Prognostic Relevance of Pretherapeutic Gamma-Glutamyltransferase in Patients with Primary Metastatic Breast Cancer

Gamma-glutamyltransferase (GGT) is a known marker for apoptotic balance and cell detoxification. Recently, an association of baseline GGT levels and breast cancer incidence, tumor progression and chemotherapy resistance was shown. The purpose of this study was to evaluate the association of pre-ther...

Celý popis

Uloženo v:

Podrobná bibliografie
Vydáno v:	PloS one Ročník 10; číslo 4; s. e0125317
Hlavní autoři:	Staudigl, Christine, Concin, Nicole, Grimm, Christoph, Pfeiler, Georg, Nehoda, Regina, Singer, Christian F., Polterauer, Stephan
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States Public Library of Science 27.04.2015 Public Library of Science (PLoS)
Témata:	Aged Analysis Apoptosis Biomarkers - blood Breast cancer Breast Neoplasms - pathology Cancer Cancer metastasis Cancer patients Care and treatment Chemoresistance Chemotherapy Detoxification Development and progression Drug Resistance, Neoplasm ErbB-2 protein Female gamma-Glutamyltransferase - blood Health aspects Histology Humans Medical diagnosis Medical prognosis Metastases Middle Aged Patients Prognosis Retrospective Studies Risk Survival Survival Analysis Tumors γ-Glutamyltransferase
ISSN:	1932-6203, 1932-6203
On-line přístup:	Získat plný text
Tagy:	Přidat tag Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!

Abstract	Gamma-glutamyltransferase (GGT) is a known marker for apoptotic balance and cell detoxification. Recently, an association of baseline GGT levels and breast cancer incidence, tumor progression and chemotherapy resistance was shown. The purpose of this study was to evaluate the association of pre-therapeutic GGT levels, clinical-pathological parameters and survival in patients with primary metastatic breast cancer (PMBC). In this multicenter analysis, pre-therapeutic GGT levels and clinical-pathological parameters of 114 patients diagnosed with PMBC between 1996 and 2012 were evaluated. The association between GGT levels and clinical-pathological parameters were analysed. Patients were stratified into four GGT risk-groups (GGT < 18.00 U/L: normal low, 18.00 to 35.99 U/L: normal high, 36.00 to 71.99 U/L: elevated and ≥ 72.00 U/L: highly elevated) and survival analyses were performed. Patients in the high risk GGT group had a poorer overall survival, when compared to the low risk group with five-year overall survival rates of 39.5% and 53.7% (p = 0.04), respectively. Patients with larger breast tumors had a trend towards higher GGT levels (p = 0.053). Pre-therapeutic GGT levels were not associated with indicators of aggressive tumor biology such as HER2-status, triple negative histology, or poorly differentiated cancers. Pre-therapeutic GGT serum level might serve as a novel prognostic factor for overall-survival in patients with PMBC.
AbstractList	Background Gamma-glutamyltransferase (GGT) is a known marker for apoptotic balance and cell detoxification. Recently, an association of baseline GGT levels and breast cancer incidence, tumor progression and chemotherapy resistance was shown. The purpose of this study was to evaluate the association of pre-therapeutic GGT levels, clinical-pathological parameters and survival in patients with primary metastatic breast cancer (PMBC). Methods In this multicenter analysis, pre-therapeutic GGT levels and clinical-pathological parameters of 114 patients diagnosed with PMBC between 1996 and 2012 were evaluated. The association between GGT levels and clinical-pathological parameters were analysed. Patients were stratified into four GGT risk-groups (GGT < 18.00 U/L: normal low, 18.00 to 35.99 U/L: normal high, 36.00 to 71.99 U/L: elevated and [greater than or equal to] 72.00 U/L: highly elevated) and survival analyses were performed. Findings Patients in the high risk GGT group had a poorer overall survival, when compared to the low risk group with five-year overall survival rates of 39.5% and 53.7% (p = 0.04), respectively. Patients with larger breast tumors had a trend towards higher GGT levels (p = 0.053). Pre-therapeutic GGT levels were not associated with indicators of aggressive tumor biology such as HER2-status, triple negative histology, or poorly differentiated cancers. Conclusion Pre-therapeutic GGT serum level might serve as a novel prognostic factor for overall-survival in patients with PMBC. Background Gamma-glutamyltransferase (GGT) is a known marker for apoptotic balance and cell detoxification. Recently, an association of baseline GGT levels and breast cancer incidence, tumor progression and chemotherapy resistance was shown. The purpose of this study was to evaluate the association of pre-therapeutic GGT levels, clinical-pathological parameters and survival in patients with primary metastatic breast cancer (PMBC). Methods In this multicenter analysis, pre-therapeutic GGT levels and clinical-pathological parameters of 114 patients diagnosed with PMBC between 1996 and 2012 were evaluated. The association between GGT levels and clinical-pathological parameters were analysed. Patients were stratified into four GGT risk-groups (GGT < 18.00 U/L: normal low, 18.00 to 35.99 U/L: normal high, 36.00 to 71.99 U/L: elevated and ≥ 72.00 U/L: highly elevated) and survival analyses were performed. Findings Patients in the high risk GGT group had a poorer overall survival, when compared to the low risk group with five-year overall survival rates of 39.5% and 53.7% (p = 0.04), respectively. Patients with larger breast tumors had a trend towards higher GGT levels (p = 0.053). Pre-therapeutic GGT levels were not associated with indicators of aggressive tumor biology such as HER2-status, triple negative histology, or poorly differentiated cancers. Conclusion Pre-therapeutic GGT serum level might serve as a novel prognostic factor for overall-survival in patients with PMBC. Gamma-glutamyltransferase (GGT) is a known marker for apoptotic balance and cell detoxification. Recently, an association of baseline GGT levels and breast cancer incidence, tumor progression and chemotherapy resistance was shown. The purpose of this study was to evaluate the association of pre-therapeutic GGT levels, clinical-pathological parameters and survival in patients with primary metastatic breast cancer (PMBC). In this multicenter analysis, pre-therapeutic GGT levels and clinical-pathological parameters of 114 patients diagnosed with PMBC between 1996 and 2012 were evaluated. The association between GGT levels and clinical-pathological parameters were analysed. Patients were stratified into four GGT risk-groups (GGT < 18.00 U/L: normal low, 18.00 to 35.99 U/L: normal high, 36.00 to 71.99 U/L: elevated and [greater than or equal to] 72.00 U/L: highly elevated) and survival analyses were performed. Pre-therapeutic GGT serum level might serve as a novel prognostic factor for overall-survival in patients with PMBC. Gamma-glutamyltransferase (GGT) is a known marker for apoptotic balance and cell detoxification. Recently, an association of baseline GGT levels and breast cancer incidence, tumor progression and chemotherapy resistance was shown. The purpose of this study was to evaluate the association of pre-therapeutic GGT levels, clinical-pathological parameters and survival in patients with primary metastatic breast cancer (PMBC).BACKGROUNDGamma-glutamyltransferase (GGT) is a known marker for apoptotic balance and cell detoxification. Recently, an association of baseline GGT levels and breast cancer incidence, tumor progression and chemotherapy resistance was shown. The purpose of this study was to evaluate the association of pre-therapeutic GGT levels, clinical-pathological parameters and survival in patients with primary metastatic breast cancer (PMBC).In this multicenter analysis, pre-therapeutic GGT levels and clinical-pathological parameters of 114 patients diagnosed with PMBC between 1996 and 2012 were evaluated. The association between GGT levels and clinical-pathological parameters were analysed. Patients were stratified into four GGT risk-groups (GGT < 18.00 U/L: normal low, 18.00 to 35.99 U/L: normal high, 36.00 to 71.99 U/L: elevated and ≥ 72.00 U/L: highly elevated) and survival analyses were performed.METHODSIn this multicenter analysis, pre-therapeutic GGT levels and clinical-pathological parameters of 114 patients diagnosed with PMBC between 1996 and 2012 were evaluated. The association between GGT levels and clinical-pathological parameters were analysed. Patients were stratified into four GGT risk-groups (GGT < 18.00 U/L: normal low, 18.00 to 35.99 U/L: normal high, 36.00 to 71.99 U/L: elevated and ≥ 72.00 U/L: highly elevated) and survival analyses were performed.Patients in the high risk GGT group had a poorer overall survival, when compared to the low risk group with five-year overall survival rates of 39.5% and 53.7% (p = 0.04), respectively. Patients with larger breast tumors had a trend towards higher GGT levels (p = 0.053). Pre-therapeutic GGT levels were not associated with indicators of aggressive tumor biology such as HER2-status, triple negative histology, or poorly differentiated cancers.FINDINGSPatients in the high risk GGT group had a poorer overall survival, when compared to the low risk group with five-year overall survival rates of 39.5% and 53.7% (p = 0.04), respectively. Patients with larger breast tumors had a trend towards higher GGT levels (p = 0.053). Pre-therapeutic GGT levels were not associated with indicators of aggressive tumor biology such as HER2-status, triple negative histology, or poorly differentiated cancers.Pre-therapeutic GGT serum level might serve as a novel prognostic factor for overall-survival in patients with PMBC.CONCLUSIONPre-therapeutic GGT serum level might serve as a novel prognostic factor for overall-survival in patients with PMBC. Gamma-glutamyltransferase (GGT) is a known marker for apoptotic balance and cell detoxification. Recently, an association of baseline GGT levels and breast cancer incidence, tumor progression and chemotherapy resistance was shown. The purpose of this study was to evaluate the association of pre-therapeutic GGT levels, clinical-pathological parameters and survival in patients with primary metastatic breast cancer (PMBC). In this multicenter analysis, pre-therapeutic GGT levels and clinical-pathological parameters of 114 patients diagnosed with PMBC between 1996 and 2012 were evaluated. The association between GGT levels and clinical-pathological parameters were analysed. Patients were stratified into four GGT risk-groups (GGT < 18.00 U/L: normal low, 18.00 to 35.99 U/L: normal high, 36.00 to 71.99 U/L: elevated and ≥ 72.00 U/L: highly elevated) and survival analyses were performed. Patients in the high risk GGT group had a poorer overall survival, when compared to the low risk group with five-year overall survival rates of 39.5% and 53.7% (p = 0.04), respectively. Patients with larger breast tumors had a trend towards higher GGT levels (p = 0.053). Pre-therapeutic GGT levels were not associated with indicators of aggressive tumor biology such as HER2-status, triple negative histology, or poorly differentiated cancers. Pre-therapeutic GGT serum level might serve as a novel prognostic factor for overall-survival in patients with PMBC. Gamma-glutamyltransferase (GGT) is a known marker for apoptotic balance and cell detoxification. Recently, an association of baseline GGT levels and breast cancer incidence, tumor progression and chemotherapy resistance was shown. The purpose of this study was to evaluate the association of pre-therapeutic GGT levels, clinical-pathological parameters and survival in patients with primary metastatic breast cancer (PMBC).In this multicenter analysis, pre-therapeutic GGT levels and clinical-pathological parameters of 114 patients diagnosed with PMBC between 1996 and 2012 were evaluated. The association between GGT levels and clinical-pathological parameters were analysed. Patients were stratified into four GGT risk-groups (GGT < 18.00 U/L: normal low, 18.00 to 35.99 U/L: normal high, 36.00 to 71.99 U/L: elevated and ≥ 72.00 U/L: highly elevated) and survival analyses were performed.Patients in the high risk GGT group had a poorer overall survival, when compared to the low risk group with five-year overall survival rates of 39.5% and 53.7% (p = 0.04), respectively. Patients with larger breast tumors had a trend towards higher GGT levels (p = 0.053). Pre-therapeutic GGT levels were not associated with indicators of aggressive tumor biology such as HER2-status, triple negative histology, or poorly differentiated cancers.Pre-therapeutic GGT serum level might serve as a novel prognostic factor for overall-survival in patients with PMBC. Background Gamma-glutamyltransferase (GGT) is a known marker for apoptotic balance and cell detoxification. Recently, an association of baseline GGT levels and breast cancer incidence, tumor progression and chemotherapy resistance was shown. The purpose of this study was to evaluate the association of pre-therapeutic GGT levels, clinical-pathological parameters and survival in patients with primary metastatic breast cancer (PMBC). Methods In this multicenter analysis, pre-therapeutic GGT levels and clinical-pathological parameters of 114 patients diagnosed with PMBC between 1996 and 2012 were evaluated. The association between GGT levels and clinical-pathological parameters were analysed. Patients were stratified into four GGT risk-groups (GGT < 18.00 U/L: normal low, 18.00 to 35.99 U/L: normal high, 36.00 to 71.99 U/L: elevated and ≥ 72.00 U/L: highly elevated) and survival analyses were performed. Findings Patients in the high risk GGT group had a poorer overall survival, when compared to the low risk group with five-year overall survival rates of 39.5% and 53.7% (p = 0.04), respectively. Patients with larger breast tumors had a trend towards higher GGT levels (p = 0.053). Pre-therapeutic GGT levels were not associated with indicators of aggressive tumor biology such as HER2-status, triple negative histology, or poorly differentiated cancers. Conclusion Pre-therapeutic GGT serum level might serve as a novel prognostic factor for overall-survival in patients with PMBC.
Audience	Academic
Author	Staudigl, Christine Grimm, Christoph Nehoda, Regina Pfeiler, Georg Concin, Nicole Singer, Christian F. Polterauer, Stephan
AuthorAffiliation	2 Department of Obstetrics and Gynecology, Medical University of Innsbruck, Innsbruck, Austria Wayne State University School of Medicine, UNITED STATES 1 Department of General Gynecology and Gynecologic Oncology, Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria
AuthorAffiliation_xml	– name: 1 Department of General Gynecology and Gynecologic Oncology, Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria – name: 2 Department of Obstetrics and Gynecology, Medical University of Innsbruck, Innsbruck, Austria – name: Wayne State University School of Medicine, UNITED STATES
Author_xml	– sequence: 1 givenname: Christine surname: Staudigl fullname: Staudigl, Christine – sequence: 2 givenname: Nicole surname: Concin fullname: Concin, Nicole – sequence: 3 givenname: Christoph surname: Grimm fullname: Grimm, Christoph – sequence: 4 givenname: Georg surname: Pfeiler fullname: Pfeiler, Georg – sequence: 5 givenname: Regina surname: Nehoda fullname: Nehoda, Regina – sequence: 6 givenname: Christian F. surname: Singer fullname: Singer, Christian F. – sequence: 7 givenname: Stephan surname: Polterauer fullname: Polterauer, Stephan
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/25915044$$D View this record in MEDLINE/PubMed
BookMark	eNqNk11v0zAUhiM0xLbCP0AQCQnBRUtsx07CBdKYYEwaWjU-bq3T5KT1lMTFdgb795ys2dROE0KREn8872v7zfFhtNfZDqPoOUtmTGTs3aXtXQfNbE3Ds4RxKVj2KDpgheBTxROxt9Xejw69v0wSKXKlnkT7XBZMJml6ELm5s8vO-mDK-AIbvIKuxNjW8dxhWKGDNfbD3Am0LUxPmj5Ae90EB52vadZjbLp4DsFgF3z824QVKU0L7jr-igF8gEH90SE14-PB3D2NHtfQeHw2fifRj8-fvh9_mZ6dn5weH51NS1XwQG_gWcoZdYoFy_OKSSbSOgNQZcoLLhBzkIWig0ghqwWoJFWVqhciq7CQqZhELze-68Z6PcblNVMZaTiXCRGnG6KycKnXm31rC0bfDFi31OBo_w3qhahyJYoak1KlIES-4GleiDpTVVEXFPQk-jCu1i9arErKw0GzY7o705mVXtornaaMJYUkgzejgbO_evRBt8aX2DTQoe1v9p3luZSKE_rqHvrw6UZqCXQA09WW1i0HU31EueZssCNq9gBFT4WtKam2akPjO4K3OwJiAv4JS-i916ffLv6fPf-5y77eYlcITVh5SwVnbOd3wRfbSd9FfFvUBKQboHTWe4f1HcISPdyd27j0cHf0eHdI9v6erDRD-drhf5nm3-K_Rv0fRQ
CitedBy_id	crossref_primary_10_1080_14737159_2019_1579644 crossref_primary_10_1007_s12282_020_01080_5 crossref_primary_10_1016_j_urolonc_2018_11_002 crossref_primary_10_1016_j_clgc_2022_02_006 crossref_primary_10_1155_2024_8491275 crossref_primary_10_1016_j_maturitas_2024_108108 crossref_primary_10_12677_WJCR_2022_122005 crossref_primary_10_3390_livers5030041 crossref_primary_10_1371_journal_pone_0172345 crossref_primary_10_1016_j_dyepig_2023_111631 crossref_primary_10_1016_j_ejogrb_2019_05_031 crossref_primary_10_1016_j_jddst_2021_103022 crossref_primary_10_3390_cancers17050891 crossref_primary_10_1155_2019_1415421 crossref_primary_10_3389_fonc_2023_1178123 crossref_primary_10_2217_fon_2023_0137 crossref_primary_10_1016_j_ygeno_2021_06_014 crossref_primary_10_1155_2017_3142926 crossref_primary_10_3390_antiox10040549 crossref_primary_10_1038_srep33757 crossref_primary_10_1002_ijc_34127 crossref_primary_10_1016_j_jtice_2015_10_040 crossref_primary_10_1007_s00262_024_03716_3 crossref_primary_10_1016_j_gassur_2025_101984 crossref_primary_10_2147_CMAR_S300869 crossref_primary_10_1186_s12885_019_6250_8 crossref_primary_10_1016_j_trac_2023_117128 crossref_primary_10_3389_fonc_2019_00347 crossref_primary_10_1016_j_jvir_2016_05_028 crossref_primary_10_1093_labmed_lmad014 crossref_primary_10_1016_j_drup_2019_100645 crossref_primary_10_1371_journal_pone_0149122 crossref_primary_10_3389_fonc_2021_648904 crossref_primary_10_3389_fonc_2024_1411096
Cites_doi	10.1111/codi.12258 10.1093/carcin/20.4.553 10.1111/j.1464-5491.2005.01581.x 10.1038/bjc.2012.16 10.1002/ijc.29084 10.1007/s10549-009-0670-0 10.1002/ijc.23714 10.6004/jnccn.2014.0058 10.1161/01.ATV.0000251993.20372.40 10.1002/cncr.20038 10.1016/j.ejca.2006.04.016 10.1038/bjc.2013.323 10.1111/j.1442-2042.2006.01719.x 10.1016/S0022-5347(01)65043-2 10.1016/j.ygyno.2011.05.027 10.1038/sj.bjc.6605719 10.1016/j.ejca.2012.12.027 10.1016/j.ejca.2011.03.010 10.1093/annonc/mds232 10.1038/bjc.2012.128 10.1080/20014091084227 10.1053/j.gastro.2008.10.052 10.1373/clinchem.2006.081620 10.1158/0008-5472.CAN-07-6686
ContentType	Journal Article
Copyright	COPYRIGHT 2015 Public Library of Science 2015 Staudigl et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. 2015 Staudigl et al 2015 Staudigl et al
Copyright_xml	– notice: COPYRIGHT 2015 Public Library of Science – notice: 2015 Staudigl et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. – notice: 2015 Staudigl et al 2015 Staudigl et al
DBID	AAYXX CITATION CGR CUY CVF ECM EIF NPM IOV ISR 3V. 7QG 7QL 7QO 7RV 7SN 7SS 7T5 7TG 7TM 7U9 7X2 7X7 7XB 88E 8AO 8C1 8FD 8FE 8FG 8FH 8FI 8FJ 8FK ABJCF ABUWG AEUYN AFKRA ARAPS ATCPS AZQEC BBNVY BENPR BGLVJ BHPHI C1K CCPQU D1I DWQXO FR3 FYUFA GHDGH GNUQQ H94 HCIFZ K9. KB. KB0 KL. L6V LK8 M0K M0S M1P M7N M7P M7S NAPCQ P5Z P62 P64 PATMY PDBOC PHGZM PHGZT PIMPY PJZUB PKEHL PPXIY PQEST PQGLB PQQKQ PQUKI PRINS PTHSS PYCSY RC3 7X8 5PM DOA
DOI	10.1371/journal.pone.0125317
DatabaseName	CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed Gale In Context: Opposing Viewpoints Gale In Context: Science ProQuest Central (Corporate) Animal Behavior Abstracts Bacteriology Abstracts (Microbiology B) Biotechnology Research Abstracts Nursing & Allied Health Database Ecology Abstracts Entomology Abstracts (Full archive) Immunology Abstracts Meteorological & Geoastrophysical Abstracts Nucleic Acids Abstracts Virology and AIDS Abstracts Agricultural Science Collection Health & Medical Collection (Proquest) ProQuest Central (purchase pre-March 2016) Medical Database (Alumni Edition) ProQuest Pharma Collection Proquest Public Health Database Technology Research Database ProQuest SciTech Collection ProQuest Technology Collection ProQuest Natural Science Collection Hospital Premium Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) ProQuest SciTech Premium Collection Technology Collection Materials Science & Engineering Database ProQuest Central (Alumni) ProQuest One Sustainability ProQuest Central UK/Ireland ProQuest SciTech Premium Collection Technology Collection Advanced Technologies & Aerospace Collection Agricultural & Environmental Science Collection ProQuest Central Essentials Biological Science Collection ProQuest Central ProQuest Technology Collection Natural Science Collection Environmental Sciences and Pollution Management ProQuest One Community College ProQuest Materials Science Collection ProQuest Central Korea Engineering Research Database Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Central Student AIDS and Cancer Research Abstracts SciTech Premium Collection ProQuest Health & Medical Complete (Alumni) Materials Science Database Nursing & Allied Health Database (Alumni Edition) Meteorological & Geoastrophysical Abstracts - Academic ProQuest Engineering Collection ProQuest Biological Science Collection Agricultural Science Database ProQuest Health & Medical Collection Medical Database Algology Mycology and Protozoology Abstracts (Microbiology C) Biological Science Database Engineering Database Nursing & Allied Health Premium Advanced Technologies & Aerospace Database ProQuest Advanced Technologies & Aerospace Collection Biotechnology and BioEngineering Abstracts Environmental Science Database Materials Science Collection ProQuest Central Premium ProQuest One Academic (New) Publicly Available Content Database (Proquest) ProQuest Health & Medical Research Collection ProQuest One Academic Middle East (New) ProQuest One Health & Nursing ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Applied & Life Sciences ProQuest One Academic (retired) ProQuest One Academic UKI Edition ProQuest Central China Engineering Collection Environmental Science Collection Genetics Abstracts MEDLINE - Academic PubMed Central (Full Participant titles) DOAJ Directory of Open Access Journals
DatabaseTitle	CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) Agricultural Science Database Publicly Available Content Database ProQuest Central Student ProQuest Advanced Technologies & Aerospace Collection ProQuest Central Essentials Nucleic Acids Abstracts SciTech Premium Collection ProQuest Central China Environmental Sciences and Pollution Management ProQuest One Applied & Life Sciences ProQuest One Sustainability Health Research Premium Collection Meteorological & Geoastrophysical Abstracts Natural Science Collection Health & Medical Research Collection Biological Science Collection ProQuest Central (New) ProQuest Medical Library (Alumni) Engineering Collection Advanced Technologies & Aerospace Collection Engineering Database Virology and AIDS Abstracts ProQuest Biological Science Collection ProQuest One Academic Eastern Edition Agricultural Science Collection ProQuest Hospital Collection ProQuest Technology Collection Health Research Premium Collection (Alumni) Biological Science Database Ecology Abstracts ProQuest Hospital Collection (Alumni) Biotechnology and BioEngineering Abstracts Environmental Science Collection Entomology Abstracts Nursing & Allied Health Premium ProQuest Health & Medical Complete ProQuest One Academic UKI Edition Environmental Science Database ProQuest Nursing & Allied Health Source (Alumni) Engineering Research Database ProQuest One Academic Meteorological & Geoastrophysical Abstracts - Academic ProQuest One Academic (New) Technology Collection Technology Research Database ProQuest One Academic Middle East (New) Materials Science Collection ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) ProQuest One Community College ProQuest One Health & Nursing ProQuest Natural Science Collection ProQuest Pharma Collection ProQuest Central ProQuest Health & Medical Research Collection Genetics Abstracts ProQuest Engineering Collection Biotechnology Research Abstracts Health and Medicine Complete (Alumni Edition) ProQuest Central Korea Bacteriology Abstracts (Microbiology B) Algology Mycology and Protozoology Abstracts (Microbiology C) Agricultural & Environmental Science Collection AIDS and Cancer Research Abstracts Materials Science Database ProQuest Materials Science Collection ProQuest Public Health ProQuest Nursing & Allied Health Source ProQuest SciTech Collection Advanced Technologies & Aerospace Database ProQuest Medical Library Animal Behavior Abstracts Materials Science & Engineering Collection Immunology Abstracts ProQuest Central (Alumni) MEDLINE - Academic
DatabaseTitleList	Agricultural Science Database MEDLINE - Academic MEDLINE
Database_xml	– sequence: 1 dbid: DOA name: DOAJ Directory of Open Access Journals url: https://www.doaj.org/ sourceTypes: Open Website – sequence: 2 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 3 dbid: PIMPY name: Publicly Available Content Database url: http://search.proquest.com/publiccontent sourceTypes: Aggregation Database
DeliveryMethod	fulltext_linktorsrc
Discipline	Sciences (General)
DocumentTitleAlternate	Gamma-Glutamyltransferase Primary Metastatic Breast Cancer
EISSN	1932-6203
ExternalDocumentID	1676152250 oai_doaj_org_article_b3d8639fe0c64a338b24893f76d9f919 PMC4411095 3667581301 A421817885 25915044 10_1371_journal_pone_0125317
Genre	Multicenter Study Journal Article
GroupedDBID	--- 123 29O 2WC 53G 5VS 7RV 7X2 7X7 7XC 88E 8AO 8C1 8CJ 8FE 8FG 8FH 8FI 8FJ A8Z AAFWJ AAUCC AAWOE AAYXX ABDBF ABIVO ABJCF ABUWG ACCTH ACGFO ACIHN ACIWK ACPRK ACUHS ADBBV ADRAZ AEAQA AENEX AEUYN AFFHD AFKRA AFPKN AFRAH AHMBA ALMA_UNASSIGNED_HOLDINGS AOIJS APEBS ARAPS ATCPS BAIFH BAWUL BBNVY BBTPI BCNDV BENPR BGLVJ BHPHI BKEYQ BPHCQ BVXVI BWKFM CCPQU CITATION CS3 D1I D1J D1K DIK DU5 E3Z EAP EAS EBD EMOBN ESX EX3 F5P FPL FYUFA GROUPED_DOAJ GX1 HCIFZ HH5 HMCUK HYE IAO IEA IGS IHR IHW INH INR IOV IPY ISE ISR ITC K6- KB. KQ8 L6V LK5 LK8 M0K M1P M48 M7P M7R M7S M~E NAPCQ O5R O5S OK1 OVT P2P P62 PATMY PDBOC PHGZM PHGZT PIMPY PJZUB PPXIY PQGLB PQQKQ PROAC PSQYO PTHSS PV9 PYCSY RNS RPM RZL SV3 TR2 UKHRP WOQ WOW ~02 ~KM ALIPV BBORY CGR CUY CVF ECM EIF IPNFZ NPM RIG 3V. 7QG 7QL 7QO 7SN 7SS 7T5 7TG 7TM 7U9 7XB 8FD 8FK AZQEC C1K DWQXO ESTFP FR3 GNUQQ H94 K9. KL. M7N P64 PKEHL PQEST PQUKI PRINS RC3 7X8 PUEGO 5PM AAPBV ABPTK N95
ID	FETCH-LOGICAL-c692t-c6a274216929b188d15134f7aa6c42923ee8a596150535dba6046d6fb37de9543
IEDL.DBID	DOA
ISICitedReferencesCount	65
ISICitedReferencesURI	http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000353659100119&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
ISSN	1932-6203
IngestDate	Sun Aug 06 00:16:02 EDT 2023 Fri Oct 03 12:53:45 EDT 2025 Tue Nov 04 01:58:38 EST 2025 Wed Oct 01 14:41:57 EDT 2025 Tue Oct 07 07:24:19 EDT 2025 Sat Nov 29 12:58:26 EST 2025 Sat Nov 29 10:05:55 EST 2025 Wed Nov 26 10:17:34 EST 2025 Wed Nov 26 09:56:19 EST 2025 Thu May 22 20:56:40 EDT 2025 Thu Apr 03 06:58:23 EDT 2025 Sat Nov 29 05:56:46 EST 2025 Tue Nov 18 22:35:26 EST 2025
IsDoiOpenAccess	true
IsOpenAccess	true
IsPeerReviewed	true
IsScholarly	true
Issue	4
Language	English
License	This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. Creative Commons Attribution License
LinkModel	DirectLink
MergedId	FETCHMERGED-LOGICAL-c692t-c6a274216929b188d15134f7aa6c42923ee8a596150535dba6046d6fb37de9543
Notes	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 Conceived and designed the experiments: SP CG CFS. Performed the experiments: SP CG CS GP. Analyzed the data: SP CG. Contributed reagents/materials/analysis tools: CS NC RN CFS GP. Wrote the paper: CS SP. Data Collection: CS NC RN. Competing Interests: The authors have declared that no competing interests exist.
OpenAccessLink	https://doaj.org/article/b3d8639fe0c64a338b24893f76d9f919
PMID	25915044
PQID	1676152250
PQPubID	1436336
ParticipantIDs	plos_journals_1676152250 doaj_primary_oai_doaj_org_article_b3d8639fe0c64a338b24893f76d9f919 pubmedcentral_primary_oai_pubmedcentral_nih_gov_4411095 proquest_miscellaneous_1677885562 proquest_journals_1676152250 gale_infotracmisc_A421817885 gale_infotracacademiconefile_A421817885 gale_incontextgauss_ISR_A421817885 gale_incontextgauss_IOV_A421817885 gale_healthsolutions_A421817885 pubmed_primary_25915044 crossref_primary_10_1371_journal_pone_0125317 crossref_citationtrail_10_1371_journal_pone_0125317
PublicationCentury	2000
PublicationDate	2015-04-27
PublicationDateYYYYMMDD	2015-04-27
PublicationDate_xml	– month: 04 year: 2015 text: 2015-04-27 day: 27
PublicationDecade	2010
PublicationPlace	United States
PublicationPlace_xml	– name: United States – name: San Francisco – name: San Francisco, CA USA
PublicationTitle	PloS one
PublicationTitleAlternate	PLoS One
PublicationYear	2015
Publisher	Public Library of Science Public Library of Science (PLoS)
Publisher_xml	– name: Public Library of Science – name: Public Library of Science (PLoS)
References	DS Lee (ref8) 2007; 27 S Polterauer (ref13) 2011; 122 WZ He (ref22) 2013; 15 AM Strasak (ref11) 2008; 68 M Franzini (ref19) 2006; 42 WJ Gradishar (ref18) 2014; 12 IS Fentiman (ref21) 2012; 106 DS Sandock (ref24) 1997; 157 DJ Kim (ref7) 2005; 22 JB Whitfield (ref6) 2001; 38 J Ruiterkamp (ref4) 2009; 120 C Grimm (ref15) 2013; 109 V Seebacher (ref14) 2012; 106 MH Hanigan (ref20) 1999; 20 T Simic (ref23) 2007; 14 IS Fentiman (ref16) 2010; 103 AM Strasak (ref10) 2008; 123 CE Ruhl (ref9) 2009; 136 L Kazemi-Shirazi (ref5) 2007; 53 SK Kunutsor (ref12) 2014; 136 F Cardoso (ref3) 2012; 23 J Ferlay (ref1) 2013; 49 M Van Hemelrijck (ref17) 2011; 47 A Corti (ref25) 2010; 30 M Sant (ref2) 2004; 100 21664662 - Gynecol Oncol. 2011 Sep;122(3):590-4 23621885 - Colorectal Dis. 2013 Aug;15(8):e443-52 17470155 - Int J Urol. 2007 Apr;14(4):289-93 23485231 - Eur J Cancer. 2013 Apr;49(6):1374-403 18483283 - Cancer Res. 2008 May 15;68(10):3970-7 24717572 - J Natl Compr Canc Netw. 2014 Apr;12(4):542-90 10223181 - Carcinogenesis. 1999 Apr;20(4):553-9 17095717 - Arterioscler Thromb Vasc Biol. 2007 Jan;27(1):127-33 23921280 - Br J Cancer. 2013 Aug 6;109(3):610-4 16108838 - Diabet Med. 2005 Sep;22(9):1134-40 25043373 - Int J Cancer. 2015 Mar 1;136(5):1162-70 22997442 - Ann Oncol. 2012 Oct;23 Suppl 7:vii11-9 20530424 - Anticancer Res. 2010 Apr;30(4):1169-81 21486691 - Eur J Cancer. 2011 Sep;47(13):2033-41 16928443 - Eur J Cancer. 2006 Oct;42(15):2623-30 17384006 - Clin Chem. 2007 May;53(5):940-6 9072569 - J Urol. 1997 Mar;157(3):798-9 22531718 - Br J Cancer. 2012 Apr 24;106(9):1467-8 20012891 - Breast Cancer Res Treat. 2010 Feb;120(1):9-16 20517309 - Br J Cancer. 2010 Jun 29;103(1):90-3 14770426 - Cancer. 2004 Feb 15;100(4):715-22 11563810 - Crit Rev Clin Lab Sci. 2001 Aug;38(4):263-355 18688855 - Int J Cancer. 2008 Oct 15;123(8):1902-6 19100265 - Gastroenterology. 2009 Feb;136(2):477-85.e11 22315051 - Br J Cancer. 2012 Apr 24;106(9):1551-5
References_xml	– volume: 15 start-page: e443 issue: 8 year: 2013 ident: ref22 article-title: Gamma-glutamyl transpeptidase level is a novel adverse prognostic indicator in human metastatic colorectal cancer publication-title: Colorectal Dis doi: 10.1111/codi.12258 – volume: 20 start-page: 553 issue: 4 year: 1999 ident: ref20 article-title: Gamma-glutamyl transpeptidase accelerates tumor growth and increases the resistance of tumors to cisplatin in vivo publication-title: Carcinogenesis doi: 10.1093/carcin/20.4.553 – volume: 22 start-page: 1134 issue: 9 year: 2005 ident: ref7 article-title: Serum gamma-glutamyltransferase within its normal concentration range is related to the presence of diabetes and cardiovascular risk factors publication-title: Diabet Med doi: 10.1111/j.1464-5491.2005.01581.x – volume: 106 start-page: 1551 issue: 9 year: 2012 ident: ref14 article-title: Prognostic significance of gamma-glutamyltransferase in patients with endometrial cancer: a multi-centre trial publication-title: Br J Cancer doi: 10.1038/bjc.2012.16 – volume: 136 start-page: 1162 issue: 5 year: 2014 ident: ref12 article-title: Gamma glutamyltransferase, alanine aminotransferase and risk of cancer: Systematic review and meta-analysis publication-title: Int J Cancer doi: 10.1002/ijc.29084 – volume: 120 start-page: 9 issue: 1 year: 2009 ident: ref4 article-title: Impact of breast surgery on survival in patients with distant metastases at initial presentation: a systematic review of the literature publication-title: Breast Cancer Res Treat doi: 10.1007/s10549-009-0670-0 – volume: 123 start-page: 1902 issue: 8 year: 2008 ident: ref10 article-title: Prospective study of the association of gamma-glutamyltransferase with cancer incidence in women publication-title: Int J Cancer doi: 10.1002/ijc.23714 – volume: 12 start-page: 542 issue: 4 year: 2014 ident: ref18 article-title: Breast cancer version 3.2014 publication-title: J Natl Compr Canc Netw doi: 10.6004/jnccn.2014.0058 – volume: 27 start-page: 127 issue: 1 year: 2007 ident: ref8 article-title: Gamma glutamyl transferase and metabolic syndrome, cardiovascular disease, and mortality risk: the Framingham Heart Study publication-title: Arterioscler Thromb Vasc Biol doi: 10.1161/01.ATV.0000251993.20372.40 – volume: 100 start-page: 715 issue: 4 year: 2004 ident: ref2 article-title: Breast carcinoma survival in Europe and the United States publication-title: Cancer doi: 10.1002/cncr.20038 – volume: 42 start-page: 2623 issue: 15 year: 2006 ident: ref19 article-title: Modulation of cell growth and cisplatin sensitivity by membrane gamma-glutamyltransferase in melanoma cells publication-title: Eur J Cancer doi: 10.1016/j.ejca.2006.04.016 – volume: 109 start-page: 610 issue: 3 year: 2013 ident: ref15 article-title: Association of gamma-glutamyltransferase with severity of disease at diagnosis and prognosis of ovarian cancer publication-title: Br J Cancer doi: 10.1038/bjc.2013.323 – volume: 14 start-page: 289 issue: 4 year: 2007 ident: ref23 article-title: Serum gamma glutamyl-transferase is a sensitive but unspecific marker of metastatic renal cell carcinoma publication-title: Int J Urol doi: 10.1111/j.1442-2042.2006.01719.x – volume: 157 start-page: 798 issue: 3 year: 1997 ident: ref24 article-title: The role of gamma-glutamyl transpeptidase in the preoperative metastatic evaluation of renal cell carcinoma publication-title: J Urol doi: 10.1016/S0022-5347(01)65043-2 – volume: 122 start-page: 590 issue: 3 year: 2011 ident: ref13 article-title: Relevance of gamma-glutamyltransferase—a marker for apoptotic balance—in predicting tumor stage and prognosis in cervical cancer publication-title: Gynecol Oncol doi: 10.1016/j.ygyno.2011.05.027 – volume: 30 start-page: 1169 issue: 4 year: 2010 ident: ref25 article-title: Gamma-glutamyltransferase of cancer cells at the crossroads of tumor progression, drug resistance and drug targeting publication-title: Anticancer Res – volume: 103 start-page: 90 issue: 1 year: 2010 ident: ref16 article-title: gamma-Glutamyl transferase and breast cancer risk publication-title: Br J Cancer doi: 10.1038/sj.bjc.6605719 – volume: 49 start-page: 1374 issue: 6 year: 2013 ident: ref1 article-title: Cancer incidence and mortality patterns in Europe: estimates for 40 countries in 2012 publication-title: Eur J Cancer doi: 10.1016/j.ejca.2012.12.027 – volume: 47 start-page: 2033 issue: 13 year: 2011 ident: ref17 article-title: Gamma-glutamyltransferase and risk of cancer in a cohort of 545,460 persons—the Swedish AMORIS study publication-title: Eur J Cancer doi: 10.1016/j.ejca.2011.03.010 – volume: 23 start-page: vii11 issue: Suppl 7 year: 2012 ident: ref3 article-title: Locally recurrent or metastatic breast cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up publication-title: Ann Oncol doi: 10.1093/annonc/mds232 – volume: 106 start-page: 1467 issue: 9 year: 2012 ident: ref21 article-title: Gamma-glutamyl transferase: risk and prognosis of cancer publication-title: Br J Cancer doi: 10.1038/bjc.2012.128 – volume: 38 start-page: 263 issue: 4 year: 2001 ident: ref6 article-title: Gamma glutamyl transferase publication-title: Crit Rev Clin Lab Sci doi: 10.1080/20014091084227 – volume: 136 start-page: 477 issue: 2 year: 2009 ident: ref9 article-title: Elevated serum alanine aminotransferase and gamma-glutamyltransferase and mortality in the United States population publication-title: Gastroenterology doi: 10.1053/j.gastro.2008.10.052 – volume: 53 start-page: 940 issue: 5 year: 2007 ident: ref5 article-title: Gamma glutamyltransferase and long-term survival: is it just the liver? publication-title: Clin Chem doi: 10.1373/clinchem.2006.081620 – volume: 68 start-page: 3970 issue: 10 year: 2008 ident: ref11 article-title: Association of gamma-glutamyltransferase and risk of cancer incidence in men: a prospective study publication-title: Cancer Res doi: 10.1158/0008-5472.CAN-07-6686 – reference: 22315051 - Br J Cancer. 2012 Apr 24;106(9):1551-5 – reference: 22531718 - Br J Cancer. 2012 Apr 24;106(9):1467-8 – reference: 16928443 - Eur J Cancer. 2006 Oct;42(15):2623-30 – reference: 21486691 - Eur J Cancer. 2011 Sep;47(13):2033-41 – reference: 25043373 - Int J Cancer. 2015 Mar 1;136(5):1162-70 – reference: 23621885 - Colorectal Dis. 2013 Aug;15(8):e443-52 – reference: 18483283 - Cancer Res. 2008 May 15;68(10):3970-7 – reference: 23921280 - Br J Cancer. 2013 Aug 6;109(3):610-4 – reference: 10223181 - Carcinogenesis. 1999 Apr;20(4):553-9 – reference: 17095717 - Arterioscler Thromb Vasc Biol. 2007 Jan;27(1):127-33 – reference: 18688855 - Int J Cancer. 2008 Oct 15;123(8):1902-6 – reference: 16108838 - Diabet Med. 2005 Sep;22(9):1134-40 – reference: 23485231 - Eur J Cancer. 2013 Apr;49(6):1374-403 – reference: 20530424 - Anticancer Res. 2010 Apr;30(4):1169-81 – reference: 22997442 - Ann Oncol. 2012 Oct;23 Suppl 7:vii11-9 – reference: 9072569 - J Urol. 1997 Mar;157(3):798-9 – reference: 11563810 - Crit Rev Clin Lab Sci. 2001 Aug;38(4):263-355 – reference: 19100265 - Gastroenterology. 2009 Feb;136(2):477-85.e11 – reference: 17384006 - Clin Chem. 2007 May;53(5):940-6 – reference: 17470155 - Int J Urol. 2007 Apr;14(4):289-93 – reference: 21664662 - Gynecol Oncol. 2011 Sep;122(3):590-4 – reference: 24717572 - J Natl Compr Canc Netw. 2014 Apr;12(4):542-90 – reference: 20012891 - Breast Cancer Res Treat. 2010 Feb;120(1):9-16 – reference: 20517309 - Br J Cancer. 2010 Jun 29;103(1):90-3 – reference: 14770426 - Cancer. 2004 Feb 15;100(4):715-22
SSID	ssj0053866
Score	2.415669
Snippet	Gamma-glutamyltransferase (GGT) is a known marker for apoptotic balance and cell detoxification. Recently, an association of baseline GGT levels and breast... Background Gamma-glutamyltransferase (GGT) is a known marker for apoptotic balance and cell detoxification. Recently, an association of baseline GGT levels and... Background Gamma-glutamyltransferase (GGT) is a known marker for apoptotic balance and cell detoxification. Recently, an association of baseline GGT levels and...
SourceID	plos doaj pubmedcentral proquest gale pubmed crossref
SourceType	Open Website Open Access Repository Aggregation Database Index Database Enrichment Source
StartPage	e0125317
SubjectTerms	Aged Analysis Apoptosis Biomarkers - blood Breast cancer Breast Neoplasms - pathology Cancer Cancer metastasis Cancer patients Care and treatment Chemoresistance Chemotherapy Detoxification Development and progression Drug Resistance, Neoplasm ErbB-2 protein Female gamma-Glutamyltransferase - blood Health aspects Histology Humans Medical diagnosis Medical prognosis Metastases Middle Aged Patients Prognosis Retrospective Studies Risk Survival Survival Analysis Tumors γ-Glutamyltransferase
SummonAdditionalLinks	– databaseName: Nursing & Allied Health Database dbid: 7RV link: http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1Lb9QwELZg4cAFKK8GChiEBBzSbuLEjk-orWjhQFktUPUWOY5TVtpNliSLxL9nxnFCgypA4rLSZsZWbI8n39jzIORFwbXmAVe-VDIEA0ULX2IkVwbQGR9NWaRssQlxcpKcncmZO3BrnFtlrxOtos4rjWfkewEHgxvAQjx9s_7mY9UovF11JTSukmsBYmOQZzE_7TUx7GXOXbgcE8GeW53ddVWaXVDMIH5i9DmyWfsH3TxZL6vmMuD5u__khQ_S0a3_HcptctNBUbrfyc4WuWLKO2TLbfaGvnIZqV_fJfWsrtAhDxjpHAPSUVRoVdBZbS4EcNFjtVop_xiEWa1-LFuLiYHaGLoo6azL4NpQPPqFljbLBf1gWoVBTdD6AP3jW3qIndf3yJejt58P3_muWIOvuQxb-FV46xvAH5kFSZIDlGBRIZTiGktiMWMSFUvMPx-zOM8UB8s850XGRG5kHLH7ZFLCwmwTmhkApUHGAHolEdMmAR2RmzjMijyfKhN7hPVrlmqXyRwLaixTez0nwKLpZjDFlU7dSnvEH1qtuzH-hf8AxWHgxTzc9kFVn6duW6cZy-HtZGGmmkcKzP0sxGw-heC5LGQgPfIUhSntgloHbZLuRwitRJLAYJ5bDszFUaKzz7naNE36_uPpPzB9mo-YXjqmooLp0MoFWMCYMMfXiHNnxAkaRY_I2yj6_aw06S-BhZa9SF9OfjaQsVN04CtNtbE82DWgbY886HbPMLNggYNURJFHxGhfjaZ-TCkXX20qdADzARgJD__8Wo_IDcC5MV4ChmKHTNp6Yx6T6_p7u2jqJ1Zn_AShoHcC priority: 102 providerName: ProQuest – databaseName: Public Library of Science (PLoS) Journals Open Access dbid: FPL link: http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV1Lb9QwELZg4cAFKK-mFDAICTikbOLEjo9txRYkKFF5qDfLcRy60m6ySrJI_HtmEm9oqlbAZaWNx5Y9Hk--iT2fCXlZcGN4wLUvtQwhQDHCl5jJlQF0xkdTFunusglxfJycnsr0T6B4YQefieCt0-neqirtHrhTMBpxndwIGecYbM3SjxvPC2uXc5ced1XN0eunY-kffPFktaiay4DmxfOS515Aszv_2_W75LaDmnS_t40tcs2W98iWW8wNfe0Yp9_cJ3VaV3jgDgTpCSacoynQqqBpbc8laNEjvVxq_wiMVS9_LdoO80JpY-m8pGnP0NpQ_LQLNTsWC_rJthqTlqD2AZ5_b-khNl4_IN9m774evvfdZQy-4TJs4Vfjrm4Af2QWJEkOUIFFhdCaG7zyilmb6Fgiv3zM4jzTHCLvnBcZE7mVccQekkkJetgmNLMAOoOMAbRKImZsAj4gt3GYFXk-1Tb2CNvMkTKOqRwvzFiobvtNQMTSa1ChYpVTrEf8odaqH-Nf5A9w-gdZ5NnuHsAMKrdsVcZy6J0s7NTwSEM4n4XI1lMInstCBtIjz9B4VJ-0OngLtR8hdBJJAoN50Ukg10aJh3l-6HXTqA-fv_-D0JeTkdArJ1RUoA6jXQIFjAk5vEaSuyNJ8BhmVLyNpr7RSqMCLmDewLNPoebG_C8vfj4UY6N4QK-01bqTwaYBTXvkUb9aBs1ChA1WEUUeEaN1NFL9uKScn3VU5wDWAwgCdq7u8WNyCzBsjBt8odglk7Ze2yfkpvnZzpv6aecffgOjFWU1 priority: 102 providerName: Public Library of Science
Title	Prognostic Relevance of Pretherapeutic Gamma-Glutamyltransferase in Patients with Primary Metastatic Breast Cancer
URI	https://www.ncbi.nlm.nih.gov/pubmed/25915044 https://www.proquest.com/docview/1676152250 https://www.proquest.com/docview/1677885562 https://pubmed.ncbi.nlm.nih.gov/PMC4411095 https://doaj.org/article/b3d8639fe0c64a338b24893f76d9f919 http://dx.doi.org/10.1371/journal.pone.0125317
Volume	10
WOSCitedRecordID	wos000353659100119&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
hasFullText	1
inHoldings	1
isFullTextHit
isPrint
journalDatabaseRights	– providerCode: PRVAON databaseName: DOAJ Directory of Open Access Journals customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: DOA dateStart: 20060101 isFulltext: true titleUrlDefault: https://www.doaj.org/ providerName: Directory of Open Access Journals – providerCode: PRVHPJ databaseName: ROAD: Directory of Open Access Scholarly Resources customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: M~E dateStart: 20060101 isFulltext: true titleUrlDefault: https://road.issn.org providerName: ISSN International Centre – providerCode: PRVPQU databaseName: Advanced Technologies & Aerospace Database customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: P5Z dateStart: 20061201 isFulltext: true titleUrlDefault: https://search.proquest.com/hightechjournals providerName: ProQuest – providerCode: PRVPQU databaseName: Agricultural Science Database customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: M0K dateStart: 20061201 isFulltext: true titleUrlDefault: https://search.proquest.com/agriculturejournals providerName: ProQuest – providerCode: PRVPQU databaseName: Biological Science Database customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: M7P dateStart: 20061201 isFulltext: true titleUrlDefault: http://search.proquest.com/biologicalscijournals providerName: ProQuest – providerCode: PRVPQU databaseName: Engineering Database customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: M7S dateStart: 20061201 isFulltext: true titleUrlDefault: http://search.proquest.com providerName: ProQuest – providerCode: PRVPQU databaseName: Environmental Science Database customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: PATMY dateStart: 20061201 isFulltext: true titleUrlDefault: http://search.proquest.com/environmentalscience providerName: ProQuest – providerCode: PRVPQU databaseName: Health & Medical Collection customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: 7X7 dateStart: 20061201 isFulltext: true titleUrlDefault: https://search.proquest.com/healthcomplete providerName: ProQuest – providerCode: PRVPQU databaseName: Materials Science Database customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: KB. dateStart: 20061201 isFulltext: true titleUrlDefault: http://search.proquest.com/materialsscijournals providerName: ProQuest – providerCode: PRVPQU databaseName: Nursing & Allied Health Database customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: 7RV dateStart: 20061201 isFulltext: true titleUrlDefault: https://search.proquest.com/nahs providerName: ProQuest – providerCode: PRVPQU databaseName: ProQuest Central customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: BENPR dateStart: 20061201 isFulltext: true titleUrlDefault: https://www.proquest.com/central providerName: ProQuest – providerCode: PRVPQU databaseName: Public Health Database customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: 8C1 dateStart: 20061201 isFulltext: true titleUrlDefault: https://search.proquest.com/publichealth providerName: ProQuest – providerCode: PRVPQU databaseName: Publicly Available Content Database customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: PIMPY dateStart: 20061201 isFulltext: true titleUrlDefault: http://search.proquest.com/publiccontent providerName: ProQuest – providerCode: PRVATS databaseName: Public Library of Science (PLoS) Journals Open Access customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: FPL dateStart: 20060101 isFulltext: true titleUrlDefault: http://www.plos.org/publications/ providerName: Public Library of Science
link	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV3db9MwELeg8MALYnytMIpBSMBDu3za8eM6rWIaK1EHU9lL5DjOqNQmU5Mi8d9z57hhQZPGAy8nNT5H8d35fFeffybkXc6UYi6TQyGFBwmK4kOBJ7lSCJ3xkeMH0lw2wafTaD4X8bWrvrAmrIEHbgS3n_pZBKtorh3FAgkJVeohXkrOWSZyYQA_PYeLbTLV-GCYxYzZg3I-d_etXkZXZaFH4JLB8HhnITJ4_a1X7l0ty-qmkPPvyslrS9HkEXloY0h60Hz7Drmji8dkx87Sin6wUNIfn5B1vC6xkg4YKd6OYvb7aZlTLDP8c_KKXsrVSmL5ei1Xv5a1CWahtdJ0UVALvVpR_M8Wehp4CrrStcTTSNA7xcL2mip8-fop-TY5-nr4aWhvWRgqJrwaqMTtWhd-iNSNogxiAD_IuZRM4V1WvtaRDAUCx4d-mKWSQUqdsTz1eaZFGPjPSK8Aue4SmmqIJt3Uh5gpCnylQXFRpkMvzbPMkTrsE38r8kRZCHK8CWOZmH01DqlII8EEFZVYRfXJsO1lx3gL_xi12fIigLZ5AGaVWLNKbjOrPnmNtpA0p1FbN5AcBBgT8SiCwbw1HAiiUWCVzqXcVFVy_OX8H5jOZh2m95YpL0EcStqTETAmBOfqcO51OMEVqE7zLlruVipV4jIOegOX7UDPrTXf3PymbcaXYuVdocuN4cFXQ5jcJ88b428lC6kzWEUQ9AnvTIuO6LstxeKHwTCHKNyF6P7F_9DVS_IAwtgQ9_g8vkd69XqjX5H76me9qNYDcpfPzpHOuaER0OjQHZB746NpPBsYxwF0En8GejIeAT11TpDy2NAzoHF4AT3i49P4-29kv3Y1
linkProvider	Directory of Open Access Journals
linkToHtml	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1R3LbtQw0CoLElyA8upCoQaBgEPaTZw48QGhttB21QerUlDFJTiOU1baTZYkC-pP8Y3MOA8aVAGXHrhESjy24sk843kQ8jThSnGbS0tI4YCDonxLYCZXBKYzPhowV5pmE_7BQXB8LEYL5EeTC4NhlY1MNII6zhT-I1-zOTjcYCx4g9ezrxZ2jcLT1aaFRkUWu_r0O7hsxavhG_i-zxxn6-3R5o5VdxWwFBdOCVeJx5M23IjIDoIYdB5zE19KrrB3E9M6kJ7AQuke8-JIcnAhY55EzI-18FwG614il13XGSAXjbxPjeQH2cF5nZ7HfHutpobVWZbqVVAEQO5-R_2ZLgGtLujNJllxnqH7e7zmGQW4deN_Q91Ncr02tel6xRuLZEGnt8hiLcwK-qKuuP3yNslHeYYBhwBIDzHhHlmBZgkd5fpMghrdltOptLaBWeX0dFIamx9GC03HKR1VFWoLir-2Yaap4kH3dSkxaQtmb2D8f0k3cfH8DvlwIXu_S3opEMISoZEGo9uOGJiWgcuUDkAGxtpzoiSOB1J7fcIaGglVXakdG4ZMQnP86IPHVmEwRMoKa8rqE6udNav2-Bf4DSS_FhbrjJsHWX4S1mIrjFgMbycSPVDclYwFkYPVihKfxyIRtuiTFSTesErabaVluO6i6egHAWzmiYHAWiMpBjOdyHlRhMN3H_8B6P1hB-h5DZRkgA4l6wQS2BPWMOtALncgQWKqzvASslqDlSL8xSAws2Gh84cft8O4KAYopjqbGxhcGryJPrlXcWuLWccTQBWu2yd-h487qO-OpOMvptQ7OCs2OEH3__xaK-TqztH-Xrg3PNh9QK6BTe_hgafjL5Nemc_1Q3JFfSvHRf7IyCtKPl80l_8EQu3Q7w
linkToPdf	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1R3LbtQw0CoLQlyA8upCoQaBgEO6mzix4wNCfbBlVViiFlDFJTiJU1baTZYkC-qv8XXM5EWDKuDSA5dIicdWPJlnPA9CHsc8DLnJlSGVtMBBCYUhMZMrANMZHw2ZrcpmE2IycY-OpLdCfjS5MBhW2cjEUlBHaYj_yAcmB4cbjAVnOIjrsAhvd_Ry8dXADlJ40tq006hIZF-ffAf3LX8x3oVv_cSyRq_e77w26g4DRsilVcBV4VGlCTcyMF03Av3H7FgoxUPs48S0dpUjsWi6w5woUBzcyYjHARORlo7NYN0L5KIAHxPDCT3nU6MFQI5wXqfqMWEOasrYXKSJ3gSlAKQvOqqw7BjQ6oXeYpbmZxm9v8dunlKGo2v_Mxqvk6u1CU63Kp5ZJSs6uUFWayGX02d1Je7nN0nmZSkGIgIgPcBEfGQRmsbUy_SpxDW6p-ZzZewBE6v5yawofQEYzTWdJtSrKtfmFH95w8yyugd9qwuFyVwwexvzAgq6g4tnt8iHc9n7bdJLgCjWCA00GONmwMDkdG0WahdkY6QdK4ijaKi00yesoRc_rCu4YyORmV8eSwrw5CoM-khlfk1lfWK0sxbVHv8Cv42k2MJi_fHyQZod-7U48wMWwdvJWA9DbivG3MDCKkax4JGMpSn7ZAMJ2a-SeVsp6m_ZaFIK14XNPCohsAZJgmR4rJZ57o_fffwHoMODDtDTGihOAR2hqhNLYE9Y26wDud6BBEkadobXkO0arOT-L2aBmQ07nT38sB3GRTFwMdHpsoTBpcHL6JM7Fee2mLUcCVRh230iOjzdQX13JJl-KUvAgxNjgnN098-vtUEuA3P7b8aT_XvkCpj6Dp6DWmKd9Ipsqe-TS-G3YppnD0rRRcnn82byn3g22bk
openUrl	ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Prognostic+Relevance+of+Pretherapeutic+Gamma-Glutamyltransferase+in+Patients+with+Primary+Metastatic+Breast+Cancer&rft.jtitle=PloS+one&rft.au=Staudigl%2C+Christine&rft.au=Concin%2C+Nicole&rft.au=Grimm%2C+Christoph&rft.au=Pfeiler%2C+Georg&rft.date=2015-04-27&rft.pub=Public+Library+of+Science&rft.issn=1932-6203&rft.eissn=1932-6203&rft.volume=10&rft.issue=4&rft_id=info:doi/10.1371%2Fjournal.pone.0125317&rft.externalDocID=A421817885
thumbnail_l	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1932-6203&client=summon
thumbnail_m	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1932-6203&client=summon
thumbnail_s	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1932-6203&client=summon