Mitochondrial Mutations in Subjects with Psychiatric Disorders

A considerable body of evidence supports the role of mitochondrial dysfunction in psychiatric disorders and mitochondrial DNA (mtDNA) mutations are known to alter brain energy metabolism, neurotransmission, and cause neurodegenerative disorders. Genetic studies focusing on common nuclear genome vari...

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Bibliographic Details
Published in:	PloS one Vol. 10; no. 5; p. e0127280
Main Authors:	Sequeira, Adolfo, Rollins, Brandi, Magnan, Christophe, van Oven, Mannis, Baldi, Pierre, Myers, Richard M., Barchas, Jack D., Schatzberg, Alan F., Watson, Stanley J., Akil, Huda, Bunney, William E., Vawter, Marquis P.
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 26.05.2015 Public Library of Science (PLoS)
Subjects:	Adult Bipolar disorder Brain Case-Control Studies Deoxyribonucleic acid Disorders DNA DNA Mutational Analysis DNA, Mitochondrial - genetics Electrophoresis, Agar Gel Energy metabolism Female Gene sequencing Genes Genetic aspects Genetic Loci Genomes Genomic instability Genomics Genotyping Heteroplasmy Humans Male Mental depression Mental disorders Mental Disorders - blood Mental Disorders - genetics Metabolism Methamphetamine Middle Aged Mitochondrial DNA Molecular Sequence Data Mutation Mutation - genetics Neurodegenerative diseases Neurotransmission Physiological aspects Prefrontal Cortex - pathology Schizophrenia Stability Studies
ISSN:	1932-6203, 1932-6203
Online Access:	Get full text
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