Restoration of the Dopamine Transporter through Cell Therapy Improves Dyskinesia in a Rat Model of Parkinson’s Disease

The dyskinesia of Parkinson's Disease is most likely due to excess levels of dopamine in the striatum. The mechanism may be due to aberrant synthesis but also, a deficiency or absence of the Dopamine Transporter. In this study we have examined the proposition that reinstating Dopamine Transport...

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Bibliographic Details
Published in:	PloS one Vol. 11; no. 4; p. e0153424
Main Authors:	Tomas, D., Stanic, D., Chua, H. K., White, K., Boon, W. C., Horne, M.
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 14.04.2016 Public Library of Science (PLoS)
Subjects:	Aberration Alcohol Analysis Animals Behavior, Animal - drug effects Biology and Life Sciences Brain - metabolism Brain - pathology Care and treatment Cell Line Cell- and Tissue-Based Therapy Cellular therapy Cloning Complications and side effects Disease Models, Animal Dopamine Dopamine - metabolism Dopamine Plasma Membrane Transport Proteins - genetics Dopamine Plasma Membrane Transport Proteins - metabolism Dopamine transporter Dyskinesia Dyskinesia, Drug-Induced - etiology Dyskinesia, Drug-Induced - metabolism Dyskinesia, Drug-Induced - therapy Grafts Health aspects Laboratory animals Levodopa - administration & dosage Levodopa - pharmacology Male Medicine and Health Sciences Mental health Mice Movement disorders Neostriatum Neural Stem Cells - cytology Neural Stem Cells - metabolism Neural Stem Cells - transplantation Neural transmission Neurodegeneration Neurodegenerative diseases Neurosciences Oxidopamine - toxicity Parkinson Disease - metabolism Parkinson Disease - pathology Parkinson Disease - therapy Parkinson's disease Physical Sciences Rats Rats, Wistar Research and Analysis Methods Restoration Rodents Stem cells Australia
ISSN:	1932-6203, 1932-6203
Online Access:	Get full text
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