TLR9 Mediates Remote Liver Injury following Severe Renal Ischemia Reperfusion

Ischemia reperfusion injury is a common cause of acute kidney injury and is characterized by tubular damage. Mitochondrial DNA is released upon severe tissue injury and can act as a damage-associated molecular pattern via the innate immune receptor TLR9. Here, we investigated the role of TLR9 in the...

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Bibliographic Details
Published in:	PloS one Vol. 10; no. 9; p. e0137511
Main Authors:	Bakker, Pieter J., Scantlebery, Angelique M., Butter, Loes M., Claessen, Nike, Teske, Gwendoline J. D., van der Poll, Tom, Florquin, Sandrine, Leemans, Jaklien C.
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 11.09.2015 Public Library of Science (PLoS)
Subjects:	Abdomen Alanine Transaminase - blood Animals Cell Line Complications and side effects Damage patterns Deoxyribonucleic acid DNA DNA damage Gangrene Genetic aspects Health aspects Hepatology Immune system Inflammation Injuries Ischemia Kidney - blood supply Kidney - metabolism Kidney - pathology Kidneys L-Lactate Dehydrogenase - blood Liver Liver - metabolism Liver - pathology Male Mice Mice, Inbred C57BL Mitochondrial DNA Necrosis Pathology Renal function Reperfusion Reperfusion injury Reperfusion Injury - metabolism Reperfusion Injury - pathology Rodents Survival TLR9 protein Toll-Like Receptor 9 - genetics Toll-Like Receptor 9 - metabolism Toll-like receptors Well being
ISSN:	1932-6203, 1932-6203
Online Access:	Get full text
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