Association between tocilizumab, sarilumab and all-cause mortality at 28 days in hospitalised patients with COVID-19: A network meta-analysis

A recent prospective meta-analysis demonstrated that interleukin-6 antagonists are associated with lower all-cause mortality in hospitalised patients with COVID-19, compared with usual care or placebo. However, emerging evidence suggests that clinicians are favouring the use of tocilizumab over sari...

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Bibliographic Details
Published in:	PloS one Vol. 17; no. 7; p. e0270668
Main Authors:	Godolphin, Peter J., Fisher, David J., Berry, Lindsay R., Derde, Lennie P. G., Diaz, Janet V., Gordon, Anthony C., Lorenzi, Elizabeth, Marshall, John C., Murthy, Srinivas, Shankar-Hari, Manu, Sterne, Jonathan A. C., Tierney, Jayne F., Vale, Claire L.
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 08.07.2022 Public Library of Science (PLoS)
Subjects:	Adrenal Cortex Hormones - therapeutic use Antibodies, Monoclonal, Humanized Bias Biology and Life Sciences Clinical trials Computer and Information Sciences Coronaviruses Corticoids Corticosteroids COVID-19 COVID-19 Drug Treatment Cytokines Extracorporeal membrane oxygenation Fatalities Health aspects Health risks Humans Interleukin 6 Medicine and Health Sciences Meta-analysis Monoclonal antibodies Mortality Patients Physical Sciences Placebos Prospective Studies Randomization Randomized Controlled Trials as Topic Research and Analysis Methods Review boards Steroids Ventilation Ventilators United Kingdom
ISSN:	1932-6203, 1932-6203
Online Access:	Get full text
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