Accumulation of advanced glycation end products evaluated by skin autofluorescence and incident frailty in older adults from the Bordeaux Three-City cohort

We analyzed the cross-sectional and prospective relationships between the accumulation of advanced glycation end products (AGE), assessed by skin autofluorescence (AF) and frailty and its components. A total of 423 participants of the Bordeaux sample of the Three-City study 75 years of age or older...

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Veröffentlicht in:PloS one Jg. 12; H. 10; S. e0186087
Hauptverfasser: Pilleron, Sophie, Rajaobelina, Kalina, Tabue Teguo, Maturin, Dartigues, Jean-François, Helmer, Catherine, Delcourt, Cécile, Rigalleau, Vincent, Féart, Catherine
Format: Journal Article
Sprache:Englisch
Veröffentlicht: United States Public Library of Science 17.10.2017
Public Library of Science (PLoS)
Schlagworte:
Accumulation
Adults
Advanced glycation end products
Advanced glycosylation end products
Age
Aged
Aged, 80 and over
Aging
Aging - metabolism
Aging - pathology
Atherosclerosis
Biology and Life Sciences
Body mass index
Cardiovascular disease
Confidence intervals
Coronary vessels
Criteria
Cross-Sectional Studies
Diabetes
Energy expenditure
Exhaustion
Fatigue - metabolism
Fatigue - pathology
Female
Fluorescence
Frail Elderly
Frailty
France
Geriatric Assessment
Glycation End Products, Advanced - metabolism
Glycosylation
Humans
Independent Living
Logistic Models
Male
Measurement
Medical research
Medicine and Health Sciences
Metabolism
Mortality
Musculoskeletal system
Odds Ratio
Older people
Optical Imaging
People and Places
Physiological aspects
Population
Prospective Studies
Regression analysis
Regression models
Risk Factors
Skin
Skin - metabolism
Skin - pathology
Skin Aging - pathology
Social Sciences
Statistical analysis
Studies
Womens health
France
ISSN:1932-6203, 1932-6203
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Beschreibung
Zusammenfassung:We analyzed the cross-sectional and prospective relationships between the accumulation of advanced glycation end products (AGE), assessed by skin autofluorescence (AF) and frailty and its components. A total of 423 participants of the Bordeaux sample of the Three-City study 75 years of age or older in 2009-2010 were included in the cross-sectional analysis. Among them, 255 initially non-frail participants were re-examined 4 years later. Skin AF (arbitrary units (AU)) was measured using the AGE Reader. Frailty was defined using Fried's criteria. Associations were assessed with logistic regression models. Mean skin AF at baseline was 2.81 ±0.68 AU and 16.8% participants were frail. Adjusted for sociodemographic and health characteristics, skin AF was associated neither with prevalent frailty as a whole (Odds Ratio (OR) = 1.2; 95% Confidence Interval: 0.8-1.9) nor with any of its components. Among 255 non-frail participants, 32 became frail over 4 years. In multivariate analyses, skin AF was not associated with incident frailty as a whole (OR = 1.0; 0.5-2.0) but with a doubled risk of incident exhaustion (OR = 2.0; 1.2-3.6) and low energy expenditure (OR = 2.0; 1.1-3.7). No association was observed with other criteria. In French older community-dwellers aged 75 years and over, the accumulation of AGEs evaluated by skin AF was not associated with prevalent or incident frailty but with the 4-year risk of exhaustion and low energy expenditure. Further studies with larger samples are needed to confirm our results.
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Competing Interests: C Féart received fees for conferences from Danone Research and Nutricia. The other authors declare no conflicts of interest. This does not alter our adherence to PLOS ONE policies on sharing data and materials.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0186087