Impact of MIF Gene Promoter Polymorphism on F508del Cystic Fibrosis Patients

Macrophage migration Inhibitory Factor (MIF) is a pro-inflammatory cytokine sustaining the acute response to gram-negative bacteria and a regulatory role for MIF in Cystic Fibrosis has been suggested by the presence of a functional, polymorphic, four-nucleotide repeat in this gene's promoter at...

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Bibliographic Details
Published in:	PloS one Vol. 9; no. 12; p. e114274
Main Authors:	Melotti, Paola, Mafficini, Andrea, Lebecque, Patrick, Ortombina, Myriam, Leal, Teresinha, Pintani, Emily, Pepermans, Xavier, Sorio, Claudio, Assael, Baroukh Maurice
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 12.12.2014 Public Library of Science (PLoS)
Subjects:	Adult Age Age of Onset Alleles Biology and life sciences Colonization Comparative analysis Cystic fibrosis Cystic Fibrosis - epidemiology Cystic Fibrosis - genetics Cystic Fibrosis - microbiology Cystic Fibrosis - physiopathology Cystic fibrosis transmembrane conductance regulator Cystic Fibrosis Transmembrane Conductance Regulator - genetics Cytokines Deoxyribonucleic acid Diabetes Disease DNA E coli Female Forced Expiratory Volume Gene polymorphism Genes Genetic aspects Genetic polymorphisms Genomes Genotype Genotypes Gram-negative bacteria Homozygote Humans Infections Inflammation Leukocyte migration Lung - microbiology Lung - physiopathology Lungs Macrophage migration inhibitory factor Macrophage Migration-Inhibitory Factors - genetics Macrophages Male Medicine and Health Sciences Multiple regression analysis Mutation Patients Physical Sciences Point mutation Polymorphism Polymorphism, Genetic Promoter Regions, Genetic - genetics Pseudomonas aeruginosa Pseudomonas aeruginosa - physiology Regression analysis Repetitive Sequences, Nucleic Acid - genetics Research and Analysis Methods Respiratory function Rheumatoid arthritis Sepsis Young Adult Belgium Italy
ISSN:	1932-6203, 1932-6203
Online Access:	Get full text
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