Glutathione S-Transferase T1, O1 and O2 Polymorphisms Are Associated with Survival in Muscle Invasive Bladder Cancer Patients

To examine the association of six glutathione transferase (GST) gene polymorphisms (GSTT1, GSTP1/rs1695, GSTO1/rs4925, GSTO2/rs156697, GSTM1, GSTA1/rs3957357) with the survival of patients with muscle invasive bladder cancer and the genotype modifying effect on chemotherapy. A total of 105 patients...

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Vydáno v:PloS one Ročník 8; číslo 9; s. e74724
Hlavní autoři: Djukic, Tatjana I., Savic-Radojevic, Ana R., Pekmezovic, Tatjana D., Matic, Marija G., Pljesa-Ercegovac, Marija S., Coric, Vesna M., Radic, Tanja M., Suvakov, Sonja R., Krivic, Biljana N., Dragicevic, Dejan P., Simic, Tatjana P.
Médium: Journal Article
Jazyk:angličtina
Vydáno: United States Public Library of Science 11.09.2013
Public Library of Science (PLoS)
Témata:
Aged
Analysis
Antineoplastic Agents - therapeutic use
Biochemistry
Bladder
Bladder cancer
Brain cancer
Cancer
Cancer patients
Cancer research
Cancer therapies
Care and treatment
Chemotherapy
Deoxyribonucleic acid
DNA
Enzymes
Female
Gene expression
Gene polymorphism
Genes
Genetic aspects
Genetic polymorphisms
Genotype
Genotypes
Glutathione
Glutathione transferase
Glutathione Transferase - genetics
GSTM1 protein
GSTT1 protein
Health risks
Humans
Influence
Invasiveness
Male
Medicine
Middle Aged
Mortality
Muscles
Neoplasm Invasiveness
Patient outcomes
Patients
Pharmacogenetics
Pharmacogenomics
Pharmacology
Polymorphism
Polymorphism, Genetic
Prognosis
Proportional Hazards Models
Survival
Survival analysis
Thiols
Treatment Outcome
Tumors
Urinary bladder
Urinary Bladder Neoplasms - drug therapy
Urinary Bladder Neoplasms - genetics
Urinary Bladder Neoplasms - mortality
Urology
Serbia
ISSN:1932-6203, 1932-6203
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Popis
Shrnutí:To examine the association of six glutathione transferase (GST) gene polymorphisms (GSTT1, GSTP1/rs1695, GSTO1/rs4925, GSTO2/rs156697, GSTM1, GSTA1/rs3957357) with the survival of patients with muscle invasive bladder cancer and the genotype modifying effect on chemotherapy. A total of 105 patients with muscle invasive bladder cancer were included in the study. The follow-up lasted 5 years. The effect of GSTs polymorphisms on predicting mortality was analyzed by the Cox proportional hazard models, while Kaplan-Meier analysis was performed to assess differences in survival. GSTT1 active, GSTO1 Asp140Asp or GSTO2 Asp142Asp genotypes were independent predictors of a higher risk of death among bladder cancer patients (HR = 2.5, P = 0.028; HR = 2.9, P = 0.022; HR = 3.9, P = 0.001; respectively) and significantly influenced the overall survival. There was no association between GSTP1, GSTM1 and GSTA1 gene variants with overall mortality. Only GSTO2 polymorphism showed a significant effect on the survival in the subgroup of patients who received chemotherapy (P = 0.006). GSTT1 active genotype and GSTO1 Asp140Asp and GSTO2 Asp142Asp genotypes may have a prognostic/pharmacogenomic role in patients with muscle invasive bladder cancer.
Bibliografie:ObjectType-Article-1
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Conceived and designed the experiments: TS ASR TP MPE. Performed the experiments: TD VC TR SS MM. Analyzed the data: TD TP ASR. Contributed reagents/materials/analysis tools: BK DD. Wrote the paper: TD TS.
Competing Interests: The authors have declared that no competing interests exist.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0074724