Somatic histone H3 alterations in pediatric diffuse intrinsic pontine gliomas and non-brainstem glioblastomas

Suzanne Baker and colleagues sequenced the whole genomes of seven pediatric brainstem glioblastomas and matched normal tissue. They found that 78% of diffuse intrinsic pontine gliomas and 22% of non-brainstem pediatric glioblastomas contained a mutation in H3F3A , encoding histone H3.3, or in the re...

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Bibliographic Details
Published in:	Nature genetics Vol. 44; no. 3; pp. 251 - 253
Main Authors:	GANG WU, BRONISCER, Alberto, JUNYUAN ZHANG, GAJJAR, Amar, DYER, Michael A, MULLIGHAN, Charles G, GILBERTSON, Richard J, MARDIS, Elaine R, WILSON, Richard K, DOWNING, James R, ELLISON, David W, JINGHUI ZHANG, MCEACHRON, Troy A, BAKER, Suzanne J, LU, Charles, PAUGH, Barbara S, BECKSFORT, Jared, CHUNXU QU, LI DING, HUETHER, Robert, PARKER, Matthew
Format:	Journal Article
Language:	English
Published:	New York Nature Publishing Group US 01.03.2012 Nature Publishing Group
Subjects:	631/208/68 631/378/1689/1690 692/699/67/2332 Agriculture Amino acids Animal Genetics and Genomics Base Sequence Binding sites Bioinformatics Biological and medical sciences Biomedical and Life Sciences Biomedicine Brain Brain cancer Brain Stem Neoplasms - genetics Brain Stem Neoplasms - pathology brief-communication Cancer Research Children & youth Epigenetics Fundamental and applied biological sciences. Psychology Gene Function Genetic aspects Genetics of eukaryotes. Biological and molecular evolution Genome, Human - genetics Genomes Glioblastoma - genetics Glioblastoma multiforme Gliomas Histones - genetics Human Genetics Humans Kinases Medical sciences Molecular Sequence Data Mutation Mutation, Missense - genetics Neurology Pediatrics Pons - pathology Proteins Risk factors Sequence Analysis, DNA Single nucleotide polymorphisms Tumors of the nervous system. Phacomatoses United States Malignant glioma Pediatrics Nervous system diseases Central nervous system disease Glioblastoma Alteration Malignant tumor Histone H3 Cancer
ISSN:	1061-4036, 1546-1718, 1546-1718
Online Access:	Get full text
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