Integrating mRNA and miRNA Weighted Gene Co-Expression Networks with eQTLs in the Nucleus Accumbens of Subjects with Alcohol Dependence

Alcohol consumption is known to lead to gene expression changes in the brain. After performing weighted gene co-expression network analyses (WGCNA) on genome-wide mRNA and microRNA (miRNA) expression in Nucleus Accumbens (NAc) of subjects with alcohol dependence (AD; N = 18) and of matched controls...

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Bibliographic Details
Published in:	PloS one Vol. 10; no. 9; p. e0137671
Main Authors:	Mamdani, Mohammed, Williamson, Vernell, McMichael, Gowon O., Blevins, Tana, Aliev, Fazil, Adkins, Amy, Hack, Laura, Bigdeli, Tim, D. van der Vaart, Andrew, Web, Bradley Todd, Bacanu, Silviu-Alin, Kalsi, Gursharan, Kendler, Kenneth S., Miles, Michael F., Dick, Danielle, Riley, Brien P., Dumur, Catherine, Vladimirov, Vladimir I.
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 18.09.2015 Public Library of Science (PLoS)
Subjects:	Alcoholism Alcoholism - genetics Alcoholism - metabolism Alcohols Analysis Astrocytes - metabolism Bioinformatics Biology Brain Brain research Cell adhesion & migration Chronic fatigue syndrome Complications and side effects Consortia Correlation Correlation analysis Drug dependence Drug use Enrichment Etiology Female Gene expression Gene Expression Profiling Gene Regulatory Networks Gene set enrichment analysis Genes Genetic analysis Genetic aspects Genetics Genomes Humans Male MAP kinase Messenger RNA MicroRNA MicroRNAs MicroRNAs - genetics MicroRNAs - metabolism Middle Aged miRNA Mitochondria Modules Network hubs Neurons - metabolism Neurosciences Nuclei Nucleus accumbens Nucleus Accumbens - metabolism Oxidative phosphorylation Phosphorylation Physiological aspects Psychiatry Quantitative Trait Loci Ribonucleic acid RNA RNA, Messenger - genetics RNA, Messenger - metabolism Signal Transduction - physiology Signaling Studies Toxicology Transcriptome Up-Regulation United States United States > US Virginia
ISSN:	1932-6203, 1932-6203
Online Access:	Get full text
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