Decreased surfactant lipids correlate with lung function in chronic obstructive pulmonary disease (COPD)

Smoke exposure is known to decrease total pulmonary surfactant and alter its composition, but the role of surfactant in chronic obstructive pulmonary disease (COPD) remains unknown. We aimed to analyze the compositional changes in the surfactant lipidome in COPD and identify specific lipids associat...

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Bibliographic Details
Published in:	PloS one Vol. 15; no. 2; p. e0228279
Main Authors:	Agudelo, Christina W., Kumley, Britta K., Area-Gomez, Estela, Xu, Yimeng, Dabo, Abdoulaye J., Geraghty, Patrick, Campos, Michael, Foronjy, Robert, Garcia-Arcos, Itsaso
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 06.02.2020 Public Library of Science (PLoS)
Subjects:	Adults Aged Alveoli Analysis Animals Asthma Biology Biology and Life Sciences Blood lipids Bronchoalveolar Lavage Fluid - chemistry Bronchus Case-Control Studies Cholesterol Chromatography Chromatography, High Pressure Liquid Chronic obstructive lung disease Chronic obstructive pulmonary disease Correlation Cytokines Demographics Disease Models, Animal Diseases Exposure House mouse Humans Lecithin Lipids Lipids - analysis Liquid chromatography Lung - metabolism Lung diseases Lungs Mass Spectrometry Mass spectroscopy Medicine Medicine and Health Sciences Membrane lipids Mice Mice, Inbred C57BL Middle Aged Obstructive lung disease Passive smoking Patients Phosphatidylcholine Phosphatidylcholines - chemistry Phosphatidylcholines - metabolism Phosphatidylglycerol Phospholipids Phospholipids - chemistry Phospholipids - metabolism Physical Sciences Plant lipids Pulmonary Disease, Chronic Obstructive - physiopathology Pulmonary functions Pulmonary Surfactants - metabolism Research and Analysis Methods Respiratory distress syndrome Respiratory function Scientific imaging Smoke Smokers Smoking Smoking cessation Species Spectroscopy Sphingomyelin Spirometry Surface active agents Surface tension Surfactants Therapeutic applications Tobacco Smoke Pollution New York United States > US California
ISSN:	1932-6203, 1932-6203
Online Access:	Get full text
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