Accelerated Aging in HIV/AIDS: Novel Biomarkers of Senescent Human CD8+ T Cells
Clinical evaluation of immune reconstitution and health status during HIV-1 infection and anti-retroviral therapy (ART) is largely based on CD4+ T cell counts and viral load, measures that fail to take into account the CD8+ T cell subset, known to show features of accelerated aging in HIV disease. H...
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| Published in: | PloS one Vol. 8; no. 5; p. e64702 |
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| Main Authors: | , , , |
| Format: | Journal Article |
| Language: | English |
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Public Library of Science
22.05.2013
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| ISSN: | 1932-6203, 1932-6203 |
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| Abstract | Clinical evaluation of immune reconstitution and health status during HIV-1 infection and anti-retroviral therapy (ART) is largely based on CD4+ T cell counts and viral load, measures that fail to take into account the CD8+ T cell subset, known to show features of accelerated aging in HIV disease. Here, we compare adenosine deaminase (ADA), glucose uptake receptor 1 (GLUT1), and leucine-rich repeat neuronal 3 (LRRN3) to CD38 expression and telomerase activity, two strong predictors of HIV disease progression. Our analysis revealed that reduced ADA, telomerase activity and LRRN3 gene expression were significantly associated with high CD38 and HLA-DR in CD8+ T cells, with % ADA+ cells being the most robust predictor of CD8+ T cell activation. Our results suggest that ADA, LRRN3 and telomerase activity in CD8+ T cells may serve as novel, clinically relevant biomarkers of immune status in HIV-1 infection, specifically by demonstrating the degree to which CD8+ T cells have progressed to the end stage of replicative senescence. Since chronological aging itself leads to the accumulation of senescent CD8+ T cells, the prolonged survival and resultant increased age of the HIV+ population may synergize with the chronic immune activation to exacerbate both immune decline and age-associated pathologies. The identification and future validation of these new biomarkers may lead to fresh immune-based HIV treatments. |
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| AbstractList | Clinical evaluation of immune reconstitution and health status during HIV-1 infection and anti-retroviral therapy (ART) is largely based on CD4+ T cell counts and viral load, measures that fail to take into account the CD8+ T cell subset, known to show features of accelerated aging in HIV disease. Here, we compare adenosine deaminase (ADA), glucose uptake receptor 1 (GLUT1), and leucine-rich repeat neuronal 3 (LRRN3) to CD38 expression and telomerase activity, two strong predictors of HIV disease progression. Our analysis revealed that reduced ADA, telomerase activity and LRRN3 gene expression were significantly associated with high CD38 and HLA-DR in CD8+ T cells, with % ADA+ cells being the most robust predictor of CD8+ T cell activation. Our results suggest that ADA, LRRN3 and telomerase activity in CD8+ T cells may serve as novel, clinically relevant biomarkers of immune status in HIV-1 infection, specifically by demonstrating the degree to which CD8+ T cells have progressed to the end stage of replicative senescence. Since chronological aging itself leads to the accumulation of senescent CD8+ T cells, the prolonged survival and resultant increased age of the HIV+ population may synergize with the chronic immune activation to exacerbate both immune decline and age-associated pathologies. The identification and future validation of these new biomarkers may lead to fresh immune-based HIV treatments. Clinical evaluation of immune reconstitution and health status during HIV-1 infection and anti-retroviral therapy (ART) is largely based on CD4+ T cell counts and viral load, measures that fail to take into account the CD8+ T cell subset, known to show features of accelerated aging in HIV disease. Here, we compare adenosine deaminase (ADA), glucose uptake receptor 1 (GLUT1), and leucine-rich repeat neuronal 3 (LRRN3) to CD38 expression and telomerase activity, two strong predictors of HIV disease progression. Our analysis revealed that reduced ADA, telomerase activity and LRRN3 gene expression were significantly associated with high CD38 and HLA-DR in CD8+ T cells, with % ADA+ cells being the most robust predictor of CD8+ T cell activation. Our results suggest that ADA, LRRN3 and telomerase activity in CD8+ T cells may serve as novel, clinically relevant biomarkers of immune status in HIV-1 infection, specifically by demonstrating the degree to which CD8+ T cells have progressed to the end stage of replicative senescence. Since chronological aging itself leads to the accumulation of senescent CD8+ T cells, the prolonged survival and resultant increased age of the HIV+ population may synergize with the chronic immune activation to exacerbate both immune decline and age-associated pathologies. The identification and future validation of these new biomarkers may lead to fresh immune-based HIV treatments.Clinical evaluation of immune reconstitution and health status during HIV-1 infection and anti-retroviral therapy (ART) is largely based on CD4+ T cell counts and viral load, measures that fail to take into account the CD8+ T cell subset, known to show features of accelerated aging in HIV disease. Here, we compare adenosine deaminase (ADA), glucose uptake receptor 1 (GLUT1), and leucine-rich repeat neuronal 3 (LRRN3) to CD38 expression and telomerase activity, two strong predictors of HIV disease progression. Our analysis revealed that reduced ADA, telomerase activity and LRRN3 gene expression were significantly associated with high CD38 and HLA-DR in CD8+ T cells, with % ADA+ cells being the most robust predictor of CD8+ T cell activation. Our results suggest that ADA, LRRN3 and telomerase activity in CD8+ T cells may serve as novel, clinically relevant biomarkers of immune status in HIV-1 infection, specifically by demonstrating the degree to which CD8+ T cells have progressed to the end stage of replicative senescence. Since chronological aging itself leads to the accumulation of senescent CD8+ T cells, the prolonged survival and resultant increased age of the HIV+ population may synergize with the chronic immune activation to exacerbate both immune decline and age-associated pathologies. The identification and future validation of these new biomarkers may lead to fresh immune-based HIV treatments. |
| Audience | Academic |
| Author | Ramirez, Christina M. Wu, Jennifer E. Chou, Jennifer P. Effros, Rita B. |
| AuthorAffiliation | 3 Department of Pathology and Laboratory Medicine, UCLA AIDS Institute, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, United States of America University of Modena & Reggio Emilia, Italy 2 Department of Biostatistics, Fielding School of Public Health, University of California Los Angeles, Los Angeles, California, United States of America 1 Department of Pathology and Laboratory Medicine, University of California Los Angeles, Los Angeles, California, United States of America |
| AuthorAffiliation_xml | – name: University of Modena & Reggio Emilia, Italy – name: 1 Department of Pathology and Laboratory Medicine, University of California Los Angeles, Los Angeles, California, United States of America – name: 3 Department of Pathology and Laboratory Medicine, UCLA AIDS Institute, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, United States of America – name: 2 Department of Biostatistics, Fielding School of Public Health, University of California Los Angeles, Los Angeles, California, United States of America |
| Author_xml | – sequence: 1 givenname: Jennifer P. surname: Chou fullname: Chou, Jennifer P. – sequence: 2 givenname: Christina M. surname: Ramirez fullname: Ramirez, Christina M. – sequence: 3 givenname: Jennifer E. surname: Wu fullname: Wu, Jennifer E. – sequence: 4 givenname: Rita B. surname: Effros fullname: Effros, Rita B. |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/23717651$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1046/j.1365-3083.1999.00505.x 10.1016/S1471-4906(02)02338-4 10.4161/onci.20387 10.1097/00042560-199710010-00003 10.1007/s10875-010-9449-7 10.1016/S0065-2776(08)60600-8 10.1002/jcb.10562 10.1016/0008-8749(86)90199-1 10.1016/S0003-2697(02)00663-2 10.1146/annurev.immunol.14.1.233 10.4049/jimmunol.0901247 10.4049/jimmunol.150.4.1147 10.4049/jimmunol.158.8.3721 10.4049/jimmunol.180.7.4476 10.1182/blood-2008-01-135442 10.1093/infdis/jit006 10.1097/QAI.0b013e3181926c28 10.1186/gb-2012-13-10-r97 10.1016/S1074-7613(02)00323-0 10.1007/978-1-4757-9613-1_24 10.1093/infdis/jiq071 10.4049/jimmunol.0903647 10.2337/diabetes.48.12.2309 10.1016/0531-5565(89)90009-0 10.4049/jimmunol.162.12.7534 10.1086/590150 10.4049/jimmunol.173.10.6303 |
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| Copyright | COPYRIGHT 2013 Public Library of Science 2013 Chou et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: https://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. 2013 Chou et al 2013 Chou et al |
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| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 ObjectType-Undefined-3 Competing Interests: The authors have declared that no competing interests exist. Conceived and designed the experiments: JPC RBE. Performed the experiments: JPC JEW. Analyzed the data: JPC CMR. Contributed reagents/materials/analysis tools: JPC CMR RBE. Wrote the paper: JPC RBE. |
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| References | W Cao (ref5) 2009; 50 SR Jacobs (ref15) 2008; 180 M Azuma (ref19) 1993; 150 NL Perillo (ref17) 1989; 24 A Ohta (ref9) 2009; 183 ST Parish (ref11) 2010; 184 RB Effros (ref4) 2008; 47 C Pupilli (ref7) 1999; 48 ST Parish (ref21) 2010; 30 JJ Butler (ref10) 2003; 89 M Dagarag (ref22) 2004; 173 GA DosReis (ref8) 1986; 101 S Horvath (ref16) 2012; 13 KA Frauwirth (ref14) 2002; 16 RC Kaplan (ref27) 2011; 203 A Valenzuela (ref12) 1997; 158 SN Saldanha (ref18) 2003; 315 ref24 Z Liu (ref6) 1997; 16 RT Bailer (ref2) 1999; 162 M Mandapathil (ref26) 2012; 1 OO Yang (ref1) 1997; 66 A Valenzuela (ref13) 1997; 421 M Lichterfeld (ref23) 2008; 112 V Appay (ref3) 2002; 23 WS Nichols (ref25) 1999; 49 DJ Lenschow (ref20) 1996; 14 |
| References_xml | – volume: 49 start-page: 302 year: 1999 ident: ref25 article-title: Increased CD4+ T-lymphocyte senescence fraction in advanced human immunodeficiency virus type 1 infection publication-title: Scand J Immunol doi: 10.1046/j.1365-3083.1999.00505.x – volume: 23 start-page: 580 year: 2002 ident: ref3 article-title: Premature ageing of the immune system: the cause of AIDS? publication-title: Trends Immunol doi: 10.1016/S1471-4906(02)02338-4 – volume: 1 start-page: 659 year: 2012 ident: ref26 article-title: CD26 expression and adenosine deaminase activity in regulatory T cells (Treg) and CD4(+) T effector cells in patients with head and neck squamous cell carcinoma publication-title: Oncoimmunology doi: 10.4161/onci.20387 – volume: 16 start-page: 83 year: 1997 ident: ref6 article-title: Elevated CD38 antigen expression on CD8+ T cells is a stronger marker for the risk of chronic HIV disease progression to AIDS and death in the Multicenter AIDS Cohort Study than CD4+ cell count, soluble immune activation markers, or combinations of HLA-DR and CD38 expression publication-title: J Acquir Immune Defic Syndr Hum Retrovirol doi: 10.1097/00042560-199710010-00003 – volume: 30 start-page: 798 year: 2010 ident: ref21 article-title: Sustained CD28 expression delays multiple features of replicative senescence in human CD8 T lymphocytes publication-title: J Clin Immunol doi: 10.1007/s10875-010-9449-7 – volume: 66 start-page: 273 year: 1997 ident: ref1 article-title: CD8+ cells in human immunodeficiency virus type I pathogenesis: cytolytic and noncytolytic inhibition of viral replication publication-title: Adv Immunol doi: 10.1016/S0065-2776(08)60600-8 – volume: 89 start-page: 975 year: 2003 ident: ref10 article-title: Adenosine inhibits activation-induced T cell expression of CD2 and CD28 co-stimulatory molecules: role of interleukin-2 and cyclic AMP signaling pathways publication-title: J Cell Biochem doi: 10.1002/jcb.10562 – volume: 101 start-page: 213 year: 1986 ident: ref8 article-title: Purinergic modulation of T-lymphocyte activation: differential susceptibility of distinct activation steps and correlation with intracellular 3′,5′-cyclic adenosine monophosphate accumulation publication-title: Cell Immunol doi: 10.1016/0008-8749(86)90199-1 – volume: 315 start-page: 1 year: 2003 ident: ref18 article-title: Analysis of telomerase activity and detection of its catalytic subunit, hTERT publication-title: Anal Biochem doi: 10.1016/S0003-2697(02)00663-2 – volume: 14 start-page: 233 year: 1996 ident: ref20 article-title: CD28/B7 system of T cell costimulation publication-title: Annu Rev Immunol doi: 10.1146/annurev.immunol.14.1.233 – volume: 183 start-page: 5487 year: 2009 ident: ref9 article-title: A2A adenosine receptor may allow expansion of T cells lacking effector functions in extracellular adenosine-rich microenvironments publication-title: J Immunol doi: 10.4049/jimmunol.0901247 – volume: 150 start-page: 1147 year: 1993 ident: ref19 article-title: CD28– T lymphocytes. Antigenic and functional properties publication-title: J Immunol doi: 10.4049/jimmunol.150.4.1147 – volume: 158 start-page: 3721 year: 1997 ident: ref12 article-title: Adenosine deaminase binding to human CD26 is inhibited by HIV-1 envelope glycoprotein gp120 and viral particles publication-title: J Immunol doi: 10.4049/jimmunol.158.8.3721 – volume: 180 start-page: 4476 year: 2008 ident: ref15 article-title: Glucose uptake is limiting in T cell activation and requires CD28-mediated Akt-dependent and independent pathways publication-title: J Immunol doi: 10.4049/jimmunol.180.7.4476 – volume: 112 start-page: 3679 year: 2008 ident: ref23 article-title: Telomerase activity of HIV–1-specific CD8+ T cells: constitutive up-regulation in controllers and selective increase by blockade of PD ligand 1 in progressors publication-title: Blood doi: 10.1182/blood-2008-01-135442 – ident: ref24 doi: 10.1093/infdis/jit006 – volume: 50 start-page: 137 year: 2009 ident: ref5 article-title: Premature aging of T cells is associated with faster HIV-1 disease progression publication-title: J Acquir Immune Defic Syndr doi: 10.1097/QAI.0b013e3181926c28 – volume: 13 start-page: R97 year: 2012 ident: ref16 article-title: Aging effects on DNA methylation modules in human brain and blood tissue publication-title: Genome Biol doi: 10.1186/gb-2012-13-10-r97 – volume: 16 start-page: 769 year: 2002 ident: ref14 article-title: The CD28 signaling pathway regulates glucose metabolism publication-title: Immunity doi: 10.1016/S1074-7613(02)00323-0 – volume: 421 start-page: 185 year: 1997 ident: ref13 article-title: HIV-1 envelope gp120 and viral particles block adenosine deaminase binding to human CD26 publication-title: Adv Exp Med Biol doi: 10.1007/978-1-4757-9613-1_24 – volume: 203 start-page: 452 year: 2011 ident: ref27 article-title: T cell activation and senescence predict subclinical carotid artery disease in HIV-infected women publication-title: J Infect Dis doi: 10.1093/infdis/jiq071 – volume: 184 start-page: 2847 year: 2010 ident: ref11 article-title: Adenosine deaminase modulation of telomerase activity and replicative senescence in human CD8 T lymphocytes publication-title: J Immunol doi: 10.4049/jimmunol.0903647 – volume: 48 start-page: 2309 year: 1999 ident: ref7 article-title: Autoantibodies to CD38 (ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase) in Caucasian patients with diabetes: effects on insulin release from human islets publication-title: Diabetes doi: 10.2337/diabetes.48.12.2309 – volume: 24 start-page: 177 year: 1989 ident: ref17 article-title: Human T lymphocytes possess a limited in vitro life span publication-title: Exp Gerontol doi: 10.1016/0531-5565(89)90009-0 – volume: 162 start-page: 7534 year: 1999 ident: ref2 article-title: IL-13 and IFN-gamma secretion by activated T cells in HIV-1 infection associated with viral suppression and a lack of disease progression publication-title: J Immunol doi: 10.4049/jimmunol.162.12.7534 – volume: 47 start-page: 542 year: 2008 ident: ref4 article-title: Aging and infectious diseases: workshop on HIV infection and aging: what is known and future research directions publication-title: Clin Infect Dis doi: 10.1086/590150 – volume: 173 start-page: 6303 year: 2004 ident: ref22 article-title: Genetic manipulation of telomerase in HIV-specific CD8+ T cells: enhanced antiviral functions accompany the increased proliferative potential and telomere length stabilization publication-title: J Immunol doi: 10.4049/jimmunol.173.10.6303 |
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| Title | Accelerated Aging in HIV/AIDS: Novel Biomarkers of Senescent Human CD8+ T Cells |
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