LCMV Glycosylation Modulates Viral Fitness and Cell Tropism

The glycoprotein (GP) of arenaviruses is glycosylated at 11 conserved N-glycosylation sites. We constructed recombinant lymphocytic choriomeningitis virus (rLCMV) featuring either additions or deletions of these N-glycans to investigate their role in the viral life cycle. N-glycosylation at two site...

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Bibliographic Details
Published in:	PloS one Vol. 8; no. 1; p. e53273
Main Authors:	Bonhomme, Cyrille J., Knopp, Kristeene A., Bederka, Lydia H., Angelini, Megan M., Buchmeier, Michael J.
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 07.01.2013 Public Library of Science (PLoS)
Subjects:	Animals Biochemistry Biology Bone (cortical) Bone marrow Cell Line Cells, Cultured Clonal deletion Construction sites Cortical bone Cytotoxicity Deletion mutant Disease Fibroblasts Fitness Glycan Glycoproteins Glycoproteins - genetics Glycoproteins - metabolism Glycosylation Health aspects HIV Human immunodeficiency virus Humans Infections Life cycle engineering Life cycles Lymphocytic Choriomeningitis - veterinary Lymphocytic Choriomeningitis - virology Lymphocytic choriomeningitis virus - genetics Lymphocytic choriomeningitis virus - growth & development Lymphocytic choriomeningitis virus - metabolism Macrophages Macrophages - virology Medicine Mice Mice, Inbred C57BL Models, Molecular Molecular biology Mutants Mutation N-glycans Neurons Neurons - virology Polysaccharides Polysaccharides - genetics Polysaccharides - metabolism Protection and preservation Proteins Tropism Viral Proteins - genetics Viral Proteins - metabolism Virology Viruses United States > US California
ISSN:	1932-6203, 1932-6203
Online Access:	Get full text
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