Association of serum 25-hydroxyvitamin D concentrations with sleep phenotypes in a German community sample

Sleep disorders and vitamin D deficiency are among the most common health problems. Few studies investigated the effect of vitamin D on objectively recorded sleep with sound methodological quality and reasonable temporal proximity. To investigate the relationship between serum 25-hydroxyvitamin D (2...

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Vydáno v:PloS one Ročník 14; číslo 7; s. e0219318
Hlavní autoři: Dogan-Sander, Ezgi, Willenberg, Anja, Batmaz, İnci, Enzenbach, Cornelia, Wirkner, Kerstin, Kohls, Elisabeth, Mergl, Roland, Thiery, Joachim, Kratzsch, Jürgen, Hegerl, Ulrich, Sander, Christian
Médium: Journal Article
Jazyk:angličtina
Vydáno: United States Public Library of Science 05.07.2019
Public Library of Science (PLoS)
Témata:
25-Hydroxyvitamin D
Adolescent
Adult
Aged
Aged, 80 and over
Alcohol use
Analysis
Biology and Life Sciences
Biomarkers
Calciferol
Civilization
Daytime
Diabetes
Electrochemiluminescence
Female
Females
Health
Health aspects
Health problems
Health Surveys
Humans
Immunoassay
Laboratories
Male
Males
Medicine and Health Sciences
Middle Aged
Night
Pain
Parameters
Phenotype
Phenotypes
Physical sciences
Physiological aspects
Psychiatry
Psychotherapy
Quality
Regression analysis
Regression models
Sleep
Sleep and wakefulness
Sleep apnea
Sleep disorders
Sleep Wake Disorders - blood
Sleep Wake Disorders - epidemiology
Sleepiness
Socioeconomic factors
Studies
Surveys and Questionnaires
Vitamin D
Vitamin D - analogs & derivatives
Vitamin D - blood
Vitamin D deficiency
Vitamin deficiency
Vitamins
Young Adult
Germany
ISSN:1932-6203, 1932-6203
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Shrnutí:Sleep disorders and vitamin D deficiency are among the most common health problems. Few studies investigated the effect of vitamin D on objectively recorded sleep with sound methodological quality and reasonable temporal proximity. To investigate the relationship between serum 25-hydroxyvitamin D (25(OH)D) concentrations and objective sleep parameters assessed within close temporal proximity in a population-based sample. It is expected that higher serum 25(OH)D concentrations are associated with 1) better objective sleep outcomes (longer sleep duration, higher sleep efficiency, earlier mid-sleep time) and 2) more positive subjective sleep evaluations. A subset of participants (n = 1045) from the LIFE-Adult-Study was analysed. Measurement of serum 25(OH)D vitamin was performed using an electrochemiluminescence immunoassay. Actigraphic assessments were performed using SenseWear Pro 3 devices. The following objective sleep parameters were calculated: total sleep duration, night sleep duration, night sleep efficiency, midsleep time and wake after sleep onset (WASO). Subjective sleep evaluations were assessed via questionnaire (sleep quality (PSQI), daytime sleepiness (ESS)). Data were analysed applying a multiple linear regression model with a stepwise approach. The regression models revealed significant associations of serum 25(OH)D concentration with night sleep duration and midsleep time. No association was found for total sleep duration and night sleep efficiency. Higher serum 25(OH)D concentration was further associated with shorter WASO in males but longer WASO in females. Moreover, serum 25(OH)D concentration did not show any significant association with subjective sleep quality and daytime sleepiness. The results indicate that a higher concentration of serum 25(OH)D is associated with longer and earlier night sleep. Although the present study was able to demonstrate an association between serum 25(OH)D concentration and objective sleep parameters, no conclusion about underlying mechanisms or causal inferences can be drawn.
Bibliografie:ObjectType-Article-1
SourceType-Scholarly Journals-1
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Competing Interests: The authors have declared that no competing interests exist.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0219318