Restoration of the Dopamine Transporter through Cell Therapy Improves Dyskinesia in a Rat Model of Parkinson’s Disease

The dyskinesia of Parkinson's Disease is most likely due to excess levels of dopamine in the striatum. The mechanism may be due to aberrant synthesis but also, a deficiency or absence of the Dopamine Transporter. In this study we have examined the proposition that reinstating Dopamine Transport...

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Vydané v:	PloS one Ročník 11; číslo 4; s. e0153424
Hlavní autori:	Tomas, D., Stanic, D., Chua, H. K., White, K., Boon, W. C., Horne, M.
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	United States Public Library of Science 14.04.2016 Public Library of Science (PLoS)
Predmet:	Aberration Alcohol Analysis Animals Behavior, Animal - drug effects Biology and Life Sciences Brain - metabolism Brain - pathology Care and treatment Cell Line Cell- and Tissue-Based Therapy Cellular therapy Cloning Complications and side effects Disease Models, Animal Dopamine Dopamine - metabolism Dopamine Plasma Membrane Transport Proteins - genetics Dopamine Plasma Membrane Transport Proteins - metabolism Dopamine transporter Dyskinesia Dyskinesia, Drug-Induced - etiology Dyskinesia, Drug-Induced - metabolism Dyskinesia, Drug-Induced - therapy Grafts Health aspects Laboratory animals Levodopa - administration & dosage Levodopa - pharmacology Male Medicine and Health Sciences Mental health Mice Movement disorders Neostriatum Neural Stem Cells - cytology Neural Stem Cells - metabolism Neural Stem Cells - transplantation Neural transmission Neurodegeneration Neurodegenerative diseases Neurosciences Oxidopamine - toxicity Parkinson Disease - metabolism Parkinson Disease - pathology Parkinson Disease - therapy Parkinson's disease Physical Sciences Rats Rats, Wistar Research and Analysis Methods Restoration Rodents Stem cells Australia
ISSN:	1932-6203, 1932-6203
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Shrnutí:	The dyskinesia of Parkinson's Disease is most likely due to excess levels of dopamine in the striatum. The mechanism may be due to aberrant synthesis but also, a deficiency or absence of the Dopamine Transporter. In this study we have examined the proposition that reinstating Dopamine Transporter expression in the striatum would reduce dyskinesia. We transplanted c17.2 cells that stably expressed the Dopamine Transporter into dyskinetic rats. There was a reduction in dyskinesia in rats that received grafts expressing the Dopamine Transporter. Strategies designed to increase Dopamine Transporter in the striatum may be useful in treating the dyskinesia associated with human Parkinson's Disease.
Bibliografia:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 Competing Interests: The authors have declared that no competing interests exist. Conceived and designed the experiments: MH WCB DS. Performed the experiments: DT DS KW HKC. Analyzed the data: MH DT. Contributed reagents/materials/analysis tools: WCB. Wrote the paper: MH.
ISSN:	1932-6203 1932-6203
DOI:	10.1371/journal.pone.0153424