Localising Loci underlying Complex Trait Variation Using Regional Genomic Relationship Mapping

The limited proportion of complex trait variance identified in genome-wide association studies may reflect the limited power of single SNP analyses to detect either rare causative alleles or those of small effect. Motivated by studies that demonstrate that loci contributing to trait variation may co...

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Bibliographic Details
Published in:	PloS one Vol. 7; no. 10; p. e46501
Main Authors:	Nagamine, Yoshitaka, Pong-Wong, Ricardo, Navarro, Pau, Vitart, Veronique, Hayward, Caroline, Rudan, Igor, Campbell, Harry, Wilson, James, Wild, Sarah, Hicks, Andrew A., Pramstaller, Peter P., Hastie, Nicholas, Wright, Alan F., Haley, Chris S.
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 15.10.2012 Public Library of Science (PLoS)
Subjects:	Alleles Analysis Association analysis Bioinformatics Biology Blood serum Chromosome Mapping Data processing Deoxyribonucleic acid DNA Gametes Gene mapping Genetic diversity Genetic Linkage Genetic variance Genome, Human Genome-wide association studies Genome-Wide Association Study Genomes Genomics Health sciences Heritability Hospitals Humans Loci Mapping Medical schools Medicine Pedigree Polymorphism, Single Nucleotide Population Power Quantitative genetics Quantitative Trait Loci Regional analysis Regional development Simulation Single nucleotide polymorphisms Single-nucleotide polymorphism Studies Uric acid Variance analysis Variation Italy Scotland Edinburgh Scotland United Kingdom > UK Germany Croatia
ISSN:	1932-6203, 1932-6203
Online Access:	Get full text
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