LCMV Glycosylation Modulates Viral Fitness and Cell Tropism

The glycoprotein (GP) of arenaviruses is glycosylated at 11 conserved N-glycosylation sites. We constructed recombinant lymphocytic choriomeningitis virus (rLCMV) featuring either additions or deletions of these N-glycans to investigate their role in the viral life cycle. N-glycosylation at two site...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	PloS one Jg. 8; H. 1; S. e53273
Hauptverfasser:	Bonhomme, Cyrille J., Knopp, Kristeene A., Bederka, Lydia H., Angelini, Megan M., Buchmeier, Michael J.
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States Public Library of Science 07.01.2013 Public Library of Science (PLoS)
Schlagworte:	Animals Biochemistry Biology Bone (cortical) Bone marrow Cell Line Cells, Cultured Clonal deletion Construction sites Cortical bone Cytotoxicity Deletion mutant Disease Fibroblasts Fitness Glycan Glycoproteins Glycoproteins - genetics Glycoproteins - metabolism Glycosylation Health aspects HIV Human immunodeficiency virus Humans Infections Life cycle engineering Life cycles Lymphocytic Choriomeningitis - veterinary Lymphocytic Choriomeningitis - virology Lymphocytic choriomeningitis virus - genetics Lymphocytic choriomeningitis virus - growth & development Lymphocytic choriomeningitis virus - metabolism Macrophages Macrophages - virology Medicine Mice Mice, Inbred C57BL Models, Molecular Molecular biology Mutants Mutation N-glycans Neurons Neurons - virology Polysaccharides Polysaccharides - genetics Polysaccharides - metabolism Protection and preservation Proteins Tropism Viral Proteins - genetics Viral Proteins - metabolism Virology Viruses United States > US California
ISSN:	1932-6203, 1932-6203
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!