Glutathione S-Transferase T1, O1 and O2 Polymorphisms Are Associated with Survival in Muscle Invasive Bladder Cancer Patients

To examine the association of six glutathione transferase (GST) gene polymorphisms (GSTT1, GSTP1/rs1695, GSTO1/rs4925, GSTO2/rs156697, GSTM1, GSTA1/rs3957357) with the survival of patients with muscle invasive bladder cancer and the genotype modifying effect on chemotherapy. A total of 105 patients...

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Vydané v:	PloS one Ročník 8; číslo 9; s. e74724
Hlavní autori:	Djukic, Tatjana I., Savic-Radojevic, Ana R., Pekmezovic, Tatjana D., Matic, Marija G., Pljesa-Ercegovac, Marija S., Coric, Vesna M., Radic, Tanja M., Suvakov, Sonja R., Krivic, Biljana N., Dragicevic, Dejan P., Simic, Tatjana P.
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	United States Public Library of Science 11.09.2013 Public Library of Science (PLoS)
Predmet:	Aged Analysis Antineoplastic Agents - therapeutic use Biochemistry Bladder Bladder cancer Brain cancer Cancer Cancer patients Cancer research Cancer therapies Care and treatment Chemotherapy Deoxyribonucleic acid DNA Enzymes Female Gene expression Gene polymorphism Genes Genetic aspects Genetic polymorphisms Genotype Genotypes Glutathione Glutathione transferase Glutathione Transferase - genetics GSTM1 protein GSTT1 protein Health risks Humans Influence Invasiveness Male Medicine Middle Aged Mortality Muscles Neoplasm Invasiveness Patient outcomes Patients Pharmacogenetics Pharmacogenomics Pharmacology Polymorphism Polymorphism, Genetic Prognosis Proportional Hazards Models Survival Survival analysis Thiols Treatment Outcome Tumors Urinary bladder Urinary Bladder Neoplasms - drug therapy Urinary Bladder Neoplasms - genetics Urinary Bladder Neoplasms - mortality Urology Serbia
ISSN:	1932-6203, 1932-6203
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Abstract	To examine the association of six glutathione transferase (GST) gene polymorphisms (GSTT1, GSTP1/rs1695, GSTO1/rs4925, GSTO2/rs156697, GSTM1, GSTA1/rs3957357) with the survival of patients with muscle invasive bladder cancer and the genotype modifying effect on chemotherapy. A total of 105 patients with muscle invasive bladder cancer were included in the study. The follow-up lasted 5 years. The effect of GSTs polymorphisms on predicting mortality was analyzed by the Cox proportional hazard models, while Kaplan-Meier analysis was performed to assess differences in survival. GSTT1 active, GSTO1 Asp140Asp or GSTO2 Asp142Asp genotypes were independent predictors of a higher risk of death among bladder cancer patients (HR = 2.5, P = 0.028; HR = 2.9, P = 0.022; HR = 3.9, P = 0.001; respectively) and significantly influenced the overall survival. There was no association between GSTP1, GSTM1 and GSTA1 gene variants with overall mortality. Only GSTO2 polymorphism showed a significant effect on the survival in the subgroup of patients who received chemotherapy (P = 0.006). GSTT1 active genotype and GSTO1 Asp140Asp and GSTO2 Asp142Asp genotypes may have a prognostic/pharmacogenomic role in patients with muscle invasive bladder cancer.
AbstractList	To examine the association of six glutathione transferase (GST) gene polymorphisms (GSTT1, GSTP1/rs1695, GSTO1/rs4925, GSTO2/rs156697, GSTM1, GSTA1/rs3957357) with the survival of patients with muscle invasive bladder cancer and the genotype modifying effect on chemotherapy. A total of 105 patients with muscle invasive bladder cancer were included in the study. The follow-up lasted 5 years. The effect of GSTs polymorphisms on predicting mortality was analyzed by the Cox proportional hazard models, while Kaplan-Meier analysis was performed to assess differences in survival. GSTT1 active, GSTO1 Asp140Asp or GSTO2 Asp142Asp genotypes were independent predictors of a higher risk of death among bladder cancer patients (HR = 2.5, P = 0.028; HR = 2.9, P = 0.022; HR = 3.9, P = 0.001; respectively) and significantly influenced the overall survival. There was no association between GSTP1, GSTM1 and GSTA1 gene variants with overall mortality. Only GSTO2 polymorphism showed a significant effect on the survival in the subgroup of patients who received chemotherapy (P = 0.006). GSTT1 active genotype and GSTO1 Asp140Asp and GSTO2 Asp142Asp genotypes may have a prognostic/pharmacogenomic role in patients with muscle invasive bladder cancer. Objective To examine the association of six glutathione transferase (GST) gene polymorphisms (GSTT1, GSTP1/rs1695, GSTO1/rs4925, GSTO2/rs156697, GSTM1, GSTA1/rs3957357) with the survival of patients with muscle invasive bladder cancer and the genotype modifying effect on chemotherapy. Patients and Methods A total of 105 patients with muscle invasive bladder cancer were included in the study. The follow-up lasted 5 years. The effect of GSTs polymorphisms on predicting mortality was analyzed by the Cox proportional hazard models, while Kaplan-Meier analysis was performed to assess differences in survival. Results GSTT1 active, GSTO1 Asp140Asp or GSTO2 Asp142Asp genotypes were independent predictors of a higher risk of death among bladder cancer patients (HR = 2.5, P = 0.028; HR = 2.9, P = 0.022; HR = 3.9, P = 0.001; respectively) and significantly influenced the overall survival. There was no association between GSTP1, GSTM1 and GSTA1 gene variants with overall mortality. Only GSTO2 polymorphism showed a significant effect on the survival in the subgroup of patients who received chemotherapy (P = 0.006). Conclusion GSTT1 active genotype and GSTO1 Asp140Asp and GSTO2 Asp142Asp genotypes may have a prognostic/pharmacogenomic role in patients with muscle invasive bladder cancer. To examine the association of six glutathione transferase (GST) gene polymorphisms (GSTT1, GSTP1/rs1695, GSTO1/rs4925, GSTO2/rs156697, GSTM1, GSTA1/rs3957357) with the survival of patients with muscle invasive bladder cancer and the genotype modifying effect on chemotherapy.OBJECTIVETo examine the association of six glutathione transferase (GST) gene polymorphisms (GSTT1, GSTP1/rs1695, GSTO1/rs4925, GSTO2/rs156697, GSTM1, GSTA1/rs3957357) with the survival of patients with muscle invasive bladder cancer and the genotype modifying effect on chemotherapy.A total of 105 patients with muscle invasive bladder cancer were included in the study. The follow-up lasted 5 years. The effect of GSTs polymorphisms on predicting mortality was analyzed by the Cox proportional hazard models, while Kaplan-Meier analysis was performed to assess differences in survival.PATIENTS AND METHODSA total of 105 patients with muscle invasive bladder cancer were included in the study. The follow-up lasted 5 years. The effect of GSTs polymorphisms on predicting mortality was analyzed by the Cox proportional hazard models, while Kaplan-Meier analysis was performed to assess differences in survival.GSTT1 active, GSTO1 Asp140Asp or GSTO2 Asp142Asp genotypes were independent predictors of a higher risk of death among bladder cancer patients (HR = 2.5, P = 0.028; HR = 2.9, P = 0.022; HR = 3.9, P = 0.001; respectively) and significantly influenced the overall survival. There was no association between GSTP1, GSTM1 and GSTA1 gene variants with overall mortality. Only GSTO2 polymorphism showed a significant effect on the survival in the subgroup of patients who received chemotherapy (P = 0.006).RESULTSGSTT1 active, GSTO1 Asp140Asp or GSTO2 Asp142Asp genotypes were independent predictors of a higher risk of death among bladder cancer patients (HR = 2.5, P = 0.028; HR = 2.9, P = 0.022; HR = 3.9, P = 0.001; respectively) and significantly influenced the overall survival. There was no association between GSTP1, GSTM1 and GSTA1 gene variants with overall mortality. Only GSTO2 polymorphism showed a significant effect on the survival in the subgroup of patients who received chemotherapy (P = 0.006).GSTT1 active genotype and GSTO1 Asp140Asp and GSTO2 Asp142Asp genotypes may have a prognostic/pharmacogenomic role in patients with muscle invasive bladder cancer.CONCLUSIONGSTT1 active genotype and GSTO1 Asp140Asp and GSTO2 Asp142Asp genotypes may have a prognostic/pharmacogenomic role in patients with muscle invasive bladder cancer. To examine the association of six glutathione transferase (GST) gene polymorphisms (GSTT1, GSTP1/rs1695, GSTO1/rs4925, GSTO2/rs156697, GSTM1, GSTA1/rs3957357) with the survival of patients with muscle invasive bladder cancer and the genotype modifying effect on chemotherapy. A total of 105 patients with muscle invasive bladder cancer were included in the study. The follow-up lasted 5 years. The effect of GSTs polymorphisms on predicting mortality was analyzed by the Cox proportional hazard models, while Kaplan-Meier analysis was performed to assess differences in survival. GSTT1 active, GSTO1 Asp140Asp or GSTO2 Asp142Asp genotypes were independent predictors of a higher risk of death among bladder cancer patients (HR = 2.5, P = 0.028; HR = 2.9, P = 0.022; HR = 3.9, P = 0.001; respectively) and significantly influenced the overall survival. There was no association between GSTP1, GSTM1 and GSTA1 gene variants with overall mortality. Only GSTO2 polymorphism showed a significant effect on the survival in the subgroup of patients who received chemotherapy (P = 0.006). GSTT1 active genotype and GSTO1 Asp140Asp and GSTO2 Asp142Asp genotypes may have a prognostic/pharmacogenomic role in patients with muscle invasive bladder cancer. Objective To examine the association of six glutathione transferase (GST) gene polymorphisms (GSTT1, GSTP1/rs1695, GSTO1/rs4925, GSTO2/rs156697, GSTM1, GSTA1/rs3957357) with the survival of patients with muscle invasive bladder cancer and the genotype modifying effect on chemotherapy. Patients and Methods A total of 105 patients with muscle invasive bladder cancer were included in the study. The follow-up lasted 5 years. The effect of GSTs polymorphisms on predicting mortality was analyzed by the Cox proportional hazard models, while Kaplan-Meier analysis was performed to assess differences in survival. Results GSTT1 active, GSTO1 Asp140Asp or GSTO2 Asp142Asp genotypes were independent predictors of a higher risk of death among bladder cancer patients (HR = 2.5, P = 0.028; HR = 2.9, P = 0.022; HR = 3.9, P = 0.001; respectively) and significantly influenced the overall survival. There was no association between GSTP1, GSTM1 and GSTA1 gene variants with overall mortality. Only GSTO2 polymorphism showed a significant effect on the survival in the subgroup of patients who received chemotherapy (P = 0.006). Conclusion GSTT1 active genotype and GSTO1 Asp140Asp and GSTO2 Asp142Asp genotypes may have a prognostic/pharmacogenomic role in patients with muscle invasive bladder cancer.
Audience	Academic
Author	Djukic, Tatjana I. Coric, Vesna M. Krivic, Biljana N. Pekmezovic, Tatjana D. Suvakov, Sonja R. Simic, Tatjana P. Pljesa-Ercegovac, Marija S. Matic, Marija G. Savic-Radojevic, Ana R. Radic, Tanja M. Dragicevic, Dejan P.
AuthorAffiliation	Nanjing Medical University, China 1 Institute of Medical and Clinical Biochemistry, Faculty of Medicine, University of Belgrade, Belgrade, Serbia 3 Clinic of Urology, Clinical Centre of Serbia, Belgrade, Serbia 4 Clinic of Urology, Clinical Centre of Serbia, Faculty of Medicine, University of Belgrade, Belgrade, Serbia 2 Institute of Epidemiology, Faculty of Medicine, University of Belgrade, Belgrade, Serbia
AuthorAffiliation_xml	– name: 4 Clinic of Urology, Clinical Centre of Serbia, Faculty of Medicine, University of Belgrade, Belgrade, Serbia – name: Nanjing Medical University, China – name: 2 Institute of Epidemiology, Faculty of Medicine, University of Belgrade, Belgrade, Serbia – name: 3 Clinic of Urology, Clinical Centre of Serbia, Belgrade, Serbia – name: 1 Institute of Medical and Clinical Biochemistry, Faculty of Medicine, University of Belgrade, Belgrade, Serbia
Author_xml	– sequence: 1 givenname: Tatjana I. surname: Djukic fullname: Djukic, Tatjana I. – sequence: 2 givenname: Ana R. surname: Savic-Radojevic fullname: Savic-Radojevic, Ana R. – sequence: 3 givenname: Tatjana D. surname: Pekmezovic fullname: Pekmezovic, Tatjana D. – sequence: 4 givenname: Marija G. surname: Matic fullname: Matic, Marija G. – sequence: 5 givenname: Marija S. surname: Pljesa-Ercegovac fullname: Pljesa-Ercegovac, Marija S. – sequence: 6 givenname: Vesna M. surname: Coric fullname: Coric, Vesna M. – sequence: 7 givenname: Tanja M. surname: Radic fullname: Radic, Tanja M. – sequence: 8 givenname: Sonja R. surname: Suvakov fullname: Suvakov, Sonja R. – sequence: 9 givenname: Biljana N. surname: Krivic fullname: Krivic, Biljana N. – sequence: 10 givenname: Dejan P. surname: Dragicevic fullname: Dragicevic, Dejan P. – sequence: 11 givenname: Tatjana P. surname: Simic fullname: Simic, Tatjana P.
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/24040330$$D View this record in MEDLINE/PubMed
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Cites_doi	10.1016/j.canlet.2005.05.020 10.1016/S0090-4295(96)00575-4 10.1038/tpj.2010.38 10.1093/jnci/94.12.936 10.1038/sj.tpj.6500242 10.1093/ndt/gfs369 10.1016/j.eururo.2007.01.046 10.1016/j.urology.2005.01.005 10.1093/annonc/mdr483 10.1146/annurev.pharmtox.45.120403.095857 10.1016/j.toxlet.2012.01.015 10.1038/nrurol.2009.49 10.7150/ijms.8.492 10.1016/j.scitotenv.2010.10.053 10.1186/1750-1326-7-13 10.1021/mp2000692 10.1158/0008-5472.CAN-04-3903 10.1016/S0076-6879(05)01005-0 10.1080/10611860701498286 10.1016/j.urolonc.2008.10.019 10.1042/bj20011713 10.1016/j.freeradbiomed.2012.10.556 10.1097/FPC.0b013e32833caa45
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Notes	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 Conceived and designed the experiments: TS ASR TP MPE. Performed the experiments: TD VC TR SS MM. Analyzed the data: TD TP ASR. Contributed reagents/materials/analysis tools: BK DD. Wrote the paper: TD TS. Competing Interests: The authors have declared that no competing interests exist.
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References	CJ Chung (ref3) 2011; 409(3) CL Berendsen (ref4) 1997; 49(4) AK Whitbread (ref9) 2005; 401 YS Ha (ref15) 2010; 29(2) MS Nørskov (ref14) 2011; 11(4) T Simic (ref17) 2005; 65(5) SB Marahatta (ref12) 2006; 236(2) S Suvakov (ref11) 2013; 28(1) A Savic-Radojevic (ref16) 2007; 52(2) C Lesseur (ref13) 2012; 210(1) Y Li (ref25) 2007; 137(10) K Johansson (ref5) 2011; 8(5) A Diedrich (ref19) 2006; 21(11) M Pljesa-Ercegovac (ref22) 2011; 29(1) A Valachis (ref26) 2011; 8(6) J Fang (ref20) 2007; 15(7–8) MV Catani (ref24) 2002; 2 V Stearns (ref8) 2004; 4(3) T Simic (ref2) 2009; 6(5) C Salinas-Souza (ref18) 2010; 20(8) JD Hayes (ref1) 2005; 45 J Stoehlmacher (ref6) 2002; 94(12) A Romero (ref21) 2012; 23(7) M Allen (ref10) 2012; 7 Y Manevich (ref23) 2013; 54 P Turella (ref7) 2005; 65(9) 22306368 - Toxicol Lett. 2012 Apr 5;210(1):100-6 23142420 - Free Radic Biol Med. 2013 Jan;54:62-70 16874663 - Histol Histopathol. 2006 Nov;21(11):1199-207 19162514 - Urol Oncol. 2011 Jan-Feb;29(1):70-7 16399380 - Methods Enzymol. 2005;401:78-99 15822171 - Annu Rev Pharmacol Toxicol. 2005;45:51-88 22494505 - Mol Neurodegener. 2012;7:13 17267100 - Eur Urol. 2007 Aug;52(2):470-7 21094982 - Sci Total Environ. 2011 Jan 1;409(3):465-70 12072547 - J Natl Cancer Inst. 2002 Jun 19;94(12):936-42 9111645 - Urology. 1997 Apr;49(4):644-51 15024382 - Pharmacogenomics J. 2004;4(3):143-53 21897762 - Int J Med Sci. 2011;8(6):492-500 21851097 - Mol Pharm. 2011 Oct 3;8(5):1698-708 22052985 - Ann Oncol. 2012 Jul;23(7):1750-6 19424176 - Nat Rev Urol. 2009 May;6(5):281-9 20514077 - Pharmacogenomics J. 2011 Aug;11(4):292-9 15867371 - Cancer Res. 2005 May 1;65(9):3751-61 15882759 - Urology. 2005 May;65(5):1035-40 20577141 - Pharmacogenet Genomics. 2010 Aug;20(8):507-15 23034843 - Nephrol Dial Transplant. 2013 Jan;28(1):202-12 15992993 - Cancer Lett. 2006 May 18;236(2):276-81 17671894 - J Drug Target. 2007 Aug-Sep;15(7-8):475-86 12023887 - Biochem J. 2002 Jun 1;364(Pt 2):441-7 21045267 - Dis Markers. 2010;29(2):81-7 17884994 - J Nutr. 2007 Oct;137(10):2171-84
References_xml	– volume: 236(2) start-page: 276 year: 2006 ident: ref12 article-title: Polymorphism of glutathione S-transferase omega gene and risk of cancer publication-title: Cancer Lett doi: 10.1016/j.canlet.2005.05.020 – volume: 49(4) start-page: 644 year: 1997 ident: ref4 article-title: Glutathione S-transferase activity and subunit composition in transitional cell cancer and mucosa of the human bladder publication-title: Urology doi: 10.1016/S0090-4295(96)00575-4 – volume: 11(4) start-page: 292 year: 2011 ident: ref14 article-title: Copy number variation in glutathione-S-transferase T1 and M1 predicts incidence and 5-year survival from prostate and bladder cancer, and incidence of corpus uteri cancer in the general population publication-title: Pharmacogenomics J doi: 10.1038/tpj.2010.38 – volume: 29(2) start-page: 81 year: 2010 ident: ref15 article-title: GSTT1 as a prognosticator for recurrence and progression in patients with non-muscle-invasive bladder cancer publication-title: Dis Markers – volume: 94(12) start-page: 936 year: 2002 ident: ref6 article-title: Association between glutathione S-transferase P1, T1, and M1 genetic polymorphism and survival of patients with metastatic colorectal cancer publication-title: J Natl Cancer Inst doi: 10.1093/jnci/94.12.936 – volume: 4(3) start-page: 143 year: 2004 ident: ref8 article-title: Pharmacogenetics in the treatment of breast cancer publication-title: Pharmacogenomics J doi: 10.1038/sj.tpj.6500242 – volume: 28(1) start-page: 202 year: 2013 ident: ref11 article-title: Glutathione S-transferase A1, M1, P1 and T1 null or low-activity genotypes are associated with enhanced oxidative damage among haemodialysis patients publication-title: Nephrol Dial Transplant doi: 10.1093/ndt/gfs369 – volume: 52(2) start-page: 470 year: 2007 ident: ref16 article-title: Glutathione S-transferase-P1 expression correlates with increased antioxidant capacity in transitional cell carcinoma of the urinary bladder publication-title: Eur Urol doi: 10.1016/j.eururo.2007.01.046 – volume: 65(5) start-page: 1035 year: 2005 ident: ref17 article-title: Glutathione S-transferase T1-1 activity upregulated in transitional cell carcinoma of urinary bladder publication-title: Urology doi: 10.1016/j.urology.2005.01.005 – volume: 23(7) start-page: 1750 year: 2012 ident: ref21 article-title: Glutathione S-transferase P1 c.313A > G polymorphism could be useful in the prediction of doxorubicin response in breast cancer patients publication-title: Ann Oncol doi: 10.1093/annonc/mdr483 – volume: 45 start-page: 51 year: 2005 ident: ref1 article-title: Glutathione transferases publication-title: Annu Rev Pharmacol Toxicol doi: 10.1146/annurev.pharmtox.45.120403.095857 – volume: 210(1) start-page: 100 year: 2012 ident: ref13 article-title: A case-control study of polymorphisms in xenobiotic and arsenic metabolism genes and arsenic-related bladder cancer in New Hampshire publication-title: Toxicol Lett doi: 10.1016/j.toxlet.2012.01.015 – volume: 6(5) start-page: 281 year: 2009 ident: ref2 article-title: Glutathione S-transferases in kidney and urinary bladder tumors publication-title: Nat Rev Urol doi: 10.1038/nrurol.2009.49 – volume: 8(6) start-page: 492 year: 2011 ident: ref26 article-title: Translational medicine and reliability of single-nucleotide polymorphism studies: can we believe in SNP reports or not publication-title: Int J Med Sci doi: 10.7150/ijms.8.492 – volume: 21(11) start-page: 1199 year: 2006 ident: ref19 article-title: Expression of glutathione S-transferase T1 (GSTT1) in human brain tumours publication-title: Histol Histopathol – volume: 409(3) start-page: 465 year: 2011 ident: ref3 article-title: Gene polymorphisms of glutathione S-transferase omega 1 and 2, urinary arsenic methylation profile and urothelial carcinoma publication-title: Sci Total Environ doi: 10.1016/j.scitotenv.2010.10.053 – volume: 7 start-page: 13 year: 2012 ident: ref10 article-title: Glutathione S-transferase omega genes in Alzheimer and Parkinson disease risk, age-at-diagnosis and brain gene expression: an association study with mechanistic implications publication-title: Mol Neurodegener doi: 10.1186/1750-1326-7-13 – volume: 8(5) start-page: 1698 year: 2011 ident: ref5 article-title: Characterization of new potential anticancer drugs designed to overcome glutathione transferase mediated resistance publication-title: Mol Pharm doi: 10.1021/mp2000692 – volume: 65(9) start-page: 3751 year: 2005 ident: ref7 article-title: Proapoptotic activity of new glutathione S-transferase inhibitors publication-title: Cancer Res doi: 10.1158/0008-5472.CAN-04-3903 – volume: 401 start-page: 78 year: 2005 ident: ref9 article-title: Characterization of the omega class of glutathione transferases publication-title: Methods Enzymol doi: 10.1016/S0076-6879(05)01005-0 – volume: 15(7–8) start-page: 475 year: 2007 ident: ref20 article-title: Tumor-targeted induction of oxystress for cancer therapy publication-title: J Drug Target doi: 10.1080/10611860701498286 – volume: 29(1) start-page: 70 year: 2011 ident: ref22 article-title: Enhanced GSTP1 expression in transitional cell carcinoma of urinary bladder is associated with altered apoptotic pathways publication-title: Urol Oncol doi: 10.1016/j.urolonc.2008.10.019 – volume: 2) start-page: 441 year: 2002 ident: ref24 article-title: Ascorbate up-regulates MLH1 (Mut L homologue-1) and p73: implications for the cellular response to DNA damage publication-title: Biochem J 364 (Pt doi: 10.1042/bj20011713 – volume: 137(10) start-page: 2171 year: 2007 ident: ref25 article-title: New developments and novel therapeutic perspectives for vitamin C. J Nutr – volume: 54 start-page: 62 year: 2013 ident: ref23 article-title: Allelic variants of glutathione S-transferase P1-1 differentially mediate the peroxidase function of peroxiredoxin VI and alter membrane lipid peroxidation publication-title: Free Radic Biol Med doi: 10.1016/j.freeradbiomed.2012.10.556 – volume: 20(8) start-page: 507 year: 2010 ident: ref18 article-title: Glutathione S-transferase polymorphisms in osteosarcoma patients publication-title: Pharmacogenet Genomics doi: 10.1097/FPC.0b013e32833caa45 – reference: 9111645 - Urology. 1997 Apr;49(4):644-51 – reference: 15992993 - Cancer Lett. 2006 May 18;236(2):276-81 – reference: 22494505 - Mol Neurodegener. 2012;7:13 – reference: 19162514 - Urol Oncol. 2011 Jan-Feb;29(1):70-7 – reference: 21094982 - Sci Total Environ. 2011 Jan 1;409(3):465-70 – reference: 17671894 - J Drug Target. 2007 Aug-Sep;15(7-8):475-86 – reference: 21045267 - Dis Markers. 2010;29(2):81-7 – reference: 17884994 - J Nutr. 2007 Oct;137(10):2171-84 – reference: 23034843 - Nephrol Dial Transplant. 2013 Jan;28(1):202-12 – reference: 21851097 - Mol Pharm. 2011 Oct 3;8(5):1698-708 – reference: 12072547 - J Natl Cancer Inst. 2002 Jun 19;94(12):936-42 – reference: 19424176 - Nat Rev Urol. 2009 May;6(5):281-9 – reference: 15882759 - Urology. 2005 May;65(5):1035-40 – reference: 20577141 - Pharmacogenet Genomics. 2010 Aug;20(8):507-15 – reference: 15822171 - Annu Rev Pharmacol Toxicol. 2005;45:51-88 – reference: 22306368 - Toxicol Lett. 2012 Apr 5;210(1):100-6 – reference: 23142420 - Free Radic Biol Med. 2013 Jan;54:62-70 – reference: 12023887 - Biochem J. 2002 Jun 1;364(Pt 2):441-7 – reference: 16399380 - Methods Enzymol. 2005;401:78-99 – reference: 16874663 - Histol Histopathol. 2006 Nov;21(11):1199-207 – reference: 15867371 - Cancer Res. 2005 May 1;65(9):3751-61 – reference: 15024382 - Pharmacogenomics J. 2004;4(3):143-53 – reference: 21897762 - Int J Med Sci. 2011;8(6):492-500 – reference: 22052985 - Ann Oncol. 2012 Jul;23(7):1750-6 – reference: 20514077 - Pharmacogenomics J. 2011 Aug;11(4):292-9 – reference: 17267100 - Eur Urol. 2007 Aug;52(2):470-7
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Snippet	To examine the association of six glutathione transferase (GST) gene polymorphisms (GSTT1, GSTP1/rs1695, GSTO1/rs4925, GSTO2/rs156697, GSTM1, GSTA1/rs3957357)... Objective To examine the association of six glutathione transferase (GST) gene polymorphisms (GSTT1, GSTP1/rs1695, GSTO1/rs4925, GSTO2/rs156697, GSTM1,... OBJECTIVE: To examine the association of six glutathione transferase (GST) gene polymorphisms (GSTT1, GSTP1/rs1695, GSTO1/rs4925, GSTO2/rs156697, GSTM1,... Objective To examine the association of six glutathione transferase (GST) gene polymorphisms (GSTT1, GSTP1/rs1695, GSTO1/rs4925, GSTO2/rs156697, GSTM1,...
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SubjectTerms	Aged Analysis Antineoplastic Agents - therapeutic use Biochemistry Bladder Bladder cancer Brain cancer Cancer Cancer patients Cancer research Cancer therapies Care and treatment Chemotherapy Deoxyribonucleic acid DNA Enzymes Female Gene expression Gene polymorphism Genes Genetic aspects Genetic polymorphisms Genotype Genotypes Glutathione Glutathione transferase Glutathione Transferase - genetics GSTM1 protein GSTT1 protein Health risks Humans Influence Invasiveness Male Medicine Middle Aged Mortality Muscles Neoplasm Invasiveness Patient outcomes Patients Pharmacogenetics Pharmacogenomics Pharmacology Polymorphism Polymorphism, Genetic Prognosis Proportional Hazards Models Survival Survival analysis Thiols Treatment Outcome Tumors Urinary bladder Urinary Bladder Neoplasms - drug therapy Urinary Bladder Neoplasms - genetics Urinary Bladder Neoplasms - mortality Urology
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Title	Glutathione S-Transferase T1, O1 and O2 Polymorphisms Are Associated with Survival in Muscle Invasive Bladder Cancer Patients
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