A Multi-Functional Imaging Approach to High-Content Protein Interaction Screening

Functional imaging can provide a level of quantification that is not possible in what might be termed traditional high-content screening. This is due to the fact that the current state-of-the-art high-content screening systems take the approach of scaling-up single cell assays, and are therefore bas...

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Veröffentlicht in:	PloS one Jg. 7; H. 4; S. e33231
Hauptverfasser:	Matthews, Daniel R., Fruhwirth, Gilbert O., Weitsman, Gregory, Carlin, Leo M., Ofo, Enyinnaya, Keppler, Melanie, Barber, Paul R., Tullis, Iain D. C., Vojnovic, Borivoj, Ng, Tony, Ameer-Beg, Simon M.
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States Public Library of Science 10.04.2012 Public Library of Science (PLoS)
Schlagworte:	Amino acids Analytical chemistry Anisotropy Assaying Biology Biophysics Biosensing Techniques - instrumentation Biosensing Techniques - methods Biosensors Cancer Cdc42 protein Cell Line, Tumor Chemokines CXCR4 protein Data analysis Detection equipment Energy transfer Fluorescence Fluorescence Polarization - instrumentation Fluorescence Polarization - methods Fluorescence resonance energy transfer Fluorescence Resonance Energy Transfer - instrumentation Fluorescence Resonance Energy Transfer - methods Green Fluorescent Proteins - chemistry Humans Image processing Information processing Instrumentation Internalization Lifetime Luminescent Proteins - chemistry Medical imaging Microscopy Oncology Photons Physics Protein interaction Protein Interaction Domains and Motifs Protein-protein interactions Proteins Proteins - chemistry Receptors, CXCR4 - chemistry Recipes Red Fluorescent Protein Scaling Screening Sensitivity and Specificity Small Molecule Libraries - chemistry Studies Time correlation functions United Kingdom > UK United States > US
ISSN:	1932-6203, 1932-6203
Online-Zugang:	Volltext
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