Associations of androgens with depressive symptoms and cognitive status in the general population

Associations between androgens and depressive symptoms were mostly reported from cross-sectional and patient-based studies. Longitudinal data from 4,110 participants of the Study of Health in Pomerania were used to assess sex-specific associations of baseline total and free testosterone, androstened...

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Vydané v:PloS one Ročník 12; číslo 5; s. e0177272
Hlavní autori: Kische, Hanna, Gross, Stefan, Wallaschofski, Henri, Grabe, Hans Jörgen, Völzke, Henry, Nauck, Matthias, Haring, Robin
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: United States Public Library of Science 12.05.2017
Public Library of Science (PLoS)
Predmet:
Adult
Age
Aged
Aged, 80 and over
Androgens
Androgens - blood
Androstenedione
Androstenedione - blood
Binding
Biology and Life Sciences
Body mass
Body mass index
Cognition
Cognition - physiology
Cognitive ability
Confidence intervals
Correlation analysis
Cross-Sectional Studies
Depression (Mood disorder)
Depression - blood
Depression - physiopathology
Female
Globulins
Hormones
Humans
Longitudinal Studies
Male
Medicine and Health Sciences
Men
Mental depression
Middle Aged
Physical activity
Physical Sciences
Population (statistical)
Population studies
Prevalence
Risk Factors
Sex
Sex Hormone-Binding Globulin - metabolism
Sex hormones
Smoking
Statistical analysis
Studies
Testosterone
Testosterone - blood
Young Adult
ISSN:1932-6203, 1932-6203
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Shrnutí:Associations between androgens and depressive symptoms were mostly reported from cross-sectional and patient-based studies. Longitudinal data from 4,110 participants of the Study of Health in Pomerania were used to assess sex-specific associations of baseline total and free testosterone, androstenedione and sex hormone-binding globulin with incident depressive symptoms and cognitive status at 5- and 10-year follow-up. Despite sex-specific differences in depressive symptoms prevalence at baseline (women: 17.4%, men: 8.1%), cross-sectional analyses showed no associations between sex hormones and depressive symptoms. In age-adjusted longitudinal analyses, total testosterone was associated with incident depressive symptoms (relative risk at 5-year follow-up: 0.73, 95% confidence interval: 0.58-0.92). Similarly, age-adjusted analyses showed a positive association between sex hormone-binding globulin and cognitive status in men (β-coefficient per standard deviation: 0.44, 95% confidence interval: 0.13-0.74). In women, age-adjusted associations of androstenedione with baseline depressive symptoms (relative risk: 0.88, 95% confidence interval: 0.77-0.99) were found. None of the observed associations remained after multivariable adjustment. The present population-based, longitudinal study revealed inverse associations between sex hormones and depressive symptoms. However, the null finding after multivariable adjustment suggests, that the observed associations were not independent of relevant confounders including body mass index, smoking and physical inactivity. Furthermore, the low number of incident endpoints in our non-clinical population-based sample limited the statistical power and reduced the chance to detect a statistically significant effect.
Bibliografia:ObjectType-Article-1
SourceType-Scholarly Journals-1
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Competing Interests: The authors have declared that no competing interests exist.
Conceptualization: HV RH HW HJG.Data curation: SG.Formal analysis: HK.Supervision: MN RH.Visualization: HK.Writing – original draft: HK RH.Writing – review & editing: HJG.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0177272