N-Cadherin Expression Is Associated with Acquisition of EMT Phenotype and with Enhanced Invasion in Erlotinib-Resistant Lung Cancer Cell Lines

The epidermal growth-factor receptor tyrosine kinase inhibitors have been effective in non-small cell lung cancer patients. However, acquired resistance eventually develops in most patients despite an initial positive response. Emerging evidence suggests that there is a molecular connection between...

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Bibliographic Details
Published in:	PloS one Vol. 8; no. 3; p. e57692
Main Authors:	Zhang, Xiaoju, Liu, Guangzhi, Kang, Yi, Dong, Zhaogang, Qian, Qiyu, Ma, Xitao
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 08.03.2013 Public Library of Science (PLoS)
Subjects:	Adenocarcinoma Adenocarcinoma - drug therapy Adenocarcinoma - metabolism Adenocarcinoma - pathology Adult Aged Analysis Antigens, CD - biosynthesis Biology Biotechnology Cadherins - biosynthesis Cancer Cancer metastasis Cancer therapies Cell adhesion & migration Cell growth Cell Line, Tumor Cell proliferation Cell Proliferation - drug effects Chemotherapy Drug Resistance, Neoplasm - drug effects E-cadherin Epidermal growth factor Epidermal growth factor receptors Epithelial-Mesenchymal Transition - drug effects Erlotinib Hydrochloride Female Flow cytometry Gene Expression Regulation, Neoplastic - drug effects Genetic aspects Genotype & phenotype Humans Inhibitor drugs Kinases Laboratories Lung cancer Lung diseases Lung Neoplasms - drug therapy Lung Neoplasms - metabolism Lung Neoplasms - pathology Male Medical prognosis Medicine Mesenchyme Metastases Metastasis Middle Aged N-Cadherin Neoplasm Invasiveness Neoplasm Proteins - biosynthesis Non-small cell lung cancer Non-small cell lung carcinoma Patients Prostate cancer Protein Kinase Inhibitors - administration & dosage Protein-tyrosine kinase receptors Quinazolines - administration & dosage Signal transduction siRNA Targeted cancer therapy Tissues Tumor cell lines Tyrosine Up-Regulation - drug effects Vimentin Western blotting China
ISSN:	1932-6203, 1932-6203
Online Access:	Get full text
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