals with subclinical atherosclerosis, before and after statin therapy. Interestingly, FDRs with subclinical atherosclerosis showed a significant increase in the number of BOEC colonies after statin therapy.BOEC proliferation of subjects with subclinical atherosclerosis is impaired compared with healthy controls. In these subjects, statin therapy significantly increased the number of circulating BOEC precursors as well as their proliferative capacity, revealing a beneficial effect of statins on endothelial regeneration.CONCLUSIONBOEC proliferation of subjects with subclinical atherosclerosis is impaired compared with healthy controls. In these subjects, statin therapy significantly increased the number of circulating BOEC precursors as well as their proliferative capacity, revealing a beneficial effect of statins on endothelial regeneration. To study the regenerative capacity of the endothelium in patients with coronary artery disease (CAD), we cultured blood outgrowth endothelial cells (BOECs) of patients with premature CAD and their first degree relatives (FDR). Additionally we evaluated the influence of statin treatment on circulating BOEC precursors in subjects with subclinical atherosclerosis. BOEC proliferation of subjects with subclinical atherosclerosis is impaired compared with healthy controls. In these subjects, statin therapy significantly increased the number of circulating BOEC precursors as well as their proliferative capacity, revealing a beneficial effect of statins on endothelial regeneration. BackgroundTo study the regenerative capacity of the endothelium in patients with coronary artery disease (CAD), we cultured blood outgrowth endothelial cells (BOECs) of patients with premature CAD and their first degree relatives (FDR). Additionally we evaluated the influence of statin treatment on circulating BOEC precursors in subjects with subclinical atherosclerosis.Methods and resultsPatients with premature CAD (men <51 yr, women <56 yr) and their FDRs were included. Based on coronary calcification (CAC) scores FDRs were divided in a group of healthy subjects (CAC = 0) and subjects with subclinical atherosclerosis (CAC>0). We did not observe differences in the number of BOEC colonies and proliferation between premature CAD patients and FDRs. FDRs with subclinical atherosclerosis had lower colony numbers compared with healthy FDRs, however this was not statistically significant, and BOEC proliferation was significantly impaired (OR = 0.45, 95% CI 0.21-0.96). Unexpectedly, the number of BOEC colonies and BOEC proliferation were similar for premature CAD patients and healthy FDRs. Since a considerable number of premature CAD patients used statins, we studied the number of BOEC precursors as well as their proliferative capacity in ten individuals with subclinical atherosclerosis, before and after statin therapy. Interestingly, FDRs with subclinical atherosclerosis showed a significant increase in the number of BOEC colonies after statin therapy.ConclusionBOEC proliferation of subjects with subclinical atherosclerosis is impaired compared with healthy controls. In these subjects, statin therapy significantly increased the number of circulating BOEC precursors as well as their proliferative capacity, revealing a beneficial effect of statins on endothelial regeneration. Background To study the regenerative capacity of the endothelium in patients with coronary artery disease (CAD), we cultured blood outgrowth endothelial cells (BOECs) of patients with premature CAD and their first degree relatives (FDR). Additionally we evaluated the influence of statin treatment on circulating BOEC precursors in subjects with subclinical atherosclerosis. Methods and Results Patients with premature CAD (men <51 yr, women <56 yr) and their FDRs were included. Based on coronary calcification (CAC) scores FDRs were divided in a group of healthy subjects (CAC = 0) and subjects with subclinical atherosclerosis (CAC>0). We did not observe differences in the number of BOEC colonies and proliferation between premature CAD patients and FDRs. FDRs with subclinical atherosclerosis had lower colony numbers compared with healthy FDRs, however this was not statistically significant, and BOEC proliferation was significantly impaired (OR = 0.45, 95% CI 0.21–0.96). Unexpectedly, the number of BOEC colonies and BOEC proliferation were similar for premature CAD patients and healthy FDRs. Since a considerable number of premature CAD patients used statins, we studied the number of BOEC precursors as well as their proliferative capacity in ten individuals with subclinical atherosclerosis, before and after statin therapy. Interestingly, FDRs with subclinical atherosclerosis showed a significant increase in the number of BOEC colonies after statin therapy. Conclusion BOEC proliferation of subjects with subclinical atherosclerosis is impaired compared with healthy controls. In these subjects, statin therapy significantly increased the number of circulating BOEC precursors as well as their proliferative capacity, revealing a beneficial effect of statins on endothelial regeneration. Background To study the regenerative capacity of the endothelium in patients with coronary artery disease (CAD), we cultured blood outgrowth endothelial cells (BOECs) of patients with premature CAD and their first degree relatives (FDR). Additionally we evaluated the influence of statin treatment on circulating BOEC precursors in subjects with subclinical atherosclerosis. Methods and Results Patients with premature CAD (men <51 yr, women 0). We did not observe differences in the number of BOEC colonies and proliferation between premature CAD patients and FDRs. FDRs with subclinical atherosclerosis had lower colony numbers compared with healthy FDRs, however this was not statistically significant, and BOEC proliferation was significantly impaired (OR = 0.45, 95% CI 0.21-0.96). Unexpectedly, the number of BOEC colonies and BOEC proliferation were similar for premature CAD patients and healthy FDRs. Since a considerable number of premature CAD patients used statins, we studied the number of BOEC precursors as well as their proliferative capacity in ten individuals with subclinical atherosclerosis, before and after statin therapy. Interestingly, FDRs with subclinical atherosclerosis showed a significant increase in the number of BOEC colonies after statin therapy. Conclusion BOEC proliferation of subjects with subclinical atherosclerosis is impaired compared with healthy controls. In these subjects, statin therapy significantly increased the number of circulating BOEC precursors as well as their proliferative capacity, revealing a beneficial effect of statins on endothelial regeneration. |
| Audience | Academic |
| Author | Martin-Ramirez, Javier Pinto-Sietsma, Sara-Joan Hofman, Menno Bierings, Ruben Creemers, Esther E. Voorberg, Jan Meijers, Joost C. M. Kok, Maayke G. M. |
| AuthorAffiliation | European Institute of Oncology, Italy 5 Department of Clinical Epidemiology, Biostatistics and Bioinformatics, Academic Medical Center, Amsterdam, The Netherlands 3 The Heart Failure Research Center, Academic Medical Center, Amsterdam, The Netherlands 1 Department of Plasma Proteins, Sanquin-AMC Landsteiner Laboratory, Amsterdam, The Netherlands 4 Department of Experimental Vascular Medicine, Academic Medical Center, Amsterdam, The Netherlands 2 Department of Vascular Medicine, Academic Medical Center, Amsterdam, The Netherlands |
| AuthorAffiliation_xml | – name: 5 Department of Clinical Epidemiology, Biostatistics and Bioinformatics, Academic Medical Center, Amsterdam, The Netherlands – name: 3 The Heart Failure Research Center, Academic Medical Center, Amsterdam, The Netherlands – name: 1 Department of Plasma Proteins, Sanquin-AMC Landsteiner Laboratory, Amsterdam, The Netherlands – name: 4 Department of Experimental Vascular Medicine, Academic Medical Center, Amsterdam, The Netherlands – name: 2 Department of Vascular Medicine, Academic Medical Center, Amsterdam, The Netherlands – name: European Institute of Oncology, Italy |
| Author_xml | – sequence: 1 givenname: Javier surname: Martin-Ramirez fullname: Martin-Ramirez, Javier – sequence: 2 givenname: Maayke G. M. surname: Kok fullname: Kok, Maayke G. M. – sequence: 3 givenname: Menno surname: Hofman fullname: Hofman, Menno – sequence: 4 givenname: Ruben surname: Bierings fullname: Bierings, Ruben – sequence: 5 givenname: Esther E. surname: Creemers fullname: Creemers, Esther E. – sequence: 6 givenname: Joost C. M. surname: Meijers fullname: Meijers, Joost C. M. – sequence: 7 givenname: Jan surname: Voorberg fullname: Voorberg, Jan – sequence: 8 givenname: Sara-Joan surname: Pinto-Sietsma fullname: Pinto-Sietsma, Sara-Joan |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/24955753$$D View this record in MEDLINE/PubMed |
| BookMark | eNqNk21rFDEQxxep2Af9BqKBgih452azT_GFcD2qPShU2qovQzY7uU3JJWeSvdoP4vc1217lrhSRwO4y-5v_ZP7M7Cc7xhpIkpc4HWNS4Q9XtneG6_EyhsdpSmlN0yfJHqYkG5VZSnY2vneTfe-v0rQgdVk-S3aznBZFVZC95PfMtGql2p5rdK1Chy76RmhllIiBSejAWS_08FQenfAVoNliyZWDFn11VisJjgdlDbISHWlrW3TWh7mz11Hq2LQ2KmgVpaagtX-PfnRKdGjKDToCdA4-2EGpuUEXIcoYdBkL8uXN8-Sp5NrDi_X7IPn2-fhyejI6Pfsym05OR6KkWRhBw4WkkOGsbjIBNS1oRTOIXRdNCrwmglZEiEpikXFKizoXoiRVJSsJeVNTcpC8vtNdauvZ2lHPcEFoTvOyxJGY3RGt5Vds6dSCuxtmuWK3AevmjLugokWsblsiZUMwFk1Om7qpIKeSkgJiUU4han1aV-ubBbQCTHBcb4lu_zGqY3O7YnlaVhkdLvN2LeDszz66xxbKi-gsN2D74d55ijEZzkFy-AB9vLs1NeexAWWkjXXFIMomOa5xVpV1GanxI1Q8LSyUiOMnVYxvJbzbSohMgF9hznvv2ezi_P_Zs-_b7JsNtgOuQ-et7ocB9Nvgq02n_1p8P_cR-HgHiDjZ3oFkQoXbQY6tKc1wyoYluzeNDUvG1ksWk_MHyff6_0z7A9pwLZM |
| CitedBy_id | crossref_primary_10_1016_j_semcdb_2023_05_001 crossref_primary_10_1016_j_tvjl_2015_10_007 crossref_primary_10_1111_jth_14715 crossref_primary_10_1371_journal_pone_0151797 crossref_primary_10_1016_j_rpth_2023_100086 crossref_primary_10_1038_s41467_019_13139_9 crossref_primary_10_1161_JAHA_115_002288 crossref_primary_10_1177_2047487315600169 |
| Cites_doi | 10.1161/CIRCRESAHA.111.243386 10.1172/JCI8071 10.4137/CMC.S2111 10.1182/blood-2004-04-1396 10.1161/ATVBAHA.107.155960 10.1161/CIRCULATIONAHA.104.504340 10.1161/01.ATV.0000036417.43987.D8 10.1161/ATVBAHA.109.191635 10.1161/01.ATV.0000114236.77009.06 10.1161/01.CIR.0000143232.67642.7A 10.1161/hh1301.093953 10.1371/journal.pone.0056377 10.1056/NEJMoa022287 10.1007/s00395-011-0220-x 10.1016/j.jacc.2012.11.002 10.1016/j.exphem.2008.09.007 10.1016/j.atherosclerosis.2010.02.007 10.1038/nprot.2012.093 10.1111/j.1365-2362.2007.01743.x 10.1161/hc0902.104353 10.1111/j.1582-4934.2008.00598.x 10.1056/NEJMoa043814 10.1067/mhj.2003.13 10.1161/hc2401.092816 10.1371/journal.pone.0038399 10.1186/1755-8794-3-18 10.1161/CIRCULATIONAHA.109.931279 |
| ContentType | Journal Article |
| Copyright | COPYRIGHT 2014 Public Library of Science 2014 Martin-Ramirez et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. 2014 Martin-Ramirez et al 2014 Martin-Ramirez et al |
| Copyright_xml | – notice: COPYRIGHT 2014 Public Library of Science – notice: 2014 Martin-Ramirez et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. – notice: 2014 Martin-Ramirez et al 2014 Martin-Ramirez et al |
| DBID | AAYXX CITATION CGR CUY CVF ECM EIF NPM IOV ISR 3V. 7QG 7QL 7QO 7RV 7SN 7SS 7T5 7TG 7TM 7U9 7X2 7X7 7XB 88E 8AO 8C1 8FD 8FE 8FG 8FH 8FI 8FJ 8FK ABJCF ABUWG AEUYN AFKRA ARAPS ATCPS AZQEC BBNVY BENPR BGLVJ BHPHI C1K CCPQU D1I DWQXO FR3 FYUFA GHDGH GNUQQ H94 HCIFZ K9. KB. KB0 KL. L6V LK8 M0K M0S M1P M7N M7P M7S NAPCQ P5Z P62 P64 PATMY PDBOC PHGZM PHGZT PIMPY PJZUB PKEHL PPXIY PQEST PQGLB PQQKQ PQUKI PRINS PTHSS PYCSY RC3 7X8 5PM DOA |
| DOI | 10.1371/journal.pone.0099890 |
| DatabaseName | CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed Gale In Context: Opposing Viewpoints Gale In Context: Science ProQuest Central (Corporate) Animal Behavior Abstracts Bacteriology Abstracts (Microbiology B) Biotechnology Research Abstracts Nursing & Allied Health Database Ecology Abstracts Entomology Abstracts (Full archive) Immunology Abstracts Meteorological & Geoastrophysical Abstracts Nucleic Acids Abstracts Virology and AIDS Abstracts Agricultural Science Collection Health & Medical Collection ProQuest Central (purchase pre-March 2016) Medical Database (Alumni Edition) ProQuest Pharma Collection Public Health Database Technology Research Database ProQuest SciTech Collection ProQuest Technology Collection ProQuest Natural Science Collection ProQuest Hospital Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) Materials Science & Engineering Collection ProQuest Central (Alumni) ProQuest One Sustainability ProQuest Central UK/Ireland Advanced Technologies & Computer Science Collection Agricultural & Environmental Science Collection ProQuest Central Essentials Biological Science Collection ProQuest Central Technology Collection Natural Science Collection Environmental Sciences and Pollution Management ProQuest One ProQuest Materials Science Collection ProQuest Central Korea Engineering Research Database Proquest Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Central Student AIDS and Cancer Research Abstracts SciTech Premium Collection ProQuest Health & Medical Complete (Alumni) ProQuest Materials Science Database Nursing & Allied Health Database (Alumni Edition) Meteorological & Geoastrophysical Abstracts - Academic ProQuest Engineering Collection ProQuest Biological Science Collection Agricultural Science Database ProQuest Health & Medical Collection Medical Database Algology Mycology and Protozoology Abstracts (Microbiology C) Biological Science Database Engineering Database Nursing & Allied Health Premium Advanced Technologies & Aerospace Database ProQuest Advanced Technologies & Aerospace Collection Biotechnology and BioEngineering Abstracts Environmental Science Database Materials Science Collection ProQuest Central Premium ProQuest One Academic (New) Publicly Available Content Database ProQuest Health & Medical Research Collection ProQuest One Academic Middle East (New) ProQuest One Health & Nursing ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Applied & Life Sciences ProQuest One Academic (retired) ProQuest One Academic UKI Edition ProQuest Central China Engineering Collection Environmental Science Collection Genetics Abstracts MEDLINE - Academic PubMed Central (Full Participant titles) DOAJ Directory of Open Access Journals |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) Agricultural Science Database Publicly Available Content Database ProQuest Central Student ProQuest Advanced Technologies & Aerospace Collection ProQuest Central Essentials Nucleic Acids Abstracts SciTech Premium Collection ProQuest Central China Environmental Sciences and Pollution Management ProQuest One Applied & Life Sciences ProQuest One Sustainability Health Research Premium Collection Meteorological & Geoastrophysical Abstracts Natural Science Collection Health & Medical Research Collection Biological Science Collection ProQuest Central (New) ProQuest Medical Library (Alumni) Engineering Collection Advanced Technologies & Aerospace Collection Engineering Database Virology and AIDS Abstracts ProQuest Biological Science Collection ProQuest One Academic Eastern Edition Agricultural Science Collection ProQuest Hospital Collection ProQuest Technology Collection Health Research Premium Collection (Alumni) Biological Science Database Ecology Abstracts ProQuest Hospital Collection (Alumni) Biotechnology and BioEngineering Abstracts Environmental Science Collection Entomology Abstracts Nursing & Allied Health Premium ProQuest Health & Medical Complete ProQuest One Academic UKI Edition Environmental Science Database ProQuest Nursing & Allied Health Source (Alumni) Engineering Research Database ProQuest One Academic Meteorological & Geoastrophysical Abstracts - Academic ProQuest One Academic (New) Technology Collection Technology Research Database ProQuest One Academic Middle East (New) Materials Science Collection ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) ProQuest One Community College ProQuest One Health & Nursing ProQuest Natural Science Collection ProQuest Pharma Collection ProQuest Central ProQuest Health & Medical Research Collection Genetics Abstracts ProQuest Engineering Collection Biotechnology Research Abstracts Health and Medicine Complete (Alumni Edition) ProQuest Central Korea Bacteriology Abstracts (Microbiology B) Algology Mycology and Protozoology Abstracts (Microbiology C) Agricultural & Environmental Science Collection AIDS and Cancer Research Abstracts Materials Science Database ProQuest Materials Science Collection ProQuest Public Health ProQuest Nursing & Allied Health Source ProQuest SciTech Collection Advanced Technologies & Aerospace Database ProQuest Medical Library Animal Behavior Abstracts Materials Science & Engineering Collection Immunology Abstracts ProQuest Central (Alumni) MEDLINE - Academic |
| DatabaseTitleList | MEDLINE MEDLINE - Academic Agricultural Science Database |
| Database_xml | – sequence: 1 dbid: DOA name: DOAJ Directory of Open Access Journals url: https://www.doaj.org/ sourceTypes: Open Website – sequence: 2 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 3 dbid: PIMPY name: Publicly Available Content Database url: http://search.proquest.com/publiccontent sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Sciences (General) Medicine |
| DocumentTitleAlternate | Subclinical Atherosclerosis Is Related to Impaired BOECs Proliferation |
| EISSN | 1932-6203 |
| ExternalDocumentID | 1539494661 oai_doaj_org_article_8dd3ffb311cb49b8b7e49f935ec63a9e PMC4067291 3347291231 A418127686 24955753 10_1371_journal_pone_0099890 |
| Genre | Research Support, Non-U.S. Gov't Journal Article |
| GroupedDBID | --- 123 29O 2WC 53G 5VS 7RV 7X2 7X7 7XC 88E 8AO 8C1 8CJ 8FE 8FG 8FH 8FI 8FJ A8Z AAFWJ AAUCC AAWOE AAYXX ABDBF ABIVO ABJCF ABUWG ACCTH ACGFO ACIHN ACIWK ACPRK ACUHS ADBBV ADRAZ AEAQA AENEX AEUYN AFFHD AFKRA AFPKN AFRAH AHMBA ALMA_UNASSIGNED_HOLDINGS AOIJS APEBS ARAPS ATCPS BAWUL BBNVY BCNDV BENPR BGLVJ BHPHI BKEYQ BPHCQ BVXVI BWKFM CCPQU CITATION CS3 D1I D1J D1K DIK DU5 E3Z EAP EAS EBD EMOBN ESX EX3 F5P FPL FYUFA GROUPED_DOAJ GX1 HCIFZ HH5 HMCUK HYE IAO IEA IGS IHR IHW INH INR IOV IPY ISE ISR ITC K6- KB. KQ8 L6V LK5 LK8 M0K M1P M48 M7P M7R M7S M~E NAPCQ O5R O5S OK1 OVT P2P P62 PATMY PDBOC PHGZM PHGZT PIMPY PJZUB PPXIY PQGLB PQQKQ PROAC PSQYO PTHSS PYCSY RNS RPM SV3 TR2 UKHRP WOQ WOW ~02 ~KM ALIPV CGR CUY CVF ECM EIF IPNFZ NPM PV9 RIG RZL BBORY 3V. 7QG 7QL 7QO 7SN 7SS 7T5 7TG 7TM 7U9 7XB 8FD 8FK AZQEC C1K DWQXO ESTFP FR3 GNUQQ H94 K9. KL. M7N P64 PKEHL PQEST PQUKI PRINS RC3 7X8 PUEGO 5PM - 02 AAPBV ABPTK ADACO BBAFP KM |
| ID | FETCH-LOGICAL-c692t-ebacf9e2128b2ce8959792e9325b0ea83c973cc7f1c2a99584cc6377f7fe4b893 |
| IEDL.DBID | 7RV |
| ISICitedReferencesCount | 10 |
| ISICitedReferencesURI | http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000338917900020&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| ISSN | 1932-6203 |
| IngestDate | Fri Nov 26 17:22:28 EST 2021 Fri Oct 03 12:51:08 EDT 2025 Tue Nov 04 01:53:28 EST 2025 Mon Sep 08 11:37:07 EDT 2025 Tue Oct 07 07:44:12 EDT 2025 Sat Nov 29 13:19:29 EST 2025 Sat Nov 29 09:58:00 EST 2025 Wed Nov 26 10:13:46 EST 2025 Wed Nov 26 09:39:48 EST 2025 Thu May 22 21:22:47 EDT 2025 Mon Jul 21 05:28:50 EDT 2025 Tue Nov 18 22:35:26 EST 2025 Sat Nov 29 03:54:46 EST 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 6 |
| Language | English |
| License | This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. Creative Commons Attribution License |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c692t-ebacf9e2128b2ce8959792e9325b0ea83c973cc7f1c2a99584cc6377f7fe4b893 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 Competing Interests: The authors have declared that no competing interest exist. Conceived and designed the experiments: MK EC JM JV SJP. Performed the experiments: JMR MK MH. Analyzed the data: MK SJP. Contributed reagents/materials/analysis tools: JMR MH. Wrote the paper: JMR MK JV SJP. Imaging of the BOECs: RB. |
| OpenAccessLink | https://www.proquest.com/docview/1539494661?pq-origsite=%requestingapplication% |
| PMID | 24955753 |
| PQID | 1539494661 |
| PQPubID | 1436336 |
| ParticipantIDs | plos_journals_1539494661 doaj_primary_oai_doaj_org_article_8dd3ffb311cb49b8b7e49f935ec63a9e pubmedcentral_primary_oai_pubmedcentral_nih_gov_4067291 proquest_miscellaneous_1540113131 proquest_journals_1539494661 gale_infotracmisc_A418127686 gale_infotracacademiconefile_A418127686 gale_incontextgauss_ISR_A418127686 gale_incontextgauss_IOV_A418127686 gale_healthsolutions_A418127686 pubmed_primary_24955753 crossref_citationtrail_10_1371_journal_pone_0099890 crossref_primary_10_1371_journal_pone_0099890 |
| PublicationCentury | 2000 |
| PublicationDate | 2014-06-23 |
| PublicationDateYYYYMMDD | 2014-06-23 |
| PublicationDate_xml | – month: 06 year: 2014 text: 2014-06-23 day: 23 |
| PublicationDecade | 2010 |
| PublicationPlace | United States |
| PublicationPlace_xml | – name: United States – name: San Francisco – name: San Francisco, USA |
| PublicationTitle | PloS one |
| PublicationTitleAlternate | PLoS One |
| PublicationYear | 2014 |
| Publisher | Public Library of Science Public Library of Science (PLoS) |
| Publisher_xml | – name: Public Library of Science – name: Public Library of Science (PLoS) |
| References | C Schmidt-Lucke (ref12) 2010; 211 LJ Laslett (ref1) 2012; 60 AD Hughes (ref20) 2007; 37 F Timmermans (ref25) 2009; 13 JM Hill (ref6) 2003; 348 RJ Medina (ref7) 2010; 3 Y Lin (ref8) 2000; 105 J Martin-Ramirez (ref17) 2012; 7 D Campioni (ref26) 2013; 8 LF Bielak (ref22) 2009; 3 N Werner (ref29) 2002; 22 ER Hauser (ref13) 2003; 145 EL Van Agtmaal (ref19) 2012; 7 P Libby (ref2) 2002; 105 C Schmidt-Lucke (ref14) 2005; 111 KK Hirschi (ref10) 2008; 28 (ref15) 2002; 106 N Werner (ref5) 2005; 353 GP Fadini (ref3) 2012; 110 DA Ingram (ref23) 2004; 104 D Van Breevoort (ref18) 2014 U Landmesser (ref30) 2004; 110 (ref16) 2002; 106 N Meneveau (ref27) 2011; 106 S Cheng (ref21) 2010; 122 M Vasa (ref11) 2001; 103 J Hur (ref24) 2004; 24 MC Yoder (ref9) 2010; 30 M Massa (ref28) 2009; 37 M Vasa (ref4) 2001; 89 24700782 - Blood. 2014 May 15;123(20):3185-94 20453169 - Arterioscler Thromb Vasc Biol. 2010 Jun;30(6):1094-103 12584367 - N Engl J Med. 2003 Feb 13;348(7):593-600 19067770 - J Cell Mol Med. 2009 Jan;13(1):87-102 11440984 - Circ Res. 2001 Jul 6;89(1):E1-7 19013004 - Exp Hematol. 2009 Jan;37(1):8-9 17181565 - Eur J Clin Invest. 2007 Jan;37(1):35-41 10619863 - J Clin Invest. 2000 Jan;105(1):71-7 22715381 - PLoS One. 2012;7(6):e38399 14699017 - Arterioscler Thromb Vasc Biol. 2004 Feb;24(2):288-93 20823386 - Circulation. 2010 Sep 21;122(12):1176-82 12377731 - Arterioscler Thromb Vasc Biol. 2002 Oct 1;22(10):1567-72 12485966 - Circulation. 2002 Dec 17;106(25):3143-421 20211468 - Atherosclerosis. 2010 Jul;211(1):249-54 15927972 - Circulation. 2005 Jun 7;111(22):2981-7 20407620 - Clin Med Cardiol. 2009 May 27;3:53-60 23257320 - J Am Coll Cardiol. 2012 Dec 25;60(25 Suppl):S1-49 11877368 - Circulation. 2002 Mar 5;105(9):1135-43 20465783 - BMC Med Genomics. 2010;3:18 15226175 - Blood. 2004 Nov 1;104(9):2752-60 18669889 - Arterioscler Thromb Vasc Biol. 2008 Sep;28(9):1584-95 23409178 - PLoS One. 2013;8(2):e56377 22918388 - Nat Protoc. 2012 Sep;7(9):1709-15 16148285 - N Engl J Med. 2005 Sep 8;353(10):999-1007 15466656 - Circulation. 2004 Oct 5;110(14):1933-9 21904841 - Basic Res Cardiol. 2011 Nov;106(6):1397-410 12679755 - Am Heart J. 2003 Apr;145(4):602-13 22343557 - Circ Res. 2012 Feb 17;110(4):624-37 11413075 - Circulation. 2001 Jun 19;103(24):2885-90 |
| References_xml | – volume: 110 start-page: 624 year: 2012 ident: ref3 article-title: Critical reevaluation of endothelial progenitor cell phenotypes for therapeutic and diagnostic use publication-title: Circ Res doi: 10.1161/CIRCRESAHA.111.243386 – volume: 105 start-page: 71 year: 2000 ident: ref8 article-title: Origins of circulating endothelial cells and endothelial outgrowth from blood publication-title: J Clin Invest doi: 10.1172/JCI8071 – volume: 3 start-page: 53 year: 2009 ident: ref22 article-title: Circulating CD34+ Cell Count is Associated with Extent of Subclinical Atherosclerosis in Asymptomatic Amish Men, Independent of 10-Year Framingham Risk publication-title: Clin Med Cardiol doi: 10.4137/CMC.S2111 – volume: 104 start-page: 2752 year: 2004 ident: ref23 article-title: Identification of a novel hierarchy of endothelial progenitor cells using human peripheral and umbilical cord blood publication-title: Blood doi: 10.1182/blood-2004-04-1396 – volume: 106 start-page: 3143 year: 2002 ident: ref15 article-title: Circulation publication-title: Circulation – volume: 28 start-page: 1584 year: 2008 ident: ref10 article-title: Assessing identity, phenotype, and fate of endothelial progenitor cells publication-title: Arterioscler Thromb Vasc Biol doi: 10.1161/ATVBAHA.107.155960 – volume: 111 start-page: 2981 year: 2005 ident: ref14 article-title: Reduced number of circulating endothelial progenitor cells predicts future cardiovascular events: proof of concept for the clinical importance of endogenous vascular repair publication-title: Circulation doi: 10.1161/CIRCULATIONAHA.104.504340 – year: 2014 ident: ref18 article-title: STXBP1 promotes Weibel-Palade body exocytosis through its interaction with the Rab27A effector Slp4-a publication-title: Blood – volume: 22 start-page: 1567 year: 2002 ident: ref29 article-title: Bone marrow-derived progenitor cells modulate vascular reendothelialization and neointimal formation: effect of 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibition publication-title: Arterioscler Thromb Vasc Biol doi: 10.1161/01.ATV.0000036417.43987.D8 – volume: 30 start-page: 1094 year: 2010 ident: ref9 article-title: Is endothelium the origin of endothelial progenitor cells? publication-title: Arterioscler Thromb Vasc Biol doi: 10.1161/ATVBAHA.109.191635 – volume: 24 start-page: 288 year: 2004 ident: ref24 article-title: Characterization of two types of endothelial progenitor cells and their different contributions to neovasculogenesis publication-title: Arterioscler Thromb Vasc Biol doi: 10.1161/01.ATV.0000114236.77009.06 – volume: 110 start-page: 1933 year: 2004 ident: ref30 article-title: Statin-induced improvement of endothelial progenitor cell mobilization, myocardial neovascularization, left ventricular function, and survival after experimental myocardial infarction requires endothelial nitric oxide synthase publication-title: Circulation doi: 10.1161/01.CIR.0000143232.67642.7A – volume: 89 start-page: e1 year: 2001 ident: ref4 article-title: Number and Migratory Activity of Circulating Endothelial Progenitor Cells Inversely Correlate With Risk Factors for Coronary Artery Disease publication-title: Circ Res doi: 10.1161/hh1301.093953 – volume: 8 start-page: e56377 year: 2013 ident: ref26 article-title: In vitro characterization of circulating endothelial progenitor cells isolated from patients with acute coronary syndrome publication-title: PLoS One doi: 10.1371/journal.pone.0056377 – volume: 348 start-page: 593 year: 2003 ident: ref6 article-title: Circulating endothelial progenitor cells, vascular function, and cardiovascular risk publication-title: N Engl J Med doi: 10.1056/NEJMoa022287 – volume: 106 start-page: 1397 year: 2011 ident: ref27 article-title: Presence of endothelial colony-forming cells is associated with reduced microvascular obstruction limiting infarct size and left ventricular remodelling in patients with acute myocardial infarction publication-title: Basic Res Cardiol doi: 10.1007/s00395-011-0220-x – volume: 60 start-page: S1 year: 2012 ident: ref1 article-title: The worldwide environment of cardiovascular disease: prevalence, diagnosis, therapy, and policy issues: a report from the American College of Cardiology publication-title: J Am Coll Cardiol doi: 10.1016/j.jacc.2012.11.002 – volume: 37 start-page: 8 year: 2009 ident: ref28 article-title: Rapid and large increase of the frequency of circulating endothelial colony-forming cells (ECFCs) generating late outgrowth endothelial cells in patients with acute myocardial infarction publication-title: Exp Hematol doi: 10.1016/j.exphem.2008.09.007 – volume: 211 start-page: 249 year: 2010 ident: ref12 article-title: Improvement of endothelial damage and regeneration indexes in patients with coronary artery disease after 4 weeks of statin therapy publication-title: Atherosclerosis doi: 10.1016/j.atherosclerosis.2010.02.007 – volume: 7 start-page: 1709 year: 2012 ident: ref17 article-title: Establishment of outgrowth endothelial cells from peripheral blood publication-title: Nat Protoc doi: 10.1038/nprot.2012.093 – volume: 37 start-page: 35 year: 2007 ident: ref20 article-title: Reduced endothelial progenitor cells in European and South Asian men with atherosclerosis publication-title: Eur J Clin Invest doi: 10.1111/j.1365-2362.2007.01743.x – volume: 106 start-page: 3143 year: 2002 ident: ref16 article-title: Circulation publication-title: Circulation – volume: 105 start-page: 1135 year: 2002 ident: ref2 article-title: Inflammation and Atherosclerosis publication-title: Circulation doi: 10.1161/hc0902.104353 – volume: 13 start-page: 87 year: 2009 ident: ref25 article-title: Endothelial progenitor cells: identity defined? publication-title: J Cell Mol Med doi: 10.1111/j.1582-4934.2008.00598.x – volume: 353 start-page: 999 year: 2005 ident: ref5 article-title: Circulating endothelial progenitor cells and cardiovascular outcomes publication-title: N Engl J Med doi: 10.1056/NEJMoa043814 – volume: 145 start-page: 602 year: 2003 ident: ref13 article-title: Design of the Genetics of Early Onset Cardiovascular Disease (GENECARD) study publication-title: Am Heart J doi: 10.1067/mhj.2003.13 – volume: 103 start-page: 2885 year: 2001 ident: ref11 article-title: Increase in Circulating Endothelial Progenitor Cells by Statin Therapy in Patients With Stable Coronary Artery Disease publication-title: Circulation doi: 10.1161/hc2401.092816 – volume: 7 start-page: e38399 year: 2012 ident: ref19 article-title: The shear stress-induced transcription factor KLF2 affects dynamics and angiopoietin-2 content of Weibel-Palade bodies publication-title: PLoS One doi: 10.1371/journal.pone.0038399 – volume: 3 start-page: 18 year: 2010 ident: ref7 article-title: Molecular analysis of endothelial progenitor cell (EPC) subtypes reveals two distinct cell populations with different identities publication-title: BMC Med Genomics doi: 10.1186/1755-8794-3-18 – volume: 122 start-page: 1176 year: 2010 ident: ref21 article-title: Association of colony-forming units with coronary artery and abdominal aortic calcification publication-title: Circulation doi: 10.1161/CIRCULATIONAHA.109.931279 – reference: 18669889 - Arterioscler Thromb Vasc Biol. 2008 Sep;28(9):1584-95 – reference: 22918388 - Nat Protoc. 2012 Sep;7(9):1709-15 – reference: 23257320 - J Am Coll Cardiol. 2012 Dec 25;60(25 Suppl):S1-49 – reference: 23409178 - PLoS One. 2013;8(2):e56377 – reference: 15927972 - Circulation. 2005 Jun 7;111(22):2981-7 – reference: 24700782 - Blood. 2014 May 15;123(20):3185-94 – reference: 12377731 - Arterioscler Thromb Vasc Biol. 2002 Oct 1;22(10):1567-72 – reference: 22343557 - Circ Res. 2012 Feb 17;110(4):624-37 – reference: 15226175 - Blood. 2004 Nov 1;104(9):2752-60 – reference: 11413075 - Circulation. 2001 Jun 19;103(24):2885-90 – reference: 20465783 - BMC Med Genomics. 2010;3:18 – reference: 15466656 - Circulation. 2004 Oct 5;110(14):1933-9 – reference: 14699017 - Arterioscler Thromb Vasc Biol. 2004 Feb;24(2):288-93 – reference: 20211468 - Atherosclerosis. 2010 Jul;211(1):249-54 – reference: 20407620 - Clin Med Cardiol. 2009 May 27;3:53-60 – reference: 16148285 - N Engl J Med. 2005 Sep 8;353(10):999-1007 – reference: 11440984 - Circ Res. 2001 Jul 6;89(1):E1-7 – reference: 21904841 - Basic Res Cardiol. 2011 Nov;106(6):1397-410 – reference: 12584367 - N Engl J Med. 2003 Feb 13;348(7):593-600 – reference: 17181565 - Eur J Clin Invest. 2007 Jan;37(1):35-41 – reference: 19013004 - Exp Hematol. 2009 Jan;37(1):8-9 – reference: 11877368 - Circulation. 2002 Mar 5;105(9):1135-43 – reference: 10619863 - J Clin Invest. 2000 Jan;105(1):71-7 – reference: 20453169 - Arterioscler Thromb Vasc Biol. 2010 Jun;30(6):1094-103 – reference: 12485966 - Circulation. 2002 Dec 17;106(25):3143-421 – reference: 22715381 - PLoS One. 2012;7(6):e38399 – reference: 19067770 - J Cell Mol Med. 2009 Jan;13(1):87-102 – reference: 12679755 - Am Heart J. 2003 Apr;145(4):602-13 – reference: 20823386 - Circulation. 2010 Sep 21;122(12):1176-82 |
| SSID | ssj0053866 |
| Score | 2.1768951 |
| Snippet | To study the regenerative capacity of the endothelium in patients with coronary artery disease (CAD), we cultured blood outgrowth endothelial cells (BOECs) of... Background To study the regenerative capacity of the endothelium in patients with coronary artery disease (CAD), we cultured blood outgrowth endothelial cells... BackgroundTo study the regenerative capacity of the endothelium in patients with coronary artery disease (CAD), we cultured blood outgrowth endothelial cells... Background To study the regenerative capacity of the endothelium in patients with coronary artery disease (CAD), we cultured blood outgrowth endothelial cells... |
| SourceID | plos doaj pubmedcentral proquest gale pubmed crossref |
| SourceType | Open Website Open Access Repository Aggregation Database Index Database Enrichment Source |
| StartPage | e99890 |
| SubjectTerms | Adult Aged Arteriosclerosis Atherosclerosis Atherosclerosis - drug therapy Atherosclerosis - metabolism Atherosclerosis - pathology Biology and Life Sciences Blood Blood pressure Calcification Calcification (ectopic) Cardiovascular agents Cardiovascular disease Cell proliferation Cell Proliferation - drug effects Cholesterol Colonies Comparative analysis Coronary artery Coronary artery disease Coronary heart disease Coronary vessels Endothelial cells Endothelial Cells - metabolism Endothelial Cells - pathology Endothelium Family medical history Female Health risk assessment Heart attacks Heart diseases Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors - administration & dosage Laboratories Male Medical imaging Medicine Medicine and Health Sciences Middle Aged Patients Plasma Proteins Regeneration Statins Statistical analysis Stem Cells - metabolism Stem Cells - pathology Studies Therapy |
| SummonAdditionalLinks | – databaseName: DOAJ Directory of Open Access Journals dbid: DOA link: http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV3di9NAEF-k-OCLeH5dtOoqggrmrslus7uPp3h4IKf4xb2F7Gb2WihJadqT-0P8f51JtqGRg_NBCnnoTpZ0ZnbmN-l8MPZSa6fR0U1jZzVggFJmsSkxWDFWFYmcphMNbXf9T-r0VJ-dmS87o74oJ6xrD9wx7lCXpfDeiiRxVhqrrQJpvBFTcJkoDJD1nSizDaY6G4ynOMtCoZxQyWGQy8GyruCAQJEmG7zjiNp-_b1VHi0XdXMV5Pw7c3LHFR3fYbcDhuRH3bPvsRtQ3WV74ZQ2_HVoJf3mHvt90tdbcXrjypuN3dZC8hb71Q1ugdd5w2fFBXCqmkQrWPIljfPx0CkIrz1vU9x5vVmfY-SOW0FVUvXWAhWY0-v_5i3_NZu7GUdhcQt81c6swZ3sJaeypXnFu2Kvy_vsx_GH7-8_xmEQQ-wyk65jsIXzBtDLaZs60AajEJMCQr-pnUChhTNKOKd84tLCGMQ0DoWjlFcepEVE9ICNKmT9PuOAmEIoIYUrpPTSmgwQ9GDYZSUgEk0iJrZSyV3oUk7DMhZ5-9ebwmilY3JOssyDLCMW93ctuy4d19C_I4H3tNRju_0CNS8Pmpdfp3kRe0bqkncFq72lyI8koSYM47KIvWgpqM9GRYk858WmafKTzz__gejb1wHRq0Dka2SHK0LxBP4m6t81oBwPKNFauMHyPin3litNjh7PSBoygKwfbxX-6uXn_TJtSsl5FdQbosEgPRH4idjD7nz0nKXR5hgRiIipwckZsH64Us1nbZtzSVkCJnn0P2T1mN1CpCspxy8VYzZarzbwhN10F-t5s3ra2o4_QqN5gg priority: 102 providerName: Directory of Open Access Journals – databaseName: Public Library of Science (PLoS) Journals Open Access dbid: FPL link: http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV1tb9MwELZQQYgvwMbLAgUMQgIkMpbYje2PbbVqlcZWjQH7FsWOs1aKkmppJ_FD-L_cJW4g0yZAlfqhvljJ2Xd-nuZeCHkrpZFw0A18o6UFgpJGvkqBrCgtkoAPwj1p6-r6h-LoSJ6dqdlvonjlDT4TwSen091lWdhdBDRSAUW_HbIowlYNk9nhxvOC7UaRS4-76crO8VNX6W99cW-Zl9V1QPNqvOQfB9Dkwf_e-kNy30FNOmz2xha5ZYttcveze5m-TbacXVf0vSs-_eER-TltM7Qo_kdLwbNssifpENFiWcFs8L2o6EFyaekUHAr4zZTOsAFQZpstRcuMjjAonh6vV-fA9WGq_SLFfK8ctjwd2zyvPtLv84WZ03FS0JGlJ3WXG5hJ_6AIghcFPW2KHjwmXyf7p-MD37Vu8E2kwpVvdWIyZeFclDo0VirgLSq0ABYHes8mkhklmDEiC0yYKAUoyJiICZGJzHINGOoJ6RWgtR1CLaAQJhhnJuE841pFFmASEDXNLWDXwCNss6KxcXXNsb1GHtcv6wTwm0bfMS5D7JbBI3571bKp6_EX-RFullYWq3LXP8B6x87IY5mmLMs0CwKjudJSC8tVptjAwsMlynrkFW61uElxbX1LPOSIs4D4RR55U0tgZY4CQ3_Ok3VVxdPjb_8g9OWkI_TOCWUlqMMkLt0CngkrfnUk-x1J8C-mM7yDhrHRShXDGak4tiUA1fc3xnL98Ot2GCfFcL7ClmuUAVofMPh45GljW61msRk6cAjmEdGxuo7quyPFYl4XRucYV6CCZzff8XNyDxAvx1i_kPVJb3Wxti_IHXO5WlQXL2tv8gu0d3X0 priority: 102 providerName: Public Library of Science |
| Title | Individual with Subclinical Atherosclerosis Have Impaired Proliferation of Blood Outgrowth Endothelial Cells, Which Can Be Restored by Statin Therapy |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/24955753 https://www.proquest.com/docview/1539494661 https://www.proquest.com/docview/1540113131 https://pubmed.ncbi.nlm.nih.gov/PMC4067291 https://doaj.org/article/8dd3ffb311cb49b8b7e49f935ec63a9e http://dx.doi.org/10.1371/journal.pone.0099890 |
| Volume | 9 |
| WOSCitedRecordID | wos000338917900020&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| journalDatabaseRights | – providerCode: PRVAON databaseName: DOAJ Directory of Open Access Journals customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: DOA dateStart: 20060101 isFulltext: true titleUrlDefault: https://www.doaj.org/ providerName: Directory of Open Access Journals – providerCode: PRVHPJ databaseName: ROAD: Directory of Open Access Scholarly Resources customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: M~E dateStart: 20060101 isFulltext: true titleUrlDefault: https://road.issn.org providerName: ISSN International Centre – providerCode: PRVPQU databaseName: Advanced Technologies & Aerospace Database customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: P5Z dateStart: 20061201 isFulltext: true titleUrlDefault: https://search.proquest.com/hightechjournals providerName: ProQuest – providerCode: PRVPQU databaseName: Agricultural Science Database customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: M0K dateStart: 20061201 isFulltext: true titleUrlDefault: https://search.proquest.com/agriculturejournals providerName: ProQuest – providerCode: PRVPQU databaseName: Biological Science Database customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: M7P dateStart: 20061201 isFulltext: true titleUrlDefault: http://search.proquest.com/biologicalscijournals providerName: ProQuest – providerCode: PRVPQU databaseName: Engineering Database customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: M7S dateStart: 20061201 isFulltext: true titleUrlDefault: http://search.proquest.com providerName: ProQuest – providerCode: PRVPQU databaseName: Environmental Science Database customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: PATMY dateStart: 20061201 isFulltext: true titleUrlDefault: http://search.proquest.com/environmentalscience providerName: ProQuest – providerCode: PRVPQU databaseName: Health & Medical Collection customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: 7X7 dateStart: 20061201 isFulltext: true titleUrlDefault: https://search.proquest.com/healthcomplete providerName: ProQuest – providerCode: PRVPQU databaseName: Nursing & Allied Health Database customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: 7RV dateStart: 20061201 isFulltext: true titleUrlDefault: https://search.proquest.com/nahs providerName: ProQuest – providerCode: PRVPQU databaseName: ProQuest Central customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: BENPR dateStart: 20061201 isFulltext: true titleUrlDefault: https://www.proquest.com/central providerName: ProQuest – providerCode: PRVPQU databaseName: ProQuest Materials Science Database customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: KB. dateStart: 20061201 isFulltext: true titleUrlDefault: http://search.proquest.com/materialsscijournals providerName: ProQuest – providerCode: PRVPQU databaseName: Public Health Database (Proquest) customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: 8C1 dateStart: 20061201 isFulltext: true titleUrlDefault: https://search.proquest.com/publichealth providerName: ProQuest – providerCode: PRVPQU databaseName: Publicly Available Content Database customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: PIMPY dateStart: 20061201 isFulltext: true titleUrlDefault: http://search.proquest.com/publiccontent providerName: ProQuest – providerCode: PRVATS databaseName: Public Library of Science (PLoS) Journals Open Access customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: FPL dateStart: 20060101 isFulltext: true titleUrlDefault: http://www.plos.org/publications/ providerName: Public Library of Science |
| link | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV3db9MwELdgQ4gXYONjhTEMQgIksi21G9tPaK02rdpX1H0weIlix9kqVUlp2iH-EP5f7hI3LGgCJFTpHuqzldh359855ztC3khpJGx0Hc9oacFBSQJPJeCsKC1in3fam9KW2fX3xeGhPD9XoTtwK1xY5dwmloY6yQ2ekW-AZiqOydD9j-OvHlaNwq-rroTGbbLoIzYGeRaDs7klBl0OAnddjgl_w63O-jjP7DpCI4mW-Np2VGbtr23zwniUFzcBz9_jJ69tSDsP_vdVHpL7DorSrUp2lsgtmy2TuwfuY_syWXJ6X9B3Ljn1-0fkR7--wUXxDJeC5ZnfrqRbiCbzAkYDOizobnxlaR8MDtjVhIZYICi1lcjRPKVdDJqnR7PpxST_BkNtZwneBxuBStCeHY2KD_TT5dBc0l6c0a6lg7IKDoykv1MEycOMnlRJER6T053tk96u50o7eCZQ7alndWxSZWHflLptrFTg16i2BTDZ0Zs2lswowYwRqW_asVKAkowJmBCpSC3XgLGekIUMlnGFUAsohQnGmYk5T7lWgQUYBY6c5hawrd8ibL7CkXF5z7H8xigqP-YJ8H-q-Y5QLiInFy3i1b3GVd6Pv_B3UXhqXszaXf6RTy4iZwQimSQsTTXzfaO50lILy1WqWMfCy8XKtshLFL2ougJb255oiyMOA8cwaJHXJQdm7sgwNOginhVF1D86-wem40GD6a1jSnOYDhO76xjwTpgRrMG52uAE-2MazSuoKPNZKaJf4g095wpwc_OruhkHxXC_zOYz5AG332fwa5Gnla7VM4vF0sHHYC0iGlrYmPpmSza8LBOnc4w7UP6zPz_Wc3IPUDHHeMA2WyUL08nMviB3zNV0WEzWSguD9FyUVAKVPX-NLHa3D8PBWnmoA3Qn3Ae6110HerC5h1SEJT0GGna-QI-wfxB-_gn5hpRU |
| linkProvider | ProQuest |
| linkToHtml | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1Lb9NAEF5VAQEXoOVRQ6ELAgESbmvvxt49IJSEVon6VAnQm_Gu122kyA5x0qo_hL_Bb2TGL2pUAZceUCQfsuOVPZ75ZsaeByEvhNACDF3b1koYCFAiz5YRBCtS-aHD2-6GMHl3_R1_b08cHcmDBfKjqoXBtMoKE3OgjlKN78jXQTMlx2bozvvJNxunRuHX1WqERiEW2-b8DEK27N3gAzzfl667tTns9e1yqoCtPenObKNCHUsDkC2Uq42Q4FJL14Af01YbJhRMS59p7ceOdkMpwUBr7THfj_3YcCWw-RJA_jXOXIZaJHp1Sglgh-eV5XnMd9ZLaVibpIlZQ1dMIPJfMH_5lIDaFrQm4zS7zNH9PV_zggHcuvO_se4uuV262rRT6MYiWTDJErmxWyYTLJHFEtcy-rpsvv3mHvk-qCvUKL6jpoCsVfUo7aC3nGawGxxHGe2Hp4YOAFDBbkT0AAcgxaZQKZrGtItFAXR_Pjuepmew1WYSYb3bGFSe9sx4nL2lX05G-oT2woR2DT3Mp_zATuqcYhAwSuiwaPpwn3y6Ek49IK0ExGaZUANeGPMZZzrkPOZKegbcRAhUFTfguzsWYZVEBbrs647jRcZB_rHSh_iu4HeAchiUcmgRuz5rUvQ1-Qt9F4W1psWu5Pkf6fQ4KEEuEFHE4lgxx9GKSyWUb7iMJWsbuLlQGousoqgHRYlvja1Bh6OfCYGvZ5HnOQV2Jkkw9ek4nGdZMNj__A9EHw8bRK9KojgFduiwLDeBe8KOZw3KlQYl4KtuLC-jYlZcyYJf6gRnVgp3-fKzehk3xXTGxKRzpOFgVxn8LPKw0O2aszgMHmIoZhG_ofUN1jdXktFJ3hieY16FdB79-bJWyc3-cHcn2BnsbT8mtyAC4Jj76LIV0ppN5-YJua5PZ6Ns-jRHN0q-XjUm_AS7uuUd |
| linkToPdf | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1Lb9NAEF5VBVVcgJZHA4UuCARIuKm9G3v3gFD6UqOWNioFejPe9bqJFNkhTlr1h_Bn-HXM2GtTowq49IAi-ZAdr-zxzDcz9jwIeSGEFmDoOo5WwkCAEvuOjCFYkSqIXN7x1oUpuuvvBwcH4uRE9ufIj6oWBtMqK0wsgDrONL4jb4NmSo7N0N12YtMi-ls778ffHJwghV9aq3EapYjsmYtzCN_yd70teNYvPW9n-3hz17ETBhztS2_qGBXpRBqAb6E8bYQE91p6Bnyajlo3kWBaBkzrIHG1F0kJxlprnwVBEiSGK4GNmAD-bwTcX_eKtMF-ZQUAR3zfluqxwG1byVgbZ6lZQ7dMoBW4ZAqLiQG1XZgfj7L8Kqf399zNS8Zw587_zMa75LZ1wWm31JlFMmfSJbLwwSYZLJFFi3c5fW2bcr-5R7736so1iu-uKSBuVVVKu-hFZznsBsdhTnejM0N7ALRgT2Lax8FIiSlVjWYJ3cBiAXo4m55OsnPYajuNsQ5uBFBAN81olL-lXwZDPaCbUUo3DD0qpv_ATuqCYnAwTOlx2QziPvl0LZx6QOZTEKFlQg14ZyxgnOmI84Qr6RtwHyGAVdyAT--2CKukK9S23zuOHRmFxUfMAOK-kt8hymRoZbJFnPqscdnv5C_0Gyi4NS12Ky_-yCanoQW_UMQxSxLFXFcrLpVQgeEykaxj4OYiaVpkFcU-LEt_a8wNuxz9TwiI_RZ5XlBgx5IUhfY0muV52Dv8_A9EH48aRK8sUZIBO3Rky1DgnrATWoNypUEJuKsby8uopBVX8vCXasGZlfJdvfysXsZNMc0xNdkMaTjYWwa_FnlY6nnNWRwSD7EVa5GggQAN1jdX0uGgaBjPMd9Cuo_-fFmrZAGgINzvHew9JrcgMOCYEumxFTI_nczME3JTn02H-eRpAXSUfL1uSPgJLRfuKQ |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Individual+with+Subclinical+Atherosclerosis+Have+Impaired+Proliferation+of+Blood+Outgrowth+Endothelial+Cells%2C+Which+Can+Be+Restored+by+Statin+Therapy&rft.jtitle=PloS+one&rft.au=Martin-Ramirez%2C+Javier&rft.au=Kok%2C+Maayke+G+M&rft.au=Hofman%2C+Menno&rft.au=Bierings%2C+Ruben&rft.date=2014-06-23&rft.pub=Public+Library+of+Science&rft.eissn=1932-6203&rft.volume=9&rft.issue=6&rft.spage=e99890&rft_id=info:doi/10.1371%2Fjournal.pone.0099890&rft.externalDBID=HAS_PDF_LINK&rft.externalDocID=3347291231 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1932-6203&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1932-6203&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1932-6203&client=summon |