Exosomes Derived from Mesenchymal Stem Cells Suppress Angiogenesis by Down-Regulating VEGF Expression in Breast Cancer Cells

Exosomes are small membrane vesicles released by a variety of cell types. Exosomes contain genetic materials, such as mRNAs and microRNAs (miRNAs), implying that they may play a pivotal role in cell-to-cell communication. Mesenchymal stem cells (MSCs), which potentially differentiate into multiple c...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	PloS one Jg. 8; H. 12; S. e84256
Hauptverfasser:	Lee, Jong-Kuen, Park, Sae-Ra, Jung, Bong-Kwang, Jeon, Yoon-Kyung, Lee, Yeong-Shin, Kim, Min-Kyoung, Kim, Yong-Goo, Jang, Ji-Young, Kim, Chul-Woo
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States Public Library of Science 31.12.2013 Public Library of Science (PLoS)
Schlagworte:	Angiogenesis Animals Biology Blotting, Western Breast cancer Breast Neoplasms - metabolism Breast Neoplasms - physiopathology Cancer Cancer cells Cell interactions Cell Line, Tumor Cell migration Development and progression DNA Primers - genetics Enzyme-Linked Immunosorbent Assay Exosomes Exosomes - metabolism Female Gene Expression Regulation, Neoplastic - physiology Hostages Immunohistochemistry Immunomodulation In vivo methods and tests Medical research Medicine Membrane vesicles Mesenchymal stem cells Mesenchymal Stem Cells - cytology Mesenchyme Mice Mice, Inbred BALB C MicroRNA MicroRNAs - metabolism miRNA Neovascularization, Pathologic - metabolism Paracrine signalling Physicians Real-Time Polymerase Chain Reaction Ribonucleic acid RNA Stem cells Tumor cells Tumor Microenvironment - physiology Tumors Vascular endothelial growth factor Vascular Endothelial Growth Factor A - metabolism Vesicles
ISSN:	1932-6203, 1932-6203
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Abstract	Exosomes are small membrane vesicles released by a variety of cell types. Exosomes contain genetic materials, such as mRNAs and microRNAs (miRNAs), implying that they may play a pivotal role in cell-to-cell communication. Mesenchymal stem cells (MSCs), which potentially differentiate into multiple cell types, can migrate to the tumor sites and have been reported to exert complex effects on tumor progression. To elucidate the role of MSCs within the tumor microenvironment, previous studies have suggested various mechanisms such as immune modulation and secreted factors of MSCs. However, the paracrine effects of MSC-derived exosomes on the tumor microenvironment remain to be explored. The hypothesis of this study was that MSC-derived exosomes might reprogram tumor behavior by transferring their molecular contents. To test this hypothesis, exosomes from MSCs were isolated and characterized. MSC-derived exosomes exhibited different protein and RNA profiles compared with their donor cells and these vesicles could be internalized by breast cancer cells. The results demonstrated that MSC-derived exosomes significantly down-regulated the expression of vascular endothelial growth factor (VEGF) in tumor cells, which lead to inhibition of angiogenesis in vitro and in vivo. Additionally, miR-16, a miRNA known to target VEGF, was enriched in MSC-derived exosomes and it was partially responsible for the anti-angiogenic effect of MSC-derived exosomes. The collective results suggest that MSC-derived exosomes may serve as a significant mediator of cell-to-cell communication within the tumor microenvironment and suppress angiogenesis by transferring anti-angiogenic molecules.
AbstractList	Exosomes are small membrane vesicles released by a variety of cell types. Exosomes contain genetic materials, such as mRNAs and microRNAs (miRNAs), implying that they may play a pivotal role in cell-to-cell communication. Mesenchymal stem cells (MSCs), which potentially differentiate into multiple cell types, can migrate to the tumor sites and have been reported to exert complex effects on tumor progression. To elucidate the role of MSCs within the tumor microenvironment, previous studies have suggested various mechanisms such as immune modulation and secreted factors of MSCs. However, the paracrine effects of MSC-derived exosomes on the tumor microenvironment remain to be explored. The hypothesis of this study was that MSC-derived exosomes might reprogram tumor behavior by transferring their molecular contents. To test this hypothesis, exosomes from MSCs were isolated and characterized. MSC-derived exosomes exhibited different protein and RNA profiles compared with their donor cells and these vesicles could be internalized by breast cancer cells. The results demonstrated that MSC-derived exosomes significantly down-regulated the expression of vascular endothelial growth factor (VEGF) in tumor cells, which lead to inhibition of angiogenesis in vitro and in vivo. Additionally, miR-16, a miRNA known to target VEGF, was enriched in MSC-derived exosomes and it was partially responsible for the anti-angiogenic effect of MSC-derived exosomes. The collective results suggest that MSC-derived exosomes may serve as a significant mediator of cell-to-cell communication within the tumor microenvironment and suppress angiogenesis by transferring anti-angiogenic molecules. Exosomes are small membrane vesicles released by a variety of cell types. Exosomes contain genetic materials, such as mRNAs and microRNAs (miRNAs), implying that they may play a pivotal role in cell-to-cell communication. Mesenchymal stem cells (MSCs), which potentially differentiate into multiple cell types, can migrate to the tumor sites and have been reported to exert complex effects on tumor progression. To elucidate the role of MSCs within the tumor microenvironment, previous studies have suggested various mechanisms such as immune modulation and secreted factors of MSCs. However, the paracrine effects of MSC-derived exosomes on the tumor microenvironment remain to be explored. The hypothesis of this study was that MSC-derived exosomes might reprogram tumor behavior by transferring their molecular contents. To test this hypothesis, exosomes from MSCs were isolated and characterized. MSC-derived exosomes exhibited different protein and RNA profiles compared with their donor cells and these vesicles could be internalized by breast cancer cells. The results demonstrated that MSC-derived exosomes significantly down-regulated the expression of vascular endothelial growth factor (VEGF) in tumor cells, which lead to inhibition of angiogenesis in vitro and in vivo. Additionally, miR-16, a miRNA known to target VEGF, was enriched in MSC-derived exosomes and it was partially responsible for the anti-angiogenic effect of MSC-derived exosomes. The collective results suggest that MSC-derived exosomes may serve as a significant mediator of cell-to-cell communication within the tumor microenvironment and suppress angiogenesis by transferring anti-angiogenic molecules.Exosomes are small membrane vesicles released by a variety of cell types. Exosomes contain genetic materials, such as mRNAs and microRNAs (miRNAs), implying that they may play a pivotal role in cell-to-cell communication. Mesenchymal stem cells (MSCs), which potentially differentiate into multiple cell types, can migrate to the tumor sites and have been reported to exert complex effects on tumor progression. To elucidate the role of MSCs within the tumor microenvironment, previous studies have suggested various mechanisms such as immune modulation and secreted factors of MSCs. However, the paracrine effects of MSC-derived exosomes on the tumor microenvironment remain to be explored. The hypothesis of this study was that MSC-derived exosomes might reprogram tumor behavior by transferring their molecular contents. To test this hypothesis, exosomes from MSCs were isolated and characterized. MSC-derived exosomes exhibited different protein and RNA profiles compared with their donor cells and these vesicles could be internalized by breast cancer cells. The results demonstrated that MSC-derived exosomes significantly down-regulated the expression of vascular endothelial growth factor (VEGF) in tumor cells, which lead to inhibition of angiogenesis in vitro and in vivo. Additionally, miR-16, a miRNA known to target VEGF, was enriched in MSC-derived exosomes and it was partially responsible for the anti-angiogenic effect of MSC-derived exosomes. The collective results suggest that MSC-derived exosomes may serve as a significant mediator of cell-to-cell communication within the tumor microenvironment and suppress angiogenesis by transferring anti-angiogenic molecules.
Audience	Academic
Author	Kim, Yong-Goo Lee, Jong-Kuen Kim, Min-Kyoung Jung, Bong-Kwang Lee, Yeong-Shin Kim, Chul-Woo Park, Sae-Ra Jeon, Yoon-Kyung Jang, Ji-Young
AuthorAffiliation	1 Tumor Immunity Medical Research Center, Cancer Research Institute, Seoul National University College of Medicine, Seoul, South Korea University of Southern California, United States of America 2 Department of Pathology, Seoul National University College of Medicine, Seoul, South Korea
AuthorAffiliation_xml	– name: 1 Tumor Immunity Medical Research Center, Cancer Research Institute, Seoul National University College of Medicine, Seoul, South Korea – name: University of Southern California, United States of America – name: 2 Department of Pathology, Seoul National University College of Medicine, Seoul, South Korea
Author_xml	– sequence: 1 givenname: Jong-Kuen surname: Lee fullname: Lee, Jong-Kuen – sequence: 2 givenname: Sae-Ra surname: Park fullname: Park, Sae-Ra – sequence: 3 givenname: Bong-Kwang surname: Jung fullname: Jung, Bong-Kwang – sequence: 4 givenname: Yoon-Kyung surname: Jeon fullname: Jeon, Yoon-Kyung – sequence: 5 givenname: Yeong-Shin surname: Lee fullname: Lee, Yeong-Shin – sequence: 6 givenname: Min-Kyoung surname: Kim fullname: Kim, Min-Kyoung – sequence: 7 givenname: Yong-Goo surname: Kim fullname: Kim, Yong-Goo – sequence: 8 givenname: Ji-Young surname: Jang fullname: Jang, Ji-Young – sequence: 9 givenname: Chul-Woo surname: Kim fullname: Kim, Chul-Woo
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/24391924$$D View this record in MEDLINE/PubMed
BookMark	eNqNk11r2zAUhs3oWD-2fzA2wWBsF8n0FcvuxaBL0y7QUWi33gpZPnZUbCmT7C6F_fjJTTqaUsYwwuLoeV_pHM7ZT3ass5AkrwkeEybIp2vXe6ua8TKGxxhnnE7SZ8keyRkdpRSznQf73WQ_hGuMJyxL0xfJLuUsJznle8nv2coF10JAx-DNDZSo8q5F3yCA1YvbVjXosoMWTaFpArrsl0sPIaAjWxtXg4VgAipu0bH7ZUcXUPeN6oyt0dXs9ATNVnewcRYZi754UKFDU2U1-LXfy-R5pZoArzb_g-THyez79Ovo7Px0Pj06G-k0p92oqIQQoAguqFaQcUxUpSguMpamk7ykRZXyvNA656xinIuSEIwZmehMYVFVjB0kb9e-y8YFuSlckIQLxjjBIo_EfE2UTl3LpTet8rfSKSPvAs7XUvnO6AZkpqGgTJRskpacUJprnWFWxj1jZYxFr8-b2_qihVKD7bxqtky3T6xZyNrdSJYJQSfDYz5sDLz72UPoZGuCjgVTFlw_vDvHYlhZRN89Qp_ObkPVKiZgbOXivXowlUdciJwKInCkxk9Q8SuhNTp2WWVifEvwcUsQmQ5WXa36EOT88uL_2fOrbfb9A3YBqukWwTV9FzspbINvHlb6b4nv2zsCh2tAexeCh0pq06nBJ6ZmGkmwHGbpvmhymCW5maUo5o_E9_7_lP0BqrcinQ
CitedBy_id	crossref_primary_10_3390_ph13090241 crossref_primary_10_3389_fcell_2022_752818 crossref_primary_10_3892_or_2015_4512 crossref_primary_10_3390_ijms21072606 crossref_primary_10_1111_jcmm_13730 crossref_primary_10_1186_s12967_023_04284_3 crossref_primary_10_1016_j_arr_2019_100979 crossref_primary_10_1186_s12964_024_01705_8 crossref_primary_10_1155_2020_8844730 crossref_primary_10_1080_10409238_2018_1508276 crossref_primary_10_1007_s00018_016_2346_3 crossref_primary_10_1007_s40883_025_00449_2 crossref_primary_10_1016_j_rvsc_2021_02_016 crossref_primary_10_1155_2016_7653489 crossref_primary_10_5582_bst_2025_01120 crossref_primary_10_1002_bies_201800199 crossref_primary_10_1186_s12935_025_03689_y crossref_primary_10_1146_annurev_pharmtox_010814_124630 crossref_primary_10_1016_j_prp_2025_155984 crossref_primary_10_1007_s10565_021_09685_y crossref_primary_10_1016_j_bcp_2017_12_020 crossref_primary_10_1155_2018_7628763 crossref_primary_10_3390_biology10030172 crossref_primary_10_1088_2516_1091_ac73c9 crossref_primary_10_3390_cells10082066 crossref_primary_10_1002_ijc_32925 crossref_primary_10_3892_mmr_2016_5625 crossref_primary_10_34172_apb_2024_052 crossref_primary_10_1007_s10565_022_09759_5 crossref_primary_10_1111_cpr_13452 crossref_primary_10_3390_cells12172144 crossref_primary_10_1016_j_prp_2024_155214 crossref_primary_10_1038_s41392_021_00779_x crossref_primary_10_3390_life12101567 crossref_primary_10_3389_fendo_2023_1202493 crossref_primary_10_3390_cancers12082179 crossref_primary_10_1007_s12094_017_1677_3 crossref_primary_10_1186_s12943_018_0831_z crossref_primary_10_3389_fimmu_2014_00518 crossref_primary_10_1155_2021_6690704 crossref_primary_10_1016_j_ijpharm_2018_07_067 crossref_primary_10_1177_0963689717738256 crossref_primary_10_1242_bio_015990 crossref_primary_10_1371_journal_pone_0129292 crossref_primary_10_3390_nano10071274 crossref_primary_10_1186_s13287_017_0600_8 crossref_primary_10_1186_s12935_022_02755_z crossref_primary_10_1016_j_molimm_2021_11_010 crossref_primary_10_1038_onc_2015_13 crossref_primary_10_1002_cbin_11691 crossref_primary_10_3389_fcvm_2021_571076 crossref_primary_10_1111_cmi_13249 crossref_primary_10_1177_1533033818821421 crossref_primary_10_1007_s10495_023_01863_z crossref_primary_10_1038_s41598_021_87153_7 crossref_primary_10_1016_j_bbcan_2014_07_011 crossref_primary_10_1002_adbi_201800079 crossref_primary_10_3390_cancers9070071 crossref_primary_10_1016_j_addr_2014_09_001 crossref_primary_10_1186_s13287_015_0214_y crossref_primary_10_1177_2047487320919894 crossref_primary_10_1016_j_isci_2022_104200 crossref_primary_10_1016_j_mehy_2024_111353 crossref_primary_10_2478_acb_2019_0013 crossref_primary_10_1016_j_trsl_2019_03_008 crossref_primary_10_1155_2022_8392509 crossref_primary_10_1186_s13287_023_03245_3 crossref_primary_10_1177_2041731418810093 crossref_primary_10_3390_ijms25031618 crossref_primary_10_1016_j_trsl_2020_04_002 crossref_primary_10_1155_2017_6305295 crossref_primary_10_1038_s41598_019_47581_y crossref_primary_10_1038_s41598_018_36855_6 crossref_primary_10_1016_j_omtn_2022_01_009 crossref_primary_10_1016_j_semcancer_2022_06_001 crossref_primary_10_1016_j_jtos_2024_10_005 crossref_primary_10_2147_IJN_S463333 crossref_primary_10_1038_s41598_017_15505_3 crossref_primary_10_1038_s41597_024_04164_5 crossref_primary_10_1016_j_bbcan_2023_188908 crossref_primary_10_1007_s13402_018_0378_4 crossref_primary_10_1007_s13577_020_00332_y crossref_primary_10_1002_1878_0261_12855 crossref_primary_10_3389_fendo_2024_1409000 crossref_primary_10_1002_jcp_28374 crossref_primary_10_3892_or_2014_3605 crossref_primary_10_1002_cbin_11884 crossref_primary_10_1007_s11064_018_2641_5 crossref_primary_10_1007_s10120_021_01269_3 crossref_primary_10_1016_j_bbcan_2024_189177 crossref_primary_10_1007_s12094_020_02504_6 crossref_primary_10_1038_srep38743 crossref_primary_10_3892_or_2024_8846 crossref_primary_10_3892_or_2015_4109 crossref_primary_10_1186_s12886_015_0138_4 crossref_primary_10_3389_fbioe_2021_797359 crossref_primary_10_1016_j_exer_2020_108271 crossref_primary_10_3389_fcell_2017_00006 crossref_primary_10_1089_scd_2016_0120 crossref_primary_10_1186_s13287_022_02764_9 crossref_primary_10_1016_j_jcyt_2017_11_006 crossref_primary_10_34133_bmr_0119 crossref_primary_10_1016_j_abb_2024_110277 crossref_primary_10_3390_ijms15034142 crossref_primary_10_3390_ijms21197362 crossref_primary_10_1016_j_tice_2017_01_007 crossref_primary_10_1373_clinchem_2015_240028 crossref_primary_10_1016_j_jddst_2024_105375 crossref_primary_10_3390_cells10030587 crossref_primary_10_1002_ijc_31796 crossref_primary_10_1016_j_jnutbio_2017_09_018 crossref_primary_10_3389_fonc_2023_1299384 crossref_primary_10_1038_s41419_018_0323_5 crossref_primary_10_3390_ijms232213974 crossref_primary_10_1186_s12935_025_03795_x crossref_primary_10_1002_stem_2829 crossref_primary_10_3389_fncel_2014_00377 crossref_primary_10_1002_bmm2_12018 crossref_primary_10_1038_s41419_022_05069_0 crossref_primary_10_3390_biom14091099 crossref_primary_10_3390_cancers11060798 crossref_primary_10_1155_2015_501581 crossref_primary_10_1016_j_lfs_2025_123472 crossref_primary_10_1155_2019_6854080 crossref_primary_10_3389_fphar_2021_692551 crossref_primary_10_3390_ijms20246180 crossref_primary_10_3390_ijms242216197 crossref_primary_10_1016_j_pharmthera_2017_02_020 crossref_primary_10_3390_ijms23062927 crossref_primary_10_1016_j_arr_2020_101106 crossref_primary_10_3390_medicines2040310 crossref_primary_10_3390_ijms20236016 crossref_primary_10_3389_fphar_2023_1136614 crossref_primary_10_1016_j_vesic_2024_100056 crossref_primary_10_1186_s12943_019_1085_0 crossref_primary_10_1155_2015_734731 crossref_primary_10_3390_ncrna3010010 crossref_primary_10_1038_emm_2017_63 crossref_primary_10_1016_j_canlet_2021_11_015 crossref_primary_10_3390_ijms241310917 crossref_primary_10_1016_j_jddst_2024_106315 crossref_primary_10_1016_j_exer_2020_108363 crossref_primary_10_3390_ph17060707 crossref_primary_10_15407_biotech7_06_102 crossref_primary_10_1007_s00266_022_03088_y crossref_primary_10_3390_ijms20122853 crossref_primary_10_1016_j_biopha_2024_116559 crossref_primary_10_3390_cells12242788 crossref_primary_10_1007_s11010_016_2927_3 crossref_primary_10_1016_j_ygeno_2022_110341 crossref_primary_10_3892_or_2024_8766 crossref_primary_10_1080_20013078_2017_1265291 crossref_primary_10_3390_cells10081959 crossref_primary_10_1002_term_2205 crossref_primary_10_1016_j_jconrel_2017_07_023 crossref_primary_10_1002_adtp_202300195 crossref_primary_10_3389_fbioe_2021_745314 crossref_primary_10_3390_app10134428 crossref_primary_10_1083_jcb_201601025 crossref_primary_10_1016_j_bbcan_2016_10_004 crossref_primary_10_1186_s12935_025_03900_0 crossref_primary_10_1111_cas_14563 crossref_primary_10_2147_IJN_S479306 crossref_primary_10_3390_biomedicines12030489 crossref_primary_10_3892_ijo_2016_3453 crossref_primary_10_7717_peerj_4196 crossref_primary_10_1371_journal_pone_0242057 crossref_primary_10_1016_j_jddst_2024_106144 crossref_primary_10_4252_wjsc_v15_i5_400 crossref_primary_10_1016_j_lfs_2016_03_024 crossref_primary_10_1177_03000605211002975 crossref_primary_10_1007_s12672_024_01590_0 crossref_primary_10_1186_s13287_021_02196_x crossref_primary_10_1038_s41417_022_00427_8 crossref_primary_10_1111_cas_13334 crossref_primary_10_1016_j_canlet_2022_216036 crossref_primary_10_1007_s11033_019_05018_9 crossref_primary_10_3389_fimmu_2022_1013506 crossref_primary_10_3390_cancers14153761 crossref_primary_10_2147_IJN_S407029 crossref_primary_10_1111_bjh_18292 crossref_primary_10_1155_2017_1758139 crossref_primary_10_3389_fncel_2016_00109 crossref_primary_10_1080_14712598_2020_1738377 crossref_primary_10_3389_fimmu_2018_01534 crossref_primary_10_1016_j_imlet_2015_06_019 crossref_primary_10_4331_wjbc_v12_i2_15 crossref_primary_10_1155_2015_120949 crossref_primary_10_3390_cancers15184425 crossref_primary_10_1016_j_gene_2018_05_003 crossref_primary_10_1111_voxs_12636 crossref_primary_10_1007_s12015_014_9545_9 crossref_primary_10_3390_biology10040307 crossref_primary_10_1016_j_bbcan_2017_06_005 crossref_primary_10_1007_s13277_015_4304_3 crossref_primary_10_3390_cancers14071851 crossref_primary_10_1016_j_semcdb_2017_12_011 crossref_primary_10_3389_fphys_2023_1247734 crossref_primary_10_3390_biomedicines13020353 crossref_primary_10_1016_j_semcdb_2015_02_011 crossref_primary_10_1016_j_canlet_2018_01_061 crossref_primary_10_1186_s12935_024_03464_5 crossref_primary_10_1155_2019_6458237 crossref_primary_10_1007_s12031_015_0539_0 crossref_primary_10_3389_fimmu_2014_00382 crossref_primary_10_1007_s40610_016_0034_6 crossref_primary_10_1002_adhm_202101296 crossref_primary_10_3390_cimb46070459 crossref_primary_10_1089_ten_teb_2019_0252 crossref_primary_10_1155_2021_6649314 crossref_primary_10_1371_journal_pone_0159163 crossref_primary_10_32604_biocell_2023_027090 crossref_primary_10_1016_j_cytogfr_2024_01_004 crossref_primary_10_3389_fonc_2019_00840 crossref_primary_10_1016_j_ccell_2018_05_012 crossref_primary_10_3390_ijms231810972 crossref_primary_10_1016_j_smim_2017_12_003 crossref_primary_10_1089_ten_tea_2016_0508 crossref_primary_10_1016_j_reth_2025_03_006 crossref_primary_10_1016_j_bcab_2023_102947 crossref_primary_10_1038_srep28433 crossref_primary_10_1007_s00018_019_03268_1 crossref_primary_10_3390_app14041639 crossref_primary_10_1007_s12011_022_03146_1 crossref_primary_10_1186_s12964_023_01111_6 crossref_primary_10_1080_1061186X_2025_2535375 crossref_primary_10_1186_s12885_024_13173_x crossref_primary_10_1089_cell_2017_0047 crossref_primary_10_1007_s10549_015_3326_2 crossref_primary_10_1016_j_intimp_2025_114782 crossref_primary_10_1186_s13045_022_01305_4 crossref_primary_10_1016_j_yexmp_2020_104569 crossref_primary_10_1016_j_ijpharm_2021_120943 crossref_primary_10_1007_s10555_019_09813_5 crossref_primary_10_1038_s41573_022_00410_w crossref_primary_10_1007_s10142_025_01531_2 crossref_primary_10_3389_fimmu_2025_1525052 crossref_primary_10_3389_fbioe_2023_1149662 crossref_primary_10_3390_ncrna5010001 crossref_primary_10_1016_j_phrs_2025_107751 crossref_primary_10_1155_2016_3409169 crossref_primary_10_3390_ph18071050 crossref_primary_10_1186_s12967_020_02426_5 crossref_primary_10_3389_fgene_2023_1134779 crossref_primary_10_1111_boc_202100081 crossref_primary_10_1007_s00709_023_01896_w crossref_primary_10_1016_j_bbrc_2024_150129 crossref_primary_10_1016_j_ejca_2020_11_033 crossref_primary_10_1089_ten_tea_2019_0175 crossref_primary_10_3390_ijms18091852 crossref_primary_10_1016_j_biomaterials_2019_119675 crossref_primary_10_1111_php_13633 crossref_primary_10_1155_2023_7059289 crossref_primary_10_1186_s13287_016_0363_7 crossref_primary_10_1517_14712598_2016_1170804 crossref_primary_10_2217_bmm_2017_0305 crossref_primary_10_3389_fimmu_2018_01767 crossref_primary_10_1007_s10735_024_10335_w crossref_primary_10_1111_ajco_13969 crossref_primary_10_3389_fonc_2025_1592006 crossref_primary_10_1007_s11010_024_04934_0 crossref_primary_10_3389_fcell_2021_731062 crossref_primary_10_3390_cells9051145 crossref_primary_10_1039_D0BM01735C crossref_primary_10_1038_mt_2015_44 crossref_primary_10_1007_s12015_019_09944_w crossref_primary_10_1186_s12907_015_0005_5 crossref_primary_10_1016_j_lfs_2021_120210 crossref_primary_10_1155_2019_1460572 crossref_primary_10_3389_fimmu_2022_1025218 crossref_primary_10_1007_s13577_019_00315_8 crossref_primary_10_1007_s13402_017_0335_7 crossref_primary_10_1016_j_repbio_2020_07_002 crossref_primary_10_1038_s41375_018_0373_9 crossref_primary_10_1186_s13058_024_01810_z crossref_primary_10_1016_j_intimp_2024_112171 crossref_primary_10_3390_ijms20163884 crossref_primary_10_1002_sctm_20_0501 crossref_primary_10_1242_jcs_216135 crossref_primary_10_1038_s41388_023_02827_y crossref_primary_10_1016_j_humimm_2020_05_009 crossref_primary_10_1080_14737175_2025_2490543 crossref_primary_10_1155_2015_701390 crossref_primary_10_3390_ijms24076363 crossref_primary_10_1080_10717544_2022_2104404 crossref_primary_10_1016_j_bbcan_2017_10_001 crossref_primary_10_3390_ijms22010014 crossref_primary_10_1007_s12079_023_00794_3 crossref_primary_10_1080_13813455_2020_1760303 crossref_primary_10_3389_fncel_2017_00055 crossref_primary_10_1111_cas_15801 crossref_primary_10_1002_bab_1561 crossref_primary_10_1038_s41598_018_20421_1 crossref_primary_10_1002_adbi_202101050 crossref_primary_10_2147_BCTT_S432750 crossref_primary_10_1007_s10616_017_0095_2 crossref_primary_10_1016_j_canlet_2015_11_016 crossref_primary_10_3389_fbioe_2022_1019459 crossref_primary_10_3389_fbioe_2023_1214190 crossref_primary_10_3390_cancers14163908 crossref_primary_10_3892_ol_2017_5824 crossref_primary_10_18632_oncotarget_9852 crossref_primary_10_15171_apb_2016_041 crossref_primary_10_1016_j_biosystems_2021_104587 crossref_primary_10_1089_cell_2022_0133 crossref_primary_10_3892_ol_2022_13476 crossref_primary_10_4993_acrt_28_3 crossref_primary_10_1134_S1990747816020112 crossref_primary_10_3390_ijms26073095 crossref_primary_10_1371_journal_pone_0148454 crossref_primary_10_4251_wjgo_v13_i12_1981 crossref_primary_10_3390_ijms25158178 crossref_primary_10_3390_cells9051171 crossref_primary_10_3390_jcm10040711 crossref_primary_10_1136_jim_2021_002194 crossref_primary_10_1007_s00109_022_02276_2 crossref_primary_10_1002_cbf_3962 crossref_primary_10_1002_1878_0261_12189 crossref_primary_10_1007_s10522_014_9510_7 crossref_primary_10_1002_gcc_22244 crossref_primary_10_1016_j_jns_2015_03_014 crossref_primary_10_5114_aoms_128387 crossref_primary_10_1016_j_bioactmat_2021_03_015 crossref_primary_10_1016_j_preteyeres_2017_04_004 crossref_primary_10_1038_s41419_018_0949_3 crossref_primary_10_1111_srt_13694 crossref_primary_10_1002_ijc_31089 crossref_primary_10_1016_j_jconrel_2023_07_059 crossref_primary_10_1016_j_genrep_2018_06_012 crossref_primary_10_1002_dvg_22871 crossref_primary_10_1007_s12015_021_10163_5 crossref_primary_10_1002_jev2_70005 crossref_primary_10_1016_j_prp_2023_154795 crossref_primary_10_3390_ncrna5010028 crossref_primary_10_1016_j_bbcan_2018_12_001 crossref_primary_10_3389_fonc_2016_00125 crossref_primary_10_1007_s11033_023_08422_4 crossref_primary_10_3390_vaccines11061028 crossref_primary_10_1016_j_biopha_2021_111875 crossref_primary_10_2147_DDDT_S239546 crossref_primary_10_1039_D4RA04512B crossref_primary_10_2147_IJN_S291956 crossref_primary_10_1177_0300060518792368 crossref_primary_10_1039_C8SC03224F crossref_primary_10_1155_2020_8813447 crossref_primary_10_1186_s40001_023_01463_2 crossref_primary_10_3390_cancers13205212 crossref_primary_10_3892_ijo_2015_3255 crossref_primary_10_3390_ijms24021012 crossref_primary_10_1016_j_semcdb_2023_01_009 crossref_primary_10_1186_s40001_023_01606_5 crossref_primary_10_1016_j_glmedi_2023_100041 crossref_primary_10_1016_j_biopha_2023_115505 crossref_primary_10_1016_j_prp_2020_153326 crossref_primary_10_1186_s13045_021_01141_y crossref_primary_10_3390_ijms222011035 crossref_primary_10_1002_jcp_29668 crossref_primary_10_1186_s40880_015_0051_5 crossref_primary_10_3389_fphys_2016_00024 crossref_primary_10_15171_apb_2019_063 crossref_primary_10_3892_ijo_2015_3001 crossref_primary_10_1186_s12935_021_01836_9 crossref_primary_10_3390_ph14040345 crossref_primary_10_1002_smll_202205739 crossref_primary_10_3389_fcell_2022_900418 crossref_primary_10_1016_j_canlet_2019_06_012 crossref_primary_10_1155_2018_4837370 crossref_primary_10_1038_celldisc_2016_15 crossref_primary_10_1002_2211_5463_12004 crossref_primary_10_3390_ijms17020171 crossref_primary_10_1038_onc_2015_89 crossref_primary_10_1111_jcmm_17024 crossref_primary_10_3389_fbioe_2023_1215650 crossref_primary_10_1186_s13287_017_0516_3 crossref_primary_10_3390_cells9020312 crossref_primary_10_1002_jcb_29130 crossref_primary_10_3389_fgene_2022_847679 crossref_primary_10_1016_j_biopha_2025_118481 crossref_primary_10_1016_j_lfs_2023_121621 crossref_primary_10_2217_nnm_2020_0256 crossref_primary_10_1016_j_chemphyslip_2022_105179 crossref_primary_10_1155_2016_1073140 crossref_primary_10_3389_fimmu_2018_00824 crossref_primary_10_32604_biocell_2023_044177 crossref_primary_10_1002_bit_28053 crossref_primary_10_1016_j_heliyon_2023_e18626 crossref_primary_10_1186_s13045_021_01208_w crossref_primary_10_3389_fphys_2019_00227 crossref_primary_10_3390_ijms17122028 crossref_primary_10_3390_ijms21207688 crossref_primary_10_3390_pharmaceutics15102462 crossref_primary_10_1016_j_jconrel_2019_07_021 crossref_primary_10_1089_scd_2015_0278 crossref_primary_10_1186_s13287_019_1398_3 crossref_primary_10_1016_j_csbj_2016_10_005 crossref_primary_10_2174_1381612825666190701143845 crossref_primary_10_1111_bph_15861 crossref_primary_10_3390_ijms21186818 crossref_primary_10_1038_gt_2017_8 crossref_primary_10_1007_s11010_021_04328_6 crossref_primary_10_1186_s11658_018_0123_z crossref_primary_10_1002_mco2_663 crossref_primary_10_1002_jcp_27326 crossref_primary_10_3892_ijmm_2022_5206 crossref_primary_10_1111_cpr_12570 crossref_primary_10_1080_08820139_2020_1712416 crossref_primary_10_3389_fcell_2022_728616 crossref_primary_10_1016_j_biopha_2025_118374 crossref_primary_10_1002_jcp_27342 crossref_primary_10_1007_s00395_021_00881_9 crossref_primary_10_1038_s41598_022_17767_y crossref_primary_10_3390_life11080784 crossref_primary_10_1016_j_critrevonc_2015_04_002 crossref_primary_10_1007_s13277_016_5394_2 crossref_primary_10_1016_j_jcyt_2015_10_008 crossref_primary_10_1186_s12935_021_01848_5 crossref_primary_10_1177_1010428317691182 crossref_primary_10_3390_ani14152147 crossref_primary_10_1007_s13577_021_00599_9 crossref_primary_10_1186_s13287_020_01943_w crossref_primary_10_1038_srep19857 crossref_primary_10_1002_jcp_28511 crossref_primary_10_2174_0115680266299112240514103048 crossref_primary_10_3390_ijms25147791 crossref_primary_10_3389_fphys_2017_00275 crossref_primary_10_1111_jcmm_12834 crossref_primary_10_3390_biology11060813 crossref_primary_10_3390_biom12010132 crossref_primary_10_1016_j_semcancer_2022_09_002 crossref_primary_10_1007_s11033_025_10794_8 crossref_primary_10_1186_s13287_021_02378_7 crossref_primary_10_1016_j_ijpharm_2024_124732 crossref_primary_10_1097_PRS_0000000000001321 crossref_primary_10_3389_fonc_2019_01135 crossref_primary_10_3390_ijms24087208 crossref_primary_10_3390_biom10010150 crossref_primary_10_1016_j_drudis_2019_06_010 crossref_primary_10_1007_s11010_017_3174_y crossref_primary_10_1158_1541_7786_MCR_16_0191
Cites_doi	10.1016/j.bbrc.2007.07.114 10.1038/sj.bjc.6604508 10.1007/s10555-010-9222-7 10.1038/leu.2008.384 10.1038/ncb1596 10.1016/j.gde.2009.04.002 10.3858/emm.2011.43.5.029 10.1002/ijc.21865 10.1074/jbc.274.43.31047 10.1634/theoncologist.5-suppl_1-3 10.1371/journal.pone.0011803 10.1084/jem.20051921 10.1186/1476-4598-10-117 10.1038/sj.onc.1210920 10.1371/journal.pone.0000116 10.1161/ATVBAHA.111.236521 10.1016/j.canlet.2011.10.002 10.1084/jem.183.3.1161 10.1371/journal.pone.0007669 10.1007/s11010-006-9361-x 10.1016/j.canlet.2008.10.021 10.1038/leu.2011.168 10.1002/stem.1247 10.1182/blood-2008-09-176198 10.1002/hep.24504 10.1111/j.1349-7006.2010.01650.x 10.1146/annurev-pharmtox-010510-100517 10.1634/stemcells.2007-0226 10.1002/stem.559 10.1182/blood-2003-04-1193 10.1371/journal.pone.0004722 10.1055/s-2007-1022548 10.1002/ijc.27657 10.1158/0008-5472.CAN-11-0241 10.1038/nrm1911 10.1038/nature06188 10.1006/meth.2001.1262 10.1007/978-3-540-68976-8_12 10.1038/ncb0309-228 10.1038/nri2395
ContentType	Journal Article
Copyright	COPYRIGHT 2013 Public Library of Science 2013 Lee et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. 2013 Lee et al 2013 Lee et al
Copyright_xml	– notice: COPYRIGHT 2013 Public Library of Science – notice: 2013 Lee et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. – notice: 2013 Lee et al 2013 Lee et al
DBID	AAYXX CITATION CGR CUY CVF ECM EIF NPM IOV ISR 3V. 7QG 7QL 7QO 7RV 7SN 7SS 7T5 7TG 7TM 7U9 7X2 7X7 7XB 88E 8AO 8C1 8FD 8FE 8FG 8FH 8FI 8FJ 8FK ABJCF ABUWG AEUYN AFKRA ARAPS ATCPS AZQEC BBNVY BENPR BGLVJ BHPHI C1K CCPQU D1I DWQXO FR3 FYUFA GHDGH GNUQQ H94 HCIFZ K9. KB. KB0 KL. L6V LK8 M0K M0S M1P M7N M7P M7S NAPCQ P5Z P62 P64 PATMY PDBOC PHGZM PHGZT PIMPY PJZUB PKEHL PPXIY PQEST PQGLB PQQKQ PQUKI PRINS PTHSS PYCSY RC3 7X8 5PM DOA
DOI	10.1371/journal.pone.0084256
DatabaseName	CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed Gale In Context: Opposing Viewpoints Gale In Context: Science ProQuest Central (Corporate) Animal Behavior Abstracts Bacteriology Abstracts (Microbiology B) Biotechnology Research Abstracts Nursing & Allied Health Database Ecology Abstracts Entomology Abstracts (Full archive) Immunology Abstracts Meteorological & Geoastrophysical Abstracts Nucleic Acids Abstracts Virology and AIDS Abstracts Agricultural Science Collection Health & Medical Collection ProQuest Central (purchase pre-March 2016) Medical Database (Alumni Edition) ProQuest Pharma Collection Public Health Database (ProQuest) Technology Research Database ProQuest SciTech Collection ProQuest Technology Collection ProQuest Natural Science Journals ProQuest Hospital Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) Materials Science & Engineering Collection ProQuest Central (Alumni) ProQuest One Sustainability ProQuest Central Advanced Technologies & Computer Science Collection Agricultural & Environmental Science Collection ProQuest Central Essentials Biological Science Collection ProQuest Central Technology Collection Natural Science Collection Environmental Sciences and Pollution Management ProQuest One ProQuest Materials Science Collection ProQuest Central Korea Engineering Research Database Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Central Student AIDS and Cancer Research Abstracts SciTech Premium Collection ProQuest Health & Medical Complete (Alumni) Materials Science Database Nursing & Allied Health Database (Alumni Edition) Meteorological & Geoastrophysical Abstracts - Academic ProQuest Engineering Collection Biological Sciences Agriculture Science Database ProQuest Health & Medical Collection Medical Database Algology Mycology and Protozoology Abstracts (Microbiology C) Biological Science Database Engineering Database Nursing & Allied Health Premium Advanced Technologies & Aerospace Database ProQuest Advanced Technologies & Aerospace Collection Biotechnology and BioEngineering Abstracts Environmental Science Database Materials Science Collection Proquest Central Premium ProQuest One Academic ProQuest Publicly Available Content Database ProQuest Health & Medical Research Collection ProQuest One Academic Middle East (New) ProQuest One Health & Nursing ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Applied & Life Sciences ProQuest One Academic (retired) ProQuest One Academic UKI Edition ProQuest Central China Engineering Collection Environmental Science Collection Genetics Abstracts MEDLINE - Academic PubMed Central (Full Participant titles) DOAJ Directory of Open Access Journals
DatabaseTitle	CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) Agricultural Science Database Publicly Available Content Database ProQuest Central Student ProQuest Advanced Technologies & Aerospace Collection ProQuest Central Essentials Nucleic Acids Abstracts SciTech Premium Collection ProQuest Central China Environmental Sciences and Pollution Management ProQuest One Applied & Life Sciences ProQuest One Sustainability Health Research Premium Collection Meteorological & Geoastrophysical Abstracts Natural Science Collection Health & Medical Research Collection Biological Science Collection ProQuest Central (New) ProQuest Medical Library (Alumni) Engineering Collection Advanced Technologies & Aerospace Collection Engineering Database Virology and AIDS Abstracts ProQuest Biological Science Collection ProQuest One Academic Eastern Edition Agricultural Science Collection ProQuest Hospital Collection ProQuest Technology Collection Health Research Premium Collection (Alumni) Biological Science Database Ecology Abstracts ProQuest Hospital Collection (Alumni) Biotechnology and BioEngineering Abstracts Environmental Science Collection Entomology Abstracts Nursing & Allied Health Premium ProQuest Health & Medical Complete ProQuest One Academic UKI Edition Environmental Science Database ProQuest Nursing & Allied Health Source (Alumni) Engineering Research Database ProQuest One Academic Meteorological & Geoastrophysical Abstracts - Academic ProQuest One Academic (New) Technology Collection Technology Research Database ProQuest One Academic Middle East (New) Materials Science Collection ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) ProQuest One Community College ProQuest One Health & Nursing ProQuest Natural Science Collection ProQuest Pharma Collection ProQuest Central ProQuest Health & Medical Research Collection Genetics Abstracts ProQuest Engineering Collection Biotechnology Research Abstracts Health and Medicine Complete (Alumni Edition) ProQuest Central Korea Bacteriology Abstracts (Microbiology B) Algology Mycology and Protozoology Abstracts (Microbiology C) Agricultural & Environmental Science Collection AIDS and Cancer Research Abstracts Materials Science Database ProQuest Materials Science Collection ProQuest Public Health ProQuest Nursing & Allied Health Source ProQuest SciTech Collection Advanced Technologies & Aerospace Database ProQuest Medical Library Animal Behavior Abstracts Materials Science & Engineering Collection Immunology Abstracts ProQuest Central (Alumni) MEDLINE - Academic
DatabaseTitleList	MEDLINE - Academic MEDLINE Agricultural Science Database
Database_xml	– sequence: 1 dbid: DOA name: DOAJ Directory of Open Access Journals url: https://www.doaj.org/ sourceTypes: Open Website – sequence: 2 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 3 dbid: PIMPY name: Publicly Available Content Database url: http://search.proquest.com/publiccontent sourceTypes: Aggregation Database
DeliveryMethod	fulltext_linktorsrc
Discipline	Sciences (General) Medicine Biology
DocumentTitleAlternate	MSC-Derived Exosomes Inhibit Angiogenesis
EISSN	1932-6203
ExternalDocumentID	1473341079 oai_doaj_org_article_8ceb237d356d41229cc803dd4133d56d PMC3877259 3170369911 A477927170 24391924 10_1371_journal_pone_0084256
Genre	Research Support, Non-U.S. Gov't Journal Article
GroupedDBID	--- 123 29O 2WC 53G 5VS 7RV 7X2 7X7 7XC 88E 8AO 8C1 8CJ 8FE 8FG 8FH 8FI 8FJ A8Z AAFWJ AAUCC AAWOE AAYXX ABDBF ABIVO ABJCF ABUWG ACCTH ACGFO ACIHN ACIWK ACPRK ACUHS ADBBV ADRAZ AEAQA AENEX AEUYN AFFHD AFKRA AFPKN AFRAH AHMBA ALMA_UNASSIGNED_HOLDINGS AOIJS APEBS ARAPS ATCPS BAWUL BBNVY BCNDV BENPR BGLVJ BHPHI BKEYQ BPHCQ BVXVI BWKFM CCPQU CITATION CS3 D1I D1J D1K DIK DU5 E3Z EAP EAS EBD EMOBN ESX EX3 F5P FPL FYUFA GROUPED_DOAJ GX1 HCIFZ HH5 HMCUK HYE IAO IEA IGS IHR IHW INH INR IOV IPNFZ IPY ISE ISR ITC K6- KB. KQ8 L6V LK5 LK8 M0K M1P M48 M7P M7R M7S M~E NAPCQ O5R O5S OK1 OVT P2P P62 PATMY PDBOC PHGZM PHGZT PIMPY PJZUB PPXIY PQGLB PQQKQ PROAC PSQYO PTHSS PYCSY RIG RNS RPM SV3 TR2 UKHRP WOQ WOW ~02 ~KM 3V. ALIPV BBORY CGR CUY CVF ECM EIF NPM PV9 RZL 7QG 7QL 7QO 7SN 7SS 7T5 7TG 7TM 7U9 7XB 8FD 8FK AZQEC C1K DWQXO ESTFP FR3 GNUQQ H94 K9. KL. M7N P64 PKEHL PQEST PQUKI PRINS RC3 7X8 PUEGO 5PM - 02 AAPBV ABPTK ADACO BBAFP KM
ID	FETCH-LOGICAL-c692t-bf777ea10b2cae8401afa20b836659d2bf649bcc943f3447d1100315c8a07ff33
IEDL.DBID	DOA
ISICitedReferencesCount	611
ISICitedReferencesURI	http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000329323900067&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
ISSN	1932-6203
IngestDate	Fri Nov 26 17:11:46 EST 2021 Fri Oct 03 12:44:09 EDT 2025 Tue Nov 04 02:00:58 EST 2025 Sun Sep 28 11:58:00 EDT 2025 Tue Oct 07 07:06:36 EDT 2025 Sat Nov 29 13:03:17 EST 2025 Sat Nov 29 10:23:38 EST 2025 Wed Nov 26 10:36:17 EST 2025 Wed Nov 26 09:37:48 EST 2025 Thu May 22 21:17:30 EDT 2025 Wed Feb 19 02:31:09 EST 2025 Sat Nov 29 05:18:44 EST 2025 Tue Nov 18 21:45:15 EST 2025
IsDoiOpenAccess	true
IsOpenAccess	true
IsPeerReviewed	true
IsScholarly	true
Issue	12
Language	English
License	This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. Creative Commons Attribution License
LinkModel	DirectLink
MergedId	FETCHMERGED-LOGICAL-c692t-bf777ea10b2cae8401afa20b836659d2bf649bcc943f3447d1100315c8a07ff33
Notes	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 Conceived and designed the experiments: JKL JYJ CWK. Performed the experiments: JKL SRP BKJ. Analyzed the data: JKL JYJ. Contributed reagents/materials/analysis tools: YSL MKK YGK. Wrote the paper: JKL YKJ JYJ. Competing Interests: The authors have declared that no competing interests exist.
OpenAccessLink	https://doaj.org/article/8ceb237d356d41229cc803dd4133d56d
PMID	24391924
PQID	1473341079
PQPubID	1436336
PageCount	e84256
ParticipantIDs	plos_journals_1473341079 doaj_primary_oai_doaj_org_article_8ceb237d356d41229cc803dd4133d56d pubmedcentral_primary_oai_pubmedcentral_nih_gov_3877259 proquest_miscellaneous_1490749078 proquest_journals_1473341079 gale_infotracmisc_A477927170 gale_infotracacademiconefile_A477927170 gale_incontextgauss_ISR_A477927170 gale_incontextgauss_IOV_A477927170 gale_healthsolutions_A477927170 pubmed_primary_24391924 crossref_citationtrail_10_1371_journal_pone_0084256 crossref_primary_10_1371_journal_pone_0084256
PublicationCentury	2000
PublicationDate	2013-12-31
PublicationDateYYYYMMDD	2013-12-31
PublicationDate_xml	– month: 12 year: 2013 text: 2013-12-31 day: 31
PublicationDecade	2010
PublicationPlace	United States
PublicationPlace_xml	– name: United States – name: San Francisco – name: San Francisco, USA
PublicationTitle	PloS one
PublicationTitleAlternate	PLoS One
PublicationYear	2013
Publisher	Public Library of Science Public Library of Science (PLoS)
Publisher_xml	– name: Public Library of Science – name: Public Library of Science (PLoS)
References	P Borgstrom (ref20) 1996; 56 F Djouad (ref13) 2003; 102 H Valadi (ref3) 2007; 9 ref10 HF Dvorak (ref40) 1999; 237 F Collino (ref28) 2010; 5 A Uccelli (ref11) 2008; 8 N Kosaka (ref9) 2010; 101 G Camussi (ref44) 2012 PN Bernatchez (ref41) 1999; 274 S Wang (ref19) 2009; 19 AE Karnoub (ref15) 2007; 449 Z Hua (ref39) 2006; 1 M Garofalo (ref6) 2011; 51 T Kogure (ref26) 2011; 54 B Hall (ref45) 2007 W Zhu (ref35) 2012; 315 G Camussi (ref4) 2011; 1 M Galie (ref14) 2008; 27 AK Olsson (ref42) 2006; 7 KJ Livak (ref27) 2001; 25 G Raposo (ref1) 1996; 183 Y Wu (ref22) 2007; 25 ref23 A Wagatsuma (ref30) 2007; 298 Y Zhu (ref17) 2009; 23 M Yang (ref8) 2011; 10 C Grange (ref7) 2011; 71 Y Wu (ref34) 2006; 119 T Itoh (ref29) 1998; 58 A Yuan (ref32) 2009; 4 S Viaud (ref2) 2008; 40 YS Lee (ref31) 2011; 43 A Chamorro-Jorganes (ref37) 2011; 31 H Yu (ref43) 2007; 361 JA Cho (ref25) 2009; 275 J Winter (ref5) 2009; 11 K Otsu (ref24) 2009; 113 E Dejean (ref38) 2011; 25 G McMahon (ref33) 2000; 5 CL Roland (ref36) 2009; 4 AH Klopp (ref18) 2011; 29 BM Beckermann (ref21) 2008; 99 SA Bergfeld (ref12) 2010; 29 AY Khakoo (ref16) 2006; 203
References_xml	– volume: 1 start-page: 98 year: 2011 ident: ref4 article-title: Exosome/microvesicle-mediated epigenetic reprogramming of cells publication-title: Am J Cancer Res – volume: 361 start-page: 946 year: 2007 ident: ref43 article-title: Inhibition of corneal neovascularization by recombinant adenovirus-mediated sFlk-1 expression publication-title: Biochem Biophys Res Commun doi: 10.1016/j.bbrc.2007.07.114 – volume: 99 start-page: 622 year: 2008 ident: ref21 article-title: VEGF expression by mesenchymal stem cells contributes to angiogenesis in pancreatic carcinoma publication-title: Br J Cancer doi: 10.1038/sj.bjc.6604508 – volume: 29 start-page: 249 year: 2010 ident: ref12 article-title: Bone marrow-derived mesenchymal stem cells and the tumor microenvironment publication-title: Cancer Metastasis Rev doi: 10.1007/s10555-010-9222-7 – volume: 23 start-page: 925 year: 2009 ident: ref17 article-title: Human mesenchymal stem cells inhibit cancer cell proliferation by secreting DKK-1 publication-title: Leukemia doi: 10.1038/leu.2008.384 – volume: 9 start-page: 654 year: 2007 ident: ref3 article-title: Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells publication-title: Nat Cell Biol doi: 10.1038/ncb1596 – volume: 19 start-page: 205 year: 2009 ident: ref19 article-title: AngiomiRs – key regulators of angiogenesis publication-title: Curr Opin Genet Dev doi: 10.1016/j.gde.2009.04.002 – volume: 43 start-page: 281 year: 2011 ident: ref31 article-title: Introduction of the CIITA gene into tumor cells produces exosomes with enhanced anti-tumor effects publication-title: Exp Mol Med doi: 10.3858/emm.2011.43.5.029 – volume: 119 start-page: 1519 year: 2006 ident: ref34 article-title: The vascular endothelial growth factor receptor (VEGFR-1) supports growth and survival of human breast carcinoma publication-title: Int J Cancer doi: 10.1002/ijc.21865 – volume: 274 start-page: 31047 year: 1999 ident: ref41 article-title: Vascular endothelial growth factor effect on endothelial cell proliferation, migration, and platelet-activating factor synthesis is Flk-1-dependent publication-title: J Biol Chem doi: 10.1074/jbc.274.43.31047 – volume: 5 start-page: 3 year: 2000 ident: ref33 article-title: VEGF receptor signaling in tumor angiogenesis publication-title: Oncologist doi: 10.1634/theoncologist.5-suppl_1-3 – volume: 5 start-page: e11803 year: 2010 ident: ref28 article-title: Microvesicles derived from adult human bone marrow and tissue specific mesenchymal stem cells shuttle selected pattern of miRNAs publication-title: PLoS One doi: 10.1371/journal.pone.0011803 – volume: 203 start-page: 1235 year: 2006 ident: ref16 article-title: Human mesenchymal stem cells exert potent antitumorigenic effects in a model of Kaposi's sarcoma publication-title: J Exp Med doi: 10.1084/jem.20051921 – volume: 10 start-page: 117 year: 2011 ident: ref8 article-title: Microvesicles secreted by macrophages shuttle invasion-potentiating microRNAs into breast cancer cells publication-title: Mol Cancer doi: 10.1186/1476-4598-10-117 – volume: 27 start-page: 2542 year: 2008 ident: ref14 article-title: Mesenchymal stem cells share molecular signature with mesenchymal tumor cells and favor early tumor growth in syngeneic mice publication-title: Oncogene doi: 10.1038/sj.onc.1210920 – volume: 1 start-page: e116 year: 2006 ident: ref39 article-title: MiRNA-directed regulation of VEGF and other angiogenic factors under hypoxia publication-title: PLoS One doi: 10.1371/journal.pone.0000116 – volume: 31 start-page: 2595 year: 2011 ident: ref37 article-title: MicroRNA-16 and microRNA-424 regulate cell-autonomous angiogenic functions in endothelial cells via targeting vascular endothelial growth factor receptor-2 and fibroblast growth factor receptor-1 publication-title: Arterioscler Thromb Vasc Biol doi: 10.1161/ATVBAHA.111.236521 – volume: 315 start-page: 28 year: 2012 ident: ref35 article-title: Exosomes derived from human bone marrow mesenchymal stem cells promote tumor growth in vivo publication-title: Cancer Lett doi: 10.1016/j.canlet.2011.10.002 – year: 2012 ident: ref44 article-title: Tumor-Derived Microvesicles and the Cancer Microenvironment publication-title: Curr Mol Med – volume: 183 start-page: 1161 year: 1996 ident: ref1 article-title: B lymphocytes secrete antigen-presenting vesicles publication-title: J Exp Med doi: 10.1084/jem.183.3.1161 – volume: 4 start-page: e7669 year: 2009 ident: ref36 article-title: Cytokine levels correlate with immune cell infiltration after anti-VEGF therapy in preclinical mouse models of breast cancer publication-title: PLoS One doi: 10.1371/journal.pone.0007669 – volume: 298 start-page: 151 year: 2007 ident: ref30 article-title: Endogenous expression of angiogenesis-related factors in response to muscle injury publication-title: Mol Cell Biochem doi: 10.1007/s11010-006-9361-x – volume: 237 start-page: 97 year: 1999 ident: ref40 article-title: Vascular permeability factor/vascular endothelial growth factor and the significance of microvascular hyperpermeability in angiogenesis publication-title: Curr Top Microbiol Immunol – volume: 275 start-page: 256 year: 2009 ident: ref25 article-title: MHC independent anti-tumor immune responses induced by Hsp70-enriched exosomes generate tumor regression in murine models publication-title: Cancer Lett doi: 10.1016/j.canlet.2008.10.021 – volume: 25 start-page: 1882 year: 2011 ident: ref38 article-title: Hypoxia-microRNA-16 downregulation induces VEGF expression in anaplastic lymphoma kinase (ALK)-positive anaplastic large-cell lymphomas publication-title: Leukemia doi: 10.1038/leu.2011.168 – ident: ref23 doi: 10.1002/stem.1247 – volume: 113 start-page: 4197 year: 2009 ident: ref24 article-title: Concentration-dependent inhibition of angiogenesis by mesenchymal stem cells publication-title: Blood doi: 10.1182/blood-2008-09-176198 – volume: 54 start-page: 1237 year: 2011 ident: ref26 article-title: Intercellular nanovesicle-mediated microRNA transfer: a mechanism of environmental modulation of hepatocellular cancer cell growth publication-title: Hepatology doi: 10.1002/hep.24504 – volume: 101 start-page: 2087 year: 2010 ident: ref9 article-title: Circulating microRNA in body fluid: a new potential biomarker for cancer diagnosis and prognosis publication-title: Cancer Sci doi: 10.1111/j.1349-7006.2010.01650.x – volume: 56 start-page: 4032 year: 1996 ident: ref20 article-title: Complete inhibition of angiogenesis and growth of microtumors by anti-vascular endothelial growth factor neutralizing antibody: novel concepts of angiostatic therapy from intravital videomicroscopy publication-title: Cancer Res – volume: 51 start-page: 25 year: 2011 ident: ref6 article-title: microRNAs: Master regulators as potential therapeutics in cancer publication-title: Annu Rev Pharmacol Toxicol doi: 10.1146/annurev-pharmtox-010510-100517 – volume: 25 start-page: 2648 year: 2007 ident: ref22 article-title: Mesenchymal stem cells enhance wound healing through differentiation and angiogenesis publication-title: Stem Cells doi: 10.1634/stemcells.2007-0226 – volume: 29 start-page: 11 year: 2011 ident: ref18 article-title: Concise review: Dissecting a discrepancy in the literature: do mesenchymal stem cells support or suppress tumor growth? publication-title: Stem Cells doi: 10.1002/stem.559 – volume: 58 start-page: 1048 year: 1998 ident: ref29 article-title: Reduced angiogenesis and tumor progression in gelatinase A-deficient mice publication-title: Cancer Res – volume: 102 start-page: 3837 year: 2003 ident: ref13 article-title: Immunosuppressive effect of mesenchymal stem cells favors tumor growth in allogeneic animals publication-title: Blood doi: 10.1182/blood-2003-04-1193 – volume: 4 start-page: e4722 year: 2009 ident: ref32 article-title: Transfer of microRNAs by embryonic stem cell microvesicles publication-title: PLoS One doi: 10.1371/journal.pone.0004722 – volume: 40 start-page: 82 year: 2008 ident: ref2 article-title: Exosomes for the treatment of human malignancies publication-title: Horm Metab Res doi: 10.1055/s-2007-1022548 – ident: ref10 doi: 10.1002/ijc.27657 – volume: 71 start-page: 5346 year: 2011 ident: ref7 article-title: Microvesicles released from human renal cancer stem cells stimulate angiogenesis and formation of lung premetastatic niche publication-title: Cancer Res doi: 10.1158/0008-5472.CAN-11-0241 – volume: 7 start-page: 359 year: 2006 ident: ref42 article-title: VEGF receptor signalling – in control of vascular function publication-title: Nat Rev Mol Cell Biol doi: 10.1038/nrm1911 – volume: 449 start-page: 557 year: 2007 ident: ref15 article-title: Mesenchymal stem cells within tumour stroma promote breast cancer metastasis publication-title: Nature doi: 10.1038/nature06188 – volume: 25 start-page: 402 year: 2001 ident: ref27 article-title: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method publication-title: Methods doi: 10.1006/meth.2001.1262 – start-page: 263 year: 2007 ident: ref45 article-title: The participation of mesenchymal stem cells in tumor stroma formation and their application as targeted-gene delivery vehicles publication-title: Handb Exp Pharmacol doi: 10.1007/978-3-540-68976-8_12 – volume: 11 start-page: 228 year: 2009 ident: ref5 article-title: Many roads to maturity: microRNA biogenesis pathways and their regulation publication-title: Nat Cell Biol doi: 10.1038/ncb0309-228 – volume: 8 start-page: 726 year: 2008 ident: ref11 article-title: Mesenchymal stem cells in health and disease publication-title: Nat Rev Immunol doi: 10.1038/nri2395
SSID	ssj0053866
Score	2.6333275
Snippet	Exosomes are small membrane vesicles released by a variety of cell types. Exosomes contain genetic materials, such as mRNAs and microRNAs (miRNAs), implying...
SourceID	plos doaj pubmedcentral proquest gale pubmed crossref
SourceType	Open Website Open Access Repository Aggregation Database Index Database Enrichment Source
StartPage	e84256
SubjectTerms	Angiogenesis Animals Biology Blotting, Western Breast cancer Breast Neoplasms - metabolism Breast Neoplasms - physiopathology Cancer Cancer cells Cell interactions Cell Line, Tumor Cell migration Development and progression DNA Primers - genetics Enzyme-Linked Immunosorbent Assay Exosomes Exosomes - metabolism Female Gene Expression Regulation, Neoplastic - physiology Hostages Immunohistochemistry Immunomodulation In vivo methods and tests Medical research Medicine Membrane vesicles Mesenchymal stem cells Mesenchymal Stem Cells - cytology Mesenchyme Mice Mice, Inbred BALB C MicroRNA MicroRNAs - metabolism miRNA Neovascularization, Pathologic - metabolism Paracrine signalling Physicians Real-Time Polymerase Chain Reaction Ribonucleic acid RNA Stem cells Tumor cells Tumor Microenvironment - physiology Tumors Vascular endothelial growth factor Vascular Endothelial Growth Factor A - metabolism Vesicles
SummonAdditionalLinks	– databaseName: Biological Science Database dbid: M7P link: http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV3db9MwELeg8MALML4WGGAQEvAQlsRpHD-hrmsBCca0QbW3KLGdrFKblKadNok_njvHDQRNgMRDpMi-WMn57uxz7n5HyAuhwByyKHZlyvHoxldG59wQlgIG66_XRFtMPvKDg_jkRBzaA7fahlVubKIx1KqSeEa-64ecgcX1uHi7-OZi1Sj8u2pLaFwl1xAlgZnQvcONJQZdjiKbLse4v2tn582iKjXCmoK4Rp3lyKD2t7a5t5hV9WUbz9_jJ39ZkMa3_vdTbpObditKB43sbJErurxDtqyy1_SVRaR-fZd8H51XdTWHxn0Q2DOtKGal0E-YuSRPL-YwyvFKz-lQz2Y1xUKh6MTTQVlMqwKN6bSm2QXdB4_fPdKFqRhWFnQyejemo3MbilvSaUn3MEZ-RYcoi8tmvHvk63j0ZfjetWUbXBmJYOVmOedcp76XBTLV4ED6aZ4GXhazKOoLFWR5FIpMShGyHPEGFaLWMb8v49Tjec7YfdIrYYq2CY1w-dSMe7nqh0qmIk7DPOOegm0NuFq5Q9hm9hJpMc2xtMYsMT_qOPg2DS8TnPPEzrlD3PapRYPp8Rf6PRSMlhYRuU1DtSwSq-BJLHUWMK5YP1KhHwRCythjCu4ZU9DmkKcoVkmT3tralWQQci4CcKo9hzw3FIjKUWLYT5Gu6zr58HnyD0THRx2il5Yor4AdMrWpFvBNiPbVodzpUIJtkZ3ubVSCDVfq5KfowpMb4b68-1nbjYNiKF-pqzXS4HkMXLFDHjR61HI2wDxwEYQO4R0N67C-21NOTw0oOovBT-yLh39-rUfkRoD1TAxS5w7prZZr_Zhcl2erab18YqzHD6r6eOQ priority: 102 providerName: ProQuest – databaseName: Public Library of Science (PLoS) Journals Open Access dbid: FPL link: http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV3db9MwELeg8MALML4WGGAQEvAQSOw0jh-7rgWkMaYNqr1Fie10ldqkatJpk_jjuUvcQKZNwEOkyD5byfk-fMndz4S8kRrMIQ8jVyUCP934utY5NwBXwMH_ek22xWRfHBxEJyfy8HegeOkPPhf-R8vTD8siNwhGCkIW3iS3GA9DTOEaH-5vLC_obhja8rjrRnbcT43S39ri3nJelFdtNC_nS_7hgMb3_vfR75O7dqtJB41sbJEbJn9Atqwyl_SdRZx-_5D8HJ0XZbGAxj0QyDOjKVad0K9YmaROLxYwy3FlFnRo5vOS4kGgGKTTQT6dFVM0lrOSphd0DyJ696g53B48Ip2MPo3p6Nym2uZ0ltNdzIGv6BBlbdXM94j8GI--Dz-79lgGV4WSVW6aCSFM4nspU4mBANFPsoR5aQQr0peapVkYyFQpGfAM8QQ1otJxv6-ixBNZxvlj0suBI9uEhugeDRdepvuBVomMkiBLhadh2wKhVOYQvlmtWFnMcjw6Yx7XP-IExC4NL2NkcWxZ7BC3HbVsMDv-Qr-LgtDSIuJ23QBrGVsFjiNlUsaF5v1QBz5jUqnI4xruOdfQ5pCXKEZxU77a2o14EAghGQTNnkNe1xSIupFjWs80WZdl_OXb5B-Ijo86RG8tUVYAO1RiSyngnRDNq0O506EE26E63dso9BuulBAICg77Gk9IGLlRhKu7X7XdOCmm6uWmWCMNfm-BK3LIk0ZvWs4yrPOGiN8hoqNRHdZ3e_LZaQ16ziOIA_vy6fVP_IzcYXhWSY3CuUN61WptnpPb6qyalasXtaX4BY72Zzw priority: 102 providerName: Public Library of Science
Title	Exosomes Derived from Mesenchymal Stem Cells Suppress Angiogenesis by Down-Regulating VEGF Expression in Breast Cancer Cells
URI	https://www.ncbi.nlm.nih.gov/pubmed/24391924 https://www.proquest.com/docview/1473341079 https://www.proquest.com/docview/1490749078 https://pubmed.ncbi.nlm.nih.gov/PMC3877259 https://doaj.org/article/8ceb237d356d41229cc803dd4133d56d http://dx.doi.org/10.1371/journal.pone.0084256
Volume	8
WOSCitedRecordID	wos000329323900067&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
hasFullText	1
inHoldings	1
isFullTextHit
isPrint
journalDatabaseRights	– providerCode: PRVAON databaseName: DOAJ Directory of Open Access Journals customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: DOA dateStart: 20060101 isFulltext: true titleUrlDefault: https://www.doaj.org/ providerName: Directory of Open Access Journals – providerCode: PRVHPJ databaseName: ROAD: Directory of Open Access Scholarly Resources customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: M~E dateStart: 20060101 isFulltext: true titleUrlDefault: https://road.issn.org providerName: ISSN International Centre – providerCode: PRVPQU databaseName: Advanced Technologies & Aerospace Database customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: P5Z dateStart: 20061201 isFulltext: true titleUrlDefault: https://search.proquest.com/hightechjournals providerName: ProQuest – providerCode: PRVPQU databaseName: Agricultural Science Database customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: M0K dateStart: 20061201 isFulltext: true titleUrlDefault: https://search.proquest.com/agriculturejournals providerName: ProQuest – providerCode: PRVPQU databaseName: Biological Science Database customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: M7P dateStart: 20061201 isFulltext: true titleUrlDefault: http://search.proquest.com/biologicalscijournals providerName: ProQuest – providerCode: PRVPQU databaseName: Engineering Database customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: M7S dateStart: 20061201 isFulltext: true titleUrlDefault: http://search.proquest.com providerName: ProQuest – providerCode: PRVPQU databaseName: Environmental Science Database customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: PATMY dateStart: 20061201 isFulltext: true titleUrlDefault: http://search.proquest.com/environmentalscience providerName: ProQuest – providerCode: PRVPQU databaseName: Health & Medical Collection customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: 7X7 dateStart: 20061201 isFulltext: true titleUrlDefault: https://search.proquest.com/healthcomplete providerName: ProQuest – providerCode: PRVPQU databaseName: Materials Science Database customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: KB. dateStart: 20061201 isFulltext: true titleUrlDefault: http://search.proquest.com/materialsscijournals providerName: ProQuest – providerCode: PRVPQU databaseName: Nursing & Allied Health Database customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: 7RV dateStart: 20061201 isFulltext: true titleUrlDefault: https://search.proquest.com/nahs providerName: ProQuest – providerCode: PRVPQU databaseName: ProQuest Central customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: BENPR dateStart: 20061201 isFulltext: true titleUrlDefault: https://www.proquest.com/central providerName: ProQuest – providerCode: PRVPQU databaseName: Public Health Database (ProQuest) customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: 8C1 dateStart: 20061201 isFulltext: true titleUrlDefault: https://search.proquest.com/publichealth providerName: ProQuest – providerCode: PRVPQU databaseName: Publicly Available Content Database customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: PIMPY dateStart: 20061201 isFulltext: true titleUrlDefault: http://search.proquest.com/publiccontent providerName: ProQuest – providerCode: PRVATS databaseName: PLOS customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: FPL dateStart: 20060101 isFulltext: true titleUrlDefault: http://www.plos.org/publications/ providerName: Public Library of Science
link	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV3db9MwELeg8MAL2vha2CgGIQEP2ZI4iZ3HdWph2laiDqrCS5TYSVdpTaqmnTaJP567xI0WNGk88NBTZV-s9Hy-87l3PxPyIVBgDpkvTBlzPLqxVbXmTBdcAQP_a9XZFuNTPhyKySQIb131hTlhNTxwLbgDISH2Y1wxz1eu7TiBlMJiCr4zpqANrS_sejbBVG2DYRX7vi6UY9w-0POyvyjyFAFNQVH9liOq8Pobq9xZXBblXVvOvzMnb7miwRZ5qveQ9LB-923yIM2fkW29Skv6SUNJf35Ofvevi7KYQ6MCTbtKFcVyEjrHkiN5cTOHURDImeLxfUnL9aJKi6VxPp0VU7SCs5ImN1RBqG4u61vrwdXRcf_LgKbXOoc2p7OcJpjcvqISlWhZj_eC_Bj0vx99NfV9C6b0A2dlJhnnPI1tK3FknELkZ8dZ7FiJYL7vBcpJMt8NEikDl2UIFKgQbo7ZnhSxxbOMsZekk4OEdwj10e-ljFuZ8lwl40DEbpZwS8F-BGKkzCBsI_xIajByvBPjMqr-YeMQlNSyjHDKIj1lBjGbpxY1GMc9_D2c14YXobSrBlCwSCtYdJ-CGeQtakVU16U2BiE6dDkPHIiGLYO8rzgQTiPHfJ1pvC7L6Pjb-B-Yzkctpo-aKStAHDLWNRLwmxCmq8W51-IEoyBb3TuowxuplBDhcQYbFosH8ORGr-_uftd046CYg5enxRp58CAFPsIgr-pl0EjWwQJuCOUNwlsLpCX6dk8-u6jQzJmAAM8LXv-PudolTxy8rqQC4twjndVynb4hj-XValYuu-QhH42RTnhFBVBxZHfJo15_GI66lQkBOghPgZ709oGeWSdIeVjRc6Ch9wueCI_Pwp9_ADS1eJ8
linkProvider	Directory of Open Access Journals
linkToHtml	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1Lb9NAEF5VBQkuQHk1UOiCQMDB1N51vPYBoTZJadQ2oLZEvRl7d-1GSu0QJ20j8Zv4jcz4BUYVcOmBQ6Rod2w5k_m-2V3Pg5AXngI65I5ryEDg0Y2lcswZNrgCDv7XLKIthntiMHCPj71PS-R7lQuDYZUVJ-ZErVKJZ-Qbli04MK4pvPeTrwZ2jcK3q1ULjcIsdvXiHLZs2bt-F_7fl4xt9446O0bZVcCQjsdmRhgJIXRgmSGTgYb9jRVEATNDlztO21MsjBzbC6X0bB5hOTyFRdW41ZZuYIoowgNQoPxrwOMWhpCJg2HF_MAdjlOm53FhbZTW8HaSJhrLqAI8nIb7y7sE1L5geTJOs8sWur_Ha_7iALdv_2-qu0NulUttullgY4Us6eQuWSnJLKOvy4rbb-6Rb72LNEtPYbALgDzTimLWDd3HzCx5sjiFuxzO9Cnt6PE4o9gIFQ8p6GYSj9IYncUoo-GCdtPzxDjQcd4RLYnpsPdhm_YuylDjhI4SuoU5ADPaQaxNi_vdJ5-vRAsPyHICJrFKqIPLA82FGam2rWTguYEdhcJUsGyDrWTUIryyFl-WNduxdcjYz19ECti7Fbr00cb80sZaxKivmhQ1S_4iv4WGWMtixfF8IJ3Gfklgvit1yLhQvO0o22LMk9I1uYLvnCsYa5F1NGO_SN-tedPftIXwmLCE2SLPcwmsOpJgWFMczLPM738c_oPQ4UFD6FUpFKWgDhmUqSTwm7CaWUNyrSEJ3Ckb06sIukormf8TKnBlBabLp5_V03hTDFVMdDpHGTxvgo_bIg8L3NaaZZjn7jG7RUQD0Q3VN2eS0Ule9J27sA9ue4_-_Fjr5MbO0f6ev9cf7D4mNxn2bsmrkq6R5dl0rp-Q6_JsNsqmT3PmouTLVeP9B3F_1XI
linkToPdf	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1Lb9NAEF5VASEuQHk1UOiCQMDB1N51vPYBoTQPiFpC1ULUm7F312mk1A5x-pL4Zfw6ZuyNwagCLj1wiBTtji1nMt_M7nrmG0KeBQrcIfd8S0YCj24cVWDOciEUcIi_dpltMdoRw6F_cBDsrpDvy1oYTKtc-sTCUatM4hn5puMKDh7XFsFmYtIidrv9t7OvFnaQwjety3YapYls6_NT2L7lbwZd-K-fM9bvfeq8t0yHAUt6AVtYcSKE0JFjx0xGGvY6TpREzI597nmtQLE48dwgljJweYLUeAoJ1rjTkn5kiyTBw1Bw_1cEByvGKvVOlV4CfsTzTKkeF86msYzXsyzVSKkKUPFqobDoGFDFhcZsmuUXLXp_z938JRj2b_7ParxFbpglOG2XmFklKzq9TVaNk8vpS8PE_eoO-dY7y_LsCAa7ANQTrShW49APWLElD8-P4C77C31EO3o6zSk2SMXDC9pOx5NsjEFkktP4nHaz09Ta0-OiU1o6pqPeuz7tnZkU5JROUrqFtQEL2kEMzsv73SWfL0UL90gjBfNYI9TDZYPmwk5Uy1UyCvzITWJhK1jOwRYzaRK-tJxQGi53bCkyDYsXlAL2dKUuQ7S30Nhbk1jVVbOSy-Qv8ltolJUsMpEXA9l8HBrHFvpSx4wLxVuech3GAil9myv4zrmCsSbZQJMOy7Leyp-GbVeIgAlH2E3ytJBANpIUDXIcHed5OPg4-geh_b2a0AsjlGSgDhmZEhP4TchyVpNcr0mCT5W16TUE4FIrefgTNnDlElgXTz-ppvGmmMKY6uwYZfAcCj5-k9wvMVxplmH9e8DcJhE1dNdUX59JJ4cFGTz3YX_cCh78-bE2yDWAebgzGG4_JNcZtnQpyErXSWMxP9aPyFV5spjk88eFE6Pky2XD_QeoiN3N
openUrl	ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Exosomes+derived+from+mesenchymal+stem+cells+suppress+angiogenesis+by+down-regulating+VEGF+expression+in+breast+cancer+cells&rft.jtitle=PloS+one&rft.au=Lee%2C+Jong-Kuen&rft.au=Park%2C+Sae-Ra&rft.au=Jung%2C+Bong-Kwang&rft.au=Jeon%2C+Yoon-Kyung&rft.date=2013-12-31&rft.issn=1932-6203&rft.eissn=1932-6203&rft.volume=8&rft.issue=12&rft.spage=e84256&rft_id=info:doi/10.1371%2Fjournal.pone.0084256&rft.externalDBID=NO_FULL_TEXT
thumbnail_l	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1932-6203&client=summon
thumbnail_m	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1932-6203&client=summon
thumbnail_s	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1932-6203&client=summon