In vitro chlorhexidine release from alginate based microbeads for periodontal therapy

Periodontitis is one of the most common infectious diseases globally that, if untreated, leads to destruction of the tooth supporting tissues and finally results in tooth loss. Evidence shows that standard procedures as mechanical root cleaning could be supported by further treatment options such as...

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Veröffentlicht in:PloS one Jg. 12; H. 10; S. e0185562
Hauptverfasser: Scholz, Malte, Reske, Thomas, Böhmer, Femke, Hornung, Anne, Grabow, Niels, Lang, Hermann
Format: Journal Article
Sprache:Englisch
Veröffentlicht: United States Public Library of Science 03.10.2017
Public Library of Science (PLoS)
Schlagworte:
Alginates - chemistry
Alginic acid
Anti-Infective Agents, Local - administration & dosage
Anti-Infective Agents, Local - therapeutic use
Bacteria
Beads
Biodegradability
Biodegradation
Biology and Life Sciences
Biomedical engineering
Biomedical materials
Care and treatment
Chlorhexidine
Chlorhexidine - administration & dosage
Chlorhexidine - therapeutic use
Chromatography
Complications and side effects
Dentistry
Development and progression
Disinfection & disinfectants
Dosage and administration
Drug delivery
Drug delivery systems
Fluid dynamics
Fluid flow
Glucuronic Acid - chemistry
Gum disease
Hexuronic Acids - chemistry
High performance liquid chromatography
Humans
In Vitro Techniques
Industrial engineering
Infectious diseases
Internet
Liquid chromatography
Manufacturing engineering
Medicine and Health Sciences
Microspheres
Nanoparticles
Particle Size
Periodontal diseases
Periodontitis
Periodontitis - drug therapy
Production costs
Research and Analysis Methods
Teeth
Therapy
Tissues
Germany
ISSN:1932-6203, 1932-6203
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Beschreibung
Zusammenfassung:Periodontitis is one of the most common infectious diseases globally that, if untreated, leads to destruction of the tooth supporting tissues and finally results in tooth loss. Evidence shows that standard procedures as mechanical root cleaning could be supported by further treatment options such as locally applied substances. Due to gingival crevicular fluid flow, substances are commonly washed out off the periodontal pockets. The evaluation of administration techniques and the development of local drug releasing devices is thus an important aspect in periodontal research. This study describes the development and examination of a new alginate based, biodegradable and easily applicable drug delivery system for chlorhexidine (CHX). Different micro beads were produced and loaded with CHX and the release profiles were investigated by high performance liquid chromatography (HPLC). The in vitro-demonstrated release of CHX from alginate based beads shows comparable releasing characteristics as clinically approved systems. Yet many characteristics of this new delivery system show to be favourable for periodontal therapy. Easy application by injection, low production costs and multifunctional adaptions to patient related specifics may improve the usage in routine care.
Bibliographie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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Competing Interests: The authors have declared that no competing interests exist.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0185562