LH and hCG Action on the Same Receptor Results in Quantitatively and Qualitatively Different Intracellular Signalling

Human luteinizing hormone (hLH) and chorionic gonadotropin (hCG) act on the same receptor (LHCGR) but it is not known whether they elicit the same cellular and molecular response. This study compares for the first time the activation of cell-signalling pathways and gene expression in response to hLH...

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Bibliographic Details
Published in:	PloS one Vol. 7; no. 10; p. e46682
Main Authors:	Casarini, Livio, Lispi, Monica, Longobardi, Salvatore, Milosa, Fabiola, La Marca, Antonio, Tagliasacchi, Daniela, Pignatti, Elisa, Simoni, Manuela
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 05.10.2012 Public Library of Science (PLoS)
Subjects:	1-Methyl-3-isobutylxanthine - pharmacology Activation Adult AKT protein Animals Apoptosis Aromatase Biology Cell activation Cell cycle Cell Shape Cercopithecus aethiops Chorionic gonadotropin Chorionic Gonadotropin - pharmacology Chorionic Gonadotropin - physiology Chorionic gonadotropins COS Cells Cyclic adenosine monophosphate Cyclic AMP Cyclic AMP - metabolism Dehydrogenases Dose-Response Relationship, Drug Epidermal growth factor Extracellular signal-regulated kinase Extracellular Signal-Regulated MAP Kinases - antagonists & inhibitors Extracellular Signal-Regulated MAP Kinases - metabolism Female Gene expression Genes Glycoproteins Gonadotropins Granulosa cells Granulosa Cells - metabolism Gynecology Hormones Humans Inhibition Intracellular Intracellular signalling Kinases Kinetics Luteinizing hormone Luteinizing Hormone - pharmacology Luteinizing Hormone - physiology Medicine Metabolism Middle Aged Neuregulin Neuregulin 1 Obstetrics Pathways Physiology Pituitary (anterior) Primary Cell Culture Progesterone Progesterone - biosynthesis Protein Kinase Inhibitors - pharmacology Proteins Proto-Oncogene Proteins c-akt - antagonists & inhibitors Proto-Oncogene Proteins c-akt - metabolism Receptors, LH - agonists Receptors, LH - metabolism Receptors, LH - physiology Rodents Secretion Signal Transduction Studies Transcription activation Transcriptome Italy
ISSN:	1932-6203, 1932-6203
Online Access:	Get full text
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