Aetiology-Specific Estimates of the Global and Regional Incidence and Mortality of Diarrhoeal Diseases Commonly Transmitted through Food

Diarrhoeal diseases are major contributors to the global burden of disease, particularly in children. However, comprehensive estimates of the incidence and mortality due to specific aetiologies of diarrhoeal diseases are not available. The objective of this study is to provide estimates of the globa...

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Vydáno v:PloS one Ročník 10; číslo 12; s. e0142927
Hlavní autoři: Pires, Sara M., Fischer-Walker, Christa L., Lanata, Claudio F., Devleesschauwer, Brecht, Hall, Aron J., Kirk, Martyn D., Duarte, Ana S. R., Black, Robert E., Angulo, Frederick J.
Médium: Journal Article
Jazyk:angličtina
Vydáno: United States Public Library of Science 03.12.2015
Public Library of Science (PLoS)
Témata:
Adolescent
Adult
Age
Age Factors
Aged
Aged, 80 and over
Australia
Caliciviridae Infections - epidemiology
Caliciviridae Infections - mortality
Child
Child, Preschool
Children
Collaboration
Cost of Illness
Demographic aspects
Denmark
Diarrhea
Diarrhea - epidemiology
Diarrhea - etiology
Diarrhea - mortality
Disease control
Disease transmission
Diseases
Dysentery, Bacillary - epidemiology
Dysentery, Bacillary - mortality
E coli
Enterotoxigenic Escherichia coli
Epidemiology
Escherichia coli
Escherichia coli Infections - epidemiology
Escherichia coli Infections - mortality
Estimates
Etiology
Fatalities
Female
Food
Foodborne Diseases - epidemiology
Foodborne Diseases - etiology
Foodborne Diseases - mortality
Gastroenteritis - epidemiology
Gastroenteritis - mortality
Giardia
Giardia lamblia
Giardiasis - epidemiology
Giardiasis - mortality
Global Health
Humans
Illnesses
Incidence
Infant
Infant, Newborn
Infections
Male
Middle Aged
Mortality
Norovirus
Pathogens
Prognosis
Public health
Shigella
Studies
Young Adult
Denmark
Australia
ISSN:1932-6203, 1932-6203
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Shrnutí:Diarrhoeal diseases are major contributors to the global burden of disease, particularly in children. However, comprehensive estimates of the incidence and mortality due to specific aetiologies of diarrhoeal diseases are not available. The objective of this study is to provide estimates of the global and regional incidence and mortality of diarrhoeal diseases caused by nine pathogens that are commonly transmitted through foods. We abstracted data from systematic reviews and, depending on the overall mortality rates of the country, applied either a national incidence estimate approach or a modified Child Health Epidemiology Reference Group (CHERG) approach to estimate the aetiology-specific incidence and mortality of diarrhoeal diseases, by age and region. The nine diarrhoeal diseases assessed caused an estimated 1.8 billion (95% uncertainty interval [UI] 1.1-3.3 billion) cases and 599,000 (95% UI 472,000-802,000) deaths worldwide in 2010. The largest number of cases were caused by norovirus (677 million; 95% UI 468-1,153 million), enterotoxigenic Escherichia coli (ETEC) (233 million; 95% UI 154-380 million), Shigella spp. (188 million; 95% UI 94-379 million) and Giardia lamblia (179 million; 95% UI 125-263); the largest number of deaths were caused by norovirus (213,515; 95% UI 171,783-266,561), enteropathogenic E. coli (121,455; 95% UI 103,657-143,348), ETEC (73,041; 95% UI 55,474-96,984) and Shigella (64,993; 95% UI 48,966-92,357). There were marked regional differences in incidence and mortality for these nine diseases. Nearly 40% of cases and 43% of deaths caused by these nine diarrhoeal diseases occurred in children under five years of age. Diarrhoeal diseases caused by these nine pathogens are responsible for a large disease burden, particularly in children. These aetiology-specific burden estimates can inform efforts to reduce diarrhoeal diseases caused by these nine pathogens commonly transmitted through foods.
Bibliografie:ObjectType-Article-1
SourceType-Scholarly Journals-1
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Competing Interests: The authors have declared that no competing interests exist.
Analyzed the data: SMP. Wrote the paper: SMP CLFW CFL BD AJH ASRD REB MDK FJA.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0142927